M3KCL_HUMAN 2019

Gene Name M3KCL

Description MAP3K7 C-terminal-like protein

Length 242

9606

Sequence

>sp|P57077|M3KCL_HUMAN MAP3K7 C-terminal-like protein
MVQLIAPLEVMWNEAADLKPLALSRRLECSGGIMAHYSPDLLGPEMESRYFAQVGLEHLASSSPPAFGFLKCLDYSISVLCSATSLAMLEDNPKVSKLATGDWMLTLKPKSITVPVEIPSSPLDDTPPEDSIPLVFPELDQQLQPLPPCHDSEESMEVFKQHCQIAEEYHEVKKEITLLEQRKKELIAKLDQAEKEKVDAAELVREFEALTEENRTLRLAQSQCVEQLEKLRIQYQKRQGSS

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

PLM_HUMAN

Phospholemman

0.365

CLC2D_HUMAN

C-type lectin domain family 2 member D

0.378

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

CLD16_HUMAN

Claudin-16

0.302

AMGO2_HUMAN

Amphoterin-induced protein 2

0.303

TM52B_HUMAN

Transmembrane protein 52B

0.306

SNTAN_HUMAN

Sentan

0.306

FYB2_HUMAN

FYN-binding protein 2

0.308

CCGL_HUMAN

Voltage-dependent calcium channel gamma-like subunit

0.335

STRA8_HUMAN

Stimulated by retinoic acid gene 8 protein homolog

0.338

MFAP3_HUMAN

Microfibril-associated glycoprotein 3

0.338

INGR1_HUMAN

Interferon gamma receptor 1

0.340

CF132_HUMAN

Uncharacterized protein C6orf132

0.342

BPIB4_HUMAN

BPI fold-containing family B member 4

0.342

CD47_HUMAN

Leukocyte surface antigen CD47

0.342

I10R1_HUMAN

Interleukin-10 receptor subunit alpha

0.344

LRAD1_HUMAN

Low-density lipoprotein receptor class A domain-containing protein 1

0.344

ODFP1_HUMAN

Outer dense fiber protein 1

0.344

MYOZ3_HUMAN

Myozenin-3

0.344

TSN32_HUMAN

Tetraspanin-32

0.346

OPT_HUMAN

Opticin

0.346

PSCA_HUMAN

Prostate stem cell antigen

0.346

CDHR3_HUMAN

Cadherin-related family member 3

0.358

THY1_HUMAN

Thy-1 membrane glycoprotein

0.358

SHPS1_HUMAN

Tyrosine-protein phosphatase non-receptor type substrate 1

0.358

RESF1_HUMAN

Retroelement silencing factor 1

0.360

S10AB_HUMAN

Protein S100-A11

0.360

ACRBP_HUMAN

Acrosin-binding protein

0.360

INGR2_HUMAN

Interferon gamma receptor 2

0.360

LIF_HUMAN

Leukemia inhibitory factor

0.360

TREM2_HUMAN

Triggering receptor expressed on myeloid cells 2

0.360

MMRN1_HUMAN

Multimerin-1

0.360

SPERT_HUMAN

Spermatid-associated protein

0.363

PML_HUMAN

Protein PML

0.363

ZN639_HUMAN

Zinc finger protein 639

0.363

ZN326_HUMAN

DBIRD complex subunit ZNF326

0.366

K2C5_HUMAN

Keratin, type II cytoskeletal 5

0.368

SCG1_HUMAN

Secretogranin-1

0.369

TNF15_HUMAN

Tumor necrosis factor ligand superfamily member 15

0.369

CD8A_HUMAN

T-cell surface glycoprotein CD8 alpha chain

0.370

SUGP2_HUMAN

SURP and G-patch domain-containing protein 2

0.371

CD40L_HUMAN

CD40 ligand

0.371

SUSD4_HUMAN

Sushi domain-containing protein 4

0.371

INAR1_HUMAN

Interferon alpha/beta receptor 1

0.371

CD34_HUMAN

Hematopoietic progenitor cell antigen CD34

0.373

COL_HUMAN

Colipase

0.373

HXD13_HUMAN

Homeobox protein Hox-D13

0.373

I13R1_HUMAN

Interleukin-13 receptor subunit alpha-1

0.376

PIANP_HUMAN

PILR alpha-associated neural protein

0.376

BCAS1_HUMAN

Breast carcinoma-amplified sequence 1

0.376

TM215_HUMAN

Transmembrane protein 215

0.376

LAPM5_HUMAN

Lysosomal-associated transmembrane protein 5

0.376

GKN1_HUMAN

Gastrokine-1

0.378

TNFL8_HUMAN

Tumor necrosis factor ligand superfamily member 8

0.378

INAR2_HUMAN

Interferon alpha/beta receptor 2

0.378

TIG1_HUMAN

Retinoic acid receptor responder protein 1

0.378

EGLN_HUMAN

Endoglin

0.378

CD72_HUMAN

B-cell differentiation antigen CD72

0.378

CAMP_HUMAN

Cathelicidin antimicrobial peptide

0.378

SHSA5_HUMAN

Protein shisa-5

0.380

ETV3_HUMAN

ETS translocation variant 3

0.383

BCLA3_HUMAN

BCLAF1 and THRAP3 family member 3

0.383

K2C80_HUMAN

Keratin, type II cytoskeletal 80

0.383

BCLF1_HUMAN

Bcl-2-associated transcription factor 1

0.385

VTDB_HUMAN

Vitamin D-binding protein

0.385

MAMD1_HUMAN

Mastermind-like domain-containing protein 1

0.385

IL17B_HUMAN

Interleukin-17B

0.385

IL5RA_HUMAN

Interleukin-5 receptor subunit alpha

0.385

RAMP2_HUMAN

Receptor activity-modifying protein 2

0.387

GSG1_HUMAN

Germ cell-specific gene 1 protein

0.390

TRI14_HUMAN

Tripartite motif-containing protein 14

0.392

VWCE_HUMAN

von Willebrand factor C and EGF domain-containing protein

0.392

TAF1D_HUMAN

TATA box-binding protein-associated factor RNA polymerase I subunit D

0.392

RAI3_HUMAN

Retinoic acid-induced protein 3

0.392

IL22_HUMAN

Interleukin-22

0.392

I22R1_HUMAN

Interleukin-22 receptor subunit alpha-1

0.392

ZN365_HUMAN

Protein ZNF365

0.393

ZN777_HUMAN

Zinc finger protein 777

0.395

IFNG_HUMAN

Interferon gamma

0.395

INLR1_HUMAN

Interferon lambda receptor 1

0.395

VEXIN_HUMAN

Vexin

0.395

ICOS_HUMAN

Inducible T-cell costimulator

0.395

CD28_HUMAN

T-cell-specific surface glycoprotein CD28

0.396

SNN_HUMAN

Stannin

0.396

SYT13_HUMAN

Synaptotagmin-13

0.396

FSD1L_HUMAN

FSD1-like protein

0.396

TOX2_HUMAN

TOX high mobility group box family member 2

0.396

GKN2_HUMAN

Gastrokine-2

0.397

CNCG_HUMAN

Retinal cone rhodopsin-sensitive cGMP 3,5-cyclic phosphodiesterase subunit gamma

0.397

PRIO_HUMAN

Major prion protein

0.397

LSME1_HUMAN

Leucine-rich single-pass membrane protein 1

0.397

TRI29_HUMAN

Tripartite motif-containing protein 29

0.398

AREG_HUMAN

Amphiregulin

0.398

GON1_HUMAN

Progonadoliberin-1

0.398

NANOG_HUMAN

Homeobox protein NANOG

0.398

CE57L_HUMAN

Centrosomal protein CEP57L1

0.398

UPK1B_HUMAN

Uroplakin-1b

0.398

LY96_HUMAN

Lymphocyte antigen 96

0.400

CI152_HUMAN

Uncharacterized protein C9orf152

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 14 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy