RX_HUMAN 2019

Gene Name RX

Description Retinal homeobox protein Rx

Length 346

9606

Sequence

>sp|Q9Y2V3|RX_HUMAN Retinal homeobox protein Rx
MHLPGCAPAMADGSFSLAGHLLRSPGGSTSRLHSIEAILGFTKDDGILGTFPAERGARGAKERDRRLGARPACPKAPEEGSEPSPPPAPAPAPEYEAPRPYCPKEPGEARPSPGLPVGPATGEAKLSEEEQPKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAGKVNLPEVRVQVWFQNRRAKWRRQEKLEVSSMKLQDSPLLSFSRSPPSATLSPLGAGPGSGGGPAGGALPLESWLGPPLPGGGATALQSLPGFGPPAQSLPASYTPPPPPPPFLNSPPLGPGLQPLAPPPPSYPCGPGFGDKFPLDEADPRNSSIAALRLKAKEHIQAIGKPWQAL

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

ACK1_HUMAN

Activated CDC42 kinase 1

0.330

DACH2_HUMAN

Dachshund homolog 2

0.330

DACH1_HUMAN

Dachshund homolog 1

0.330

BTBD7_HUMAN

BTB/POZ domain-containing protein 7

0.330

ZO2_HUMAN

Tight junction protein ZO-2

0.330

MYT1L_HUMAN

Myelin transcription factor 1-like protein

0.333

EVX1_HUMAN

Homeobox even-skipped homolog protein 1

0.337

HES1_HUMAN

Transcription factor HES-1

0.337

RORA_HUMAN

Nuclear receptor ROR-alpha

0.341

SPRC_HUMAN

SPARC

0.341

AMRP_HUMAN

Alpha-2-macroglobulin receptor-associated protein

0.341

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.357

E41L5_HUMAN

Band 4.1-like protein 5

0.357

ZO1_HUMAN

Tight junction protein ZO-1

0.357

RIPL1_HUMAN

RILP-like protein 1

0.357

TPD53_HUMAN

Tumor protein D53

0.361

MECOM_HUMAN

Histone-lysine N-methyltransferase MECOM

0.361

DAG1_HUMAN

Dystroglycan

0.361

SP9_HUMAN

Transcription factor Sp9

0.361

GULP1_HUMAN

PTB domain-containing engulfment adapter protein 1

0.361

NR2C1_HUMAN

Nuclear receptor subfamily 2 group C member 1

0.365

HME2_HUMAN

Homeobox protein engrailed-2

0.365

HAND2_HUMAN

Heart- and neural crest derivatives-expressed protein 2

0.365

ST18_HUMAN

Suppression of tumorigenicity 18 protein

0.365

CRYA2_HUMAN

Alpha-crystallin A2 chain

0.365

JIP1_HUMAN

C-Jun-amino-terminal kinase-interacting protein 1

0.365

UBAP2_HUMAN

Ubiquitin-associated protein 2

0.365

MYT1_HUMAN

Myelin transcription factor 1

0.365

GDF11_HUMAN

Growth/differentiation factor 11

0.369

OTOP1_HUMAN

Proton channel OTOP1

0.369

LEG8_HUMAN

Galectin-8

0.369

PRD16_HUMAN

Histone-lysine N-methyltransferase PRDM16

0.369

RORB_HUMAN

Nuclear receptor ROR-beta

0.369

LRIG1_HUMAN

Leucine-rich repeats and immunoglobulin-like domains protein 1

0.374

TMM47_HUMAN

Transmembrane protein 47

0.374

FERM2_HUMAN

Fermitin family homolog 2

0.378

FERM1_HUMAN

Fermitin family homolog 1

0.378

BARH1_HUMAN

BarH-like 1 homeobox protein

0.382

NUMB_HUMAN

Protein numb homolog

0.382

RUND1_HUMAN

RUN domain-containing protein 1

0.382

EPHA4_HUMAN

Ephrin type-A receptor 4

0.382

AT1B4_HUMAN

Protein ATP1B4

0.382

HLF_HUMAN

Hepatic leukemia factor

0.382

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.382

FLI1_HUMAN

Friend leukemia integration 1 transcription factor

0.386

CSTN1_HUMAN

Calsyntenin-1

0.386

E41L1_HUMAN

Band 4.1-like protein 1

0.386

NPC2_HUMAN

NPC intracellular cholesterol transporter 2

0.386

AVR2B_HUMAN

Activin receptor type-2B

0.386

MSX1_HUMAN

Homeobox protein MSX-1

0.386

OTX2_HUMAN

Homeobox protein OTX2

0.386

NR2C2_HUMAN

Nuclear receptor subfamily 2 group C member 2

0.386

ERBB4_HUMAN

Receptor tyrosine-protein kinase erbB-4

0.386

RIMS1_HUMAN

Regulating synaptic membrane exocytosis protein 1

0.386

MB211_HUMAN

Putative nucleotidyltransferase MAB21L1

0.386

FOXP2_HUMAN

Forkhead box protein P2

0.386

ACM3_HUMAN

Muscarinic acetylcholine receptor M3

0.390

ACM2_HUMAN

Muscarinic acetylcholine receptor M2

0.390

K2013_HUMAN

Uncharacterized protein KIAA2013

0.390

AKAP1_HUMAN

A-kinase anchor protein 1, mitochondrial

0.390

PRDM1_HUMAN

PR domain zinc finger protein 1

0.390

XKR6_HUMAN

XK-related protein 6

0.390

S12A8_HUMAN

Solute carrier family 12 member 8

0.390

CHSS2_HUMAN

Chondroitin sulfate synthase 2

0.394

HXA1_HUMAN

Homeobox protein Hox-A1

0.394

SYTL5_HUMAN

Synaptotagmin-like protein 5

0.394

HXB9_HUMAN

Homeobox protein Hox-B9

0.394

NEGR1_HUMAN

Neuronal growth regulator 1

0.394

MBTD1_HUMAN

MBT domain-containing protein 1

0.394

CTCF_HUMAN

Transcriptional repressor CTCF

0.399

NR4A2_HUMAN

Nuclear receptor subfamily 4 group A member 2

0.399

GDF8_HUMAN

Growth/differentiation factor 8

0.399

HXB1_HUMAN

Homeobox protein Hox-B1

0.399

LRIG2_HUMAN

Leucine-rich repeats and immunoglobulin-like domains protein 2

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

ACK1_HUMAN

Activated CDC42 kinase 1

0.330

DACH2_HUMAN

Dachshund homolog 2

0.330

DACH1_HUMAN

Dachshund homolog 1

0.330

BTBD7_HUMAN

BTB/POZ domain-containing protein 7

0.330

ZO2_HUMAN

Tight junction protein ZO-2

0.330

MYT1L_HUMAN

Myelin transcription factor 1-like protein

0.333

EVX1_HUMAN

Homeobox even-skipped homolog protein 1

0.337

HES1_HUMAN

Transcription factor HES-1

0.337

RORA_HUMAN

Nuclear receptor ROR-alpha

0.341

SPRC_HUMAN

SPARC

0.341

AMRP_HUMAN

Alpha-2-macroglobulin receptor-associated protein

0.341

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.357

E41L5_HUMAN

Band 4.1-like protein 5

0.357

ZO1_HUMAN

Tight junction protein ZO-1

0.357

RIPL1_HUMAN

RILP-like protein 1

0.357

TPD53_HUMAN

Tumor protein D53

0.361

MECOM_HUMAN

Histone-lysine N-methyltransferase MECOM

0.361

DAG1_HUMAN

Dystroglycan

0.361

SP9_HUMAN

Transcription factor Sp9

0.361

GULP1_HUMAN

PTB domain-containing engulfment adapter protein 1

0.361

NR2C1_HUMAN

Nuclear receptor subfamily 2 group C member 1

0.365

HME2_HUMAN

Homeobox protein engrailed-2

0.365

HAND2_HUMAN

Heart- and neural crest derivatives-expressed protein 2

0.365

ST18_HUMAN

Suppression of tumorigenicity 18 protein

0.365

CRYA2_HUMAN

Alpha-crystallin A2 chain

0.365

JIP1_HUMAN

C-Jun-amino-terminal kinase-interacting protein 1

0.365

UBAP2_HUMAN

Ubiquitin-associated protein 2

0.365

MYT1_HUMAN

Myelin transcription factor 1

0.365

GDF11_HUMAN

Growth/differentiation factor 11

0.369

OTOP1_HUMAN

Proton channel OTOP1

0.369

LEG8_HUMAN

Galectin-8

0.369

PRD16_HUMAN

Histone-lysine N-methyltransferase PRDM16

0.369

RORB_HUMAN

Nuclear receptor ROR-beta

0.369

LRIG1_HUMAN

Leucine-rich repeats and immunoglobulin-like domains protein 1

0.374

TMM47_HUMAN

Transmembrane protein 47

0.374

FERM2_HUMAN

Fermitin family homolog 2

0.378

FERM1_HUMAN

Fermitin family homolog 1

0.378

BARH1_HUMAN

BarH-like 1 homeobox protein

0.382

NUMB_HUMAN

Protein numb homolog

0.382

RUND1_HUMAN

RUN domain-containing protein 1

0.382

EPHA4_HUMAN

Ephrin type-A receptor 4

0.382

AT1B4_HUMAN

Protein ATP1B4

0.382

HLF_HUMAN

Hepatic leukemia factor

0.382

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.382

FLI1_HUMAN

Friend leukemia integration 1 transcription factor

0.386

CSTN1_HUMAN

Calsyntenin-1

0.386

E41L1_HUMAN

Band 4.1-like protein 1

0.386

NPC2_HUMAN

NPC intracellular cholesterol transporter 2

0.386

AVR2B_HUMAN

Activin receptor type-2B

0.386

MSX1_HUMAN

Homeobox protein MSX-1

0.386

OTX2_HUMAN

Homeobox protein OTX2

0.386

NR2C2_HUMAN

Nuclear receptor subfamily 2 group C member 2

0.386

ERBB4_HUMAN

Receptor tyrosine-protein kinase erbB-4

0.386

RIMS1_HUMAN

Regulating synaptic membrane exocytosis protein 1

0.386

MB211_HUMAN

Putative nucleotidyltransferase MAB21L1

0.386

FOXP2_HUMAN

Forkhead box protein P2

0.386

ACM3_HUMAN

Muscarinic acetylcholine receptor M3

0.390

ACM2_HUMAN

Muscarinic acetylcholine receptor M2

0.390

K2013_HUMAN

Uncharacterized protein KIAA2013

0.390

AKAP1_HUMAN

A-kinase anchor protein 1, mitochondrial

0.390

PRDM1_HUMAN

PR domain zinc finger protein 1

0.390

XKR6_HUMAN

XK-related protein 6

0.390

S12A8_HUMAN

Solute carrier family 12 member 8

0.390

CHSS2_HUMAN

Chondroitin sulfate synthase 2

0.394

HXA1_HUMAN

Homeobox protein Hox-A1

0.394

SYTL5_HUMAN

Synaptotagmin-like protein 5

0.394

HXB9_HUMAN

Homeobox protein Hox-B9

0.394

NEGR1_HUMAN

Neuronal growth regulator 1

0.394

MBTD1_HUMAN

MBT domain-containing protein 1

0.394

CTCF_HUMAN

Transcriptional repressor CTCF

0.399

NR4A2_HUMAN

Nuclear receptor subfamily 4 group A member 2

0.399

GDF8_HUMAN

Growth/differentiation factor 8

0.399

HXB1_HUMAN

Homeobox protein Hox-B1

0.399

LRIG2_HUMAN

Leucine-rich repeats and immunoglobulin-like domains protein 2

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 42 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy