APOA1_HUMAN 2019

Gene Name APOA1

Description Apolipoprotein A-I

Length 267

9606

Sequence

>sp|P02647|APOA1_HUMAN Apolipoprotein A-I
MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

Z518B_HUMAN

Zinc finger protein 518B

0.000

LAPM5_HUMAN

Lysosomal-associated transmembrane protein 5

0.277

I13R1_HUMAN

Interleukin-13 receptor subunit alpha-1

0.277

XKR2_HUMAN

XK-related protein 2

0.277

ZBTB6_HUMAN

Zinc finger and BTB domain-containing protein 6

0.277

IL5RA_HUMAN

Interleukin-5 receptor subunit alpha

0.378

CD40L_HUMAN

CD40 ligand

0.378

VWCE_HUMAN

von Willebrand factor C and EGF domain-containing protein

0.378

MFAP3_HUMAN

Microfibril-associated glycoprotein 3

0.378

AREG_HUMAN

Amphiregulin

0.378

MSLN_HUMAN

Mesothelin

0.378

TRI14_HUMAN

Tripartite motif-containing protein 14

0.378

CLD16_HUMAN

Claudin-16

0.378

PIANP_HUMAN

PILR alpha-associated neural protein

0.378

ZC21C_HUMAN

Zinc finger C2HC domain-containing protein 1C

0.378

NPY5R_HUMAN

Neuropeptide Y receptor type 5

0.378

O52B2_HUMAN

Olfactory receptor 52B2

0.392

P2Y13_HUMAN

P2Y purinoceptor 13

0.392

ZN770_HUMAN

Zinc finger protein 770

0.392

KCNE3_HUMAN

Potassium voltage-gated channel subfamily E member 3

0.392

F174A_HUMAN

Membrane protein FAM174A

0.392

GKN1_HUMAN

Gastrokine-1

0.392

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

LAPM5_HUMAN

Lysosomal-associated transmembrane protein 5

0.306

GKN1_HUMAN

Gastrokine-1

0.308

TRI14_HUMAN

Tripartite motif-containing protein 14

0.327

AREG_HUMAN

Amphiregulin

0.338

CD40L_HUMAN

CD40 ligand

0.340

MFAP3_HUMAN

Microfibril-associated glycoprotein 3

0.340

CLD16_HUMAN

Claudin-16

0.342

INGR1_HUMAN

Interferon gamma receptor 1

0.342

I13R1_HUMAN

Interleukin-13 receptor subunit alpha-1

0.344

ZBTB6_HUMAN

Zinc finger and BTB domain-containing protein 6

0.344

MYOZ3_HUMAN

Myozenin-3

0.346

EGLN_HUMAN

Endoglin

0.346

ACRO_HUMAN

Acrosin

0.349

OPT_HUMAN

Opticin

0.349

ZN770_HUMAN

Zinc finger protein 770

0.351

IL5RA_HUMAN

Interleukin-5 receptor subunit alpha

0.356

THY1_HUMAN

Thy-1 membrane glycoprotein

0.360

RESF1_HUMAN

Retroelement silencing factor 1

0.363

IL22_HUMAN

Interleukin-22

0.363

LIF_HUMAN

Leukemia inhibitory factor

0.363

ZC21C_HUMAN

Zinc finger C2HC domain-containing protein 1C

0.363

TREM2_HUMAN

Triggering receptor expressed on myeloid cells 2

0.363

ZN639_HUMAN

Zinc finger protein 639

0.365

LSME1_HUMAN

Leucine-rich single-pass membrane protein 1

0.368

TNF15_HUMAN

Tumor necrosis factor ligand superfamily member 15

0.371

SCG1_HUMAN

Secretogranin-1

0.371

GON1_HUMAN

Progonadoliberin-1

0.371

CCGL_HUMAN

Voltage-dependent calcium channel gamma-like subunit

0.371

SUSD4_HUMAN

Sushi domain-containing protein 4

0.373

SUGP2_HUMAN

SURP and G-patch domain-containing protein 2

0.373

INAR1_HUMAN

Interferon alpha/beta receptor 1

0.373

FA83A_HUMAN

Protein FAM83A

0.376

CD34_HUMAN

Hematopoietic progenitor cell antigen CD34

0.376

BCAS1_HUMAN

Breast carcinoma-amplified sequence 1

0.378

AMGO2_HUMAN

Amphoterin-induced protein 2

0.378

BPIB4_HUMAN

BPI fold-containing family B member 4

0.378

Z518B_HUMAN

Zinc finger protein 518B

0.378

PIANP_HUMAN

PILR alpha-associated neural protein

0.378

TM215_HUMAN

Transmembrane protein 215

0.378

CF132_HUMAN

Uncharacterized protein C6orf132

0.378

CD47_HUMAN

Leukocyte surface antigen CD47

0.378

CKLF6_HUMAN

CKLF-like MARVEL transmembrane domain-containing protein 6

0.380

ODFP1_HUMAN

Outer dense fiber protein 1

0.380

TM171_HUMAN

Transmembrane protein 171

0.380

SNTAN_HUMAN

Sentan

0.380

TM52B_HUMAN

Transmembrane protein 52B

0.380

CAMP_HUMAN

Cathelicidin antimicrobial peptide

0.380

CD72_HUMAN

B-cell differentiation antigen CD72

0.380

LRAD1_HUMAN

Low-density lipoprotein receptor class A domain-containing protein 1

0.380

ICOSL_HUMAN

ICOS ligand

0.380

TPO_HUMAN

Thrombopoietin

0.383

KCD18_HUMAN

BTB/POZ domain-containing protein KCTD18

0.383

PSPC_HUMAN

Pulmonary surfactant-associated protein C

0.386

VTDB_HUMAN

Vitamin D-binding protein

0.387

IL17B_HUMAN

Interleukin-17B

0.387

BCLF1_HUMAN

Bcl-2-associated transcription factor 1

0.387

ALBU_HUMAN

Serum albumin

0.390

CK074_HUMAN

Protein C11orf74

0.390

GSG1_HUMAN

Germ cell-specific gene 1 protein

0.392

CDHR3_HUMAN

Cadherin-related family member 3

0.392

SHPS1_HUMAN

Tyrosine-protein phosphatase non-receptor type substrate 1

0.392

FSHB_HUMAN

Follitropin subunit beta

0.392

CSF3_HUMAN

Granulocyte colony-stimulating factor

0.392

RAI3_HUMAN

Retinoic acid-induced protein 3

0.395

TAF1D_HUMAN

TATA box-binding protein-associated factor RNA polymerase I subunit D

0.395

MMRN1_HUMAN

Multimerin-1

0.395

S10AB_HUMAN

Protein S100-A11

0.395

ACRBP_HUMAN

Acrosin-binding protein

0.395

INGR2_HUMAN

Interferon gamma receptor 2

0.395

SPERT_HUMAN

Spermatid-associated protein

0.397

IFNG_HUMAN

Interferon gamma

0.397

ICOS_HUMAN

Inducible T-cell costimulator

0.397

F174A_HUMAN

Membrane protein FAM174A

0.397

PML_HUMAN

Protein PML

0.397

SIAL_HUMAN

Bone sialoprotein 2

0.397

ZN777_HUMAN

Zinc finger protein 777

0.397

INLR1_HUMAN

Interferon lambda receptor 1

0.397

ZN326_HUMAN

DBIRD complex subunit ZNF326

0.398

CD28_HUMAN

T-cell-specific surface glycoprotein CD28

0.398

LRIF1_HUMAN

Ligand-dependent nuclear receptor-interacting factor 1

0.398

TOX2_HUMAN

TOX high mobility group box family member 2

0.398

SNN_HUMAN

Stannin

0.398

RARR2_HUMAN

Retinoic acid receptor responder protein 2

0.400

GKN2_HUMAN

Gastrokine-2

0.400

CX3C1_HUMAN

CX3C chemokine receptor 1

0.400

OSTB_HUMAN

Organic solute transporter subunit beta

0.400

EXPH5_HUMAN

Exophilin-5

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 12 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy