FA76B_HUMAN 2019

Gene Name FA76B

Description Protein FAM76B

Length 339

9606

Sequence

>sp|Q5HYJ3|FA76B_HUMAN Protein FAM76B
MAASALYACTKCTQRYPFEELSQGQQLCKECRIAHPIVKCTYCRSEFQQESKTNTICKKCAQNVKQFGTPKPCQYCNIIAAFIGTKCQRCTNSEKKYGPPQTCEQCKQQCAFDRKEEGRRKVDGKLLCWLCTLSYKRVLQKTKEQRKSLGSSHSNSSSSSLTEKDQHHPKHHHHHHHHHHRHSSSHHKISNLSPEEEQGLWKQSHKSSATIQNETPKKKPKLESKPSNGDSSSINQSADSGGTDNFVLISQLKEEVMSLKRLLQQRDQTILEKDKKLTELKADFQYQESNLRTKMNSMEKAHKETVEQLQAKNRELLKQVAALSKGKKFDKSGSILTSP

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

FA76A_HUMAN

Protein FAM76A

0.343

NLK_HUMAN

Serine/threonine-protein kinase NLK

0.363

ROR2_HUMAN

Tyrosine-protein kinase transmembrane receptor ROR2

0.367

ROR1_HUMAN

Inactive tyrosine-protein kinase transmembrane receptor ROR1

0.389

KMT5A_HUMAN

N-lysine methyltransferase KMT5A

0.391

CD5R1_HUMAN

Cyclin-dependent kinase 5 activator 1

0.392

HDC_HUMAN

Headcase protein homolog

0.392

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

FA76A_HUMAN

Protein FAM76A

0.338

HDC_HUMAN

Headcase protein homolog

0.349

BMP2_HUMAN

Bone morphogenetic protein 2

0.368

MIGA2_HUMAN

Mitoguardin 2

0.369

HINFP_HUMAN

Histone H4 transcription factor

0.369

SC5A8_HUMAN

Sodium-coupled monocarboxylate transporter 1

0.369

RB6I2_HUMAN

ELKS/Rab6-interacting/CAST family member 1

0.372

ITB6_HUMAN

Integrin beta-6

0.372

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.373

FERM2_HUMAN

Fermitin family homolog 2

0.375

WLS_HUMAN

Protein wntless homolog

0.375

FERM1_HUMAN

Fermitin family homolog 1

0.375

TPST1_HUMAN

Protein-tyrosine sulfotransferase 1

0.376

MIGA1_HUMAN

Mitoguardin 1

0.376

PP4P2_HUMAN

Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

0.377

ACK1_HUMAN

Activated CDC42 kinase 1

0.378

ROR1_HUMAN

Inactive tyrosine-protein kinase transmembrane receptor ROR1

0.378

KMT5A_HUMAN

N-lysine methyltransferase KMT5A

0.379

CSRN3_HUMAN

Cysteine/serine-rich nuclear protein 3

0.380

AT1B4_HUMAN

Protein ATP1B4

0.381

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.381

PARD3_HUMAN

Partitioning defective 3 homolog

0.381

BMP4_HUMAN

Bone morphogenetic protein 4

0.381

GLCE_HUMAN

D-glucuronyl C5-epimerase

0.381

RSBN1_HUMAN

Lysine-specific demethylase 9

0.381

ILF2_HUMAN

Interleukin enhancer-binding factor 2

0.381

BTBDA_HUMAN

BTB/POZ domain-containing protein 10

0.381

NR5A2_HUMAN

Nuclear receptor subfamily 5 group A member 2

0.383

ITB1_HUMAN

Integrin beta-1

0.384

SMCE1_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

0.385

FBX25_HUMAN

F-box only protein 25

0.385

ARFP1_HUMAN

Arfaptin-1

0.386

RSBNL_HUMAN

Round spermatid basic protein 1-like protein

0.386

PTC1_HUMAN

Protein patched homolog 1

0.386

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.387

TRIO_HUMAN

Triple functional domain protein

0.387

APBA2_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 2

0.387

SMAD1_HUMAN

Mothers against decapentaplegic homolog 1

0.388

CSTN1_HUMAN

Calsyntenin-1

0.389

FEM1C_HUMAN

Protein fem-1 homolog C

0.389

UNC5D_HUMAN

Netrin receptor UNC5D

0.389

CPEB1_HUMAN

Cytoplasmic polyadenylation element-binding protein 1

0.389

ERP44_HUMAN

Endoplasmic reticulum resident protein 44

0.390

FHOD3_HUMAN

FH1/FH2 domain-containing protein 3

0.390

SYT1_HUMAN

Synaptotagmin-1

0.390

CSKP_HUMAN

Peripheral plasma membrane protein CASK

0.390

MIER1_HUMAN

Mesoderm induction early response protein 1

0.391

PDXD1_HUMAN

Pyridoxal-dependent decarboxylase domain-containing protein 1

0.391

BAP18_HUMAN

Chromatin complexes subunit BAP18

0.392

ITB3_HUMAN

Integrin beta-3

0.392

TRAM2_HUMAN

Translocating chain-associated membrane protein 2

0.392

PICK1_HUMAN

PRKCA-binding protein

0.392

MAPK3_HUMAN

MAP kinase-activated protein kinase 3

0.393

ST7_HUMAN

Suppressor of tumorigenicity 7 protein

0.393

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.393

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.393

BICD1_HUMAN

Protein bicaudal D homolog 1

0.394

TSN5_HUMAN

Tetraspanin-5

0.394

BARH2_HUMAN

BarH-like 2 homeobox protein

0.394

AFAD_HUMAN

Afadin

0.394

XKR6_HUMAN

XK-related protein 6

0.395

BMP5_HUMAN

Bone morphogenetic protein 5

0.395

CSPG4_HUMAN

Chondroitin sulfate proteoglycan 4

0.396

VRK1_HUMAN

Serine/threonine-protein kinase VRK1

0.397

DVL3_HUMAN

Segment polarity protein dishevelled homolog DVL-3

0.397

NAB1_HUMAN

NGFI-A-binding protein 1

0.397

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.398

PAR6B_HUMAN

Partitioning defective 6 homolog beta

0.398

RASF8_HUMAN

Ras association domain-containing protein 8

0.398

BICD2_HUMAN

Protein bicaudal D homolog 2

0.399

TM39B_HUMAN

Transmembrane protein 39B

0.399

HLF_HUMAN

Hepatic leukemia factor

0.399

MADD_HUMAN

MAP kinase-activating death domain protein

0.399

SSRD_HUMAN

Translocon-associated protein subunit delta

0.399

RN146_HUMAN

E3 ubiquitin-protein ligase RNF146

0.399

RIPL1_HUMAN

RILP-like protein 1

0.400

LRRF2_HUMAN

Leucine-rich repeat flightless-interacting protein 2

0.400

NLK_HUMAN

Serine/threonine-protein kinase NLK

0.400

FLI1_HUMAN

Friend leukemia integration 1 transcription factor

0.400

GIT2_HUMAN

ARF GTPase-activating protein GIT2

0.400

BCL7B_HUMAN

B-cell CLL/lymphoma 7 protein family member B

0.400

WDFY2_HUMAN

WD repeat and FYVE domain-containing protein 2

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 51 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy