NECA1_HUMAN 2019

Gene Name NECA1

Description N-terminal EF-hand calcium-binding protein 1

Length 351

9606

Sequence

>sp|Q8N987|NECA1_HUMAN N-terminal EF-hand calcium-binding protein 1
MEDSQETSPSSNNSSEELSSALHLSKGMSIFLDILRRADKNDDGKLSFEEFKAYFADGVLSGEELHELFHTIDTHNTNNLDTEELCEYFSQHLGEYENVLAALEDLNLSILKAMGKTKKDYQEASNLEQFVTRFLLKETLNQLQSLQNSLECAMETTEEQTRQERQGPAKPEVLSIQWPGKRSSRRVQRHNSFSPNSPQFNVSGPGLLEEDNQWMTQINRLQKLIDRLEKKDLKLEPPEEEIIEGNTKSHIMLVQRQMSVIEEDLEEFQLALKHYVESASSQSGCLRISIQKLSNESRYMIYEFWENSSVWNSHLQTNYSKTFQRSNVDFLETPELTSTMLVPASWWILNN

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

DEND3_HUMAN

DENN domain-containing protein 3

0.302

KNDC1_HUMAN

Kinase non-catalytic C-lobe domain-containing protein 1

0.330

MID51_HUMAN

Mitochondrial dynamics protein MID51

0.333

AGRV1_HUMAN

Adhesion G-protein coupled receptor V1

0.335

CCNF_HUMAN

Cyclin-F

0.341

F167A_HUMAN

Protein FAM167A

0.342

STRA6_HUMAN

Receptor for retinol uptake STRA6

0.350

MIEAP_HUMAN

Mitochondria-eating protein

0.352

USPL1_HUMAN

SUMO-specific isopeptidase USPL1

0.355

AFAP1_HUMAN

Actin filament-associated protein 1

0.358

F199X_HUMAN

Protein FAM199X

0.358

USH2A_HUMAN

Usherin

0.360

NECA2_HUMAN

N-terminal EF-hand calcium-binding protein 2

0.360

SLF2_HUMAN

SMC5-SMC6 complex localization factor protein 2

0.360

FBX4_HUMAN

F-box only protein 4

0.363

STXB4_HUMAN

Syntaxin-binding protein 4

0.364

MTBP_HUMAN

Mdm2-binding protein

0.366

PARI_HUMAN

PCNA-interacting partner

0.366

TM168_HUMAN

Transmembrane protein 168

0.366

LRC42_HUMAN

Leucine-rich repeat-containing protein 42

0.366

SPICE_HUMAN

Spindle and centriole-associated protein 1

0.366

NCOA4_HUMAN

Nuclear receptor coactivator 4

0.368

SNP47_HUMAN

Synaptosomal-associated protein 47

0.368

SFRP3_HUMAN

Secreted frizzled-related protein 3

0.371

WDR41_HUMAN

WD repeat-containing protein 41

0.373

IKBP1_HUMAN

Interleukin-1 receptor-associated kinase 1-binding protein 1

0.375

HECD4_HUMAN

Probable E3 ubiquitin-protein ligase HECTD4

0.375

FBXL5_HUMAN

F-box/LRR-repeat protein 5

0.375

HUNK_HUMAN

Hormonally up-regulated neu tumor-associated kinase

0.376

CEP85_HUMAN

Centrosomal protein of 85 kDa

0.376

GP161_HUMAN

G-protein coupled receptor 161

0.376

NUSAP_HUMAN

Nucleolar and spindle-associated protein 1

0.380

AMPO_HUMAN

Aminopeptidase O

0.380

CSPG2_HUMAN

Versican core protein

0.381

LBN_HUMAN

Limbin

0.381

ZFAT_HUMAN

Zinc finger protein ZFAT

0.381

M1AP_HUMAN

Meiosis 1 arrest protein

0.383

AF1L2_HUMAN

Actin filament-associated protein 1-like 2

0.383

AF1L1_HUMAN

Actin filament-associated protein 1-like 1

0.383

MPP9_HUMAN

M-phase phosphoprotein 9

0.383

GSDME_HUMAN

Gasdermin-E

0.383

HNMT_HUMAN

Histamine N-methyltransferase

0.385

TALD3_HUMAN

Protein TALPID3

0.385

HPLN1_HUMAN

Hyaluronan and proteoglycan link protein 1

0.385

NAGPA_HUMAN

N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

0.386

BOREA_HUMAN

Borealin

0.388

TXD16_HUMAN

Thioredoxin domain-containing protein 16

0.388

CENPM_HUMAN

Centromere protein M

0.388

TICRR_HUMAN

Treslin

0.388

WDCP_HUMAN

WD repeat and coiled-coil-containing protein

0.390

CCD18_HUMAN

Coiled-coil domain-containing protein 18

0.391

CF062_HUMAN

Uncharacterized protein C6orf62

0.391

MOONR_HUMAN

Protein moonraker

0.391

PRDM4_HUMAN

PR domain zinc finger protein 4

0.393

MK06_HUMAN

Mitogen-activated protein kinase 6

0.393

HRH2_HUMAN

Histamine H2 receptor

0.393

CTHR1_HUMAN

Collagen triple helix repeat-containing protein 1

0.393

CP20A_HUMAN

Cytochrome P450 20A1

0.394

DERM_HUMAN

Dermatopontin

0.395

SLAI2_HUMAN

SLAIN motif-containing protein 2

0.395

TNF10_HUMAN

Tumor necrosis factor ligand superfamily member 10

0.395

MTFR1_HUMAN

Mitochondrial fission regulator 1

0.395

NTF3_HUMAN

Neurotrophin-3

0.395

CLN6_HUMAN

Ceroid-lipofuscinosis neuronal protein 6

0.395

ICE1_HUMAN

Little elongation complex subunit 1

0.395

GP173_HUMAN

Probable G-protein coupled receptor 173

0.395

TR11B_HUMAN

Tumor necrosis factor receptor superfamily member 11B

0.395

ZN451_HUMAN

E3 SUMO-protein ligase ZNF451

0.395

GARE1_HUMAN

GRB2-associated and regulator of MAPK protein 1

0.396

IRF2_HUMAN

Interferon regulatory factor 2

0.396

IRF1_HUMAN

Interferon regulatory factor 1

0.396

ENO4_HUMAN

Enolase 4

0.396

PRDM2_HUMAN

PR domain zinc finger protein 2

0.397

DSE_HUMAN

Dermatan-sulfate epimerase

0.397

TARSH_HUMAN

Target of Nesh-SH3

0.397

ANKH_HUMAN

Progressive ankylosis protein homolog

0.397

OIT3_HUMAN

Oncoprotein-induced transcript 3 protein

0.397

CE034_HUMAN

Uncharacterized protein C5orf34

0.397

RD3_HUMAN

Protein RD3

0.399

CEP63_HUMAN

Centrosomal protein of 63 kDa

0.399

NKAP1_HUMAN

Uncharacterized protein NKAPD1

0.399

EPDR1_HUMAN

Mammalian ependymin-related protein 1

0.399

GNPTG_HUMAN

N-acetylglucosamine-1-phosphotransferase subunit gamma

0.400

DIXC1_HUMAN

Dixin

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 26 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy