SOCS5_HUMAN 2019

Gene Name SOCS5

Description Suppressor of cytokine signaling 5

Length 536

9606

Sequence

>sp|O75159|SOCS5_HUMAN Suppressor of cytokine signaling 5
MDKVGKMWNNFKYRCQNLFGHEGGSRSENVDMNSNRCLSVKEKNISIGDSTPQQQSSPLRENIALQLGLSPSKNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGTRLARRDSYSRHAPWGGKKKHSCSTKTQSSLDADKKFGRTRSGLQRRERRYGVSSVHDMDSVSSRTVGSRSLRQRLQDTVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPVSPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLGPKLAPGMTEISGDSSAIPQANCDSEEDTTTLCLQSRRQKQRQISGDSHTHVSRQGAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREPVKAK

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

SPRC_HUMAN

SPARC

0.316

PA2G3_HUMAN

Group 3 secretory phospholipase A2

0.320

OAF_HUMAN

Out at first protein homolog

0.324

SHRM3_HUMAN

Protein Shroom3

0.324

ZN703_HUMAN

Zinc finger protein 703

0.329

MCF2L_HUMAN

Guanine nucleotide exchange factor DBS

0.345

JIP1_HUMAN

C-Jun-amino-terminal kinase-interacting protein 1

0.345

KIBRA_HUMAN

Protein KIBRA

0.349

GDF11_HUMAN

Growth/differentiation factor 11

0.349

PRD16_HUMAN

Histone-lysine N-methyltransferase PRDM16

0.349

MTMRA_HUMAN

Myotubularin-related protein 10

0.354

TDRKH_HUMAN

Tudor and KH domain-containing protein

0.354

NKAI1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

0.354

SHRM2_HUMAN

Protein Shroom2

0.358

VGLL2_HUMAN

Transcription cofactor vestigial-like protein 2

0.358

NKRF_HUMAN

NF-kappa-B-repressing factor

0.358

JIP2_HUMAN

C-Jun-amino-terminal kinase-interacting protein 2

0.378

HXA1_HUMAN

Homeobox protein Hox-A1

0.378

GAB2_HUMAN

GRB2-associated-binding protein 2

0.378

NEGR1_HUMAN

Neuronal growth regulator 1

0.378

EVX1_HUMAN

Homeobox even-skipped homolog protein 1

0.378

CTCF_HUMAN

Transcriptional repressor CTCF

0.383

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.383

PTN21_HUMAN

Tyrosine-protein phosphatase non-receptor type 21

0.383

AMRP_HUMAN

Alpha-2-macroglobulin receptor-associated protein

0.383

SCHI1_HUMAN

Schwannomin-interacting protein 1

0.383

GDF8_HUMAN

Growth/differentiation factor 8

0.383

IGLO5_HUMAN

IgLON family member 5

0.383

MTMRC_HUMAN

Myotubularin-related protein 12

0.387

SPRE2_HUMAN

Sprouty-related, EVH1 domain-containing protein 2

0.387

CHRD_HUMAN

Chordin

0.387

IQIP1_HUMAN

IQCJ-SCHIP1 readthrough transcript protein

0.387

FA43A_HUMAN

Protein FAM43A

0.387

SGCE_HUMAN

Epsilon-sarcoglycan

0.387

GBX2_HUMAN

Homeobox protein GBX-2

0.392

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.392

ZN423_HUMAN

Zinc finger protein 423

0.392

ZN503_HUMAN

Zinc finger protein 503

0.392

ENOX1_HUMAN

Ecto-NOX disulfide-thiol exchanger 1

0.392

BAG2_HUMAN

BAG family molecular chaperone regulator 2

0.392

T183A_HUMAN

Transmembrane protein 183A

0.397

DAG1_HUMAN

Dystroglycan

0.399

SP9_HUMAN

Transcription factor Sp9

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

RAB30_HUMAN

Ras-related protein Rab-30

0.340

SEM6D_HUMAN

Semaphorin-6D

0.343

PDZD2_HUMAN

PDZ domain-containing protein 2

0.352

SEM6A_HUMAN

Semaphorin-6A

0.355

CYTIP_HUMAN

Cytohesin-interacting protein

0.358

SOCS4_HUMAN

Suppressor of cytokine signaling 4

0.360

SEM5B_HUMAN

Semaphorin-5B

0.361

PRIC2_HUMAN

Prickle-like protein 2

0.363

SGCE_HUMAN

Epsilon-sarcoglycan

0.366

JIP1_HUMAN

C-Jun-amino-terminal kinase-interacting protein 1

0.366

NAB1_HUMAN

NGFI-A-binding protein 1

0.366

LEG8_HUMAN

Galectin-8

0.367

CSTN1_HUMAN

Calsyntenin-1

0.369

BAG2_HUMAN

BAG family molecular chaperone regulator 2

0.371

CASL_HUMAN

Enhancer of filamentation 1

0.374

TTC17_HUMAN

Tetratricopeptide repeat protein 17

0.375

MTMRA_HUMAN

Myotubularin-related protein 10

0.376

TSHR_HUMAN

Thyrotropin receptor

0.378

SH2D3_HUMAN

SH2 domain-containing protein 3C

0.379

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.380

BCAR3_HUMAN

Breast cancer anti-estrogen resistance protein 3

0.380

NEO1_HUMAN

Neogenin

0.381

FA20C_HUMAN

Extracellular serine/threonine protein kinase FAM20C

0.382

ANKF1_HUMAN

Ankyrin repeat and fibronectin type-III domain-containing protein 1

0.383

PRIC1_HUMAN

Prickle-like protein 1

0.384

AKAP1_HUMAN

A-kinase anchor protein 1, mitochondrial

0.385

TRIB2_HUMAN

Tribbles homolog 2

0.385

SC5A8_HUMAN

Sodium-coupled monocarboxylate transporter 1

0.385

HINFP_HUMAN

Histone H4 transcription factor

0.385

SEM5A_HUMAN

Semaphorin-5A

0.387

TP8L3_HUMAN

Tumor necrosis factor alpha-induced protein 8-like protein 3

0.387

TEF_HUMAN

Thyrotroph embryonic factor

0.387

RUND1_HUMAN

RUN domain-containing protein 1

0.387

BARH2_HUMAN

BarH-like 2 homeobox protein

0.387

NAB2_HUMAN

NGFI-A-binding protein 2

0.388

MPRIP_HUMAN

Myosin phosphatase Rho-interacting protein

0.388

RM39_HUMAN

39S ribosomal protein L39, mitochondrial

0.388

F13A_HUMAN

Coagulation factor XIII A chain

0.388

GNRHR_HUMAN

Gonadotropin-releasing hormone receptor

0.389

ELF2_HUMAN

ETS-related transcription factor Elf-2

0.389

5HT1B_HUMAN

5-hydroxytryptamine receptor 1B

0.389

TMCC3_HUMAN

Transmembrane and coiled-coil domain protein 3

0.390

SMAD4_HUMAN

Mothers against decapentaplegic homolog 4

0.390

APBP2_HUMAN

Amyloid protein-binding protein 2

0.391

ETS1_HUMAN

Protein C-ets-1

0.392

TRIO_HUMAN

Triple functional domain protein

0.392

BNC2_HUMAN

Zinc finger protein basonuclin-2

0.392

HLF_HUMAN

Hepatic leukemia factor

0.393

FLI1_HUMAN

Friend leukemia integration 1 transcription factor

0.394

ORAI2_HUMAN

Protein orai-2

0.394

BCL7B_HUMAN

B-cell CLL/lymphoma 7 protein family member B

0.394

SPDEF_HUMAN

SAM pointed domain-containing Ets transcription factor

0.394

CTNL1_HUMAN

Alpha-catulin

0.394

ACK1_HUMAN

Activated CDC42 kinase 1

0.395

AHR_HUMAN

Aryl hydrocarbon receptor

0.395

SRCN1_HUMAN

SRC kinase signaling inhibitor 1

0.395

MYT1L_HUMAN

Myelin transcription factor 1-like protein

0.396

MESD_HUMAN

LRP chaperone MESD

0.396

BMP2_HUMAN

Bone morphogenetic protein 2

0.396

FBSP1_HUMAN

F-box/SPRY domain-containing protein 1

0.397

NDUB5_HUMAN

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

0.397

SALL1_HUMAN

Sal-like protein 1

0.397

NID1_HUMAN

Nidogen-1

0.397

SPRE1_HUMAN

Sprouty-related, EVH1 domain-containing protein 1

0.397

SPRE2_HUMAN

Sprouty-related, EVH1 domain-containing protein 2

0.397

AT1B4_HUMAN

Protein ATP1B4

0.397

AKA10_HUMAN

A-kinase anchor protein 10, mitochondrial

0.397

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.397

RBCC1_HUMAN

RB1-inducible coiled-coil protein 1

0.397

BMP4_HUMAN

Bone morphogenetic protein 4

0.398

GLCE_HUMAN

D-glucuronyl C5-epimerase

0.398

MED19_HUMAN

Mediator of RNA polymerase II transcription subunit 19

0.398

LSHR_HUMAN

Lutropin-choriogonadotropic hormone receptor

0.399

HES1_HUMAN

Transcription factor HES-1

0.399

SKT_HUMAN

Sickle tail protein homolog

0.399

TM39A_HUMAN

Transmembrane protein 39A

0.399

CRYA2_HUMAN

Alpha-crystallin A2 chain

0.400

TMCC1_HUMAN

Transmembrane and coiled-coil domains protein 1

0.400

ZO1_HUMAN

Tight junction protein ZO-1

0.400

CYLD_HUMAN

Ubiquitin carboxyl-terminal hydrolase CYLD

0.400

JKAMP_HUMAN

JNK1/MAPK8-associated membrane protein

0.400

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 37 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy