DHR11_HUMAN 2019

Gene Name DHR11

Description Dehydrogenase/reductase SDR family member 11

Length 260

9606

Sequence

>sp|Q6UWP2|DHR11_HUMAN Dehydrogenase/reductase SDR family member 11
MARPGMERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQTHIRATCISPGVVETQFAFKLHDKDPEKAAATYEQMKCLKPEDVAEAVIYVLSTPAHIQIGDIQMRPTEQVT

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

ACON_HUMAN

Aconitate hydratase, mitochondrial

0.332

AADAT_HUMAN

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

0.342

TOM70_HUMAN

Mitochondrial import receptor subunit TOM70

0.353

NPRL2_HUMAN

GATOR complex protein NPRL2

0.354

PAK2_HUMAN

Serine/threonine-protein kinase PAK 2

0.359

AL4A1_HUMAN

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

0.363

ACATN_HUMAN

Acetyl-coenzyme A transporter 1

0.363

CCHL_HUMAN

Cytochrome c-type heme lyase

0.364

SLMAP_HUMAN

Sarcolemmal membrane-associated protein

0.365

PAK3_HUMAN

Serine/threonine-protein kinase PAK 3

0.366

GGPPS_HUMAN

Geranylgeranyl pyrophosphate synthase

0.368

SOS1_HUMAN

Son of sevenless homolog 1

0.369

PAK1_HUMAN

Serine/threonine-protein kinase PAK 1

0.369

POMT2_HUMAN

Protein O-mannosyl-transferase 2

0.371

FBXW7_HUMAN

F-box/WD repeat-containing protein 7

0.371

VIGLN_HUMAN

Vigilin

0.372

SEPT7_HUMAN

Septin-7

0.372

WDR59_HUMAN

GATOR complex protein WDR59

0.373

CLCN5_HUMAN

H(+)/Cl(-) exchange transporter 5

0.375

SYRM_HUMAN

Probable arginine--tRNA ligase, mitochondrial

0.376

RICTR_HUMAN

Rapamycin-insensitive companion of mTOR

0.377

TSC2_HUMAN

Tuberin

0.377

STRP1_HUMAN

Striatin-interacting protein 1

0.377

DEPD5_HUMAN

GATOR complex protein DEPDC5

0.378

CLCN3_HUMAN

H(+)/Cl(-) exchange transporter 3

0.378

SURF4_HUMAN

Surfeit locus protein 4

0.378

CLCN4_HUMAN

H(+)/Cl(-) exchange transporter 4

0.378

DPP4_HUMAN

Dipeptidyl peptidase 4

0.378

CACP_HUMAN

Carnitine O-acetyltransferase

0.378

ZNT1_HUMAN

Zinc transporter 1

0.378

ERGI2_HUMAN

Endoplasmic reticulum-Golgi intermediate compartment protein 2

0.378

CMC1_HUMAN

Calcium-binding mitochondrial carrier protein Aralar1

0.379

DPOG1_HUMAN

DNA polymerase subunit gamma-1

0.379

HEM1_HUMAN

5-aminolevulinate synthase, nonspecific, mitochondrial

0.381

PAN2_HUMAN

PAN2-PAN3 deadenylation complex catalytic subunit PAN2

0.381

PAN3_HUMAN

PAN2-PAN3 deadenylation complex subunit PAN3

0.383

DPP10_HUMAN

Inactive dipeptidyl peptidase 10

0.383

CNDP2_HUMAN

Cytosolic non-specific dipeptidase

0.384

GATA4_HUMAN

Transcription factor GATA-4

0.384

SUPT3_HUMAN

Transcription initiation protein SPT3 homolog

0.384

RRAGC_HUMAN

Ras-related GTP-binding protein C

0.385

SOS2_HUMAN

Son of sevenless homolog 2

0.386

RRAGA_HUMAN

Ras-related GTP-binding protein A

0.386

PP2BA_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

0.386

PYC_HUMAN

Pyruvate carboxylase, mitochondrial

0.387

GOLP3_HUMAN

Golgi phosphoprotein 3

0.387

TBC20_HUMAN

TBC1 domain family member 20

0.387

S2536_HUMAN

Solute carrier family 25 member 36

0.387

GATA5_HUMAN

Transcription factor GATA-5

0.388

BAT1_HUMAN

b(0,+)-type amino acid transporter 1

0.388

C560_HUMAN

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

0.389

TM9S2_HUMAN

Transmembrane 9 superfamily member 2

0.389

KDM4A_HUMAN

Lysine-specific demethylase 4A

0.390

CUL1_HUMAN

Cullin-1

0.390

SYCC_HUMAN

Cysteine--tRNA ligase, cytoplasmic

0.391

AT2C1_HUMAN

Calcium-transporting ATPase type 2C member 1

0.391

OXDD_HUMAN

D-aspartate oxidase

0.391

SYNC_HUMAN

Asparagine--tRNA ligase, cytoplasmic

0.392

RCC1_HUMAN

Regulator of chromosome condensation

0.392

OGFD1_HUMAN

Prolyl 3-hydroxylase OGFOD1

0.392

DCPS_HUMAN

m7GpppX diphosphatase

0.393

HIP1_HUMAN

Huntingtin-interacting protein 1

0.393

GATA6_HUMAN

Transcription factor GATA-6

0.394

DYHC1_HUMAN

Cytoplasmic dynein 1 heavy chain 1

0.394

H33_HUMAN

Histone H3.3

0.394

SEPR_HUMAN

Prolyl endopeptidase FAP

0.395

AVL9_HUMAN

Late secretory pathway protein AVL9 homolog

0.395

COX5A_HUMAN

Cytochrome c oxidase subunit 5A, mitochondrial

0.395

SORL_HUMAN

Sortilin-related receptor

0.395

NIF3L_HUMAN

NIF3-like protein 1

0.395

PLPL6_HUMAN

Neuropathy target esterase

0.396

PBDC1_HUMAN

Protein PBDC1

0.396

KDM4C_HUMAN

Lysine-specific demethylase 4C

0.396

M3K4_HUMAN

Mitogen-activated protein kinase kinase kinase 4

0.396

S39A9_HUMAN

Zinc transporter ZIP9

0.396

KAP2_HUMAN

cAMP-dependent protein kinase type II-alpha regulatory subunit

0.397

DOT1L_HUMAN

Histone-lysine N-methyltransferase, H3 lysine-79 specific

0.397

GSH1_HUMAN

Glutamate--cysteine ligase catalytic subunit

0.397

PGPS1_HUMAN

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

0.398

TRM44_HUMAN

Probable tRNA (uracil-O(2)-)-methyltransferase

0.398

AT133_HUMAN

Probable cation-transporting ATPase 13A3

0.398

SYYC_HUMAN

Tyrosine--tRNA ligase, cytoplasmic

0.399

PLPL7_HUMAN

Patatin-like phospholipase domain-containing protein 7

0.399

KAP3_HUMAN

cAMP-dependent protein kinase type II-beta regulatory subunit

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 96 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy