CYTIP_HUMAN 2019

Gene Name CYTIP

Description Cytohesin-interacting protein

Length 359

9606

Sequence

>sp|O60759|CYTIP_HUMAN Cytohesin-interacting protein
MSLQRLLQHSSNGNLADFCAGPAYSSYSTLTGSLTMDDNRRIQMLADTVATLPRGRKQLALTRSSSLSDFSWSQRKLVTVEKQDNETFGFEIQSYRPQNQNACSSEMFTLICKIQEDSPAHCAGLQAGDVLANINGVSTEGFTYKQVVDLIRSSGNLLTIETLNGTMILKRTELEAKLQVLKQTLKQKWVEYRSLQLQEHRLLHGDAANCPSLENMDLDELSLFGPLPGPGPALVDRNRLSSESSCKSWLSSMTMDSEDGYQTCVSEDSSRGAFSRQTSTDDECFIPKEGDDFLRRSSSRRNRSISNTSSGSMSPLWEGNLSSMFGTLPRKSRKGSVRKQLLKFIPGLHRAVEEEESRF

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

GRASP_HUMAN

General receptor for phosphoinositides 1-associated scaffold protein

0.305

CEBPG_HUMAN

CCAAT/enhancer-binding protein gamma

0.337

HEXI1_HUMAN

Protein HEXIM1

0.345

TDRKH_HUMAN

Tudor and KH domain-containing protein

0.378

BAKOR_HUMAN

Beclin 1-associated autophagy-related key regulator

0.399

TRIB2_HUMAN

Tribbles homolog 2

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

TRIB2_HUMAN

Tribbles homolog 2

0.328

PDZD2_HUMAN

PDZ domain-containing protein 2

0.336

SH2D3_HUMAN

SH2 domain-containing protein 3C

0.336

PRIC2_HUMAN

Prickle-like protein 2

0.349

BCAR3_HUMAN

Breast cancer anti-estrogen resistance protein 3

0.352

RAB30_HUMAN

Ras-related protein Rab-30

0.354

SOCS5_HUMAN

Suppressor of cytokine signaling 5

0.358

PEBB_HUMAN

Core-binding factor subunit beta

0.361

TEF_HUMAN

Thyrotroph embryonic factor

0.361

TRIB1_HUMAN

Tribbles homolog 1

0.362

SMAD4_HUMAN

Mothers against decapentaplegic homolog 4

0.364

TSHR_HUMAN

Thyrotropin receptor

0.364

BAKOR_HUMAN

Beclin 1-associated autophagy-related key regulator

0.367

HLF_HUMAN

Hepatic leukemia factor

0.367

MED1_HUMAN

Mediator of RNA polymerase II transcription subunit 1

0.368

ANKF1_HUMAN

Ankyrin repeat and fibronectin type-III domain-containing protein 1

0.369

SEM6D_HUMAN

Semaphorin-6D

0.370

SKIL_HUMAN

Ski-like protein

0.370

PRIC1_HUMAN

Prickle-like protein 1

0.370

TFIP8_HUMAN

Tumor necrosis factor alpha-induced protein 8

0.371

RYK_HUMAN

Tyrosine-protein kinase RYK

0.372

HINFP_HUMAN

Histone H4 transcription factor

0.372

CASL_HUMAN

Enhancer of filamentation 1

0.373

SEM5B_HUMAN

Semaphorin-5B

0.373

FGOP2_HUMAN

FGFR1 oncogene partner 2

0.373

CYLD_HUMAN

Ubiquitin carboxyl-terminal hydrolase CYLD

0.375

MED24_HUMAN

Mediator of RNA polymerase II transcription subunit 24

0.376

TMCC3_HUMAN

Transmembrane and coiled-coil domain protein 3

0.376

ETS1_HUMAN

Protein C-ets-1

0.378

GRASP_HUMAN

General receptor for phosphoinositides 1-associated scaffold protein

0.378

TXD11_HUMAN

Thioredoxin domain-containing protein 11

0.379

SEM6A_HUMAN

Semaphorin-6A

0.381

KPCD3_HUMAN

Serine/threonine-protein kinase D3

0.383

STON2_HUMAN

Stonin-2

0.383

AT1B4_HUMAN

Protein ATP1B4

0.384

RBCC1_HUMAN

RB1-inducible coiled-coil protein 1

0.384

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.384

BIG3_HUMAN

Brefeldin A-inhibited guanine nucleotide-exchange protein 3

0.385

SEM5A_HUMAN

Semaphorin-5A

0.386

TP8L3_HUMAN

Tumor necrosis factor alpha-induced protein 8-like protein 3

0.386

MCF2_HUMAN

Proto-oncogene DBL

0.386

TTC17_HUMAN

Tetratricopeptide repeat protein 17

0.386

TMCC1_HUMAN

Transmembrane and coiled-coil domains protein 1

0.387

FSHR_HUMAN

Follicle-stimulating hormone receptor

0.387

TBK1_HUMAN

Serine/threonine-protein kinase TBK1

0.387

F13A_HUMAN

Coagulation factor XIII A chain

0.387

SMOC2_HUMAN

SPARC-related modular calcium-binding protein 2

0.388

RBTN1_HUMAN

Rhombotin-1

0.389

HD_HUMAN

Huntingtin

0.389

RT30_HUMAN

39S ribosomal protein S30, mitochondrial

0.390

NAB1_HUMAN

NGFI-A-binding protein 1

0.390

DOXA2_HUMAN

Dual oxidase maturation factor 2

0.390

TRIO_HUMAN

Triple functional domain protein

0.391

APBA2_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 2

0.391

WLS_HUMAN

Protein wntless homolog

0.391

OFUT1_HUMAN

GDP-fucose protein O-fucosyltransferase 1

0.391

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.391

DAG1_HUMAN

Dystroglycan

0.391

TMCC2_HUMAN

Transmembrane and coiled-coil domains protein 2

0.392

UNC79_HUMAN

Protein unc-79 homolog

0.393

CSTN1_HUMAN

Calsyntenin-1

0.393

BCL7B_HUMAN

B-cell CLL/lymphoma 7 protein family member B

0.393

FA20C_HUMAN

Extracellular serine/threonine protein kinase FAM20C

0.393

SMAD5_HUMAN

Mothers against decapentaplegic homolog 5

0.394

SRCN1_HUMAN

SRC kinase signaling inhibitor 1

0.394

MESD_HUMAN

LRP chaperone MESD

0.395

BMP2_HUMAN

Bone morphogenetic protein 2

0.395

AKAP1_HUMAN

A-kinase anchor protein 1, mitochondrial

0.396

UBR5_HUMAN

E3 ubiquitin-protein ligase UBR5

0.396

AKA10_HUMAN

A-kinase anchor protein 10, mitochondrial

0.396

CRYAB_HUMAN

Alpha-crystallin B chain

0.397

RT22_HUMAN

28S ribosomal protein S22, mitochondrial

0.397

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.397

FOXO3_HUMAN

Forkhead box protein O3

0.397

LSHR_HUMAN

Lutropin-choriogonadotropic hormone receptor

0.398

SKT_HUMAN

Sickle tail protein homolog

0.398

HES1_HUMAN

Transcription factor HES-1

0.398

SMAD9_HUMAN

Mothers against decapentaplegic homolog 9

0.398

RUND1_HUMAN

RUN domain-containing protein 1

0.398

RM39_HUMAN

39S ribosomal protein L39, mitochondrial

0.399

BCAR1_HUMAN

Breast cancer anti-estrogen resistance protein 1

0.399

ZO1_HUMAN

Tight junction protein ZO-1

0.399

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.399

ITB1_HUMAN

Integrin beta-1

0.399

5HT1B_HUMAN

5-hydroxytryptamine receptor 1B

0.400

CNTP1_HUMAN

Contactin-associated protein 1

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 39 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy