NR4A2_HUMAN 2019

Gene Name NR4A2

Description Nuclear receptor subfamily 4 group A member 2

Length 598

9606

Sequence

>sp|P43354|NR4A2_HUMAN Nuclear receptor subfamily 4 group A member 2
MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSMDLTNTEITATTSLPSFSTFMDNYSTGYDVKPPCLYQMPLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMPHSGSVYYKPSSPPTPTTPGFQVQHSPMWDDPGSLHNFHQNYVATTHMIEQRKTPVSRLSLFSFKQSPPGTPVSSCQMRFDGPLHVPMNPEPAGSHHVVDGQTFAVPNPIRKPASMGFPGLQIGHASQLLDTQVPSPPSRGSPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQEPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

NR4A1_HUMAN

Nuclear receptor subfamily 4 group A member 1

0.274

RORA_HUMAN

Nuclear receptor ROR-alpha

0.312

CTCF_HUMAN

Transcriptional repressor CTCF

0.312

CHRD_HUMAN

Chordin

0.316

MECOM_HUMAN

Histone-lysine N-methyltransferase MECOM

0.337

RORB_HUMAN

Nuclear receptor ROR-beta

0.345

LEG8_HUMAN

Galectin-8

0.345

OTOP1_HUMAN

Proton channel OTOP1

0.345

FRPD4_HUMAN

FERM and PDZ domain-containing protein 4

0.345

TMM47_HUMAN

Transmembrane protein 47

0.349

TUTLB_HUMAN

Protein turtle homolog B

0.349

SPIR2_HUMAN

Protein spire homolog 2

0.349

VGLL2_HUMAN

Transcription cofactor vestigial-like protein 2

0.354

BCAP_HUMAN

Phosphoinositide 3-kinase adapter protein 1

0.358

ERBB4_HUMAN

Receptor tyrosine-protein kinase erbB-4

0.365

DACH2_HUMAN

Dachshund homolog 2

0.365

NR2C2_HUMAN

Nuclear receptor subfamily 2 group C member 2

0.365

DACH1_HUMAN

Dachshund homolog 1

0.365

ACK1_HUMAN

Activated CDC42 kinase 1

0.365

PRDM1_HUMAN

PR domain zinc finger protein 1

0.369

INT12_HUMAN

Integrator complex subunit 12

0.369

ACM2_HUMAN

Muscarinic acetylcholine receptor M2

0.369

ZEB2_HUMAN

Zinc finger E-box-binding homeobox 2

0.369

ACM3_HUMAN

Muscarinic acetylcholine receptor M3

0.369

MYT1L_HUMAN

Myelin transcription factor 1-like protein

0.369

EVX1_HUMAN

Homeobox even-skipped homolog protein 1

0.374

MBTD1_HUMAN

MBT domain-containing protein 1

0.374

HES1_HUMAN

Transcription factor HES-1

0.374

SYT4_HUMAN

Synaptotagmin-4

0.374

HXB9_HUMAN

Homeobox protein Hox-B9

0.374

HXA1_HUMAN

Homeobox protein Hox-A1

0.374

SPRC_HUMAN

SPARC

0.378

AMRP_HUMAN

Alpha-2-macroglobulin receptor-associated protein

0.378

HXB1_HUMAN

Homeobox protein Hox-B1

0.378

SSR2_HUMAN

Somatostatin receptor type 2

0.383

TWSG1_HUMAN

Twisted gastrulation protein homolog 1

0.383

ZN423_HUMAN

Zinc finger protein 423

0.387

EMX2_HUMAN

Homeobox protein EMX2

0.390

NR5A2_HUMAN

Nuclear receptor subfamily 5 group A member 2

0.390

RIPL1_HUMAN

RILP-like protein 1

0.390

LRP2_HUMAN

Low-density lipoprotein receptor-related protein 2

0.390

FABP7_HUMAN

Fatty acid-binding protein, brain

0.390

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.390

LZTS3_HUMAN

Leucine zipper putative tumor suppressor 3

0.392

FJX1_HUMAN

Four-jointed box protein 1

0.392

INSC_HUMAN

Protein inscuteable homolog

0.392

ERBB2_HUMAN

Receptor tyrosine-protein kinase erbB-2

0.394

PEBB_HUMAN

Core-binding factor subunit beta

0.394

RXRA_HUMAN

Retinoic acid receptor RXR-alpha

0.394

SP9_HUMAN

Transcription factor Sp9

0.394

LRRF2_HUMAN

Leucine-rich repeat flightless-interacting protein 2

0.394

ZEB1_HUMAN

Zinc finger E-box-binding homeobox 1

0.394

CUBN_HUMAN

Cubilin

0.394

TPD53_HUMAN

Tumor protein D53

0.394

ZFHX3_HUMAN

Zinc finger homeobox protein 3

0.394

RX_HUMAN

Retinal homeobox protein Rx

0.399

BNC2_HUMAN

Zinc finger protein basonuclin-2

0.399

HME2_HUMAN

Homeobox protein engrailed-2

0.399

NR2C1_HUMAN

Nuclear receptor subfamily 2 group C member 1

0.399

KIRR3_HUMAN

Kin of IRRE-like protein 3

0.399

ST18_HUMAN

Suppression of tumorigenicity 18 protein

0.399

PROX1_HUMAN

Prospero homeobox protein 1

0.399

FOXA1_HUMAN

Hepatocyte nuclear factor 3-alpha

0.399

OPCM_HUMAN

Opioid-binding protein/cell adhesion molecule

0.399

TMEM9_HUMAN

Transmembrane protein 9

0.399

UBAP2_HUMAN

Ubiquitin-associated protein 2

0.399

JIP1_HUMAN

C-Jun-amino-terminal kinase-interacting protein 1

0.399

MYT1_HUMAN

Myelin transcription factor 1

0.399

TMM9B_HUMAN

Transmembrane protein 9B

0.399

5HT1B_HUMAN

5-hydroxytryptamine receptor 1B

0.399

CAPON_HUMAN

Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

NR4A1_HUMAN

Nuclear receptor subfamily 4 group A member 1

0.274

RORA_HUMAN

Nuclear receptor ROR-alpha

0.312

CTCF_HUMAN

Transcriptional repressor CTCF

0.312

CHRD_HUMAN

Chordin

0.316

MECOM_HUMAN

Histone-lysine N-methyltransferase MECOM

0.337

RORB_HUMAN

Nuclear receptor ROR-beta

0.345

LEG8_HUMAN

Galectin-8

0.345

OTOP1_HUMAN

Proton channel OTOP1

0.345

FRPD4_HUMAN

FERM and PDZ domain-containing protein 4

0.345

TMM47_HUMAN

Transmembrane protein 47

0.349

TUTLB_HUMAN

Protein turtle homolog B

0.349

SPIR2_HUMAN

Protein spire homolog 2

0.349

VGLL2_HUMAN

Transcription cofactor vestigial-like protein 2

0.354

BCAP_HUMAN

Phosphoinositide 3-kinase adapter protein 1

0.358

ERBB4_HUMAN

Receptor tyrosine-protein kinase erbB-4

0.365

DACH2_HUMAN

Dachshund homolog 2

0.365

NR2C2_HUMAN

Nuclear receptor subfamily 2 group C member 2

0.365

DACH1_HUMAN

Dachshund homolog 1

0.365

ACK1_HUMAN

Activated CDC42 kinase 1

0.365

PRDM1_HUMAN

PR domain zinc finger protein 1

0.369

INT12_HUMAN

Integrator complex subunit 12

0.369

ACM2_HUMAN

Muscarinic acetylcholine receptor M2

0.369

ZEB2_HUMAN

Zinc finger E-box-binding homeobox 2

0.369

ACM3_HUMAN

Muscarinic acetylcholine receptor M3

0.369

MYT1L_HUMAN

Myelin transcription factor 1-like protein

0.369

EVX1_HUMAN

Homeobox even-skipped homolog protein 1

0.374

MBTD1_HUMAN

MBT domain-containing protein 1

0.374

HES1_HUMAN

Transcription factor HES-1

0.374

SYT4_HUMAN

Synaptotagmin-4

0.374

HXB9_HUMAN

Homeobox protein Hox-B9

0.374

HXA1_HUMAN

Homeobox protein Hox-A1

0.374

SPRC_HUMAN

SPARC

0.378

AMRP_HUMAN

Alpha-2-macroglobulin receptor-associated protein

0.378

HXB1_HUMAN

Homeobox protein Hox-B1

0.378

SSR2_HUMAN

Somatostatin receptor type 2

0.383

TWSG1_HUMAN

Twisted gastrulation protein homolog 1

0.383

ZN423_HUMAN

Zinc finger protein 423

0.387

EMX2_HUMAN

Homeobox protein EMX2

0.390

NR5A2_HUMAN

Nuclear receptor subfamily 5 group A member 2

0.390

RIPL1_HUMAN

RILP-like protein 1

0.390

LRP2_HUMAN

Low-density lipoprotein receptor-related protein 2

0.390

FABP7_HUMAN

Fatty acid-binding protein, brain

0.390

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.390

LZTS3_HUMAN

Leucine zipper putative tumor suppressor 3

0.392

FJX1_HUMAN

Four-jointed box protein 1

0.392

INSC_HUMAN

Protein inscuteable homolog

0.392

ERBB2_HUMAN

Receptor tyrosine-protein kinase erbB-2

0.394

PEBB_HUMAN

Core-binding factor subunit beta

0.394

RXRA_HUMAN

Retinoic acid receptor RXR-alpha

0.394

SP9_HUMAN

Transcription factor Sp9

0.394

LRRF2_HUMAN

Leucine-rich repeat flightless-interacting protein 2

0.394

ZEB1_HUMAN

Zinc finger E-box-binding homeobox 1

0.394

CUBN_HUMAN

Cubilin

0.394

TPD53_HUMAN

Tumor protein D53

0.394

ZFHX3_HUMAN

Zinc finger homeobox protein 3

0.394

RX_HUMAN

Retinal homeobox protein Rx

0.399

BNC2_HUMAN

Zinc finger protein basonuclin-2

0.399

HME2_HUMAN

Homeobox protein engrailed-2

0.399

NR2C1_HUMAN

Nuclear receptor subfamily 2 group C member 1

0.399

KIRR3_HUMAN

Kin of IRRE-like protein 3

0.399

ST18_HUMAN

Suppression of tumorigenicity 18 protein

0.399

PROX1_HUMAN

Prospero homeobox protein 1

0.399

FOXA1_HUMAN

Hepatocyte nuclear factor 3-alpha

0.399

OPCM_HUMAN

Opioid-binding protein/cell adhesion molecule

0.399

TMEM9_HUMAN

Transmembrane protein 9

0.399

UBAP2_HUMAN

Ubiquitin-associated protein 2

0.399

JIP1_HUMAN

C-Jun-amino-terminal kinase-interacting protein 1

0.399

MYT1_HUMAN

Myelin transcription factor 1

0.399

TMM9B_HUMAN

Transmembrane protein 9B

0.399

5HT1B_HUMAN

5-hydroxytryptamine receptor 1B

0.399

CAPON_HUMAN

Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 39 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy