APLP1_HUMAN 2019

Gene Name APLP1

Description Amyloid-like protein 1

Length 650

9606

Sequence

>sp|P51693|APLP1_HUMAN Amyloid-like protein 1
MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

FOXO3_HUMAN

Forkhead box protein O3

0.330

AP2B_HUMAN

Transcription factor AP-2-beta

0.330

AP2A_HUMAN

Transcription factor AP-2-alpha

0.330

ZO1_HUMAN

Tight junction protein ZO-1

0.330

NFIA_HUMAN

Nuclear factor 1 A-type

0.330

HMX3_HUMAN

Homeobox protein HMX3

0.333

HNF6_HUMAN

Hepatocyte nuclear factor 6

0.337

CRYA2_HUMAN

Alpha-crystallin A2 chain

0.337

AT1B4_HUMAN

Protein ATP1B4

0.357

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.357

NET1_HUMAN

Netrin-1

0.357

RHG42_HUMAN

Rho GTPase-activating protein 42

0.357

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.357

HLF_HUMAN

Hepatic leukemia factor

0.357

BTBD7_HUMAN

BTB/POZ domain-containing protein 7

0.361

NFIC_HUMAN

Nuclear factor 1 C-type

0.361

DACH1_HUMAN

Dachshund homolog 1

0.361

ZO2_HUMAN

Tight junction protein ZO-2

0.361

DACH2_HUMAN

Dachshund homolog 2

0.361

PO4F3_HUMAN

POU domain, class 4, transcription factor 3

0.361

RIMS1_HUMAN

Regulating synaptic membrane exocytosis protein 1

0.361

APBA2_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 2

0.361

NID1_HUMAN

Nidogen-1

0.365

DAB1_HUMAN

Disabled homolog 1

0.365

S12A8_HUMAN

Solute carrier family 12 member 8

0.365

FEZF1_HUMAN

Fez family zinc finger protein 1

0.365

K2013_HUMAN

Uncharacterized protein KIAA2013

0.365

FBX42_HUMAN

F-box only protein 42

0.365

DLX6_HUMAN

Homeobox protein DLX-6

0.369

CELR1_HUMAN

Cadherin EGF LAG seven-pass G-type receptor 1

0.369

STAU2_HUMAN

Double-stranded RNA-binding protein Staufen homolog 2

0.374

WLS_HUMAN

Protein wntless homolog

0.382

GFI1_HUMAN

Zinc finger protein Gfi-1

0.382

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.386

ITF2_HUMAN

Transcription factor 4

0.386

TSN5_HUMAN

Tetraspanin-5

0.386

TFE2_HUMAN

Transcription factor E2-alpha

0.386

VANG1_HUMAN

Vang-like protein 1

0.386

RIPL1_HUMAN

RILP-like protein 1

0.386

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.386

FA8A1_HUMAN

Protein FAM8A1

0.386

NFIB_HUMAN

Nuclear factor 1 B-type

0.386

HINFP_HUMAN

Histone H4 transcription factor

0.386

E41L5_HUMAN

Band 4.1-like protein 5

0.386

FABP7_HUMAN

Fatty acid-binding protein, brain

0.386

FOXO1_HUMAN

Forkhead box protein O1

0.386

TEF_HUMAN

Thyrotroph embryonic factor

0.386

JPH3_HUMAN

Junctophilin-3

0.386

PTPRN_HUMAN

Receptor-type tyrosine-protein phosphatase-like N

0.386

AHR_HUMAN

Aryl hydrocarbon receptor

0.390

DAG1_HUMAN

Dystroglycan

0.390

NDUBA_HUMAN

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

0.390

ZER1_HUMAN

Protein zer-1 homolog

0.390

RXRA_HUMAN

Retinoic acid receptor RXR-alpha

0.390

GFI1B_HUMAN

Zinc finger protein Gfi-1b

0.390

AT1B2_HUMAN

Sodium/potassium-transporting ATPase subunit beta-2

0.390

PEBB_HUMAN

Core-binding factor subunit beta

0.390

ONEC2_HUMAN

One cut domain family member 2

0.390

RT30_HUMAN

39S ribosomal protein S30, mitochondrial

0.390

DLX1_HUMAN

Homeobox protein DLX-1

0.390

AKA10_HUMAN

A-kinase anchor protein 10, mitochondrial

0.390

NR2C1_HUMAN

Nuclear receptor subfamily 2 group C member 1

0.394

GRASP_HUMAN

General receptor for phosphoinositides 1-associated scaffold protein

0.394

JIP1_HUMAN

C-Jun-amino-terminal kinase-interacting protein 1

0.394

DAB2_HUMAN

Disabled homolog 2

0.394

OVOL1_HUMAN

Putative transcription factor Ovo-like 1

0.394

MB212_HUMAN

Protein mab-21-like 2

0.394

PITX1_HUMAN

Pituitary homeobox 1

0.394

HAND2_HUMAN

Heart- and neural crest derivatives-expressed protein 2

0.394

CELR3_HUMAN

Cadherin EGF LAG seven-pass G-type receptor 3

0.394

HME2_HUMAN

Homeobox protein engrailed-2

0.394

VSX2_HUMAN

Visual system homeobox 2

0.399

EFNB1_HUMAN

Ephrin-B1

0.399

STOX1_HUMAN

Storkhead-box protein 1

0.399

AP2E_HUMAN

Transcription factor AP-2-epsilon

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

EPHB4_HUMAN

Ephrin type-B receptor 4

0.345

AT1B2_HUMAN

Sodium/potassium-transporting ATPase subunit beta-2

0.347

APLP2_HUMAN

Amyloid-like protein 2

0.349

DVL2_HUMAN

Segment polarity protein dishevelled homolog DVL-2

0.352

EPHA4_HUMAN

Ephrin type-A receptor 4

0.368

A4_HUMAN

Amyloid-beta precursor protein

0.369

HNF6_HUMAN

Hepatocyte nuclear factor 6

0.370

DCC_HUMAN

Netrin receptor DCC

0.371

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.373

HLF_HUMAN

Hepatic leukemia factor

0.374

SMAD1_HUMAN

Mothers against decapentaplegic homolog 1

0.374

OVOL1_HUMAN

Putative transcription factor Ovo-like 1

0.375

STAU2_HUMAN

Double-stranded RNA-binding protein Staufen homolog 2

0.375

AKAP1_HUMAN

A-kinase anchor protein 1, mitochondrial

0.378

ACADV_HUMAN

Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

0.378

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.379

AT1B4_HUMAN

Protein ATP1B4

0.379

DAB2_HUMAN

Disabled homolog 2

0.379

ONEC2_HUMAN

One cut domain family member 2

0.379

NPHN_HUMAN

Nephrin

0.379

MED19_HUMAN

Mediator of RNA polymerase II transcription subunit 19

0.380

TSN17_HUMAN

Tetraspanin-17

0.380

ECSIT_HUMAN

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

0.381

H6ST2_HUMAN

Heparan-sulfate 6-O-sulfotransferase 2

0.382

JIP1_HUMAN

C-Jun-amino-terminal kinase-interacting protein 1

0.385

GRASP_HUMAN

General receptor for phosphoinositides 1-associated scaffold protein

0.385

APBA2_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 2

0.385

PP4P1_HUMAN

Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

0.386

PHKG2_HUMAN

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

0.387

ZER1_HUMAN

Protein zer-1 homolog

0.388

IP3KC_HUMAN

Inositol-trisphosphate 3-kinase C

0.389

TM38B_HUMAN

Trimeric intracellular cation channel type B

0.390

SC5A8_HUMAN

Sodium-coupled monocarboxylate transporter 1

0.391

AKA10_HUMAN

A-kinase anchor protein 10, mitochondrial

0.391

BIG3_HUMAN

Brefeldin A-inhibited guanine nucleotide-exchange protein 3

0.391

RT24_HUMAN

28S ribosomal protein S24, mitochondrial

0.391

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.392

GLCE_HUMAN

D-glucuronyl C5-epimerase

0.392

TEF_HUMAN

Thyrotroph embryonic factor

0.393

ANLN_HUMAN

Anillin

0.393

TTC17_HUMAN

Tetratricopeptide repeat protein 17

0.393

TSN5_HUMAN

Tetraspanin-5

0.393

CSRN2_HUMAN

Cysteine/serine-rich nuclear protein 2

0.393

CYLD_HUMAN

Ubiquitin carboxyl-terminal hydrolase CYLD

0.394

PRIC2_HUMAN

Prickle-like protein 2

0.394

BAF_HUMAN

Barrier-to-autointegration factor

0.394

KPCD2_HUMAN

Serine/threonine-protein kinase D2

0.394

ITB1_HUMAN

Integrin beta-1

0.394

DAB1_HUMAN

Disabled homolog 1

0.396

TSHR_HUMAN

Thyrotropin receptor

0.396

DVL3_HUMAN

Segment polarity protein dishevelled homolog DVL-3

0.396

PXDC2_HUMAN

Plexin domain-containing protein 2

0.397

CNTP4_HUMAN

Contactin-associated protein-like 4

0.397

EPHA7_HUMAN

Ephrin type-A receptor 7

0.397

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.397

TRIO_HUMAN

Triple functional domain protein

0.397

OFUT1_HUMAN

GDP-fucose protein O-fucosyltransferase 1

0.397

FERM2_HUMAN

Fermitin family homolog 2

0.397

WLS_HUMAN

Protein wntless homolog

0.397

ELF4_HUMAN

ETS-related transcription factor Elf-4

0.397

RHG42_HUMAN

Rho GTPase-activating protein 42

0.398

DTNB_HUMAN

Dystrobrevin beta

0.398

NEO1_HUMAN

Neogenin

0.399

KPCD1_HUMAN

Serine/threonine-protein kinase D1

0.399

GIT2_HUMAN

ARF GTPase-activating protein GIT2

0.399

CELR3_HUMAN

Cadherin EGF LAG seven-pass G-type receptor 3

0.400

STAU1_HUMAN

Double-stranded RNA-binding protein Staufen homolog 1

0.400

ROBO2_HUMAN

Roundabout homolog 2

0.400

AP2B_HUMAN

Transcription factor AP-2-beta

0.400

ANKF1_HUMAN

Ankyrin repeat and fibronectin type-III domain-containing protein 1

0.400

H6ST1_HUMAN

Heparan-sulfate 6-O-sulfotransferase 1

0.400

FOXO1_HUMAN

Forkhead box protein O1

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 40 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy