IMPA3_HUMAN 2019

Gene Name IMPA3

Description Inositol monophosphatase 3

Length 359

9606

Sequence

>sp|Q9NX62|IMPA3_HUMAN Inositol monophosphatase 3
MAPMGIRLSPLGVAVFCLLGLGVLYHLYSGFLAGRFSLFGLGGEPGGGAAGPAAAADGGTVDLREMLAVSVLAAVRGGDEVRRVRESNVLHEKSKGKTREGAEDKMTSGDVLSNRKMFYLLKTAFPSVQINTEEHVDAADQEVILWDHKIPEDILKEVTTPKEVPAESVTVWIDPLDATQEYTEDLRKYVTTMVCVAVNGKPMLGVIHKPFSEYTAWAMVDGGSNVKARSSYNEKTPRIVVSRSHSGMVKQVALQTFGNQTTIIPAGGAGYKVLALLDVPDKSQEKADLYIHVTYIKKWDICAGNAILKALGGHMTTLSGEEISYTGSDGIEGGLLASIRMNHQALVRKLPDLEKTGHK

Domains

Loading...

Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

SMCE1_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

0.348

TRIO_HUMAN

Triple functional domain protein

0.349

BMP2_HUMAN

Bone morphogenetic protein 2

0.354

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.359

HS2ST_HUMAN

Heparan sulfate 2-O-sulfotransferase 1

0.359

SPRY7_HUMAN

SPRY domain-containing protein 7

0.361

APBA2_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 2

0.362

PP4P2_HUMAN

Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

0.363

HINFP_HUMAN

Histone H4 transcription factor

0.367

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.367

PICK1_HUMAN

PRKCA-binding protein

0.367

AT1B4_HUMAN

Protein ATP1B4

0.367

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.368

GLCE_HUMAN

D-glucuronyl C5-epimerase

0.368

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.368

ILF2_HUMAN

Interleukin enhancer-binding factor 2

0.368

ITB1_HUMAN

Integrin beta-1

0.371

DVL3_HUMAN

Segment polarity protein dishevelled homolog DVL-3

0.373

FERM1_HUMAN

Fermitin family homolog 1

0.374

FERM2_HUMAN

Fermitin family homolog 2

0.374

PAR6B_HUMAN

Partitioning defective 6 homolog beta

0.374

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.374

WLS_HUMAN

Protein wntless homolog

0.374

TPST1_HUMAN

Protein-tyrosine sulfotransferase 1

0.374

MADD_HUMAN

MAP kinase-activating death domain protein

0.374

FLI1_HUMAN

Friend leukemia integration 1 transcription factor

0.375

RIPL1_HUMAN

RILP-like protein 1

0.375

NLK_HUMAN

Serine/threonine-protein kinase NLK

0.375

SETB1_HUMAN

Histone-lysine N-methyltransferase SETDB1

0.376

ATX1_HUMAN

Ataxin-1

0.377

ERP44_HUMAN

Endoplasmic reticulum resident protein 44

0.377

FHOD3_HUMAN

FH1/FH2 domain-containing protein 3

0.377

CSKP_HUMAN

Peripheral plasma membrane protein CASK

0.377

OPA1_HUMAN

Dynamin-like 120 kDa protein, mitochondrial

0.378

SC5A8_HUMAN

Sodium-coupled monocarboxylate transporter 1

0.379

MIGA2_HUMAN

Mitoguardin 2

0.379

ANKL2_HUMAN

Ankyrin repeat and LEM domain-containing protein 2

0.379

NUMB_HUMAN

Protein numb homolog

0.380

BMP4_HUMAN

Bone morphogenetic protein 4

0.380

RT25_HUMAN

28S ribosomal protein S25, mitochondrial

0.380

MAPK3_HUMAN

MAP kinase-activated protein kinase 3

0.380

RT22_HUMAN

28S ribosomal protein S22, mitochondrial

0.380

TTC17_HUMAN

Tetratricopeptide repeat protein 17

0.381

BICD1_HUMAN

Protein bicaudal D homolog 1

0.381

RUND1_HUMAN

RUN domain-containing protein 1

0.381

HTF4_HUMAN

Transcription factor 12

0.381

AFAD_HUMAN

Afadin

0.381

MIER3_HUMAN

Mesoderm induction early response protein 3

0.381

MACOI_HUMAN

Macoilin

0.381

ZO1_HUMAN

Tight junction protein ZO-1

0.381

MPDZ_HUMAN

Multiple PDZ domain protein

0.383

VRK1_HUMAN

Serine/threonine-protein kinase VRK1

0.384

ARFP1_HUMAN

Arfaptin-1

0.384

RSBNL_HUMAN

Round spermatid basic protein 1-like protein

0.384

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.385

MAPK2_HUMAN

MAP kinase-activated protein kinase 2

0.385

BICD2_HUMAN

Protein bicaudal D homolog 2

0.386

CSTN1_HUMAN

Calsyntenin-1

0.387

LRRF2_HUMAN

Leucine-rich repeat flightless-interacting protein 2

0.387

STON1_HUMAN

Stonin-1

0.387

ZER1_HUMAN

Protein zer-1 homolog

0.388

AHR_HUMAN

Aryl hydrocarbon receptor

0.388

ACK1_HUMAN

Activated CDC42 kinase 1

0.388

TM38B_HUMAN

Trimeric intracellular cation channel type B

0.389

TRPM3_HUMAN

Transient receptor potential cation channel subfamily M member 3

0.389

ITB3_HUMAN

Integrin beta-3

0.390

UBR5_HUMAN

E3 ubiquitin-protein ligase UBR5

0.390

CACB2_HUMAN

Voltage-dependent L-type calcium channel subunit beta-2

0.390

FOXP2_HUMAN

Forkhead box protein P2

0.390

MED19_HUMAN

Mediator of RNA polymerase II transcription subunit 19

0.391

CD109_HUMAN

CD109 antigen

0.391

FOXO3_HUMAN

Forkhead box protein O3

0.391

RIMB2_HUMAN

RIMS-binding protein 2

0.391

C43BP_HUMAN

Collagen type IV alpha-3-binding protein

0.391

ANLN_HUMAN

Anillin

0.392

TEF_HUMAN

Thyrotroph embryonic factor

0.392

TSN5_HUMAN

Tetraspanin-5

0.392

TRAK1_HUMAN

Trafficking kinesin-binding protein 1

0.392

NDST1_HUMAN

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

0.392

RB6I2_HUMAN

ELKS/Rab6-interacting/CAST family member 1

0.393

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.393

FOXP1_HUMAN

Forkhead box protein P1

0.393

FA8A1_HUMAN

Protein FAM8A1

0.393

IP3KB_HUMAN

Inositol-trisphosphate 3-kinase B

0.393

TMOD3_HUMAN

Tropomodulin-3

0.393

ELF2_HUMAN

ETS-related transcription factor Elf-2

0.394

TAOK1_HUMAN

Serine/threonine-protein kinase TAO1

0.394

ZSWM8_HUMAN

Zinc finger SWIM domain-containing protein 8

0.395

PDC10_HUMAN

Programmed cell death protein 10

0.395

CBL_HUMAN

E3 ubiquitin-protein ligase CBL

0.395

MTA1_HUMAN

Metastasis-associated protein MTA1

0.396

CACB4_HUMAN

Voltage-dependent L-type calcium channel subunit beta-4

0.396

TNIK_HUMAN

TRAF2 and NCK-interacting protein kinase

0.396

OFUT1_HUMAN

GDP-fucose protein O-fucosyltransferase 1

0.396

TM39B_HUMAN

Transmembrane protein 39B

0.397

RHG42_HUMAN

Rho GTPase-activating protein 42

0.397

SMAD1_HUMAN

Mothers against decapentaplegic homolog 1

0.397

CTNA1_HUMAN

Catenin alpha-1

0.397

HLF_HUMAN

Hepatic leukemia factor

0.397

MIGA1_HUMAN

Mitoguardin 1

0.397

ZC4H2_HUMAN

Zinc finger C4H2 domain-containing protein

0.397

NDST2_HUMAN

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

0.397

TF3C1_HUMAN

General transcription factor 3C polypeptide 1

0.398

TF7L2_HUMAN

Transcription factor 7-like 2

0.398

UNC79_HUMAN

Protein unc-79 homolog

0.398

BCL7B_HUMAN

B-cell CLL/lymphoma 7 protein family member B

0.398

STIM2_HUMAN

Stromal interaction molecule 2

0.398

KBRS2_HUMAN

NF-kappa-B inhibitor-interacting Ras-like protein 2

0.399

FOXO1_HUMAN

Forkhead box protein O1

0.399

PROX1_HUMAN

Prospero homeobox protein 1

0.399

UNC5D_HUMAN

Netrin receptor UNC5D

0.399

ZO2_HUMAN

Tight junction protein ZO-2

0.399

JIP3_HUMAN

C-Jun-amino-terminal kinase-interacting protein 3

0.399

CUL5_HUMAN

Cullin-5

0.399

MYT1L_HUMAN

Myelin transcription factor 1-like protein

0.400

MAGI3_HUMAN

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

0.400

MIER1_HUMAN

Mesoderm induction early response protein 1

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 53 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy