A4_HUMAN 2019

Gene Name A4

Description Amyloid-beta precursor protein

Length 770

9606

Sequence

>sp|P05067|A4_HUMAN Amyloid-beta precursor protein
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

ZO1_HUMAN

Tight junction protein ZO-1

0.326

TPD52_HUMAN

Tumor protein D52

0.330

ONEC2_HUMAN

One cut domain family member 2

0.330

HMX3_HUMAN

Homeobox protein HMX3

0.330

NET1_HUMAN

Netrin-1

0.354

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.354

AT1B4_HUMAN

Protein ATP1B4

0.354

SMAD1_HUMAN

Mothers against decapentaplegic homolog 1

0.354

ZO2_HUMAN

Tight junction protein ZO-2

0.357

FEZF2_HUMAN

Fez family zinc finger protein 2

0.361

K2013_HUMAN

Uncharacterized protein KIAA2013

0.361

FEZF1_HUMAN

Fez family zinc finger protein 1

0.361

BIG3_HUMAN

Brefeldin A-inhibited guanine nucleotide-exchange protein 3

0.365

WLS_HUMAN

Protein wntless homolog

0.378

GFI1_HUMAN

Zinc finger protein Gfi-1

0.378

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.382

VANG1_HUMAN

Vang-like protein 1

0.382

FABP7_HUMAN

Fatty acid-binding protein, brain

0.382

HINFP_HUMAN

Histone H4 transcription factor

0.382

AT1B3_HUMAN

Sodium/potassium-transporting ATPase subunit beta-3

0.382

NFIB_HUMAN

Nuclear factor 1 B-type

0.382

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.382

NFIA_HUMAN

Nuclear factor 1 A-type

0.382

PTPRN_HUMAN

Receptor-type tyrosine-protein phosphatase-like N

0.382

SMAD9_HUMAN

Mothers against decapentaplegic homolog 9

0.382

NKX61_HUMAN

Homeobox protein Nkx-6.1

0.382

RIPL1_HUMAN

RILP-like protein 1

0.382

TSN5_HUMAN

Tetraspanin-5

0.382

CNTP4_HUMAN

Contactin-associated protein-like 4

0.386

GFI1B_HUMAN

Zinc finger protein Gfi-1b

0.386

CNTP1_HUMAN

Contactin-associated protein 1

0.386

TPD53_HUMAN

Tumor protein D53

0.386

TPD54_HUMAN

Tumor protein D54

0.386

RT30_HUMAN

39S ribosomal protein S30, mitochondrial

0.386

CRYA2_HUMAN

Alpha-crystallin A2 chain

0.390

PO4F2_HUMAN

POU domain, class 4, transcription factor 2

0.390

SYT1_HUMAN

Synaptotagmin-1

0.400

RUNX2_HUMAN

Runt-related transcription factor 2

0.400

FERM2_HUMAN

Fermitin family homolog 2

0.400

FERM1_HUMAN

Fermitin family homolog 1

0.400

TM38B_HUMAN

Trimeric intracellular cation channel type B

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

APLP2_HUMAN

Amyloid-like protein 2

0.346

BIG3_HUMAN

Brefeldin A-inhibited guanine nucleotide-exchange protein 3

0.363

AT1B4_HUMAN

Protein ATP1B4

0.364

APLP1_HUMAN

Amyloid-like protein 1

0.369

HLF_HUMAN

Hepatic leukemia factor

0.371

RUNX1_HUMAN

Runt-related transcription factor 1

0.375

TM38B_HUMAN

Trimeric intracellular cation channel type B

0.375

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.376

AT1B3_HUMAN

Sodium/potassium-transporting ATPase subunit beta-3

0.378

EPHA4_HUMAN

Ephrin type-A receptor 4

0.378

SMAD9_HUMAN

Mothers against decapentaplegic homolog 9

0.378

WLS_HUMAN

Protein wntless homolog

0.383

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.383

APBA2_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 2

0.383

SMAD1_HUMAN

Mothers against decapentaplegic homolog 1

0.383

APC_HUMAN

Adenomatous polyposis coli protein

0.385

STON2_HUMAN

Stonin-2

0.386

KPCD3_HUMAN

Serine/threonine-protein kinase D3

0.386

BMP2_HUMAN

Bone morphogenetic protein 2

0.387

AKAP1_HUMAN

A-kinase anchor protein 1, mitochondrial

0.387

RT31_HUMAN

28S ribosomal protein S31, mitochondrial

0.387

RBCC1_HUMAN

RB1-inducible coiled-coil protein 1

0.388

TRAM2_HUMAN

Translocating chain-associated membrane protein 2

0.388

SC5A8_HUMAN

Sodium-coupled monocarboxylate transporter 1

0.388

HINFP_HUMAN

Histone H4 transcription factor

0.388

AKA10_HUMAN

A-kinase anchor protein 10, mitochondrial

0.388

CACB2_HUMAN

Voltage-dependent L-type calcium channel subunit beta-2

0.388

CRYAB_HUMAN

Alpha-crystallin B chain

0.388

ONEC2_HUMAN

One cut domain family member 2

0.388

MED19_HUMAN

Mediator of RNA polymerase II transcription subunit 19

0.389

ILF2_HUMAN

Interleukin enhancer-binding factor 2

0.389

GLCE_HUMAN

D-glucuronyl C5-epimerase

0.389

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.389

ANLN_HUMAN

Anillin

0.390

TTC17_HUMAN

Tetratricopeptide repeat protein 17

0.390

TEF_HUMAN

Thyrotroph embryonic factor

0.390

FSHR_HUMAN

Follicle-stimulating hormone receptor

0.390

AFAD_HUMAN

Afadin

0.390

PRIC2_HUMAN

Prickle-like protein 2

0.391

RHG10_HUMAN

Rho GTPase-activating protein 10

0.391

MACOI_HUMAN

Macoilin

0.391

CYLD_HUMAN

Ubiquitin carboxyl-terminal hydrolase CYLD

0.391

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.391

IP3KB_HUMAN

Inositol-trisphosphate 3-kinase B

0.391

ITB1_HUMAN

Integrin beta-1

0.391

HNF6_HUMAN

Hepatocyte nuclear factor 6

0.392

EPHB3_HUMAN

Ephrin type-B receptor 3

0.392

MPDZ_HUMAN

Multiple PDZ domain protein

0.392

TSHR_HUMAN

Thyrotropin receptor

0.393

JIP1_HUMAN

C-Jun-amino-terminal kinase-interacting protein 1

0.394

NFIB_HUMAN

Nuclear factor 1 B-type

0.394

PXDC2_HUMAN

Plexin domain-containing protein 2

0.394

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.394

TRIO_HUMAN

Triple functional domain protein

0.394

FERM2_HUMAN

Fermitin family homolog 2

0.394

OFUT1_HUMAN

GDP-fucose protein O-fucosyltransferase 1

0.394

K2013_HUMAN

Uncharacterized protein KIAA2013

0.395

CTNA1_HUMAN

Catenin alpha-1

0.395

KPCD1_HUMAN

Serine/threonine-protein kinase D1

0.396

TF7L2_HUMAN

Transcription factor 7-like 2

0.396

LRRF2_HUMAN

Leucine-rich repeat flightless-interacting protein 2

0.396

PP4P2_HUMAN

Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

0.396

BCL7B_HUMAN

B-cell CLL/lymphoma 7 protein family member B

0.396

CSTN1_HUMAN

Calsyntenin-1

0.396

FLI1_HUMAN

Friend leukemia integration 1 transcription factor

0.396

STAU1_HUMAN

Double-stranded RNA-binding protein Staufen homolog 1

0.397

STAU2_HUMAN

Double-stranded RNA-binding protein Staufen homolog 2

0.397

ANKF1_HUMAN

Ankyrin repeat and fibronectin type-III domain-containing protein 1

0.397

ZER1_HUMAN

Protein zer-1 homolog

0.397

SMAD5_HUMAN

Mothers against decapentaplegic homolog 5

0.397

HYI_HUMAN

Putative hydroxypyruvate isomerase

0.397

ERP44_HUMAN

Endoplasmic reticulum resident protein 44

0.397

ROBO1_HUMAN

Roundabout homolog 1

0.399

PICK1_HUMAN

PRKCA-binding protein

0.399

DAB2_HUMAN

Disabled homolog 2

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 42 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy