GDF8_HUMAN 2019

Gene Name GDF8

Description Growth/differentiation factor 8

Length 375

9606

Sequence

>sp|O14793|GDF8_HUMAN Growth/differentiation factor 8
MQKLQLCVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

GDF11_HUMAN

Growth/differentiation factor 11

0.271

NEGR1_HUMAN

Neuronal growth regulator 1

0.309

EVX1_HUMAN

Homeobox even-skipped homolog protein 1

0.309

TMCC2_HUMAN

Transmembrane and coiled-coil domains protein 2

0.312

SPRC_HUMAN

SPARC

0.312

AMRP_HUMAN

Alpha-2-macroglobulin receptor-associated protein

0.312

DAG1_HUMAN

Dystroglycan

0.337

MCF2L_HUMAN

Guanine nucleotide exchange factor DBS

0.341

JIP1_HUMAN

C-Jun-amino-terminal kinase-interacting protein 1

0.341

NR2C1_HUMAN

Nuclear receptor subfamily 2 group C member 1

0.341

LEG8_HUMAN

Galectin-8

0.345

GNRHR_HUMAN

Gonadotropin-releasing hormone receptor

0.345

PRD16_HUMAN

Histone-lysine N-methyltransferase PRDM16

0.345

CRTC1_HUMAN

CREB-regulated transcription coactivator 1

0.349

SSR5_HUMAN

Somatostatin receptor type 5

0.354

DACH2_HUMAN

Dachshund homolog 2

0.365

DACH1_HUMAN

Dachshund homolog 1

0.365

BTBD7_HUMAN

BTB/POZ domain-containing protein 7

0.365

NID2_HUMAN

Nidogen-2

0.365

ACK1_HUMAN

Activated CDC42 kinase 1

0.365

CSTN1_HUMAN

Calsyntenin-1

0.365

MYT1L_HUMAN

Myelin transcription factor 1-like protein

0.369

ZEB2_HUMAN

Zinc finger E-box-binding homeobox 2

0.369

NID1_HUMAN

Nidogen-1

0.369

S12A8_HUMAN

Solute carrier family 12 member 8

0.369

CEBPG_HUMAN

CCAAT/enhancer-binding protein gamma

0.369

HXA1_HUMAN

Homeobox protein Hox-A1

0.374

BNC1_HUMAN

Zinc finger protein basonuclin-1

0.374

JIP2_HUMAN

C-Jun-amino-terminal kinase-interacting protein 2

0.374

HES1_HUMAN

Transcription factor HES-1

0.374

TMCC3_HUMAN

Transmembrane and coiled-coil domain protein 3

0.374

MBTD1_HUMAN

MBT domain-containing protein 1

0.374

AMOL1_HUMAN

Angiomotin-like protein 1

0.378

HXB1_HUMAN

Homeobox protein Hox-B1

0.378

STAU2_HUMAN

Double-stranded RNA-binding protein Staufen homolog 2

0.378

IGLO5_HUMAN

IgLON family member 5

0.378

CTCF_HUMAN

Transcriptional repressor CTCF

0.378

CHRD_HUMAN

Chordin

0.383

PA2G3_HUMAN

Group 3 secretory phospholipase A2

0.383

SOCS5_HUMAN

Suppressor of cytokine signaling 5

0.383

SHRM3_HUMAN

Protein Shroom3

0.387

STON1_HUMAN

Stonin-1

0.390

EVA1C_HUMAN

Protein eva-1 homolog C

0.390

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.390

AP2B_HUMAN

Transcription factor AP-2-beta

0.390

RIPL1_HUMAN

RILP-like protein 1

0.390

HINFP_HUMAN

Histone H4 transcription factor

0.390

AHR_HUMAN

Aryl hydrocarbon receptor

0.394

MECOM_HUMAN

Histone-lysine N-methyltransferase MECOM

0.394

SP9_HUMAN

Transcription factor Sp9

0.394

CUBN_HUMAN

Cubilin

0.394

ZEB1_HUMAN

Zinc finger E-box-binding homeobox 1

0.394

PEBB_HUMAN

Core-binding factor subunit beta

0.394

MYT1_HUMAN

Myelin transcription factor 1

0.399

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.399

HME2_HUMAN

Homeobox protein engrailed-2

0.399

HNF6_HUMAN

Hepatocyte nuclear factor 6

0.399

RX_HUMAN

Retinal homeobox protein Rx

0.399

CRYA2_HUMAN

Alpha-crystallin A2 chain

0.399

OPCM_HUMAN

Opioid-binding protein/cell adhesion molecule

0.399

SKT_HUMAN

Sickle tail protein homolog

0.399

TSHR_HUMAN

Thyrotropin receptor

0.399

GRASP_HUMAN

General receptor for phosphoinositides 1-associated scaffold protein

0.399

HAND2_HUMAN

Heart- and neural crest derivatives-expressed protein 2

0.399

BNC2_HUMAN

Zinc finger protein basonuclin-2

0.399

K1143_HUMAN

Uncharacterized protein KIAA1143

0.399

ST18_HUMAN

Suppression of tumorigenicity 18 protein

0.399

IKKE_HUMAN

Inhibitor of nuclear factor kappa-B kinase subunit epsilon

0.399

SRCN1_HUMAN

SRC kinase signaling inhibitor 1

0.399

UBAP2_HUMAN

Ubiquitin-associated protein 2

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

GDF11_HUMAN

Growth/differentiation factor 11

0.271

NEGR1_HUMAN

Neuronal growth regulator 1

0.309

EVX1_HUMAN

Homeobox even-skipped homolog protein 1

0.309

TMCC2_HUMAN

Transmembrane and coiled-coil domains protein 2

0.312

SPRC_HUMAN

SPARC

0.312

AMRP_HUMAN

Alpha-2-macroglobulin receptor-associated protein

0.312

DAG1_HUMAN

Dystroglycan

0.337

MCF2L_HUMAN

Guanine nucleotide exchange factor DBS

0.341

JIP1_HUMAN

C-Jun-amino-terminal kinase-interacting protein 1

0.341

NR2C1_HUMAN

Nuclear receptor subfamily 2 group C member 1

0.341

LEG8_HUMAN

Galectin-8

0.345

GNRHR_HUMAN

Gonadotropin-releasing hormone receptor

0.345

PRD16_HUMAN

Histone-lysine N-methyltransferase PRDM16

0.345

CRTC1_HUMAN

CREB-regulated transcription coactivator 1

0.349

SSR5_HUMAN

Somatostatin receptor type 5

0.354

DACH2_HUMAN

Dachshund homolog 2

0.365

DACH1_HUMAN

Dachshund homolog 1

0.365

BTBD7_HUMAN

BTB/POZ domain-containing protein 7

0.365

NID2_HUMAN

Nidogen-2

0.365

ACK1_HUMAN

Activated CDC42 kinase 1

0.365

CSTN1_HUMAN

Calsyntenin-1

0.365

MYT1L_HUMAN

Myelin transcription factor 1-like protein

0.369

ZEB2_HUMAN

Zinc finger E-box-binding homeobox 2

0.369

NID1_HUMAN

Nidogen-1

0.369

S12A8_HUMAN

Solute carrier family 12 member 8

0.369

CEBPG_HUMAN

CCAAT/enhancer-binding protein gamma

0.369

HXA1_HUMAN

Homeobox protein Hox-A1

0.374

BNC1_HUMAN

Zinc finger protein basonuclin-1

0.374

JIP2_HUMAN

C-Jun-amino-terminal kinase-interacting protein 2

0.374

HES1_HUMAN

Transcription factor HES-1

0.374

TMCC3_HUMAN

Transmembrane and coiled-coil domain protein 3

0.374

MBTD1_HUMAN

MBT domain-containing protein 1

0.374

AMOL1_HUMAN

Angiomotin-like protein 1

0.378

HXB1_HUMAN

Homeobox protein Hox-B1

0.378

STAU2_HUMAN

Double-stranded RNA-binding protein Staufen homolog 2

0.378

IGLO5_HUMAN

IgLON family member 5

0.378

CTCF_HUMAN

Transcriptional repressor CTCF

0.378

CHRD_HUMAN

Chordin

0.383

PA2G3_HUMAN

Group 3 secretory phospholipase A2

0.383

SOCS5_HUMAN

Suppressor of cytokine signaling 5

0.383

SHRM3_HUMAN

Protein Shroom3

0.387

STON1_HUMAN

Stonin-1

0.390

EVA1C_HUMAN

Protein eva-1 homolog C

0.390

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.390

AP2B_HUMAN

Transcription factor AP-2-beta

0.390

RIPL1_HUMAN

RILP-like protein 1

0.390

HINFP_HUMAN

Histone H4 transcription factor

0.390

AHR_HUMAN

Aryl hydrocarbon receptor

0.394

MECOM_HUMAN

Histone-lysine N-methyltransferase MECOM

0.394

SP9_HUMAN

Transcription factor Sp9

0.394

CUBN_HUMAN

Cubilin

0.394

ZEB1_HUMAN

Zinc finger E-box-binding homeobox 1

0.394

PEBB_HUMAN

Core-binding factor subunit beta

0.394

MYT1_HUMAN

Myelin transcription factor 1

0.399

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.399

HME2_HUMAN

Homeobox protein engrailed-2

0.399

HNF6_HUMAN

Hepatocyte nuclear factor 6

0.399

RX_HUMAN

Retinal homeobox protein Rx

0.399

CRYA2_HUMAN

Alpha-crystallin A2 chain

0.399

OPCM_HUMAN

Opioid-binding protein/cell adhesion molecule

0.399

SKT_HUMAN

Sickle tail protein homolog

0.399

TSHR_HUMAN

Thyrotropin receptor

0.399

GRASP_HUMAN

General receptor for phosphoinositides 1-associated scaffold protein

0.399

HAND2_HUMAN

Heart- and neural crest derivatives-expressed protein 2

0.399

BNC2_HUMAN

Zinc finger protein basonuclin-2

0.399

K1143_HUMAN

Uncharacterized protein KIAA1143

0.399

ST18_HUMAN

Suppression of tumorigenicity 18 protein

0.399

IKKE_HUMAN

Inhibitor of nuclear factor kappa-B kinase subunit epsilon

0.399

SRCN1_HUMAN

SRC kinase signaling inhibitor 1

0.399

UBAP2_HUMAN

Ubiquitin-associated protein 2

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 39 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy