VSIG1_HUMAN 2019

Gene Name VSIG1

Description V-set and immunoglobulin domain-containing protein 1

Length 387

9606

Sequence

>sp|Q86XK7|VSIG1_HUMAN V-set and immunoglobulin domain-containing protein 1
MVFAFWKVFLILSCLAGQVSVVQVTIPDGFVNVTVGSNVTLICIYTTTVASREQLSIQWSFFHKKEMEPISIYFSQGGQAVAIGQFKDRITGSNDPGNASITISHMQPADSGIYICDVNNPPDFLGQNQGILNVSVLVKPSKPLCSVQGRPETGHTISLSCLSALGTPSPVYYWHKLEGRDIVPVKENFNPTTGILVIGNLTNFEQGYYQCTAINRLGNSSCEIDLTSSHPEVGIIVGALIGSLVGAAIIISVVCFARNKAKAKAKERNSKTIAELEPMTKINPRGESEAMPREDATQLEVTLPSSIHETGPDTIQEPDYEPKPTQEPAPEPAPGSEPMAVPDLDIELELEPETQSELEPEPEPEPESEPGVVVEPLSEDEKGVVKA

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

CC122_HUMAN

Coiled-coil domain-containing protein 122

0.243

CLMP_HUMAN

CXADR-like membrane protein

0.324

CA052_HUMAN

UPF0690 protein C1orf52

0.324

ZHX1_HUMAN

Zinc fingers and homeoboxes protein 1

0.324

C1QT1_HUMAN

Complement C1q tumor necrosis factor-related protein 1

0.324

IGS11_HUMAN

Immunoglobulin superfamily member 11

0.324

CITE2_HUMAN

Cbp/p300-interacting transactivator 2

0.324

PRDM6_HUMAN

Putative histone-lysine N-methyltransferase PRDM6

0.324

CDN2B_HUMAN

Cyclin-dependent kinase 4 inhibitor B

0.324

MEI4_HUMAN

Meiosis-specific protein MEI4

0.324

GSG1L_HUMAN

Germ cell-specific gene 1-like protein

0.324

ASTN2_HUMAN

Astrotactin-2

0.324

LRC19_HUMAN

Leucine-rich repeat-containing protein 19

0.333

LYVE1_HUMAN

Lymphatic vessel endothelial hyaluronic acid receptor 1

0.333

TM159_HUMAN

Promethin

0.333

VSI10_HUMAN

V-set and immunoglobulin domain-containing protein 10

0.333

PD1L1_HUMAN

Programmed cell death 1 ligand 1

0.333

CENPQ_HUMAN

Centromere protein Q

0.333

ILDR2_HUMAN

Immunoglobulin-like domain-containing receptor 2

0.333

PALB2_HUMAN

Partner and localizer of BRCA2

0.333

T3JAM_HUMAN

TRAF3-interacting JNK-activating modulator

0.333

UIF_HUMAN

UAP56-interacting factor

0.333

IL1R2_HUMAN

Interleukin-1 receptor type 2

0.333

ZN750_HUMAN

Zinc finger protein 750

0.333

CU062_HUMAN

Uncharacterized protein C21orf62

0.343

HBAZ_HUMAN

Hemoglobin subunit zeta

0.387

CDN2C_HUMAN

Cyclin-dependent kinase 4 inhibitor C

0.387

EDNRA_HUMAN

Endothelin-1 receptor

0.387

EFCC1_HUMAN

EF-hand and coiled-coil domain-containing protein 1

0.387

EDNRB_HUMAN

Endothelin receptor type B

0.387

NTNG1_HUMAN

Netrin-G1

0.387

PCLI1_HUMAN

PTB-containing, cubilin and LRP1-interacting protein

0.387

I10R2_HUMAN

Interleukin-10 receptor subunit beta

0.387

LRAD3_HUMAN

Low-density lipoprotein receptor class A domain-containing protein 3

0.387

S1PR3_HUMAN

Sphingosine 1-phosphate receptor 3

0.387

EURL_HUMAN

Protein EURL homolog

0.387

RFXAP_HUMAN

Regulatory factor X-associated protein

0.387

CRBA1_HUMAN

Beta-crystallin A3

0.387

C2C4C_HUMAN

C2 calcium-dependent domain-containing protein 4C

0.387

LGI1_HUMAN

Leucine-rich glioma-inactivated protein 1

0.387

ZN148_HUMAN

Zinc finger protein 148

0.387

RLF_HUMAN

Zinc finger protein Rlf

0.387

GAK1B_HUMAN

Golgi-associated kinase 1B

0.387

RAMP3_HUMAN

Receptor activity-modifying protein 3

0.387

ZBT10_HUMAN

Zinc finger and BTB domain-containing protein 10

0.387

S3TC1_HUMAN

SH3 domain and tetratricopeptide repeat-containing protein 1

0.387

PGBD5_HUMAN

PiggyBac transposable element-derived protein 5

0.387

IMPG2_HUMAN

Interphotoreceptor matrix proteoglycan 2

0.387

PTN_HUMAN

Pleiotrophin

0.387

LRC52_HUMAN

Leucine-rich repeat-containing protein 52

0.387

LARGN_HUMAN

Protein Largen

0.387

T255A_HUMAN

Transmembrane protein 255A

0.387

CC172_HUMAN

Coiled-coil domain-containing protein 172

0.387

SCG3_HUMAN

Secretogranin-3

0.387

TSN18_HUMAN

Tetraspanin-18

0.387

LGI2_HUMAN

Leucine-rich repeat LGI family member 2

0.387

F181A_HUMAN

Protein FAM181A

0.387

PRLHR_HUMAN

Prolactin-releasing peptide receptor

0.387

PRLR_HUMAN

Prolactin receptor

0.387

CCDC3_HUMAN

Coiled-coil domain-containing protein 3

0.387

TPA_HUMAN

Tissue-type plasminogen activator

0.387

ZN653_HUMAN

Zinc finger protein 653

0.397

INSY2_HUMAN

Inhibitory synaptic factor 2A

0.397

ZN652_HUMAN

Zinc finger protein 652

0.397

PIGR_HUMAN

Polymeric immunoglobulin receptor

0.397

GPR18_HUMAN

N-arachidonyl glycine receptor

0.397

LPAR6_HUMAN

Lysophosphatidic acid receptor 6

0.397

FNDC4_HUMAN

Fibronectin type III domain-containing protein 4

0.397

CNBP1_HUMAN

Beta-catenin-interacting protein 1

0.397

ATOH7_HUMAN

Protein atonal homolog 7

0.397

IGSF3_HUMAN

Immunoglobulin superfamily member 3

0.397

ACKR4_HUMAN

Atypical chemokine receptor 4

0.397

NMI_HUMAN

N-myc-interactor

0.397

CD3Z_HUMAN

T-cell surface glycoprotein CD3 zeta chain

0.397

CLD12_HUMAN

Claudin-12

0.397

GP174_HUMAN

Probable G-protein coupled receptor 174

0.397

ANGL3_HUMAN

Angiopoietin-related protein 3

0.397

IL21R_HUMAN

Interleukin-21 receptor

0.397

LPAR4_HUMAN

Lysophosphatidic acid receptor 4

0.397

GP149_HUMAN

Probable G-protein coupled receptor 149

0.397

MAP9_HUMAN

Microtubule-associated protein 9

0.397

GOGB1_HUMAN

Golgin subfamily B member 1

0.397

ZBTB5_HUMAN

Zinc finger and BTB domain-containing protein 5

0.397

APC16_HUMAN

Anaphase-promoting complex subunit 16

0.397

TIFA_HUMAN

TRAF-interacting protein with FHA domain-containing protein A

0.397

SMPX_HUMAN

Small muscular protein

0.397

GPIX_HUMAN

Platelet glycoprotein IX

0.397

CRF_HUMAN

Corticoliberin

0.397

ANFC_HUMAN

C-type natriuretic peptide

0.397

XCR1_HUMAN

Chemokine XC receptor 1

0.397

CX021_HUMAN

Uncharacterized protein CXorf21

0.397

CC152_HUMAN

Coiled-coil domain-containing protein 152

0.397

CNTFR_HUMAN

Ciliary neurotrophic factor receptor subunit alpha

0.397

NUCKS_HUMAN

Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

0.397

MANS4_HUMAN

MANSC domain-containing protein 4

0.397

GPR34_HUMAN

Probable G-protein coupled receptor 34

0.397

MYNN_HUMAN

Myoneurin

0.397

ZBT25_HUMAN

Zinc finger and BTB domain-containing protein 25

0.397

AZI2_HUMAN

5-azacytidine-induced protein 2

0.397

DSG2_HUMAN

Desmoglein-2

0.397

PCD10_HUMAN

Protocadherin-10

0.397

C99L2_HUMAN

CD99 antigen-like protein 2

0.397

CD44_HUMAN

CD44 antigen

0.397

TAC2N_HUMAN

Tandem C2 domains nuclear protein

0.397

CCR4_HUMAN

C-C chemokine receptor type 4

0.397

CD3G_HUMAN

T-cell surface glycoprotein CD3 gamma chain

0.397

CLTR1_HUMAN

Cysteinyl leukotriene receptor 1

0.397

CC126_HUMAN

Coiled-coil domain-containing protein 126

0.397

CE030_HUMAN

UNC119-binding protein C5orf30

0.397

P2RY1_HUMAN

P2Y purinoceptor 1

0.397

BRNP1_HUMAN

BMP/retinoic acid-inducible neural-specific protein 1

0.397

DQA1_HUMAN

HLA class II histocompatibility antigen, DQ alpha 1 chain

0.397

PECA1_HUMAN

Platelet endothelial cell adhesion molecule

0.397

EMB_HUMAN

Embigin

0.397

ZBT38_HUMAN

Zinc finger and BTB domain-containing protein 38

0.397

COGA1_HUMAN

Collagen alpha-1(XVI) chain

0.397

ZN711_HUMAN

Zinc finger protein 711

0.397

EDN1_HUMAN

Endothelin-1

0.397

NHLC1_HUMAN

E3 ubiquitin-protein ligase NHLRC1

0.397

CMGA_HUMAN

Chromogranin-A

0.397

PTGDS_HUMAN

Prostaglandin-H2 D-isomerase

0.397

DQA2_HUMAN

HLA class II histocompatibility antigen, DQ alpha 2 chain

0.397

PAR1_HUMAN

Proteinase-activated receptor 1

0.397

H13_HUMAN

Histone H1.3

0.397

CQ058_HUMAN

UPF0450 protein C17orf58

0.397

FGF23_HUMAN

Fibroblast growth factor 23

0.397

CXCR5_HUMAN

C-X-C chemokine receptor type 5

0.397

H14_HUMAN

Histone H1.4

0.397

MYCT1_HUMAN

Myc target protein 1

0.397

GPR1_HUMAN

G-protein coupled receptor 1

0.397

IL10_HUMAN

Interleukin-10

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

IGS11_HUMAN

Immunoglobulin superfamily member 11

0.333

CE030_HUMAN

UNC119-binding protein C5orf30

0.364

ILDR2_HUMAN

Immunoglobulin-like domain-containing receptor 2

0.366

IGSF3_HUMAN

Immunoglobulin superfamily member 3

0.366

ILDR1_HUMAN

Immunoglobulin-like domain-containing receptor 1

0.369

VSI10_HUMAN

V-set and immunoglobulin domain-containing protein 10

0.378

SLAF8_HUMAN

SLAM family member 8

0.378

CLD18_HUMAN

Claudin-18

0.391

SNN_HUMAN

Stannin

0.396

PIGR_HUMAN

Polymeric immunoglobulin receptor

0.396

CCGL_HUMAN

Voltage-dependent calcium channel gamma-like subunit

0.398

IGS21_HUMAN

Immunoglobulin superfamily member 21

0.398

IGSF6_HUMAN

Immunoglobulin superfamily member 6

0.400

IGJ_HUMAN

Immunoglobulin J chain

0.400

IGSF1_HUMAN

Immunoglobulin superfamily member 1

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 16 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy