KMT5A_HUMAN 2019

Gene Name KMT5A

Description N-lysine methyltransferase KMT5A

Length 393

9606

Sequence

>sp|Q9NQR1|KMT5A_HUMAN N-lysine methyltransferase KMT5A
MGEGGAAAALVAAAAAAAAAAAAVVAGQRRRRLGRRARCHGPGRAAGGKMSKPCAVEAAAAAVAATAPGPEMVERRGPGRPRTDGENVFTGQSKIYSYMSPNKCSGMRFPLQEENSVTHHEVKCQGKPLAGIYRKREEKRNAGNAVRSAMKSEEQKIKDARKGPLVPFPNQKSEAAEPPKTPPSSCDSTNAAIAKQALKKPIKGKQAPRKKAQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIEAHPWLKH

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

ARFP1_HUMAN

Arfaptin-1

0.391

OPA1_HUMAN

Dynamin-like 120 kDa protein, mitochondrial

0.391

ECSIT_HUMAN

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

0.391

FA76B_HUMAN

Protein FAM76B

0.391

BTBDA_HUMAN

BTB/POZ domain-containing protein 10

0.391

MIGA1_HUMAN

Mitoguardin 1

0.394

VRK1_HUMAN

Serine/threonine-protein kinase VRK1

0.394

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.394

ANKL2_HUMAN

Ankyrin repeat and LEM domain-containing protein 2

0.394

IQEC3_HUMAN

IQ motif and SEC7 domain-containing protein 3

0.398

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

ERP44_HUMAN

Endoplasmic reticulum resident protein 44

0.347

AFAD_HUMAN

Afadin

0.352

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.353

BMP2_HUMAN

Bone morphogenetic protein 2

0.360

ANKL2_HUMAN

Ankyrin repeat and LEM domain-containing protein 2

0.361

ITB1_HUMAN

Integrin beta-1

0.364

PDC10_HUMAN

Programmed cell death protein 10

0.366

ARFP1_HUMAN

Arfaptin-1

0.366

VRK1_HUMAN

Serine/threonine-protein kinase VRK1

0.366

CBL_HUMAN

E3 ubiquitin-protein ligase CBL

0.366

FERM2_HUMAN

Fermitin family homolog 2

0.367

FERM1_HUMAN

Fermitin family homolog 1

0.367

WDR37_HUMAN

WD repeat-containing protein 37

0.367

PTC1_HUMAN

Protein patched homolog 1

0.367

CSKP_HUMAN

Peripheral plasma membrane protein CASK

0.370

OPA1_HUMAN

Dynamin-like 120 kDa protein, mitochondrial

0.371

UBR5_HUMAN

E3 ubiquitin-protein ligase UBR5

0.372

CACB2_HUMAN

Voltage-dependent L-type calcium channel subunit beta-2

0.372

PICK1_HUMAN

PRKCA-binding protein

0.372

MIGA2_HUMAN

Mitoguardin 2

0.372

RIMB2_HUMAN

RIMS-binding protein 2

0.373

PACN3_HUMAN

Protein kinase C and casein kinase substrate in neurons protein 3

0.373

NUDT9_HUMAN

ADP-ribose pyrophosphatase, mitochondrial

0.374

DVL3_HUMAN

Segment polarity protein dishevelled homolog DVL-3

0.377

RSBNL_HUMAN

Round spermatid basic protein 1-like protein

0.377

MAPK2_HUMAN

MAP kinase-activated protein kinase 2

0.378

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.378

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.378

CACB4_HUMAN

Voltage-dependent L-type calcium channel subunit beta-4

0.378

PAR6B_HUMAN

Partitioning defective 6 homolog beta

0.378

PACN1_HUMAN

Protein kinase C and casein kinase substrate in neurons protein 1

0.378

SNX5_HUMAN

Sorting nexin-5

0.379

FA76B_HUMAN

Protein FAM76B

0.379

SNRK_HUMAN

SNF-related serine/threonine-protein kinase

0.381

FHOD3_HUMAN

FH1/FH2 domain-containing protein 3

0.381

TM38B_HUMAN

Trimeric intracellular cation channel type B

0.382

MIER1_HUMAN

Mesoderm induction early response protein 1

0.382

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.383

AT1B4_HUMAN

Protein ATP1B4

0.383

ITB3_HUMAN

Integrin beta-3

0.383

ARFP2_HUMAN

Arfaptin-2

0.384

ILF2_HUMAN

Interleukin enhancer-binding factor 2

0.384

RT22_HUMAN

28S ribosomal protein S22, mitochondrial

0.384

SNX6_HUMAN

Sorting nexin-6

0.384

BMP4_HUMAN

Bone morphogenetic protein 4

0.384

MAPK3_HUMAN

MAP kinase-activated protein kinase 3

0.384

BTBDA_HUMAN

BTB/POZ domain-containing protein 10

0.384

C43BP_HUMAN

Collagen type IV alpha-3-binding protein

0.384

TTC17_HUMAN

Tetratricopeptide repeat protein 17

0.385

NDUAA_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

0.385

GALT1_HUMAN

Polypeptide N-acetylgalactosaminyltransferase 1

0.386

HS2ST_HUMAN

Heparan sulfate 2-O-sulfotransferase 1

0.386

IP3KB_HUMAN

Inositol-trisphosphate 3-kinase B

0.386

PACS1_HUMAN

Phosphofurin acidic cluster sorting protein 1

0.386

SMCE1_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

0.387

TAOK1_HUMAN

Serine/threonine-protein kinase TAO1

0.387

PACN2_HUMAN

Protein kinase C and casein kinase substrate in neurons protein 2

0.388

TNIK_HUMAN

TRAF2 and NCK-interacting protein kinase

0.389

MTA1_HUMAN

Metastasis-associated protein MTA1

0.389

TRIO_HUMAN

Triple functional domain protein

0.389

APBA2_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 2

0.389

OFUT1_HUMAN

GDP-fucose protein O-fucosyltransferase 1

0.389

WLS_HUMAN

Protein wntless homolog

0.389

MIGA1_HUMAN

Mitoguardin 1

0.390

SMAD1_HUMAN

Mothers against decapentaplegic homolog 1

0.390

PP4P2_HUMAN

Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

0.390

WDFY2_HUMAN

WD repeat and FYVE domain-containing protein 2

0.391

SL9A3_HUMAN

Sodium/hydrogen exchanger 3

0.392

MAGI3_HUMAN

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

0.393

HINFP_HUMAN

Histone H4 transcription factor

0.394

WDFY1_HUMAN

WD repeat and FYVE domain-containing protein 1

0.394

HECD1_HUMAN

E3 ubiquitin-protein ligase HECTD1

0.394

SC5A8_HUMAN

Sodium-coupled monocarboxylate transporter 1

0.394

RSBN1_HUMAN

Lysine-specific demethylase 9

0.394

GLCE_HUMAN

D-glucuronyl C5-epimerase

0.394

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.394

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.394

NUMB_HUMAN

Protein numb homolog

0.394

IQEC3_HUMAN

IQ motif and SEC7 domain-containing protein 3

0.395

OFUT2_HUMAN

GDP-fucose protein O-fucosyltransferase 2

0.395

SMAD9_HUMAN

Mothers against decapentaplegic homolog 9

0.395

BICD1_HUMAN

Protein bicaudal D homolog 1

0.395

HTF4_HUMAN

Transcription factor 12

0.395

SSRG_HUMAN

Translocon-associated protein subunit gamma

0.396

NDST1_HUMAN

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

0.396

MIER3_HUMAN

Mesoderm induction early response protein 3

0.396

FA8A1_HUMAN

Protein FAM8A1

0.396

RHG17_HUMAN

Rho GTPase-activating protein 17

0.396

MPDZ_HUMAN

Multiple PDZ domain protein

0.397

PCX1_HUMAN

Pecanex-like protein 1

0.397

TAOK3_HUMAN

Serine/threonine-protein kinase TAO3

0.398

SNX27_HUMAN

Sorting nexin-27

0.399

TRAM1_HUMAN

Translocating chain-associated membrane protein 1

0.399

DDX1_HUMAN

ATP-dependent RNA helicase DDX1

0.399

TM39B_HUMAN

Transmembrane protein 39B

0.400

RHG42_HUMAN

Rho GTPase-activating protein 42

0.400

CTNA1_HUMAN

Catenin alpha-1

0.400

TPST1_HUMAN

Protein-tyrosine sulfotransferase 1

0.400

BICD2_HUMAN

Protein bicaudal D homolog 2

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 58 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy