ATX1_HUMAN 2019

Gene Name ATX1

Description Ataxin-1

Length 815

9606

Sequence

>sp|P54253|ATX1_HUMAN Ataxin-1
MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRHGPAGTSVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQYAHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHFVPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRHVVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQHLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQSAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADGLAGSRHRYAEQENGINQGSAQMLSENGELKFPEKMGLPAAPFLTKIEPSKPAATRKRRWSAPESRKLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

ATX1L_HUMAN

Ataxin-1-like

0.156

KALM_HUMAN

Anosmin-1

0.341

JIP3_HUMAN

C-Jun-amino-terminal kinase-interacting protein 3

0.357

AT1B4_HUMAN

Protein ATP1B4

0.357

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.357

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.357

BICD1_HUMAN

Protein bicaudal D homolog 1

0.361

DACH1_HUMAN

Dachshund homolog 1

0.361

MB211_HUMAN

Putative nucleotidyltransferase MAB21L1

0.361

E41L1_HUMAN

Band 4.1-like protein 1

0.361

DACH2_HUMAN

Dachshund homolog 2

0.361

BICD2_HUMAN

Protein bicaudal D homolog 2

0.361

PAR3L_HUMAN

Partitioning defective 3 homolog B

0.365

MYT1L_HUMAN

Myelin transcription factor 1-like protein

0.365

C102A_HUMAN

Coiled-coil domain-containing protein 102A

0.365

MB12B_HUMAN

Multivesicular body subunit 12B

0.369

MBTD1_HUMAN

MBT domain-containing protein 1

0.369

OSTM1_HUMAN

Osteopetrosis-associated transmembrane protein 1

0.378

CTNA1_HUMAN

Catenin alpha-1

0.382

GFI1_HUMAN

Zinc finger protein Gfi-1

0.382

CPEB3_HUMAN

Cytoplasmic polyadenylation element-binding protein 3

0.382

WLS_HUMAN

Protein wntless homolog

0.382

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.386

FOXO1_HUMAN

Forkhead box protein O1

0.386

FEM1C_HUMAN

Protein fem-1 homolog C

0.386

HINFP_HUMAN

Histone H4 transcription factor

0.386

AP2A_HUMAN

Transcription factor AP-2-alpha

0.386

FOXO3_HUMAN

Forkhead box protein O3

0.386

AP2B_HUMAN

Transcription factor AP-2-beta

0.386

VANG1_HUMAN

Vang-like protein 1

0.386

FA8A1_HUMAN

Protein FAM8A1

0.386

E41L5_HUMAN

Band 4.1-like protein 5

0.386

FABP7_HUMAN

Fatty acid-binding protein, brain

0.386

AVR2A_HUMAN

Activin receptor type-2A

0.386

RIPL1_HUMAN

RILP-like protein 1

0.386

EMX2_HUMAN

Homeobox protein EMX2

0.386

PEBB_HUMAN

Core-binding factor subunit beta

0.390

GO45_HUMAN

Golgin-45

0.390

FEM1B_HUMAN

Protein fem-1 homolog B

0.390

NDUBA_HUMAN

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

0.390

FBX25_HUMAN

F-box only protein 25

0.390

DLX1_HUMAN

Homeobox protein DLX-1

0.390

TPD52_HUMAN

Tumor protein D52

0.390

TPD53_HUMAN

Tumor protein D53

0.390

RXRA_HUMAN

Retinoic acid receptor RXR-alpha

0.390

TPD54_HUMAN

Tumor protein D54

0.390

CSRN2_HUMAN

Cysteine/serine-rich nuclear protein 2

0.394

TRAK2_HUMAN

Trafficking kinesin-binding protein 2

0.394

JIP1_HUMAN

C-Jun-amino-terminal kinase-interacting protein 1

0.394

CRYA2_HUMAN

Alpha-crystallin A2 chain

0.394

CSRN3_HUMAN

Cysteine/serine-rich nuclear protein 3

0.394

PO4F2_HUMAN

POU domain, class 4, transcription factor 2

0.394

NAB1_HUMAN

NGFI-A-binding protein 1

0.394

DAB2_HUMAN

Disabled homolog 2

0.394

ST18_HUMAN

Suppression of tumorigenicity 18 protein

0.394

HAND2_HUMAN

Heart- and neural crest derivatives-expressed protein 2

0.394

MYT1_HUMAN

Myelin transcription factor 1

0.394

CASL_HUMAN

Enhancer of filamentation 1

0.394

FEZ1_HUMAN

Fasciculation and elongation protein zeta-1

0.399

STAU1_HUMAN

Double-stranded RNA-binding protein Staufen homolog 1

0.399

MPRIP_HUMAN

Myosin phosphatase Rho-interacting protein

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

ATX1L_HUMAN

Ataxin-1-like

0.236

TDIF1_HUMAN

Deoxynucleotidyltransferase terminal-interacting protein 1

0.357

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.363

BMP2_HUMAN

Bone morphogenetic protein 2

0.370

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.371

AT1B4_HUMAN

Protein ATP1B4

0.371

HINFP_HUMAN

Histone H4 transcription factor

0.371

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.372

BICD1_HUMAN

Protein bicaudal D homolog 1

0.373

ZO1_HUMAN

Tight junction protein ZO-1

0.374

IMPA3_HUMAN

Inositol monophosphatase 3

0.377

DVL3_HUMAN

Segment polarity protein dishevelled homolog DVL-3

0.377

MB12B_HUMAN

Multivesicular body subunit 12B

0.378

TRIO_HUMAN

Triple functional domain protein

0.378

APBA2_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 2

0.378

MADD_HUMAN

MAP kinase-activating death domain protein

0.379

PP4P2_HUMAN

Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

0.380

NLK_HUMAN

Serine/threonine-protein kinase NLK

0.380

RIPL1_HUMAN

RILP-like protein 1

0.380

KALM_HUMAN

Anosmin-1

0.380

RM55_HUMAN

39S ribosomal protein L55, mitochondrial

0.380

ZER1_HUMAN

Protein zer-1 homolog

0.381

E41L5_HUMAN

Band 4.1-like protein 5

0.381

ERP44_HUMAN

Endoplasmic reticulum resident protein 44

0.382

SC5A8_HUMAN

Sodium-coupled monocarboxylate transporter 1

0.383

FOXO3_HUMAN

Forkhead box protein O3

0.384

ILF2_HUMAN

Interleukin enhancer-binding factor 2

0.384

BMP4_HUMAN

Bone morphogenetic protein 4

0.384

RT22_HUMAN

28S ribosomal protein S22, mitochondrial

0.384

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.384

GLCE_HUMAN

D-glucuronyl C5-epimerase

0.384

HTF4_HUMAN

Transcription factor 12

0.385

ANLN_HUMAN

Anillin

0.385

TTC17_HUMAN

Tetratricopeptide repeat protein 17

0.385

AFAD_HUMAN

Afadin

0.386

ITB1_HUMAN

Integrin beta-1

0.387

ELF2_HUMAN

ETS-related transcription factor Elf-2

0.387

ZSWM8_HUMAN

Zinc finger SWIM domain-containing protein 8

0.388

C102A_HUMAN

Coiled-coil domain-containing protein 102A

0.388

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.390

FERM2_HUMAN

Fermitin family homolog 2

0.390

FERM1_HUMAN

Fermitin family homolog 1

0.390

WLS_HUMAN

Protein wntless homolog

0.390

TM39B_HUMAN

Transmembrane protein 39B

0.391

BICD2_HUMAN

Protein bicaudal D homolog 2

0.391

TRAK2_HUMAN

Trafficking kinesin-binding protein 2

0.391

FLI1_HUMAN

Friend leukemia integration 1 transcription factor

0.392

CSTN1_HUMAN

Calsyntenin-1

0.392

ZO2_HUMAN

Tight junction protein ZO-2

0.393

UNC5D_HUMAN

Netrin receptor UNC5D

0.393

FOXO1_HUMAN

Forkhead box protein O1

0.393

AHR_HUMAN

Aryl hydrocarbon receptor

0.393

FHOD3_HUMAN

FH1/FH2 domain-containing protein 3

0.393

CSKP_HUMAN

Peripheral plasma membrane protein CASK

0.393

MYT1L_HUMAN

Myelin transcription factor 1-like protein

0.394

UNC5B_HUMAN

Netrin receptor UNC5B

0.394

TM38B_HUMAN

Trimeric intracellular cation channel type B

0.394

OPA1_HUMAN

Dynamin-like 120 kDa protein, mitochondrial

0.394

ROBO1_HUMAN

Roundabout homolog 1

0.395

RT31_HUMAN

28S ribosomal protein S31, mitochondrial

0.395

MIGA2_HUMAN

Mitoguardin 2

0.395

CACB2_HUMAN

Voltage-dependent L-type calcium channel subunit beta-2

0.395

RBCC1_HUMAN

RB1-inducible coiled-coil protein 1

0.395

ITB3_HUMAN

Integrin beta-3

0.395

PICK1_HUMAN

PRKCA-binding protein

0.395

BIG3_HUMAN

Brefeldin A-inhibited guanine nucleotide-exchange protein 3

0.396

DAB2_HUMAN

Disabled homolog 2

0.396

NUMB_HUMAN

Protein numb homolog

0.396

ST7_HUMAN

Suppressor of tumorigenicity 7 protein

0.396

RT25_HUMAN

28S ribosomal protein S25, mitochondrial

0.396

CD109_HUMAN

CD109 antigen

0.396

MAPK3_HUMAN

MAP kinase-activated protein kinase 3

0.396

TEF_HUMAN

Thyrotroph embryonic factor

0.397

FA8A1_HUMAN

Protein FAM8A1

0.398

HS2ST_HUMAN

Heparan sulfate 2-O-sulfotransferase 1

0.398

PO4F3_HUMAN

POU domain, class 4, transcription factor 3

0.399

SMCE1_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

0.399

TPD54_HUMAN

Tumor protein D54

0.400

FBX25_HUMAN

F-box only protein 25

0.400

MYT1_HUMAN

Myelin transcription factor 1

0.400

NFASC_HUMAN

Neurofascin

0.400

DAB1_HUMAN

Disabled homolog 1

0.400

CSPG4_HUMAN

Chondroitin sulfate proteoglycan 4

0.400

ST18_HUMAN

Suppression of tumorigenicity 18 protein

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 41 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy