KAP2_HUMAN 2019

Gene Name KAP2

Description cAMP-dependent protein kinase type II-alpha regulatory subunit

Length 404

9606

Sequence

>sp|P13861|KAP2_HUMAN cAMP-dependent protein kinase type II-alpha regulatory subunit
MSHIQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLREARAPASVLPAATPRQSLGHPPPEPGPDRVADAKGDSESEEDEDLEVPVPSRFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSSVDLGNLGQ

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

KAP3_HUMAN

cAMP-dependent protein kinase type II-beta regulatory subunit

0.163

SORL_HUMAN

Sortilin-related receptor

0.350

TM9S2_HUMAN

Transmembrane 9 superfamily member 2

0.352

ARGI2_HUMAN

Arginase-2, mitochondrial

0.362

POMT2_HUMAN

Protein O-mannosyl-transferase 2

0.364

BAT1_HUMAN

b(0,+)-type amino acid transporter 1

0.365

GGPPS_HUMAN

Geranylgeranyl pyrophosphate synthase

0.368

CLCN3_HUMAN

H(+)/Cl(-) exchange transporter 3

0.368

ERGI2_HUMAN

Endoplasmic reticulum-Golgi intermediate compartment protein 2

0.369

TOM70_HUMAN

Mitochondrial import receptor subunit TOM70

0.369

H33_HUMAN

Histone H3.3

0.371

CLCN5_HUMAN

H(+)/Cl(-) exchange transporter 5

0.371

SLMAP_HUMAN

Sarcolemmal membrane-associated protein

0.372

NIF3L_HUMAN

NIF3-like protein 1

0.373

HEM1_HUMAN

5-aminolevulinate synthase, nonspecific, mitochondrial

0.374

CLCN4_HUMAN

H(+)/Cl(-) exchange transporter 4

0.375

ACATN_HUMAN

Acetyl-coenzyme A transporter 1

0.375

PGPS1_HUMAN

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

0.377

PAK2_HUMAN

Serine/threonine-protein kinase PAK 2

0.378

VIGLN_HUMAN

Vigilin

0.378

PAN2_HUMAN

PAN2-PAN3 deadenylation complex catalytic subunit PAN2

0.378

DPP4_HUMAN

Dipeptidyl peptidase 4

0.378

SEPT7_HUMAN

Septin-7

0.378

COR1C_HUMAN

Coronin-1C

0.379

PAN3_HUMAN

PAN2-PAN3 deadenylation complex subunit PAN3

0.380

PP2BA_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

0.380

CUL1_HUMAN

Cullin-1

0.381

AL4A1_HUMAN

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

0.381

DPP10_HUMAN

Inactive dipeptidyl peptidase 10

0.383

UBE3C_HUMAN

Ubiquitin-protein ligase E3C

0.383

AADAT_HUMAN

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

0.384

SYYC_HUMAN

Tyrosine--tRNA ligase, cytoplasmic

0.385

SYCC_HUMAN

Cysteine--tRNA ligase, cytoplasmic

0.385

GOLP3_HUMAN

Golgi phosphoprotein 3

0.386

ARGI1_HUMAN

Arginase-1

0.387

PAK1_HUMAN

Serine/threonine-protein kinase PAK 1

0.387

TMED9_HUMAN

Transmembrane emp24 domain-containing protein 9

0.387

PAK3_HUMAN

Serine/threonine-protein kinase PAK 3

0.387

LIPT_HUMAN

Lipoyltransferase 1, mitochondrial

0.387

DOP1_HUMAN

Protein dopey-1

0.388

ATP9B_HUMAN

Probable phospholipid-transporting ATPase IIB

0.388

GSH1_HUMAN

Glutamate--cysteine ligase catalytic subunit

0.389

RCC1_HUMAN

Regulator of chromosome condensation

0.389

SIR2_HUMAN

NAD-dependent protein deacetylase sirtuin-2

0.391

CCHL_HUMAN

Cytochrome c-type heme lyase

0.391

DEPD5_HUMAN

GATOR complex protein DEPDC5

0.392

CNDP2_HUMAN

Cytosolic non-specific dipeptidase

0.392

ATP9A_HUMAN

Probable phospholipid-transporting ATPase IIA

0.393

SURF4_HUMAN

Surfeit locus protein 4

0.393

DYHC1_HUMAN

Cytoplasmic dynein 1 heavy chain 1

0.393

ACON_HUMAN

Aconitate hydratase, mitochondrial

0.394

SEPR_HUMAN

Prolyl endopeptidase FAP

0.394

RRAGA_HUMAN

Ras-related GTP-binding protein A

0.394

SYNC_HUMAN

Asparagine--tRNA ligase, cytoplasmic

0.395

RRAGC_HUMAN

Ras-related GTP-binding protein C

0.396

NPRL2_HUMAN

GATOR complex protein NPRL2

0.397

DHR11_HUMAN

Dehydrogenase/reductase SDR family member 11

0.397

DPOG1_HUMAN

DNA polymerase subunit gamma-1

0.397

SYRM_HUMAN

Probable arginine--tRNA ligase, mitochondrial

0.397

MK14_HUMAN

Mitogen-activated protein kinase 14

0.398

S2611_HUMAN

Sodium-independent sulfate anion transporter

0.398

CC14A_HUMAN

Dual specificity protein phosphatase CDC14A

0.398

GATA4_HUMAN

Transcription factor GATA-4

0.398

S39A9_HUMAN

Zinc transporter ZIP9

0.399

ADCK5_HUMAN

Uncharacterized aarF domain-containing protein kinase 5

0.399

GATA5_HUMAN

Transcription factor GATA-5

0.399

COR2B_HUMAN

Coronin-2B

0.399

RICTR_HUMAN

Rapamycin-insensitive companion of mTOR

0.400

UB2G2_HUMAN

Ubiquitin-conjugating enzyme E2 G2

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 105 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy