ZC21C_HUMAN 2019

Gene Name ZC21C

Description Zinc finger C2HC domain-containing protein 1C

Length 456

9606

Sequence

>sp|Q53FD0|ZC21C_HUMAN Zinc finger C2HC domain-containing protein 1C
MAGLQRLASHLPVGVMLPHNTTEAPGPHSAKQDSYEQGDSSQQSLKGHLRNNFQKQLLSNKELILDKVYTHPKWNTQTKARSYSYPHCTGISQQDPESDSQGQGNGLFYSSGPQSWYPKANNQDFIPFTKKRVGVDRAFPLKPMVHRKSCSTGEAGTDGDHNVYPRPPEPREFSSRNFGVRNQGNFSVVGTVLAATQAEKAVANFDRTEWVQIRRLEAAGESLEEEIRRKQILLRGKLKKTEEELRRIQTQKEQAKENENGELQKIILPRSRVKGNKSNTMYKPIFSPEFEFEEEFSRDRREDETWGRSQQNSGPFQFSDYRIQRLKRERLVASNNKIRDPVSEPSVEKFSPPSETPVGALQGSARNSSLSMAPDSSGSSGSIEEPQLGECSHCGRKFLSFRLERHSNICSRMRGSKRKVFDSSRARAKGTELEQYLNWKGPASAKAEPPQKSNWR

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

ZBTB6_HUMAN

Zinc finger and BTB domain-containing protein 6

0.267

MSLN_HUMAN

Mesothelin

0.365

CLD16_HUMAN

Claudin-16

0.365

MFAP3_HUMAN

Microfibril-associated glycoprotein 3

0.365

PIANP_HUMAN

PILR alpha-associated neural protein

0.365

TRI14_HUMAN

Tripartite motif-containing protein 14

0.365

VWCE_HUMAN

von Willebrand factor C and EGF domain-containing protein

0.365

NPY5R_HUMAN

Neuropeptide Y receptor type 5

0.365

AREG_HUMAN

Amphiregulin

0.365

CD40L_HUMAN

CD40 ligand

0.365

Z518B_HUMAN

Zinc finger protein 518B

0.378

F174A_HUMAN

Membrane protein FAM174A

0.378

P2Y13_HUMAN

P2Y purinoceptor 13

0.378

GKN1_HUMAN

Gastrokine-1

0.378

APOA1_HUMAN

Apolipoprotein A-I

0.378

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

EGLN_HUMAN

Endoglin

0.306

TRI14_HUMAN

Tripartite motif-containing protein 14

0.324

CD40L_HUMAN

CD40 ligand

0.338

MFAP3_HUMAN

Microfibril-associated glycoprotein 3

0.338

INGR1_HUMAN

Interferon gamma receptor 1

0.340

CLD16_HUMAN

Claudin-16

0.340

CD34_HUMAN

Hematopoietic progenitor cell antigen CD34

0.340

CD47_HUMAN

Leukocyte surface antigen CD47

0.342

ODFP1_HUMAN

Outer dense fiber protein 1

0.344

GKN1_HUMAN

Gastrokine-1

0.344

CD72_HUMAN

B-cell differentiation antigen CD72

0.344

THY1_HUMAN

Thy-1 membrane glycoprotein

0.358

SHPS1_HUMAN

Tyrosine-protein phosphatase non-receptor type substrate 1

0.358

IL22_HUMAN

Interleukin-22

0.360

RESF1_HUMAN

Retroelement silencing factor 1

0.360

ACRBP_HUMAN

Acrosin-binding protein

0.360

INLR1_HUMAN

Interferon lambda receptor 1

0.363

SPERT_HUMAN

Spermatid-associated protein

0.363

TB182_HUMAN

182 kDa tankyrase-1-binding protein

0.363

SIAL_HUMAN

Bone sialoprotein 2

0.363

APOA1_HUMAN

Apolipoprotein A-I

0.363

PML_HUMAN

Protein PML

0.363

GKN2_HUMAN

Gastrokine-2

0.365

TNF15_HUMAN

Tumor necrosis factor ligand superfamily member 15

0.369

AREG_HUMAN

Amphiregulin

0.369

CCGL_HUMAN

Voltage-dependent calcium channel gamma-like subunit

0.369

INAR1_HUMAN

Interferon alpha/beta receptor 1

0.371

SUGP2_HUMAN

SURP and G-patch domain-containing protein 2

0.371

COL_HUMAN

Colipase

0.373

ZN654_HUMAN

Zinc finger protein 654

0.373

CF132_HUMAN

Uncharacterized protein C6orf132

0.376

AMGO2_HUMAN

Amphoterin-induced protein 2

0.376

LAPM5_HUMAN

Lysosomal-associated transmembrane protein 5

0.376

BPIB4_HUMAN

BPI fold-containing family B member 4

0.376

BCAS1_HUMAN

Breast carcinoma-amplified sequence 1

0.376

I13R1_HUMAN

Interleukin-13 receptor subunit alpha-1

0.376

PPR17_HUMAN

Protein phosphatase 1 regulatory subunit 17

0.376

KCD19_HUMAN

BTB/POZ domain-containing protein KCTD19

0.376

PIANP_HUMAN

PILR alpha-associated neural protein

0.376

CAMP_HUMAN

Cathelicidin antimicrobial peptide

0.378

TM171_HUMAN

Transmembrane protein 171

0.378

I10R1_HUMAN

Interleukin-10 receptor subunit alpha

0.378

SNTAN_HUMAN

Sentan

0.378

MYOZ3_HUMAN

Myozenin-3

0.378

TNFL8_HUMAN

Tumor necrosis factor ligand superfamily member 8

0.378

TM52B_HUMAN

Transmembrane protein 52B

0.378

ECSCR_HUMAN

Endothelial cell-specific chemotaxis regulator

0.378

IL15_HUMAN

Interleukin-15

0.380

TPO_HUMAN

Thrombopoietin

0.380

MSLN_HUMAN

Mesothelin

0.380

KCD18_HUMAN

BTB/POZ domain-containing protein KCTD18

0.380

BCLA3_HUMAN

BCLAF1 and THRAP3 family member 3

0.383

OSTP_HUMAN

Osteopontin

0.383

VTDB_HUMAN

Vitamin D-binding protein

0.385

IL5RA_HUMAN

Interleukin-5 receptor subunit alpha

0.385

MROH7_HUMAN

Maestro heat-like repeat-containing protein family member 7

0.386

SPT16_HUMAN

Spermatogenesis-associated protein 16

0.387

CK074_HUMAN

Protein C11orf74

0.387

CDHR3_HUMAN

Cadherin-related family member 3

0.390

FSHB_HUMAN

Follitropin subunit beta

0.390

GSG1_HUMAN

Germ cell-specific gene 1 protein

0.390

MFAP5_HUMAN

Microfibrillar-associated protein 5

0.392

BRNP2_HUMAN

BMP/retinoic acid-inducible neural-specific protein 2

0.392

VWCE_HUMAN

von Willebrand factor C and EGF domain-containing protein

0.392

TAF1D_HUMAN

TATA box-binding protein-associated factor RNA polymerase I subunit D

0.392

RAI3_HUMAN

Retinoic acid-induced protein 3

0.392

LIF_HUMAN

Leukemia inhibitory factor

0.392

INGR2_HUMAN

Interferon gamma receptor 2

0.392

S10AB_HUMAN

Protein S100-A11

0.392

I22R1_HUMAN

Interleukin-22 receptor subunit alpha-1

0.392

TREM2_HUMAN

Triggering receptor expressed on myeloid cells 2

0.392

IFNG_HUMAN

Interferon gamma

0.395

F174A_HUMAN

Membrane protein FAM174A

0.395

ZN639_HUMAN

Zinc finger protein 639

0.395

ZN777_HUMAN

Zinc finger protein 777

0.395

VEXIN_HUMAN

Vexin

0.395

ICOS_HUMAN

Inducible T-cell costimulator

0.395

TOX2_HUMAN

TOX high mobility group box family member 2

0.396

CD28_HUMAN

T-cell-specific surface glycoprotein CD28

0.396

ZN326_HUMAN

DBIRD complex subunit ZNF326

0.396

CL050_HUMAN

Uncharacterized protein C12orf50

0.397

CX3C1_HUMAN

CX3C chemokine receptor 1

0.397

MB214_HUMAN

Protein mab-21-like 4

0.397

UPK1B_HUMAN

Uroplakin-1b

0.398

SCG1_HUMAN

Secretogranin-1

0.398

CE57L_HUMAN

Centrosomal protein CEP57L1

0.398

IGJ_HUMAN

Immunoglobulin J chain

0.400

IGSF1_HUMAN

Immunoglobulin superfamily member 1

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 14 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy