LRC73_HUMAN 2019

Gene Name LRC73

Description Leucine-rich repeat-containing protein 73

Length 316

9606

Sequence

>sp|Q5JTD7|LRC73_HUMAN Leucine-rich repeat-containing protein 73
MLPSSIQISGEPLSGAEVRDICRGLRDNAVRLLSLRGCRLCDRDFGRICRALAGATSLAQLNLNLGVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGDCMLGDEAINLICGLLPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAENSISPELQQQICDLLSEGEEEEEVAGGAGDTQEWERGREPAAHQRGSSSWMCPSDPSSQMVLMTSGLGDSLLAETEM

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

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What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

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What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

TXD16_HUMAN

Thioredoxin domain-containing protein 16

0.327

CRADD_HUMAN

Death domain-containing protein CRADD

0.327

SNP47_HUMAN

Synaptosomal-associated protein 47

0.333

AP1AR_HUMAN

AP-1 complex-associated regulatory protein

0.333

F124A_HUMAN

Protein FAM124A

0.333

F167A_HUMAN

Protein FAM167A

0.333

I17RD_HUMAN

Interleukin-17 receptor D

0.340

TM196_HUMAN

Transmembrane protein 196

0.340

TNF10_HUMAN

Tumor necrosis factor ligand superfamily member 10

0.340

AF1L2_HUMAN

Actin filament-associated protein 1-like 2

0.340

AF1L1_HUMAN

Actin filament-associated protein 1-like 1

0.340

F199X_HUMAN

Protein FAM199X

0.340

IKBP1_HUMAN

Interleukin-1 receptor-associated kinase 1-binding protein 1

0.371

CRLF3_HUMAN

Cytokine receptor-like factor 3

0.371

SPICE_HUMAN

Spindle and centriole-associated protein 1

0.378

CH034_HUMAN

Uncharacterized protein C8orf34

0.378

OIT3_HUMAN

Oncoprotein-induced transcript 3 protein

0.378

RD3_HUMAN

Protein RD3

0.378

LRC28_HUMAN

Leucine-rich repeat-containing protein 28

0.378

CE85L_HUMAN

Centrosomal protein of 85 kDa-like

0.378

CPLN1_HUMAN

Ciliogenesis and planar polarity effector 1

0.378

FBXW2_HUMAN

F-box/WD repeat-containing protein 2

0.378

HAUS8_HUMAN

HAUS augmin-like complex subunit 8

0.385

WDCP_HUMAN

WD repeat and coiled-coil-containing protein

0.385

SFRP3_HUMAN

Secreted frizzled-related protein 3

0.385

SLAI1_HUMAN

SLAIN motif-containing protein 1

0.385

FSIP1_HUMAN

Fibrous sheath-interacting protein 1

0.385

CCD14_HUMAN

Coiled-coil domain-containing protein 14

0.385

CC171_HUMAN

Coiled-coil domain-containing protein 171

0.385

AKNA_HUMAN

Microtubule organization protein AKNA

0.385

CIKS_HUMAN

Adapter protein CIKS

0.385

AFAP1_HUMAN

Actin filament-associated protein 1

0.385

KNDC1_HUMAN

Kinase non-catalytic C-lobe domain-containing protein 1

0.385

NUSAP_HUMAN

Nucleolar and spindle-associated protein 1

0.385

VWC2_HUMAN

Brorin

0.392

FADS6_HUMAN

Fatty acid desaturase 6

0.392

LPAR1_HUMAN

Lysophosphatidic acid receptor 1

0.392

I17RA_HUMAN

Interleukin-17 receptor A

0.392

AROS_HUMAN

Active regulator of SIRT1

0.392

PEA15_HUMAN

Astrocytic phosphoprotein PEA-15

0.392

DERM_HUMAN

Dermatopontin

0.392

S1PR1_HUMAN

Sphingosine 1-phosphate receptor 1

0.392

CCD66_HUMAN

Coiled-coil domain-containing protein 66

0.392

MASP1_HUMAN

Mannan-binding lectin serine protease 1

0.392

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

SNP47_HUMAN

Synaptosomal-associated protein 47

0.316

IKBP1_HUMAN

Interleukin-1 receptor-associated kinase 1-binding protein 1

0.326

CEP85_HUMAN

Centrosomal protein of 85 kDa

0.327

KNDC1_HUMAN

Kinase non-catalytic C-lobe domain-containing protein 1

0.329

F199X_HUMAN

Protein FAM199X

0.332

F167A_HUMAN

Protein FAM167A

0.341

SPICE_HUMAN

Spindle and centriole-associated protein 1

0.341

CC157_HUMAN

Coiled-coil domain-containing protein 157

0.350

RD3_HUMAN

Protein RD3

0.354

CSPG2_HUMAN

Versican core protein

0.357

AP1AR_HUMAN

AP-1 complex-associated regulatory protein

0.357

MID51_HUMAN

Mitochondrial dynamics protein MID51

0.357

AF1L1_HUMAN

Actin filament-associated protein 1-like 1

0.358

AF1L2_HUMAN

Actin filament-associated protein 1-like 2

0.358

FBXW8_HUMAN

F-box/WD repeat-containing protein 8

0.363

CCNF_HUMAN

Cyclin-F

0.363

STXB4_HUMAN

Syntaxin-binding protein 4

0.363

FBXW2_HUMAN

F-box/WD repeat-containing protein 2

0.364

TXD16_HUMAN

Thioredoxin domain-containing protein 16

0.364

MTBP_HUMAN

Mdm2-binding protein

0.364

RGS22_HUMAN

Regulator of G-protein signaling 22

0.364

TICRR_HUMAN

Treslin

0.364

LRC42_HUMAN

Leucine-rich repeat-containing protein 42

0.364

WDCP_HUMAN

WD repeat and coiled-coil-containing protein

0.366

ARL15_HUMAN

ADP-ribosylation factor-like protein 15

0.366

F124A_HUMAN

Protein FAM124A

0.368

CF062_HUMAN

Uncharacterized protein C6orf62

0.368

SLAI2_HUMAN

SLAIN motif-containing protein 2

0.371

ZN451_HUMAN

E3 SUMO-protein ligase ZNF451

0.371

DERM_HUMAN

Dermatopontin

0.371

TNF10_HUMAN

Tumor necrosis factor ligand superfamily member 10

0.371

CLN6_HUMAN

Ceroid-lipofuscinosis neuronal protein 6

0.371

IQCB1_HUMAN

IQ calmodulin-binding motif-containing protein 1

0.371

ENO4_HUMAN

Enolase 4

0.373

IRF2_HUMAN

Interferon regulatory factor 2

0.373

MIEAP_HUMAN

Mitochondria-eating protein

0.373

IRF1_HUMAN

Interferon regulatory factor 1

0.373

CE034_HUMAN

Uncharacterized protein C5orf34

0.375

OIT3_HUMAN

Oncoprotein-induced transcript 3 protein

0.375

TSN3_HUMAN

Tetraspanin-3

0.375

RADIL_HUMAN

Ras-associating and dilute domain-containing protein

0.375

HUNK_HUMAN

Hormonally up-regulated neu tumor-associated kinase

0.375

USPL1_HUMAN

SUMO-specific isopeptidase USPL1

0.376

CH034_HUMAN

Uncharacterized protein C8orf34

0.378

AMPO_HUMAN

Aminopeptidase O

0.378

CS044_HUMAN

Uncharacterized protein C19orf44

0.378

DIXC1_HUMAN

Dixin

0.378

NUSAP_HUMAN

Nucleolar and spindle-associated protein 1

0.378

AFAP1_HUMAN

Actin filament-associated protein 1

0.380

ZFAT_HUMAN

Zinc finger protein ZFAT

0.380

NSMF_HUMAN

NMDA receptor synaptonuclear signaling and neuronal migration factor

0.380

PRD12_HUMAN

PR domain zinc finger protein 12

0.380

LBN_HUMAN

Limbin

0.380

SG196_HUMAN

Protein O-mannose kinase

0.381

SLAI1_HUMAN

SLAIN motif-containing protein 1

0.381

GSDME_HUMAN

Gasdermin-E

0.381

BCL10_HUMAN

B-cell lymphoma/leukemia 10

0.381

TMM72_HUMAN

Transmembrane protein 72

0.381

MPP9_HUMAN

M-phase phosphoprotein 9

0.381

CNST_HUMAN

Consortin

0.381

FBX4_HUMAN

F-box only protein 4

0.383

M3K14_HUMAN

Mitogen-activated protein kinase kinase kinase 14

0.383

I17RD_HUMAN

Interleukin-17 receptor D

0.383

HPLN1_HUMAN

Hyaluronan and proteoglycan link protein 1

0.383

TM168_HUMAN

Transmembrane protein 168

0.386

PARI_HUMAN

PCNA-interacting partner

0.386

SOST_HUMAN

Sclerostin

0.387

NCOA4_HUMAN

Nuclear receptor coactivator 4

0.388

FBX41_HUMAN

F-box only protein 41

0.388

PAWR_HUMAN

PRKC apoptosis WT1 regulator protein

0.388

NPAT_HUMAN

Protein NPAT

0.388

CPLN1_HUMAN

Ciliogenesis and planar polarity effector 1

0.390

CCD18_HUMAN

Coiled-coil domain-containing protein 18

0.390

TM101_HUMAN

Transmembrane protein 101

0.390

MIPO1_HUMAN

Mirror-image polydactyly gene 1 protein

0.390

SFRP3_HUMAN

Secreted frizzled-related protein 3

0.391

TM196_HUMAN

Transmembrane protein 196

0.391

CC181_HUMAN

Coiled-coil domain-containing protein 181

0.391

MK06_HUMAN

Mitogen-activated protein kinase 6

0.391

STRA6_HUMAN

Receptor for retinol uptake STRA6

0.392

CP20A_HUMAN

Cytochrome P450 20A1

0.392

GEMI4_HUMAN

Gem-associated protein 4

0.393

CNMD_HUMAN

Leukocyte cell-derived chemotaxin 1

0.393

RN219_HUMAN

RING finger protein 219

0.394

GARE1_HUMAN

GRB2-associated and regulator of MAPK protein 1

0.394

FBXL5_HUMAN

F-box/LRR-repeat protein 5

0.394

DEND3_HUMAN

DENN domain-containing protein 3

0.396

GP161_HUMAN

G-protein coupled receptor 161

0.396

NKAP1_HUMAN

Uncharacterized protein NKAPD1

0.397

GPR26_HUMAN

G-protein coupled receptor 26

0.399

FXL18_HUMAN

F-box/LRR-repeat protein 18

0.399

LAP2A_HUMAN

Lamina-associated polypeptide 2, isoform alpha

0.399

F219A_HUMAN

Protein FAM219A

0.399

CNTLN_HUMAN

Centlein

0.399

RAB20_HUMAN

Ras-related protein Rab-20

0.399

PTTG_HUMAN

Pituitary tumor-transforming gene 1 protein-interacting protein

0.400

CE112_HUMAN

Centrosomal protein of 112 kDa

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 106 organisms (of 929)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy