K2C80_HUMAN 2019

Gene Name K2C80

Description Keratin, type II cytoskeletal 80

Length 452

9606

Sequence

>sp|Q6KB66|K2C80_HUMAN Keratin, type II cytoskeletal 80
MACRSCVVGFSSLSSCEVTPVGSPRPGTSGWDSCRAPGPGFSSRSLTGCWSAGTISKVTVNPGLLVPLDVKLDPAVQQLKNQEKEEMKALNDKFASLIGKVQALEQRNQLLETRWSFLQGQDSAIFDLGHLYEEYQGRLQEELRKVSQERGQLEANLLQVLEKVEEFRIRYEDEISKRTDMEFTFVQLKKDLDAECLHRTELETKLKSLESFVELMKTIYEQELKDLAAQVKDVSVTVGMDSRCHIDLSGIVEEVKAQYDAVAARSLEEAEAYSRSQLEEQAARSAEYGSSLQSSRSEIADLNVRIQKLRSQILSVKSHCLKLEENIKTAEEQGELAFQDAKTKLAQLEAALQQAKQDMARQLRKYQELMNVKLALDIEIATYRKLVEGEEGRMDSPSATVVSAVQSRCKTAASRSGLSKAPSRKKKGSKGPVIKITEMSEKYFSQESEVSE

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

K2C5_HUMAN

Keratin, type II cytoskeletal 5

0.302

K2C6B_HUMAN

Keratin, type II cytoskeletal 6B

0.302

K1210_HUMAN

Acrosomal protein KIAA1210

0.316

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

ODFP1_HUMAN

Outer dense fiber protein 1

0.289

FYB2_HUMAN

FYN-binding protein 2

0.291

S10AB_HUMAN

Protein S100-A11

0.310

I22R1_HUMAN

Interleukin-22 receptor subunit alpha-1

0.310

ZN777_HUMAN

Zinc finger protein 777

0.312

VEXIN_HUMAN

Vexin

0.312

CA094_HUMAN

Uncharacterized protein C1orf94

0.312

SPERT_HUMAN

Spermatid-associated protein

0.312

CL050_HUMAN

Uncharacterized protein C12orf50

0.314

GKN2_HUMAN

Gastrokine-2

0.314

IL1RA_HUMAN

Interleukin-1 receptor antagonist protein

0.319

KCD19_HUMAN

BTB/POZ domain-containing protein KCTD19

0.329

CD47_HUMAN

Leukocyte surface antigen CD47

0.329

CF132_HUMAN

Uncharacterized protein C6orf132

0.329

EGLN_HUMAN

Endoglin

0.331

TM52B_HUMAN

Transmembrane protein 52B

0.331

TNFL8_HUMAN

Tumor necrosis factor ligand superfamily member 8

0.331

SNTAN_HUMAN

Sentan

0.331

IL15_HUMAN

Interleukin-15

0.333

EPCR_HUMAN

Endothelial protein C receptor

0.333

S10A9_HUMAN

Protein S100-A9

0.343

INGR2_HUMAN

Interferon gamma receptor 2

0.349

INLR1_HUMAN

Interferon lambda receptor 1

0.351

PML_HUMAN

Protein PML

0.351

SIAL_HUMAN

Bone sialoprotein 2

0.351

LSME1_HUMAN

Leucine-rich single-pass membrane protein 1

0.354

XCL1_HUMAN

Lymphotactin

0.354

K2C5_HUMAN

Keratin, type II cytoskeletal 5

0.356

K1C23_HUMAN

Keratin, type I cytoskeletal 23

0.356

DMB_HUMAN

HLA class II histocompatibility antigen, DM beta chain

0.356

IL2RA_HUMAN

Interleukin-2 receptor subunit alpha

0.359

TRI41_HUMAN

E3 ubiquitin-protein ligase TRIM41

0.359

VPRE3_HUMAN

Pre-B lymphocyte protein 3

0.359

CLD16_HUMAN

Claudin-16

0.363

INGR1_HUMAN

Interferon gamma receptor 1

0.363

BPIB4_HUMAN

BPI fold-containing family B member 4

0.365

CD72_HUMAN

B-cell differentiation antigen CD72

0.368

I10R1_HUMAN

Interleukin-10 receptor subunit alpha

0.368

MYOZ3_HUMAN

Myozenin-3

0.368

TM171_HUMAN

Transmembrane protein 171

0.368

CAMP_HUMAN

Cathelicidin antimicrobial peptide

0.368

INAR2_HUMAN

Interferon alpha/beta receptor 2

0.368

LRAD1_HUMAN

Low-density lipoprotein receptor class A domain-containing protein 1

0.368

PDCD1_HUMAN

Programmed cell death protein 1

0.370

GP162_HUMAN

Probable G-protein coupled receptor 162

0.370

SHSA5_HUMAN

Protein shisa-5

0.370

OPT_HUMAN

Opticin

0.370

TPO_HUMAN

Thrombopoietin

0.370

TM139_HUMAN

Transmembrane protein 139

0.370

PSCA_HUMAN

Prostate stem cell antigen

0.370

CD5_HUMAN

T-cell surface glycoprotein CD5

0.373

TM156_HUMAN

Transmembrane protein 156

0.373

CD019_HUMAN

Uncharacterized protein C4orf19

0.373

OSTP_HUMAN

Osteopontin

0.373

NXPH3_HUMAN

Neurexophilin-3

0.375

MROH7_HUMAN

Maestro heat-like repeat-containing protein family member 7

0.375

SHLD1_HUMAN

Shieldin complex subunit 1

0.375

HMGN1_HUMAN

Non-histone chromosomal protein HMG-14

0.375

SMRP1_HUMAN

Spermatid-specific manchette-related protein 1

0.375

MTCP1_HUMAN

Protein p13 MTCP-1

0.375

JAML_HUMAN

Junctional adhesion molecule-like

0.375

PDPN_HUMAN

Podoplanin

0.375

THY1_HUMAN

Thy-1 membrane glycoprotein

0.380

GSG1_HUMAN

Germ cell-specific gene 1 protein

0.380

SHPS1_HUMAN

Tyrosine-protein phosphatase non-receptor type substrate 1

0.380

TM247_HUMAN

Transmembrane protein 247

0.381

TREM2_HUMAN

Triggering receptor expressed on myeloid cells 2

0.383

RESF1_HUMAN

Retroelement silencing factor 1

0.383

AKAP8_HUMAN

A-kinase anchor protein 8

0.383

M3KCL_HUMAN

MAP3K7 C-terminal-like protein

0.383

IL22_HUMAN

Interleukin-22

0.383

ACRBP_HUMAN

Acrosin-binding protein

0.383

BRNP2_HUMAN

BMP/retinoic acid-inducible neural-specific protein 2

0.383

LIF_HUMAN

Leukemia inhibitory factor

0.383

MFAP5_HUMAN

Microfibrillar-associated protein 5

0.383

TB182_HUMAN

182 kDa tankyrase-1-binding protein

0.386

ICOS_HUMAN

Inducible T-cell costimulator

0.386

ZN639_HUMAN

Zinc finger protein 639

0.386

CX3C1_HUMAN

CX3C chemokine receptor 1

0.388

IL9R_HUMAN

Interleukin-9 receptor

0.388

TRIM7_HUMAN

E3 ubiquitin-protein ligase TRIM7

0.388

CE57L_HUMAN

Centrosomal protein CEP57L1

0.390

MUCEN_HUMAN

Endomucin

0.391

LY96_HUMAN

Lymphocyte antigen 96

0.391

MISSL_HUMAN

MAPK-interacting and spindle-stabilizing protein-like

0.391

MFAP3_HUMAN

Microfibril-associated glycoprotein 3

0.392

INAR1_HUMAN

Interferon alpha/beta receptor 1

0.392

SUGP2_HUMAN

SURP and G-patch domain-containing protein 2

0.392

ZPBP1_HUMAN

Zona pellucida-binding protein 1

0.394

TMM40_HUMAN

Transmembrane protein 40

0.394

HRG_HUMAN

Histidine-rich glycoprotein

0.394

DMA_HUMAN

HLA class II histocompatibility antigen, DM alpha chain

0.394

CD8A_HUMAN

T-cell surface glycoprotein CD8 alpha chain

0.394

CCL17_HUMAN

C-C motif chemokine 17

0.394

PLAC9_HUMAN

Placenta-specific protein 9

0.394

COL_HUMAN

Colipase

0.395

CD34_HUMAN

Hematopoietic progenitor cell antigen CD34

0.395

RSPO4_HUMAN

R-spondin-4

0.395

LY86_HUMAN

Lymphocyte antigen 86

0.395

FA71D_HUMAN

Protein FAM71D

0.396

TNR8_HUMAN

Tumor necrosis factor receptor superfamily member 8

0.396

AMGO2_HUMAN

Amphoterin-induced protein 2

0.397

5NT1B_HUMAN

Cytosolic 5-nucleotidase 1B

0.397

BCAS1_HUMAN

Breast carcinoma-amplified sequence 1

0.397

PIANP_HUMAN

PILR alpha-associated neural protein

0.397

GKN1_HUMAN

Gastrokine-1

0.400

A1AG1_HUMAN

Alpha-1-acid glycoprotein 1

0.400

LRC55_HUMAN

Leucine-rich repeat-containing protein 55

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 10 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy