SYTL5_HUMAN 2019

Gene Name SYTL5

Description Synaptotagmin-like protein 5

Length 730

9606

Sequence

>sp|Q8TDW5|SYTL5_HUMAN Synaptotagmin-like protein 5
MSKNSEFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQEASRVCVHCHRNLGLIFDRGDPCQACSLRVCRECRVAGPNGSWKCTVCDKIAQLRIITGEWFFEEKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTSPVAGKKASHDGPKRKGFLLSKFRSATRGEIITPKTDTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLNDQEPGPRTPKSSRSNGVTPGTQSSPAPSTRTVTSVISREYGFENSMDLAAIEGTSQELTKSHRRNTSGTPSIAVSGTSLSSDQSRSELDLSESFTEDSEDTVSIRSKSVPGALDKDSLEETEESIDALVSSQLSTNTHRLASGLSTTSLNSMMSVYSETGDYGNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRTGTNPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPTDEWFVLQPKVEFAPDIGLQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFEGVLMLRSSMGKCRL

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

SYTL4_HUMAN

Synaptotagmin-like protein 4

0.156

DIK2A_HUMAN

Divergent protein kinase domain 2A

0.267

41_HUMAN

Protein 4.1

0.302

GABPA_HUMAN

GA-binding protein alpha chain

0.302

CRERF_HUMAN

CREB3 regulatory factor

0.305

BICL1_HUMAN

BICD family-like cargo adapter 1

0.305

HMGX4_HUMAN

HMG domain-containing protein 4

0.309

ELF2_HUMAN

ETS-related transcription factor Elf-2

0.333

E41L2_HUMAN

Band 4.1-like protein 2

0.337

SYT14_HUMAN

Synaptotagmin-14

0.341

CRBL2_HUMAN

cAMP-responsive element-binding protein-like 2

0.341

OTOP1_HUMAN

Proton channel OTOP1

0.341

LIN37_HUMAN

Protein lin-37 homolog

0.341

LHPL2_HUMAN

LHFPL tetraspan subfamily member 2 protein

0.345

TCF21_HUMAN

Transcription factor 21

0.345

GCM2_HUMAN

Chorion-specific transcription factor GCMb

0.345

NDUF4_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

0.349

SKI_HUMAN

Ski oncogene

0.361

NPC2_HUMAN

NPC intracellular cholesterol transporter 2

0.361

CSTN1_HUMAN

Calsyntenin-1

0.361

ACK1_HUMAN

Activated CDC42 kinase 1

0.361

CASP7_HUMAN

Caspase-7

0.361

SNAI2_HUMAN

Zinc finger protein SNAI2

0.365

AXIN1_HUMAN

Axin-1

0.365

PHC2_HUMAN

Polyhomeotic-like protein 2

0.365

SKIL_HUMAN

Ski-like protein

0.365

MUSK_HUMAN

Muscle, skeletal receptor tyrosine-protein kinase

0.369

E41L3_HUMAN

Band 4.1-like protein 3

0.369

NRF1_HUMAN

Nuclear respiratory factor 1

0.369

SYT16_HUMAN

Synaptotagmin-16

0.374

BEGIN_HUMAN

Brain-enriched guanylate kinase-associated protein

0.374

CA043_HUMAN

Uncharacterized protein C1orf43

0.378

RFX7_HUMAN

DNA-binding protein RFX7

0.378

SHCAF_HUMAN

SIN3-HDAC complex-associated factor

0.378

CASZ1_HUMAN

Zinc finger protein castor homolog 1

0.378

CPEB3_HUMAN

Cytoplasmic polyadenylation element-binding protein 3

0.382

PAR6B_HUMAN

Partitioning defective 6 homolog beta

0.382

KAZD1_HUMAN

Kazal-type serine protease inhibitor domain-containing protein 1

0.383

HINFP_HUMAN

Histone H4 transcription factor

0.386

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.386

MED1_HUMAN

Mediator of RNA polymerase II transcription subunit 1

0.386

RIPL1_HUMAN

RILP-like protein 1

0.386

STON1_HUMAN

Stonin-1

0.386

CNTP1_HUMAN

Contactin-associated protein 1

0.390

CNTP4_HUMAN

Contactin-associated protein-like 4

0.390

SP9_HUMAN

Transcription factor Sp9

0.390

ZN609_HUMAN

Zinc finger protein 609

0.390

MECOM_HUMAN

Histone-lysine N-methyltransferase MECOM

0.390

AHR_HUMAN

Aryl hydrocarbon receptor

0.390

ZEB1_HUMAN

Zinc finger E-box-binding homeobox 1

0.390

AXIN2_HUMAN

Axin-2

0.394

HAND2_HUMAN

Heart- and neural crest derivatives-expressed protein 2

0.394

OPCM_HUMAN

Opioid-binding protein/cell adhesion molecule

0.394

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.394

SCMH1_HUMAN

Polycomb protein SCMH1

0.394

RX_HUMAN

Retinal homeobox protein Rx

0.394

ZN704_HUMAN

Zinc finger protein 704

0.394

BNC2_HUMAN

Zinc finger protein basonuclin-2

0.394

TJAP1_HUMAN

Tight junction-associated protein 1

0.399

KSYK_HUMAN

Tyrosine-protein kinase SYK

0.399

DSCL1_HUMAN

Down syndrome cell adhesion molecule-like protein 1

0.399

GTSF1_HUMAN

Gametocyte-specific factor 1

0.399

PRD13_HUMAN

PR domain zinc finger protein 13

0.399

G2E3_HUMAN

G2/M phase-specific E3 ubiquitin-protein ligase

0.399

BAG4_HUMAN

BAG family molecular chaperone regulator 4

0.399

ZAP70_HUMAN

Tyrosine-protein kinase ZAP-70

0.399

PRD16_HUMAN

Histone-lysine N-methyltransferase PRDM16

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

SYTL4_HUMAN

Synaptotagmin-like protein 4

0.156

DIK2A_HUMAN

Divergent protein kinase domain 2A

0.267

41_HUMAN

Protein 4.1

0.302

GABPA_HUMAN

GA-binding protein alpha chain

0.302

CRERF_HUMAN

CREB3 regulatory factor

0.305

BICL1_HUMAN

BICD family-like cargo adapter 1

0.305

HMGX4_HUMAN

HMG domain-containing protein 4

0.309

ELF2_HUMAN

ETS-related transcription factor Elf-2

0.333

E41L2_HUMAN

Band 4.1-like protein 2

0.337

SYT14_HUMAN

Synaptotagmin-14

0.341

CRBL2_HUMAN

cAMP-responsive element-binding protein-like 2

0.341

OTOP1_HUMAN

Proton channel OTOP1

0.341

LIN37_HUMAN

Protein lin-37 homolog

0.341

LHPL2_HUMAN

LHFPL tetraspan subfamily member 2 protein

0.345

TCF21_HUMAN

Transcription factor 21

0.345

GCM2_HUMAN

Chorion-specific transcription factor GCMb

0.345

NDUF4_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

0.349

SKI_HUMAN

Ski oncogene

0.361

NPC2_HUMAN

NPC intracellular cholesterol transporter 2

0.361

CSTN1_HUMAN

Calsyntenin-1

0.361

ACK1_HUMAN

Activated CDC42 kinase 1

0.361

CASP7_HUMAN

Caspase-7

0.361

SNAI2_HUMAN

Zinc finger protein SNAI2

0.365

AXIN1_HUMAN

Axin-1

0.365

PHC2_HUMAN

Polyhomeotic-like protein 2

0.365

SKIL_HUMAN

Ski-like protein

0.365

MUSK_HUMAN

Muscle, skeletal receptor tyrosine-protein kinase

0.369

E41L3_HUMAN

Band 4.1-like protein 3

0.369

NRF1_HUMAN

Nuclear respiratory factor 1

0.369

SYT16_HUMAN

Synaptotagmin-16

0.374

BEGIN_HUMAN

Brain-enriched guanylate kinase-associated protein

0.374

CA043_HUMAN

Uncharacterized protein C1orf43

0.378

RFX7_HUMAN

DNA-binding protein RFX7

0.378

SHCAF_HUMAN

SIN3-HDAC complex-associated factor

0.378

CASZ1_HUMAN

Zinc finger protein castor homolog 1

0.378

CPEB3_HUMAN

Cytoplasmic polyadenylation element-binding protein 3

0.382

PAR6B_HUMAN

Partitioning defective 6 homolog beta

0.382

KAZD1_HUMAN

Kazal-type serine protease inhibitor domain-containing protein 1

0.383

HINFP_HUMAN

Histone H4 transcription factor

0.386

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.386

MED1_HUMAN

Mediator of RNA polymerase II transcription subunit 1

0.386

RIPL1_HUMAN

RILP-like protein 1

0.386

STON1_HUMAN

Stonin-1

0.386

CNTP1_HUMAN

Contactin-associated protein 1

0.390

CNTP4_HUMAN

Contactin-associated protein-like 4

0.390

SP9_HUMAN

Transcription factor Sp9

0.390

ZN609_HUMAN

Zinc finger protein 609

0.390

MECOM_HUMAN

Histone-lysine N-methyltransferase MECOM

0.390

AHR_HUMAN

Aryl hydrocarbon receptor

0.390

ZEB1_HUMAN

Zinc finger E-box-binding homeobox 1

0.390

AXIN2_HUMAN

Axin-2

0.394

HAND2_HUMAN

Heart- and neural crest derivatives-expressed protein 2

0.394

OPCM_HUMAN

Opioid-binding protein/cell adhesion molecule

0.394

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.394

SCMH1_HUMAN

Polycomb protein SCMH1

0.394

RX_HUMAN

Retinal homeobox protein Rx

0.394

ZN704_HUMAN

Zinc finger protein 704

0.394

BNC2_HUMAN

Zinc finger protein basonuclin-2

0.394

TJAP1_HUMAN

Tight junction-associated protein 1

0.399

KSYK_HUMAN

Tyrosine-protein kinase SYK

0.399

DSCL1_HUMAN

Down syndrome cell adhesion molecule-like protein 1

0.399

GTSF1_HUMAN

Gametocyte-specific factor 1

0.399

PRD13_HUMAN

PR domain zinc finger protein 13

0.399

G2E3_HUMAN

G2/M phase-specific E3 ubiquitin-protein ligase

0.399

BAG4_HUMAN

BAG family molecular chaperone regulator 4

0.399

ZAP70_HUMAN

Tyrosine-protein kinase ZAP-70

0.399

PRD16_HUMAN

Histone-lysine N-methyltransferase PRDM16

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 41 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy