ZBTB6_HUMAN 2019

Gene Name ZBTB6

Description Zinc finger and BTB domain-containing protein 6

Length 424

9606

Sequence

>sp|Q15916|ZBTB6_HUMAN Zinc finger and BTB domain-containing protein 6
MAAESDVLHFQFEQQGDVVLQKMNLLRQQNLFCDVSIYINDTEFQGHKVILAACSTFMRDQFLLTQSKHVRITILQSAEVGRKLLLSCYTGALEVKRKELLKYLTAASYLQMVHIVEKCTEALSKYLEIDLSMKNNNQHTDLCQSSDPDVKNEDENSDKDCEIIEISEDSPVNIDFHVKEEESNALQSTVESLTSERKEMKSPELSTVDIGFKDNEICILHVESISTAGVENGQFSQPCTSSKASMYFSETQHSLINSTVESRVAEVPGNQDQGLFCENTEGSYGTVSEIQNLEEGYSLRHQCPRCPRGFLHVENYLRHLKMHKLFLCLQCGKTFTQKKNLNRHIRGHMGIRPFQCTVCLKTFTAKSTLQDHLNIHSGDRPYKCHCCDMDFKHKSALKKHLTSVHGRSSGEKLSRPDLKRQSLL

Domains

Loading...

Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

ZC21C_HUMAN

Zinc finger C2HC domain-containing protein 1C

0.267

CD40L_HUMAN

CD40 ligand

0.267

NPY5R_HUMAN

Neuropeptide Y receptor type 5

0.267

MFAP3_HUMAN

Microfibril-associated glycoprotein 3

0.267

AREG_HUMAN

Amphiregulin

0.267

CLD16_HUMAN

Claudin-16

0.267

VWCE_HUMAN

von Willebrand factor C and EGF domain-containing protein

0.267

TRI14_HUMAN

Tripartite motif-containing protein 14

0.267

PIANP_HUMAN

PILR alpha-associated neural protein

0.267

MSLN_HUMAN

Mesothelin

0.267

APOA1_HUMAN

Apolipoprotein A-I

0.277

F174A_HUMAN

Membrane protein FAM174A

0.277

P2Y13_HUMAN

P2Y purinoceptor 13

0.277

GKN1_HUMAN

Gastrokine-1

0.277

Z518B_HUMAN

Zinc finger protein 518B

0.277

TNF15_HUMAN

Tumor necrosis factor ligand superfamily member 15

0.365

CU062_HUMAN

Uncharacterized protein C21orf62

0.365

ZP2_HUMAN

Zona pellucida sperm-binding protein 2

0.365

CD6_HUMAN

T-cell differentiation antigen CD6

0.365

CD28_HUMAN

T-cell-specific surface glycoprotein CD28

0.365

IRAK2_HUMAN

Interleukin-1 receptor-associated kinase-like 2

0.378

ZN654_HUMAN

Zinc finger protein 654

0.378

LPAR5_HUMAN

Lysophosphatidic acid receptor 5

0.378

ICOSL_HUMAN

ICOS ligand

0.378

REG4_HUMAN

Regenerating islet-derived protein 4

0.378

TAF1D_HUMAN

TATA box-binding protein-associated factor RNA polymerase I subunit D

0.378

PRR36_HUMAN

Proline-rich protein 36

0.378

I13R1_HUMAN

Interleukin-13 receptor subunit alpha-1

0.378

INGR1_HUMAN

Interferon gamma receptor 1

0.378

IL22_HUMAN

Interleukin-22

0.378

INGR2_HUMAN

Interferon gamma receptor 2

0.378

GIMD1_HUMAN

GTPase IMAP family member GIMD1

0.378

XKR2_HUMAN

XK-related protein 2

0.378

LAPM5_HUMAN

Lysosomal-associated transmembrane protein 5

0.378

LRC8B_HUMAN

Volume-regulated anion channel subunit LRRC8B

0.378

AKND1_HUMAN

Protein AKNAD1

0.378

CCD68_HUMAN

Coiled-coil domain-containing protein 68

0.378

CNCG_HUMAN

Retinal cone rhodopsin-sensitive cGMP 3,5-cyclic phosphodiesterase subunit gamma

0.378

IGSF1_HUMAN

Immunoglobulin superfamily member 1

0.378

FETA_HUMAN

Alpha-fetoprotein

0.378

SRTD1_HUMAN

SERTA domain-containing protein 1

0.392

FNDC9_HUMAN

Fibronectin type III domain-containing protein 9

0.392

RESF1_HUMAN

Retroelement silencing factor 1

0.392

IGJ_HUMAN

Immunoglobulin J chain

0.392

MAS_HUMAN

Proto-oncogene Mas

0.392

CXCR6_HUMAN

C-X-C chemokine receptor type 6

0.392

OR5V1_HUMAN

Olfactory receptor 5V1

0.392

GPR35_HUMAN

G-protein coupled receptor 35

0.392

PSYR_HUMAN

Psychosine receptor

0.392

ZN639_HUMAN

Zinc finger protein 639

0.392

TM171_HUMAN

Transmembrane protein 171

0.392

TM140_HUMAN

Transmembrane protein 140

0.392

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

GKN1_HUMAN

Gastrokine-1

0.283

MFAP3_HUMAN

Microfibril-associated glycoprotein 3

0.318

APOA1_HUMAN

Apolipoprotein A-I

0.344

CD28_HUMAN

T-cell-specific surface glycoprotein CD28

0.349

LRIF1_HUMAN

Ligand-dependent nuclear receptor-interacting factor 1

0.349

AREG_HUMAN

Amphiregulin

0.351

CD40L_HUMAN

CD40 ligand

0.354

INGR1_HUMAN

Interferon gamma receptor 1

0.356

CLD16_HUMAN

Claudin-16

0.356

LAPM5_HUMAN

Lysosomal-associated transmembrane protein 5

0.358

TM52B_HUMAN

Transmembrane protein 52B

0.360

MYOZ3_HUMAN

Myozenin-3

0.360

TNAP2_HUMAN

Tumor necrosis factor alpha-induced protein 2

0.362

OPT_HUMAN

Opticin

0.363

TPO_HUMAN

Thrombopoietin

0.363

BCLF1_HUMAN

Bcl-2-associated transcription factor 1

0.369

CO8A1_HUMAN

Collagen alpha-1(VIII) chain

0.373

THY1_HUMAN

Thy-1 membrane glycoprotein

0.373

CSF3_HUMAN

Granulocyte colony-stimulating factor

0.373

IL22_HUMAN

Interleukin-22

0.376

INGR2_HUMAN

Interferon gamma receptor 2

0.376

TREM2_HUMAN

Triggering receptor expressed on myeloid cells 2

0.376

S10AB_HUMAN

Protein S100-A11

0.376

RESF1_HUMAN

Retroelement silencing factor 1

0.376

TRI14_HUMAN

Tripartite motif-containing protein 14

0.376

CRTAM_HUMAN

Cytotoxic and regulatory T-cell molecule

0.378

TNF15_HUMAN

Tumor necrosis factor ligand superfamily member 15

0.383

SCG1_HUMAN

Secretogranin-1

0.383

CD6_HUMAN

T-cell differentiation antigen CD6

0.383

CCGL_HUMAN

Voltage-dependent calcium channel gamma-like subunit

0.383

INAR1_HUMAN

Interferon alpha/beta receptor 1

0.385

SUGP2_HUMAN

SURP and G-patch domain-containing protein 2

0.385

SUSD4_HUMAN

Sushi domain-containing protein 4

0.385

CD34_HUMAN

Hematopoietic progenitor cell antigen CD34

0.387

PIANP_HUMAN

PILR alpha-associated neural protein

0.390

CD47_HUMAN

Leukocyte surface antigen CD47

0.390

BPIB4_HUMAN

BPI fold-containing family B member 4

0.390

CD8B_HUMAN

T-cell surface glycoprotein CD8 beta chain

0.390

CF132_HUMAN

Uncharacterized protein C6orf132

0.390

I13R1_HUMAN

Interleukin-13 receptor subunit alpha-1

0.390

AMGO2_HUMAN

Amphoterin-induced protein 2

0.390

BCAS1_HUMAN

Breast carcinoma-amplified sequence 1

0.390

PALB2_HUMAN

Partner and localizer of BRCA2

0.391

SNTAN_HUMAN

Sentan

0.392

TM171_HUMAN

Transmembrane protein 171

0.392

CAMP_HUMAN

Cathelicidin antimicrobial peptide

0.392

LRAD1_HUMAN

Low-density lipoprotein receptor class A domain-containing protein 1

0.392

ICOSL_HUMAN

ICOS ligand

0.392

ODFP1_HUMAN

Outer dense fiber protein 1

0.392

EGLN_HUMAN

Endoglin

0.392

FYB2_HUMAN

FYN-binding protein 2

0.395

MSLN_HUMAN

Mesothelin

0.395

ZFX_HUMAN

Zinc finger X-chromosomal protein

0.396

BCLA3_HUMAN

BCLAF1 and THRAP3 family member 3

0.396

PSPC_HUMAN

Pulmonary surfactant-associated protein C

0.397

IL17B_HUMAN

Interleukin-17B

0.398

TEDC2_HUMAN

Tubulin epsilon and delta complex protein 2

0.398

IL5RA_HUMAN

Interleukin-5 receptor subunit alpha

0.398

VTDB_HUMAN

Vitamin D-binding protein

0.398

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 73 organisms (of 929)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy