X3CL1_HUMAN 2019

Gene Name X3CL1

Description Fractalkine

Length 397

9606

Sequence

>sp|P78423|X3CL1_HUMAN Fractalkine
MAPISLSWLLRLATFCHLTVLLAGQHHGVTKCNITCSKMTSKIPVALLIHYQQNQASCGKRAIILETRQHRLFCADPKEQWVKDAMQHLDRQAAALTRNGGTFEKQIGEVKPRTTPAAGGMDESVVLEPEATGESSSLEPTPSSQEAQRALGTSPELPTGVTGSSGTRLPPTPKAQDGGPVGTELFRVPPVSTAATWQSSAPHQPGPSLWAEAKTSEAPSTQDPSTQASTASSPAPEENAPSEGQRVWGQGQSPRPENSLEREEMGPVPAHTDAFQDWGPGSMAHVSVVPVSSEGTPSREPVASGSWTPKAEEPIHATMDPQRLGVLITPVPDAQAATRRQAVGLLAFLGLLFCLGVAMFTYQSLQGCPRKMAGEMAEGLRYIPRSCGSNSYVLVPV

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

ZN316_HUMAN

Zinc finger protein 316

0.000

SPT25_HUMAN

Spermatogenesis-associated protein 25

0.000

TRML1_HUMAN

Trem-like transcript 1 protein

0.000

CD20_HUMAN

B-lymphocyte antigen CD20

0.000

OR5T1_HUMAN

Olfactory receptor 5T1

0.000

OR5T2_HUMAN

Olfactory receptor 5T2

0.000

RAB42_HUMAN

Ras-related protein Rab-42

0.000

VSIG8_HUMAN

V-set and immunoglobulin domain-containing protein 8

0.333

DAF_HUMAN

Complement decay-accelerating factor

0.333

SPAT9_HUMAN

Spermatogenesis-associated protein 9

0.333

OR6Y1_HUMAN

Olfactory receptor 6Y1

0.333

O13A1_HUMAN

Olfactory receptor 13A1

0.333

OR6F1_HUMAN

Olfactory receptor 6F1

0.333

O11G2_HUMAN

Olfactory receptor 11G2

0.333

CD69_HUMAN

Early activation antigen CD69

0.333

O5AS1_HUMAN

Olfactory receptor 5AS1

0.333

LMTD2_HUMAN

Lamin tail domain-containing protein 2

0.333

T200B_HUMAN

Transmembrane protein 200B

0.333

FAIM3_HUMAN

Fas apoptotic inhibitory molecule 3

0.333

O11H6_HUMAN

Olfactory receptor 11H6

0.333

KISS1_HUMAN

Metastasis-suppressor KiSS-1

0.333

B2LA1_HUMAN

Bcl-2-related protein A1

0.333

OR4E2_HUMAN

Olfactory receptor 4E2

0.333

O10D4_HUMAN

Putative olfactory receptor 10D4

0.333

OR4S2_HUMAN

Olfactory receptor 4S2

0.333

CNPY1_HUMAN

Protein canopy homolog 1

0.333

FNDC8_HUMAN

Fibronectin type III domain-containing protein 8

0.333

NIBL2_HUMAN

Niban-like protein 2

0.333

ZN496_HUMAN

Zinc finger protein 496

0.354

SG3A2_HUMAN

Secretoglobin family 3A member 2

0.354

CI040_HUMAN

Uncharacterized protein C9orf40

0.354

OR5L2_HUMAN

Olfactory receptor 5L2

0.354

OR4B1_HUMAN

Olfactory receptor 4B1

0.354

O2AG2_HUMAN

Olfactory receptor 2AG2

0.354

CC196_HUMAN

Putative coiled-coil domain-containing protein 196

0.354

CCL22_HUMAN

C-C motif chemokine 22

0.354

O4A15_HUMAN

Olfactory receptor 4A15

0.354

CC116_HUMAN

Coiled-coil domain-containing protein 116

0.354

O13C7_HUMAN

Olfactory receptor 13C7

0.354

GAPT_HUMAN

Protein GAPT

0.354

O51A7_HUMAN

Olfactory receptor 51A7

0.354

MASTR_HUMAN

MEF2-activating motif and SAP domain-containing transcriptional regulator

0.354

T53G5_HUMAN

TP53-target gene 5 protein

0.354

AHSP_HUMAN

Alpha-hemoglobin-stabilizing protein

0.354

EP3A_HUMAN

Epididymal secretory protein E3-alpha

0.354

S10A8_HUMAN

Protein S100-A8

0.354

ODAM_HUMAN

Odontogenic ameloblast-associated protein

0.354

PA2GC_HUMAN

Putative inactive group IIC secretory phospholipase A2

0.354

OR1L6_HUMAN

Olfactory receptor 1L6

0.354

ZNF3_HUMAN

Zinc finger protein 3

0.354

OR2V1_HUMAN

Olfactory receptor 2V1

0.354

OR5A1_HUMAN

Olfactory receptor 5A1

0.354

OR5L1_HUMAN

Olfactory receptor 5L1

0.354

ZN746_HUMAN

Zinc finger protein 746

0.354

O2T33_HUMAN

Olfactory receptor 2T33

0.354

ACTT3_HUMAN

Actin-related protein T3

0.354

TCHL1_HUMAN

Trichohyalin-like protein 1

0.354

T2R38_HUMAN

Taste receptor type 2 member 38

0.354

MROH9_HUMAN

Maestro heat-like repeat-containing protein family member 9

0.354

CITE4_HUMAN

Cbp/p300-interacting transactivator 4

0.354

O52B4_HUMAN

Olfactory receptor 52B4

0.354

O10K2_HUMAN

Olfactory receptor 10K2

0.354

PRS42_HUMAN

Putative serine protease 42

0.354

MUC20_HUMAN

Mucin-20

0.354

ZN428_HUMAN

Zinc finger protein 428

0.354

STP1_HUMAN

Spermatid nuclear transition protein 1

0.354

PILRA_HUMAN

Paired immunoglobulin-like type 2 receptor alpha

0.354

OR5MB_HUMAN

Olfactory receptor 5M11

0.354

OR5M9_HUMAN

Olfactory receptor 5M9

0.354

COPRS_HUMAN

Coordinator of PRMT5 and differentiation stimulator

0.354

CDRT4_HUMAN

CMT1A duplicated region transcript 4 protein

0.354

S100G_HUMAN

Protein S100-G

0.354

EP3B_HUMAN

Epididymal secretory protein E3-beta

0.354

PAHO_HUMAN

Pancreatic prohormone

0.354

CLD9_HUMAN

Claudin-9

0.354

ZN641_HUMAN

Zinc finger protein 641

0.354

TRML2_HUMAN

Trem-like transcript 2 protein

0.354

TSP50_HUMAN

Probable threonine protease PRSS50

0.354

PRND_HUMAN

Prion-like protein doppel

0.354

OR5R1_HUMAN

Olfactory receptor 5R1

0.354

C5AR2_HUMAN

C5a anaphylatoxin chemotactic receptor 2

0.354

TEX46_HUMAN

Testis-expressed protein 46

0.354

LY6H_HUMAN

Lymphocyte antigen 6H

0.354

LAT_HUMAN

Linker for activation of T-cells family member 1

0.354

G6B_HUMAN

Megakaryocyte and platelet inhibitory receptor G6b

0.354

OR4CC_HUMAN

Olfactory receptor 4C12

0.354

LCN1_HUMAN

Lipocalin-1

0.354

RNS12_HUMAN

Probable inactive ribonuclease-like protein 12

0.354

ZKSC2_HUMAN

Zinc finger protein with KRAB and SCAN domains 2

0.354

K1C26_HUMAN

Keratin, type I cytoskeletal 26

0.354

O52W1_HUMAN

Olfactory receptor 52W1

0.354

ZN697_HUMAN

Zinc finger protein 697

0.354

PKHH3_HUMAN

Pleckstrin homology domain-containing family H member 3

0.354

IL5_HUMAN

Interleukin-5

0.354

FCG3A_HUMAN

Low affinity immunoglobulin gamma Fc region receptor III-A

0.354

CP054_HUMAN

Transmembrane protein C16orf54

0.354

OR9A4_HUMAN

Olfactory receptor 9A4

0.354

O10G7_HUMAN

Olfactory receptor 10G7

0.354

BPIA1_HUMAN

BPI fold-containing family A member 1

0.354

M4A13_HUMAN

Membrane-spanning 4-domains subfamily A member 13

0.354

O51V1_HUMAN

Olfactory receptor 51V1

0.354

DLL3_HUMAN

Delta-like protein 3

0.354

LAX1_HUMAN

Lymphocyte transmembrane adapter 1

0.354

CS2IP_HUMAN

Casein kinase II subunit alpha-interacting protein

0.354

TM202_HUMAN

Transmembrane protein 202

0.354

ZN250_HUMAN

Zinc finger protein 250

0.354

OR6K2_HUMAN

Olfactory receptor 6K2

0.354

OR5G3_HUMAN

Olfactory receptor 5G3

0.354

GPR31_HUMAN

12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor

0.354

PRS37_HUMAN

Probable inactive serine protease 37

0.354

OR9K2_HUMAN

Olfactory receptor 9K2

0.354

PILRB_HUMAN

Paired immunoglobulin-like type 2 receptor beta

0.354

CK086_HUMAN

Uncharacterized protein C11orf86

0.354

CCD54_HUMAN

Coiled-coil domain-containing protein 54

0.354

PS1C2_HUMAN

Psoriasis susceptibility 1 candidate gene 2 protein

0.354

BPIB3_HUMAN

BPI fold-containing family B member 3

0.354

KRBA1_HUMAN

Protein KRBA1

0.354

ZCCHL_HUMAN

Zinc finger CCCH-type antiviral protein 1-like

0.354

O4C46_HUMAN

Olfactory receptor 4C46

0.354

ATP8_HUMAN

ATP synthase protein 8

0.354

DBND2_HUMAN

Dysbindin domain-containing protein 2

0.354

SCND1_HUMAN

SCAN domain-containing protein 1

0.354

O51S1_HUMAN

Olfactory receptor 51S1

0.354

CC188_HUMAN

Coiled-coil domain-containing protein 188

0.354

OR5C1_HUMAN

Olfactory receptor 5C1

0.354

IL7_HUMAN

Interleukin-7

0.354

O51F2_HUMAN

Olfactory receptor 51F2

0.354

IL36A_HUMAN

Interleukin-36 alpha

0.354

IL1A_HUMAN

Interleukin-1 alpha

0.354

O51B6_HUMAN

Olfactory receptor 51B6

0.354

MROH8_HUMAN

Protein MROH8

0.354

FFAR1_HUMAN

Free fatty acid receptor 1

0.354

TM225_HUMAN

Transmembrane protein 225

0.354

OR8K1_HUMAN

Olfactory receptor 8K1

0.354

CYLC2_HUMAN

Cylicin-2

0.354

O2AG1_HUMAN

Olfactory receptor 2AG1

0.354

O2T12_HUMAN

Olfactory receptor 2T12

0.354

O10AG_HUMAN

Olfactory receptor 10AG1

0.354

CCR10_HUMAN

C-C chemokine receptor type 10

0.354

CD036_HUMAN

Uncharacterized protein C4orf36

0.354

OR8D4_HUMAN

Olfactory receptor 8D4

0.354

IGSF2_HUMAN

Immunoglobulin superfamily member 2

0.354

PRS58_HUMAN

Serine protease 58

0.354

Z286A_HUMAN

Zinc finger protein 286A

0.354

ABC3B_HUMAN

DNA dC->dU-editing enzyme APOBEC-3B

0.354

ZSC20_HUMAN

Zinc finger and SCAN domain-containing protein 20

0.354

ZSC10_HUMAN

Zinc finger and SCAN domain-containing protein 10

0.354

TM219_HUMAN

Insulin-like growth factor-binding protein 3 receptor

0.354

TNFL4_HUMAN

Tumor necrosis factor ligand superfamily member 4

0.354

ODAPH_HUMAN

Odontogenesis associated phosphoprotein

0.354

HMGN5_HUMAN

High mobility group nucleosome-binding domain-containing protein 5

0.354

OR8G5_HUMAN

Olfactory receptor 8G5

0.354

S10A3_HUMAN

Protein S100-A3

0.354

CJ120_HUMAN

Uncharacterized protein C10orf120

0.354

PRR19_HUMAN

Proline-rich protein 19

0.354

CCRL2_HUMAN

C-C chemokine receptor-like 2

0.354

OR5MA_HUMAN

Olfactory receptor 5M10

0.354

KRA33_HUMAN

Keratin-associated protein 3-3

0.354

O13J1_HUMAN

Olfactory receptor 13J1

0.354

TREM1_HUMAN

Triggering receptor expressed on myeloid cells 1

0.354

TMC5A_HUMAN

Transmembrane and coiled-coil domain-containing protein 5A

0.354

OR8U1_HUMAN

Olfactory receptor 8U1

0.354

OR4CF_HUMAN

Olfactory receptor 4C15

0.354

F229B_HUMAN

Protein FAM229B

0.354

ZKSC5_HUMAN

Zinc finger protein with KRAB and SCAN domains 5

0.354

INSL3_HUMAN

Insulin-like 3

0.354

FCERB_HUMAN

High affinity immunoglobulin epsilon receptor subunit beta

0.354

TIGIT_HUMAN

T-cell immunoreceptor with Ig and ITIM domains

0.354

BPIB1_HUMAN

BPI fold-containing family B member 1

0.354

OR4X2_HUMAN

Olfactory receptor 4X2

0.354

GON7_HUMAN

EKC/KEOPS complex subunit GON7

0.354

OR6A2_HUMAN

Olfactory receptor 6A2

0.354

OR6P1_HUMAN

Olfactory receptor 6P1

0.354

OR5B3_HUMAN

Olfactory receptor 5B3

0.354

TROAP_HUMAN

Tastin

0.354

OR4C6_HUMAN

Olfactory receptor 4C6

0.354

OR5P3_HUMAN

Olfactory receptor 5P3

0.354

CQ080_HUMAN

Uncharacterized protein C17orf80

0.354

OR8A1_HUMAN

Olfactory receptor 8A1

0.354

ZN202_HUMAN

Zinc finger protein 202

0.354

CTF1_HUMAN

Cardiotrophin-1

0.354

CK094_HUMAN

Uncharacterized protein C11orf94

0.354

RAGE_HUMAN

Advanced glycosylation end product-specific receptor

0.354

REPI1_HUMAN

Replication initiator 1

0.354

CL071_HUMAN

Uncharacterized protein C12orf71

0.354

OCEL1_HUMAN

Occludin/ELL domain-containing protein 1

0.354

TEX50_HUMAN

Testis-expressed protein 50

0.354

OR5M1_HUMAN

Olfactory receptor 5M1

0.354

OR2K2_HUMAN

Olfactory receptor 2K2

0.354

OR5W2_HUMAN

Olfactory receptor 5W2

0.354

O51T1_HUMAN

Olfactory receptor 51T1

0.354

NGAL_HUMAN

Neutrophil gelatinase-associated lipocalin

0.354

SCIMP_HUMAN

SLP adapter and CSK-interacting membrane protein

0.354

ZN672_HUMAN

Zinc finger protein 672

0.354

O51F1_HUMAN

Olfactory receptor 51F1

0.354

O13F1_HUMAN

Olfactory receptor 13F1

0.354

SPRN_HUMAN

Shadow of prion protein

0.354

CAVN3_HUMAN

Caveolae-associated protein 3

0.354

OR2LD_HUMAN

Olfactory receptor 2L13

0.354

CD70_HUMAN

CD70 antigen

0.354

EQTN_HUMAN

Equatorin

0.354

OR6K6_HUMAN

Olfactory receptor 6K6

0.354

T2R16_HUMAN

Taste receptor type 2 member 16

0.354

K1C25_HUMAN

Keratin, type I cytoskeletal 25

0.354

ZN263_HUMAN

Zinc finger protein 263

0.354

OPALI_HUMAN

Opalin

0.354

TMCO2_HUMAN

Transmembrane and coiled-coil domain-containing protein 2

0.354

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

GSDMD_HUMAN

Gasdermin-D

0.326

LIF_HUMAN

Leukemia inhibitory factor

0.333

PML_HUMAN

Protein PML

0.336

SIAL_HUMAN

Bone sialoprotein 2

0.336

TB182_HUMAN

182 kDa tankyrase-1-binding protein

0.336

INLR1_HUMAN

Interferon lambda receptor 1

0.336

TM109_HUMAN

Transmembrane protein 109

0.343

CCL17_HUMAN

C-C motif chemokine 17

0.343

TNFL4_HUMAN

Tumor necrosis factor ligand superfamily member 4

0.346

CF132_HUMAN

Uncharacterized protein C6orf132

0.351

CD47_HUMAN

Leukocyte surface antigen CD47

0.351

BPIB4_HUMAN

BPI fold-containing family B member 4

0.351

ODFP1_HUMAN

Outer dense fiber protein 1

0.354

TNFL8_HUMAN

Tumor necrosis factor ligand superfamily member 8

0.354

CD72_HUMAN

B-cell differentiation antigen CD72

0.354

EGLN_HUMAN

Endoglin

0.354

I10R1_HUMAN

Interleukin-10 receptor subunit alpha

0.354

TM139_HUMAN

Transmembrane protein 139

0.356

IL15_HUMAN

Interleukin-15

0.356

PDCD1_HUMAN

Programmed cell death protein 1

0.356

OSTP_HUMAN

Osteopontin

0.359

TM156_HUMAN

Transmembrane protein 156

0.359

CC198_HUMAN

Uncharacterized protein CCDC198

0.359

MROH7_HUMAN

Maestro heat-like repeat-containing protein family member 7

0.361

IL23A_HUMAN

Interleukin-23 subunit alpha

0.367

THY1_HUMAN

Thy-1 membrane glycoprotein

0.368

IL4_HUMAN

Interleukin-4

0.369

IL27A_HUMAN

Interleukin-27 subunit alpha

0.369

CD20_HUMAN

B-lymphocyte antigen CD20

0.369

BRNP2_HUMAN

BMP/retinoic acid-inducible neural-specific protein 2

0.370

RESF1_HUMAN

Retroelement silencing factor 1

0.370

RAGE_HUMAN

Advanced glycosylation end product-specific receptor

0.372

TM219_HUMAN

Insulin-like growth factor-binding protein 3 receptor

0.372

SPERT_HUMAN

Spermatid-associated protein

0.373

ICOS_HUMAN

Inducible T-cell costimulator

0.373

VEXIN_HUMAN

Vexin

0.373

IFNG_HUMAN

Interferon gamma

0.373

ZN777_HUMAN

Zinc finger protein 777

0.373

XCL1_HUMAN

Lymphotactin

0.375

RARR2_HUMAN

Retinoic acid receptor responder protein 2

0.375

B2LA1_HUMAN

Bcl-2-related protein A1

0.375

IL9R_HUMAN

Interleukin-9 receptor

0.375

CL050_HUMAN

Uncharacterized protein C12orf50

0.375

MB214_HUMAN

Protein mab-21-like 4

0.375

CX3C1_HUMAN

CX3C chemokine receptor 1

0.375

OSTB_HUMAN

Organic solute transporter subunit beta

0.375

K1C23_HUMAN

Keratin, type I cytoskeletal 23

0.378

CP071_HUMAN

Uncharacterized protein C16orf71

0.381

TRI41_HUMAN

E3 ubiquitin-protein ligase TRIM41

0.381

INGR1_HUMAN

Interferon gamma receptor 1

0.383

GUC2B_HUMAN

Guanylate cyclase activator 2B

0.383

BCAS1_HUMAN

Breast carcinoma-amplified sequence 1

0.386

FNDC8_HUMAN

Fibronectin type III domain-containing protein 8

0.386

T53G5_HUMAN

TP53-target gene 5 protein

0.386

A1AG1_HUMAN

Alpha-1-acid glycoprotein 1

0.388

ECSCR_HUMAN

Endothelial cell-specific chemotaxis regulator

0.388

IL23R_HUMAN

Interleukin-23 receptor

0.388

LRC55_HUMAN

Leucine-rich repeat-containing protein 55

0.388

CKLF6_HUMAN

CKLF-like MARVEL transmembrane domain-containing protein 6

0.388

CAMP_HUMAN

Cathelicidin antimicrobial peptide

0.388

ZN202_HUMAN

Zinc finger protein 202

0.389

PA2GF_HUMAN

Group IIF secretory phospholipase A2

0.389

LAX1_HUMAN

Lymphocyte transmembrane adapter 1

0.389

NKG7_HUMAN

Protein NKG7

0.389

TRML1_HUMAN

Trem-like transcript 1 protein

0.389

TSN32_HUMAN

Tetraspanin-32

0.391

EPCR_HUMAN

Endothelial protein C receptor

0.391

SHSA5_HUMAN

Protein shisa-5

0.391

LAT_HUMAN

Linker for activation of T-cells family member 1

0.392

CENPA_HUMAN

Histone H3-like centromeric protein A

0.394

CD5_HUMAN

T-cell surface glycoprotein CD5

0.394

CDSN_HUMAN

Corneodesmosin

0.395

ZN398_HUMAN

Zinc finger protein 398

0.396

JAML_HUMAN

Junctional adhesion molecule-like

0.396

PDPN_HUMAN

Podoplanin

0.396

SPT46_HUMAN

Spermatogenesis-associated protein 46

0.396

SMRP1_HUMAN

Spermatid-specific manchette-related protein 1

0.396

LAD1_HUMAN

Ladinin-1

0.397

BPIB2_HUMAN

BPI fold-containing family B member 2

0.399

GSDMA_HUMAN

Gasdermin-A

0.399

ARM12_HUMAN

Armadillo repeat-containing protein 12

0.399

FSCN3_HUMAN

Fascin-3

0.399

CQ064_HUMAN

Uncharacterized protein C17orf64

0.399

CUL7_HUMAN

Cullin-7

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 8 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy