STAP2_HUMAN 2019

Gene Name STAP2

Description Signal-transducing adaptor protein 2

Length 403

9606

Sequence

>sp|Q9UGK3|STAP2_HUMAN Signal-transducing adaptor protein 2
MASALRPPRVPKPKGVLPSHYYESFLEKKGPCDRDYKKFWAGLQGLTIYFYNSNRDFQHVEKLNLGAFEKLTDEIPWGSSRDPGTHFSLILRDQEIKFKVETLECREMWKGFILTVVELRVPTDLTLLPGHLYMMSEVLAKEEARRALETPSCFLKVSRLEAQLLLERYPECGNLLLRPSGDGADGVSVTTRQMHNGTHVVRHYKVKREGPKYVIDVEQPFSCTSLDAVVNYFVSHTKKALVPFLLDEDYEKVLGYVEADKENGENVWVAPSAPGPGPAPCTGGPKPLSPASSQDKLPPLPPLPNQEENYVTPIGDGPAVDYENQDVASSSWPVILKPKKLPKPPAKLPKPPVGPKPEPKVFNGGLGRKLPVSSAQPLFPTAGLADMTAELQKKLEKRRALEH

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

SE6L2_HUMAN

Seizure 6-like protein 2

0.243

TRI44_HUMAN

Tripartite motif-containing protein 44

0.243

INSY1_HUMAN

Inhibitory synaptic factor 1

0.324

CD276_HUMAN

CD276 antigen

0.324

SOCS3_HUMAN

Suppressor of cytokine signaling 3

0.324

S3TC2_HUMAN

SH3 domain and tetratricopeptide repeat-containing protein 2

0.324

SOGA1_HUMAN

Protein SOGA1

0.324

MBD1_HUMAN

Methyl-CpG-binding domain protein 1

0.333

LURA1_HUMAN

Leucine rich adaptor protein 1

0.333

CK053_HUMAN

Uncharacterized protein C11orf53

0.333

CLD15_HUMAN

Claudin-15

0.333

HEMO_HUMAN

Hemopexin

0.333

CC106_HUMAN

Coiled-coil domain-containing protein 106

0.333

INKA1_HUMAN

PAK4-inhibitor INKA1

0.333

F1712_HUMAN

Protein FAM171A2

0.333

MAZ_HUMAN

Myc-associated zinc finger protein

0.343

ZN574_HUMAN

Zinc finger protein 574

0.343

ZN668_HUMAN

Zinc finger protein 668

0.343

SCG3_HUMAN

Secretogranin-3

0.387

PCLI1_HUMAN

PTB-containing, cubilin and LRP1-interacting protein

0.387

LRAD3_HUMAN

Low-density lipoprotein receptor class A domain-containing protein 3

0.387

HPLN4_HUMAN

Hyaluronan and proteoglycan link protein 4

0.387

EURL_HUMAN

Protein EURL homolog

0.387

RFXAP_HUMAN

Regulatory factor X-associated protein

0.387

I10R2_HUMAN

Interleukin-10 receptor subunit beta

0.387

RET2_HUMAN

Retinol-binding protein 2

0.387

ZN148_HUMAN

Zinc finger protein 148

0.387

EDNRA_HUMAN

Endothelin-1 receptor

0.387

RLF_HUMAN

Zinc finger protein Rlf

0.387

R4RL1_HUMAN

Reticulon-4 receptor-like 1

0.387

GAK1B_HUMAN

Golgi-associated kinase 1B

0.387

RAMP3_HUMAN

Receptor activity-modifying protein 3

0.387

PGBD5_HUMAN

PiggyBac transposable element-derived protein 5

0.387

PTN_HUMAN

Pleiotrophin

0.387

TPA_HUMAN

Tissue-type plasminogen activator

0.387

LARGN_HUMAN

Protein Largen

0.387

EDNRB_HUMAN

Endothelin receptor type B

0.387

TSN18_HUMAN

Tetraspanin-18

0.387

CRBA1_HUMAN

Beta-crystallin A3

0.387

C2C4C_HUMAN

C2 calcium-dependent domain-containing protein 4C

0.387

LGI1_HUMAN

Leucine-rich glioma-inactivated protein 1

0.387

PRLR_HUMAN

Prolactin receptor

0.387

ZBT10_HUMAN

Zinc finger and BTB domain-containing protein 10

0.387

CCDC3_HUMAN

Coiled-coil domain-containing protein 3

0.387

T255A_HUMAN

Transmembrane protein 255A

0.387

HBAZ_HUMAN

Hemoglobin subunit zeta

0.387

PRLHR_HUMAN

Prolactin-releasing peptide receptor

0.387

LGI2_HUMAN

Leucine-rich repeat LGI family member 2

0.387

NR0B1_HUMAN

Nuclear receptor subfamily 0 group B member 1

0.387

EFCC1_HUMAN

EF-hand and coiled-coil domain-containing protein 1

0.387

T150B_HUMAN

Modulator of macroautophagy TMEM150B

0.397

DNHD1_HUMAN

Dynein heavy chain domain-containing protein 1

0.397

ASC_HUMAN

Apoptosis-associated speck-like protein containing a CARD

0.397

CK2N2_HUMAN

Calcium/calmodulin-dependent protein kinase II inhibitor 2

0.397

HEG1_HUMAN

Protein HEG homolog 1

0.397

PDYN_HUMAN

Proenkephalin-B

0.397

K2C8_HUMAN

Keratin, type II cytoskeletal 8

0.397

PR15L_HUMAN

Proline-rich protein 15-like protein

0.397

VTM2L_HUMAN

V-set and transmembrane domain-containing protein 2-like protein

0.397

K1107_HUMAN

AP2-interacting clathrin-endocytosis protein

0.397

CALCB_HUMAN

Calcitonin gene-related peptide 2

0.397

CLUS_HUMAN

Clusterin

0.397

GPR17_HUMAN

Uracil nucleotide/cysteinyl leukotriene receptor

0.397

GPC5C_HUMAN

G-protein coupled receptor family C group 5 member C

0.397

HIC1_HUMAN

Hypermethylated in cancer 1 protein

0.397

EPOR_HUMAN

Erythropoietin receptor

0.397

FA83C_HUMAN

Protein FAM83C

0.397

ZBT22_HUMAN

Zinc finger and BTB domain-containing protein 22

0.397

UIMC1_HUMAN

BRCA1-A complex subunit RAP80

0.397

GAK1A_HUMAN

Golgi-associated kinase 1A

0.397

OCSTP_HUMAN

Osteoclast stimulatory transmembrane protein

0.397

CAD26_HUMAN

Cadherin-like protein 26

0.397

F131B_HUMAN

Protein FAM131B

0.397

TZAP_HUMAN

Telomere zinc finger-associated protein

0.397

SCAR3_HUMAN

Scavenger receptor class A member 3

0.397

MAG_HUMAN

Myelin-associated glycoprotein

0.397

LSR_HUMAN

Lipolysis-stimulated lipoprotein receptor

0.397

CX038_HUMAN

Uncharacterized protein CXorf38

0.397

SOM2_HUMAN

Growth hormone variant

0.397

INHA_HUMAN

Inhibin alpha chain

0.397

CEAM5_HUMAN

Carcinoembryonic antigen-related cell adhesion molecule 5

0.397

ZN217_HUMAN

Zinc finger protein 217

0.397

ICAL_HUMAN

Calpastatin

0.397

NSL1_HUMAN

Kinetochore-associated protein NSL1 homolog

0.397

IL3RB_HUMAN

Cytokine receptor common subunit beta

0.397

TOR4A_HUMAN

Torsin-4A

0.397

ESAM_HUMAN

Endothelial cell-selective adhesion molecule

0.397

K1C14_HUMAN

Keratin, type I cytoskeletal 14

0.397

SPRY4_HUMAN

SPRY domain-containing protein 4

0.397

PRR35_HUMAN

Proline-rich protein 35

0.397

CRBA4_HUMAN

Beta-crystallin A4

0.397

CART_HUMAN

Cocaine- and amphetamine-regulated transcript protein

0.397

CSH2_HUMAN

Chorionic somatomammotropin hormone 2

0.397

IL2RG_HUMAN

Cytokine receptor common subunit gamma

0.397

SIG15_HUMAN

Sialic acid-binding Ig-like lectin 15

0.397

CNRG_HUMAN

Retinal rod rhodopsin-sensitive cGMP 3,5-cyclic phosphodiesterase subunit gamma

0.397

LRRN4_HUMAN

Leucine-rich repeat neuronal protein 4

0.397

CLD4_HUMAN

Claudin-4

0.397

SOMA_HUMAN

Somatotropin

0.397

CSH1_HUMAN

Chorionic somatomammotropin hormone 1

0.397

ARTN_HUMAN

Artemin

0.397

RHNO1_HUMAN

RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

0.397

PERF_HUMAN

Perforin-1

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

TRI44_HUMAN

Tripartite motif-containing protein 44

0.312

CC106_HUMAN

Coiled-coil domain-containing protein 106

0.331

LSR_HUMAN

Lipolysis-stimulated lipoprotein receptor

0.345

CLD15_HUMAN

Claudin-15

0.347

CLC11_HUMAN

C-type lectin domain family 11 member A

0.349

SPRY4_HUMAN

SPRY domain-containing protein 4

0.360

EPOR_HUMAN

Erythropoietin receptor

0.360

CX038_HUMAN

Uncharacterized protein CXorf38

0.362

CC136_HUMAN

Coiled-coil domain-containing protein 136

0.362

CCG6_HUMAN

Voltage-dependent calcium channel gamma-6 subunit

0.366

MAG_HUMAN

Myelin-associated glycoprotein

0.374

IL27B_HUMAN

Interleukin-27 subunit beta

0.374

TELT_HUMAN

Telethonin

0.376

SCN1B_HUMAN

Sodium channel subunit beta-1

0.376

EX3L2_HUMAN

Exocyst complex component 3-like protein 2

0.378

NYAP1_HUMAN

Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1

0.378

SE6L2_HUMAN

Seizure 6-like protein 2

0.378

RHBD3_HUMAN

Rhomboid domain-containing protein 3

0.378

CK095_HUMAN

Uncharacterized protein C11orf95

0.383

FBX50_HUMAN

F-box only protein 50

0.383

BAD_HUMAN

Bcl2-associated agonist of cell death

0.383

SHBG_HUMAN

Sex hormone-binding globulin

0.383

EMIL1_HUMAN

EMILIN-1

0.384

CD79A_HUMAN

B-cell antigen receptor complex-associated protein alpha chain

0.385

APOM_HUMAN

Apolipoprotein M

0.385

HEMO_HUMAN

Hemopexin

0.387

NECT2_HUMAN

Nectin-2

0.387

PROP_HUMAN

Properdin

0.387

CIART_HUMAN

Circadian-associated transcriptional repressor

0.387

PGS1_HUMAN

Biglycan

0.389

ECM1_HUMAN

Extracellular matrix protein 1

0.391

CD276_HUMAN

CD276 antigen

0.392

EPO_HUMAN

Erythropoietin

0.396

K2C8_HUMAN

Keratin, type II cytoskeletal 8

0.397

TTC22_HUMAN

Tetratricopeptide repeat protein 22

0.399

CK053_HUMAN

Uncharacterized protein C11orf53

0.399

IKZF4_HUMAN

Zinc finger protein Eos

0.399

BORG5_HUMAN

Cdc42 effector protein 1

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 79 organisms (of 929)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy