BEGIN_HUMAN 2019

Gene Name BEGIN

Description Brain-enriched guanylate kinase-associated protein

Length 593

9606

Sequence

>sp|Q9BUH8|BEGIN_HUMAN Brain-enriched guanylate kinase-associated protein
MEKLSALQEQKGELRKRLSYTTHKLEKLETEFDSTRHYLEIELRRAQEELEKVTEKLRRIQSNYMALQRINQELEDKLYRMGQHYEEEKRALSHEIVALNSHLLEAKVTIDKLSEDNELYRKDCNLAAQLLQCSQTYGRVHKVSELPSDFQERVSLHMEKHGCSLPSPLCHPAYADSVPTCVIAKVLEKPDPASLSSRLSDASARDLAFCDGVEKPGPRPPYKGDIYCSDTALYCPEERRRDRRPSVDAPVTDVGFLRAQNSTDSAAEEEEEAEAAAFPAGFQHEAFPSYAGSLPTSSSYSSFSATSEEKEHAQASTLTASQQAIYLNSRDELFDRKPPATTYEGSPRFAKATAAVAAPLEAEVAPGFGRTMSPYPAETFRFPASPGPQQALMPPNLWSLRAKPGTARLPGEDMRGQWRPLSVEDIGAYSYPVSAAGRASPCSFSERYYGGAGGSPGKKADGRASPLYASYKADSFSEGDDLSQGHLAEPCFLRAGGDLSLSPGRSADPLPGYAPSEGGDGDRLGVQLCGTASSPEPEQGSRDSLEPSSMEASPEMHPAARLSPQQAFPRTGGSGLSRKDSLTKAQLYGTLLN

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

TJAP1_HUMAN

Tight junction-associated protein 1

0.158

SKIL_HUMAN

Ski-like protein

0.305

BICL1_HUMAN

BICD family-like cargo adapter 1

0.309

CC28B_HUMAN

Coiled-coil domain-containing protein 28B

0.312

HMGX4_HUMAN

HMG domain-containing protein 4

0.312

OPCM_HUMAN

Opioid-binding protein/cell adhesion molecule

0.341

SYT14_HUMAN

Synaptotagmin-14

0.345

OTOP1_HUMAN

Proton channel OTOP1

0.345

DIK2A_HUMAN

Divergent protein kinase domain 2A

0.345

RXFP1_HUMAN

Relaxin receptor 1

0.349

ELL_HUMAN

RNA polymerase II elongation factor ELL

0.349

SHRM2_HUMAN

Protein Shroom2

0.354

NINJ1_HUMAN

Ninjurin-1

0.354

TMED6_HUMAN

Transmembrane emp24 domain-containing protein 6

0.354

SKI_HUMAN

Ski oncogene

0.365

CSTN1_HUMAN

Calsyntenin-1

0.365

VAS1_HUMAN

V-type proton ATPase subunit S1

0.365

GATD1_HUMAN

GATA zinc finger domain-containing protein 1

0.369

PTF1A_HUMAN

Pancreas transcription factor 1 subunit alpha

0.369

ZFYV9_HUMAN

Zinc finger FYVE domain-containing protein 9

0.369

ZEB2_HUMAN

Zinc finger E-box-binding homeobox 2

0.369

KI26B_HUMAN

Kinesin-like protein KIF26B

0.374

SYTL5_HUMAN

Synaptotagmin-like protein 5

0.374

FEZ2_HUMAN

Fasciculation and elongation protein zeta-2

0.374

RM39_HUMAN

39S ribosomal protein L39, mitochondrial

0.374

FBX28_HUMAN

F-box only protein 28

0.378

SYT16_HUMAN

Synaptotagmin-16

0.378

CC28A_HUMAN

Coiled-coil domain-containing protein 28A

0.383

DRD1_HUMAN

D(1A) dopamine receptor

0.383

RFX7_HUMAN

DNA-binding protein RFX7

0.383

CHRD_HUMAN

Chordin

0.383

SHCAF_HUMAN

SIN3-HDAC complex-associated factor

0.383

CASZ1_HUMAN

Zinc finger protein castor homolog 1

0.383

RASF2_HUMAN

Ras association domain-containing protein 2

0.383

TWSG1_HUMAN

Twisted gastrulation protein homolog 1

0.383

FBXW5_HUMAN

F-box/WD repeat-containing protein 5

0.383

BOK_HUMAN

Bcl-2-related ovarian killer protein

0.387

DRD5_HUMAN

D(1B) dopamine receptor

0.387

ZN503_HUMAN

Zinc finger protein 503

0.387

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.387

ROR2_HUMAN

Tyrosine-protein kinase transmembrane receptor ROR2

0.390

HINFP_HUMAN

Histone H4 transcription factor

0.390

MED1_HUMAN

Mediator of RNA polymerase II transcription subunit 1

0.390

RIPL1_HUMAN

RILP-like protein 1

0.390

TPD53_HUMAN

Tumor protein D53

0.394

FBX25_HUMAN

F-box only protein 25

0.394

ZEB1_HUMAN

Zinc finger E-box-binding homeobox 1

0.394

PORCN_HUMAN

Protein-serine O-palmitoleoyltransferase porcupine

0.394

MERL_HUMAN

Merlin

0.399

SRCN1_HUMAN

SRC kinase signaling inhibitor 1

0.399

HAND2_HUMAN

Heart- and neural crest derivatives-expressed protein 2

0.399

SKT_HUMAN

Sickle tail protein homolog

0.399

TXD11_HUMAN

Thioredoxin domain-containing protein 11

0.399

SCMH1_HUMAN

Polycomb protein SCMH1

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

TJAP1_HUMAN

Tight junction-associated protein 1

0.158

SKIL_HUMAN

Ski-like protein

0.305

BICL1_HUMAN

BICD family-like cargo adapter 1

0.309

CC28B_HUMAN

Coiled-coil domain-containing protein 28B

0.312

HMGX4_HUMAN

HMG domain-containing protein 4

0.312

OPCM_HUMAN

Opioid-binding protein/cell adhesion molecule

0.341

SYT14_HUMAN

Synaptotagmin-14

0.345

OTOP1_HUMAN

Proton channel OTOP1

0.345

DIK2A_HUMAN

Divergent protein kinase domain 2A

0.345

RXFP1_HUMAN

Relaxin receptor 1

0.349

ELL_HUMAN

RNA polymerase II elongation factor ELL

0.349

SHRM2_HUMAN

Protein Shroom2

0.354

NINJ1_HUMAN

Ninjurin-1

0.354

TMED6_HUMAN

Transmembrane emp24 domain-containing protein 6

0.354

SKI_HUMAN

Ski oncogene

0.365

CSTN1_HUMAN

Calsyntenin-1

0.365

VAS1_HUMAN

V-type proton ATPase subunit S1

0.365

GATD1_HUMAN

GATA zinc finger domain-containing protein 1

0.369

PTF1A_HUMAN

Pancreas transcription factor 1 subunit alpha

0.369

ZFYV9_HUMAN

Zinc finger FYVE domain-containing protein 9

0.369

ZEB2_HUMAN

Zinc finger E-box-binding homeobox 2

0.369

KI26B_HUMAN

Kinesin-like protein KIF26B

0.374

SYTL5_HUMAN

Synaptotagmin-like protein 5

0.374

FEZ2_HUMAN

Fasciculation and elongation protein zeta-2

0.374

RM39_HUMAN

39S ribosomal protein L39, mitochondrial

0.374

FBX28_HUMAN

F-box only protein 28

0.378

SYT16_HUMAN

Synaptotagmin-16

0.378

CC28A_HUMAN

Coiled-coil domain-containing protein 28A

0.383

DRD1_HUMAN

D(1A) dopamine receptor

0.383

RFX7_HUMAN

DNA-binding protein RFX7

0.383

CHRD_HUMAN

Chordin

0.383

SHCAF_HUMAN

SIN3-HDAC complex-associated factor

0.383

CASZ1_HUMAN

Zinc finger protein castor homolog 1

0.383

RASF2_HUMAN

Ras association domain-containing protein 2

0.383

TWSG1_HUMAN

Twisted gastrulation protein homolog 1

0.383

FBXW5_HUMAN

F-box/WD repeat-containing protein 5

0.383

BOK_HUMAN

Bcl-2-related ovarian killer protein

0.387

DRD5_HUMAN

D(1B) dopamine receptor

0.387

ZN503_HUMAN

Zinc finger protein 503

0.387

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.387

ROR2_HUMAN

Tyrosine-protein kinase transmembrane receptor ROR2

0.390

HINFP_HUMAN

Histone H4 transcription factor

0.390

MED1_HUMAN

Mediator of RNA polymerase II transcription subunit 1

0.390

RIPL1_HUMAN

RILP-like protein 1

0.390

TPD53_HUMAN

Tumor protein D53

0.394

FBX25_HUMAN

F-box only protein 25

0.394

ZEB1_HUMAN

Zinc finger E-box-binding homeobox 1

0.394

PORCN_HUMAN

Protein-serine O-palmitoleoyltransferase porcupine

0.394

MERL_HUMAN

Merlin

0.399

SRCN1_HUMAN

SRC kinase signaling inhibitor 1

0.399

HAND2_HUMAN

Heart- and neural crest derivatives-expressed protein 2

0.399

SKT_HUMAN

Sickle tail protein homolog

0.399

TXD11_HUMAN

Thioredoxin domain-containing protein 11

0.399

SCMH1_HUMAN

Polycomb protein SCMH1

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 39 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy