GATA5_HUMAN 2019

Gene Name GATA5

Description Transcription factor GATA-5

Length 397

9606

Sequence

>sp|Q9BWX5|GATA5_HUMAN Transcription factor GATA-5
MYQSLALAASPRQAAYADSGSFLHAPGAGSPMFVPPARVPSMLSYLSGCEPSPQPPELAARPGWAQTATADSSAFGPGSPHPPAAHPPGATAFPFAHSPSGPGSGGSAGGRDGSAYQGALLPREQFAAPLGRPVGTSYSATYPAYVSPDVAQSWTAGPFDGSVLHGLPGRRPTFVSDFLEEFPGEGRECVNCGALSTPLWRRDGTGHYLCNACGLYHKMNGVNRPLVRPQKRLSSSRRAGLCCTNCHTTNTTLWRRNSEGEPVCNACGLYMKLHGVPRPLAMKKESIQTRKRKPKTIAKARGSSGSTRNASASPSAVASTDSSAATSKAKPSLASPVCPGPSMAPQASGQEDDSLAPGHLEFKFEPEDFAFPSTAPSPQAGLRGALRQEAWCALALA

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

GATA6_HUMAN

Transcription factor GATA-6

0.185

GATA4_HUMAN

Transcription factor GATA-4

0.236

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

GATA6_HUMAN

Transcription factor GATA-6

0.201

GATA4_HUMAN

Transcription factor GATA-4

0.213

POMT2_HUMAN

Protein O-mannosyl-transferase 2

0.312

SYRM_HUMAN

Probable arginine--tRNA ligase, mitochondrial

0.324

SEPT7_HUMAN

Septin-7

0.324

GOLP3_HUMAN

Golgi phosphoprotein 3

0.325

SLMAP_HUMAN

Sarcolemmal membrane-associated protein

0.326

GATA3_HUMAN

Trans-acting T-cell-specific transcription factor GATA-3

0.327

TOM70_HUMAN

Mitochondrial import receptor subunit TOM70

0.331

GATA2_HUMAN

Endothelial transcription factor GATA-2

0.331

RHOA_HUMAN

Transforming protein RhoA

0.343

SUPT3_HUMAN

Transcription initiation protein SPT3 homolog

0.343

SYNC_HUMAN

Asparagine--tRNA ligase, cytoplasmic

0.344

SURF4_HUMAN

Surfeit locus protein 4

0.344

RAGP1_HUMAN

Ran GTPase-activating protein 1

0.346

FBXW7_HUMAN

F-box/WD repeat-containing protein 7

0.347

VIGLN_HUMAN

Vigilin

0.348

BAT1_HUMAN

b(0,+)-type amino acid transporter 1

0.351

CLCN5_HUMAN

H(+)/Cl(-) exchange transporter 5

0.351

CLCN4_HUMAN

H(+)/Cl(-) exchange transporter 4

0.351

CLCN3_HUMAN

H(+)/Cl(-) exchange transporter 3

0.354

DPOG1_HUMAN

DNA polymerase subunit gamma-1

0.356

NIF3L_HUMAN

NIF3-like protein 1

0.356

DPP10_HUMAN

Inactive dipeptidyl peptidase 10

0.357

ERGI2_HUMAN

Endoplasmic reticulum-Golgi intermediate compartment protein 2

0.358

RHOC_HUMAN

Rho-related GTP-binding protein RhoC

0.358

PAK2_HUMAN

Serine/threonine-protein kinase PAK 2

0.358

COX5A_HUMAN

Cytochrome c oxidase subunit 5A, mitochondrial

0.359

PBDC1_HUMAN

Protein PBDC1

0.360

DPP4_HUMAN

Dipeptidyl peptidase 4

0.361

PAK1_HUMAN

Serine/threonine-protein kinase PAK 1

0.362

PAK3_HUMAN

Serine/threonine-protein kinase PAK 3

0.362

ACON_HUMAN

Aconitate hydratase, mitochondrial

0.364

RCC1_HUMAN

Regulator of chromosome condensation

0.365

SEPR_HUMAN

Prolyl endopeptidase FAP

0.366

AL4A1_HUMAN

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

0.368

GYS2_HUMAN

Glycogen [starch] synthase, liver

0.369

IQGA1_HUMAN

Ras GTPase-activating-like protein IQGAP1

0.369

SRF_HUMAN

Serum response factor

0.370

ZNT1_HUMAN

Zinc transporter 1

0.371

GATA1_HUMAN

Erythroid transcription factor

0.372

HIP1R_HUMAN

Huntingtin-interacting protein 1-related protein

0.373

GYS1_HUMAN

Glycogen [starch] synthase, muscle

0.374

PLPL6_HUMAN

Neuropathy target esterase

0.374

PLPL7_HUMAN

Patatin-like phospholipase domain-containing protein 7

0.375

H33_HUMAN

Histone H3.3

0.376

OGFD1_HUMAN

Prolyl 3-hydroxylase OGFOD1

0.377

S39A9_HUMAN

Zinc transporter ZIP9

0.377

DYR_HUMAN

Dihydrofolate reductase

0.377

SOS1_HUMAN

Son of sevenless homolog 1

0.377

DPP6_HUMAN

Dipeptidyl aminopeptidase-like protein 6

0.379

CUL1_HUMAN

Cullin-1

0.380

CACP_HUMAN

Carnitine O-acetyltransferase

0.381

HIP1_HUMAN

Huntingtin-interacting protein 1

0.381

NPRL2_HUMAN

GATOR complex protein NPRL2

0.382

GDE_HUMAN

Glycogen debranching enzyme

0.382

PAN3_HUMAN

PAN2-PAN3 deadenylation complex subunit PAN3

0.382

SNX12_HUMAN

Sorting nexin-12

0.383

YLAT2_HUMAN

Y+L amino acid transporter 2

0.383

SIR2_HUMAN

NAD-dependent protein deacetylase sirtuin-2

0.385

DOT1L_HUMAN

Histone-lysine N-methyltransferase, H3 lysine-79 specific

0.385

HYAS3_HUMAN

Hyaluronan synthase 3

0.385

AVL9_HUMAN

Late secretory pathway protein AVL9 homolog

0.385

SOS2_HUMAN

Son of sevenless homolog 2

0.385

M3K4_HUMAN

Mitogen-activated protein kinase kinase kinase 4

0.386

DHR11_HUMAN

Dehydrogenase/reductase SDR family member 11

0.388

AT2C1_HUMAN

Calcium-transporting ATPase type 2C member 1

0.388

ATP9B_HUMAN

Probable phospholipid-transporting ATPase IIB

0.388

HYAS2_HUMAN

Hyaluronan synthase 2

0.389

DCPS_HUMAN

m7GpppX diphosphatase

0.389

ATP9A_HUMAN

Probable phospholipid-transporting ATPase IIA

0.389

S38AB_HUMAN

Putative sodium-coupled neutral amino acid transporter 11

0.391

UB2G2_HUMAN

Ubiquitin-conjugating enzyme E2 G2

0.391

YLAT1_HUMAN

Y+L amino acid transporter 1

0.392

TRM44_HUMAN

Probable tRNA (uracil-O(2)-)-methyltransferase

0.392

TSC2_HUMAN

Tuberin

0.392

S2536_HUMAN

Solute carrier family 25 member 36

0.392

AADAT_HUMAN

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

0.393

DOP1_HUMAN

Protein dopey-1

0.393

SNX3_HUMAN

Sorting nexin-3

0.394

CCHL_HUMAN

Cytochrome c-type heme lyase

0.394

DEPD5_HUMAN

GATOR complex protein DEPDC5

0.395

ACATN_HUMAN

Acetyl-coenzyme A transporter 1

0.395

TM9S2_HUMAN

Transmembrane 9 superfamily member 2

0.395

AT133_HUMAN

Probable cation-transporting ATPase 13A3

0.395

GGPPS_HUMAN

Geranylgeranyl pyrophosphate synthase

0.395

SYYC_HUMAN

Tyrosine--tRNA ligase, cytoplasmic

0.395

KC1G2_HUMAN

Casein kinase I isoform gamma-2

0.396

PEX13_HUMAN

Peroxisomal membrane protein PEX13

0.397

DOCK3_HUMAN

Dedicator of cytokinesis protein 3

0.397

MOT4_HUMAN

Monocarboxylate transporter 4

0.397

PP2BA_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

0.397

C560_HUMAN

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

0.397

STRP1_HUMAN

Striatin-interacting protein 1

0.398

PB1_HUMAN

Protein polybromo-1

0.398

DOCK5_HUMAN

Dedicator of cytokinesis protein 5

0.398

PAN2_HUMAN

PAN2-PAN3 deadenylation complex catalytic subunit PAN2

0.398

KAP3_HUMAN

cAMP-dependent protein kinase type II-beta regulatory subunit

0.399

KAP2_HUMAN

cAMP-dependent protein kinase type II-alpha regulatory subunit

0.399

WDR59_HUMAN

GATOR complex protein WDR59

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 85 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy