ACRO_HUMAN 2019

Gene Name ACRO

Description Acrosin

Length 421

9606

Sequence

>sp|P10323|ACRO_HUMAN Acrosin
MVEMLPTAILLVLAVSVVAKDNATCDGPCGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRLVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPYLNWIASKIGSNALRMIQSATPPPPTTRPPPIRPPFSHPISAHLPWYFQPPPRPLPPRPPAAQPRPPPSPPPPPPPPASPLPPPPPPPPPTPSSTTKLPQGLSFAKRLQQLIEVLKGKTYSDGKNHYDMETTELPELTSTS

Domains

Loading...

Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

KCNE3_HUMAN

Potassium voltage-gated channel subfamily E member 3

0.277

XKR2_HUMAN

XK-related protein 2

0.378

LAPM5_HUMAN

Lysosomal-associated transmembrane protein 5

0.378

TAF1D_HUMAN

TATA box-binding protein-associated factor RNA polymerase I subunit D

0.378

I13R1_HUMAN

Interleukin-13 receptor subunit alpha-1

0.378

IGSF1_HUMAN

Immunoglobulin superfamily member 1

0.378

REG4_HUMAN

Regenerating islet-derived protein 4

0.378

CKLF6_HUMAN

CKLF-like MARVEL transmembrane domain-containing protein 6

0.378

INGR1_HUMAN

Interferon gamma receptor 1

0.378

IL22_HUMAN

Interleukin-22

0.378

ZN654_HUMAN

Zinc finger protein 654

0.378

LPAR5_HUMAN

Lysophosphatidic acid receptor 5

0.378

IRAK2_HUMAN

Interleukin-1 receptor-associated kinase-like 2

0.378

DRB3_HUMAN

HLA class II histocompatibility antigen, DR beta 3 chain

0.392

2B1F_HUMAN

HLA class II histocompatibility antigen, DRB1-15 beta chain

0.392

IFNL1_HUMAN

Interferon lambda-1

0.392

DQB2_HUMAN

HLA class II histocompatibility antigen, DQ beta 2 chain

0.392

CD8B_HUMAN

T-cell surface glycoprotein CD8 beta chain

0.392

CC160_HUMAN

Coiled-coil domain-containing protein 160

0.392

CD8B2_HUMAN

Putative T-cell surface glycoprotein CD8 beta-2 chain

0.392

IFNL3_HUMAN

Interferon lambda-3

0.392

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

THY1_HUMAN

Thy-1 membrane glycoprotein

0.306

IL22_HUMAN

Interleukin-22

0.308

TRI14_HUMAN

Tripartite motif-containing protein 14

0.308

LSME1_HUMAN

Leucine-rich single-pass membrane protein 1

0.312

INGR1_HUMAN

Interferon gamma receptor 1

0.324

PIANP_HUMAN

PILR alpha-associated neural protein

0.327

BPIB4_HUMAN

BPI fold-containing family B member 4

0.327

LAPM5_HUMAN

Lysosomal-associated transmembrane protein 5

0.327

I13R1_HUMAN

Interleukin-13 receptor subunit alpha-1

0.327

CKLF6_HUMAN

CKLF-like MARVEL transmembrane domain-containing protein 6

0.329

MYOZ3_HUMAN

Myozenin-3

0.329

TAF1D_HUMAN

TATA box-binding protein-associated factor RNA polymerase I subunit D

0.346

LIF_HUMAN

Leukemia inhibitory factor

0.346

TREM2_HUMAN

Triggering receptor expressed on myeloid cells 2

0.346

INLR1_HUMAN

Interferon lambda receptor 1

0.349

APOA1_HUMAN

Apolipoprotein A-I

0.349

MISSL_HUMAN

MAPK-interacting and spindle-stabilizing protein-like

0.354

INAR1_HUMAN

Interferon alpha/beta receptor 1

0.358

SUGP2_HUMAN

SURP and G-patch domain-containing protein 2

0.358

MFAP3_HUMAN

Microfibril-associated glycoprotein 3

0.358

CD34_HUMAN

Hematopoietic progenitor cell antigen CD34

0.360

CLD16_HUMAN

Claudin-16

0.360

BCAS1_HUMAN

Breast carcinoma-amplified sequence 1

0.363

CF132_HUMAN

Uncharacterized protein C6orf132

0.363

GKN1_HUMAN

Gastrokine-1

0.365

TM52B_HUMAN

Transmembrane protein 52B

0.365

ODFP1_HUMAN

Outer dense fiber protein 1

0.365

I10R1_HUMAN

Interleukin-10 receptor subunit alpha

0.365

EGLN_HUMAN

Endoglin

0.365

CD72_HUMAN

B-cell differentiation antigen CD72

0.365

GIP_HUMAN

Gastric inhibitory polypeptide

0.368

MSLN_HUMAN

Mesothelin

0.368

PDCD1_HUMAN

Programmed cell death protein 1

0.368

OPT_HUMAN

Opticin

0.368

TM139_HUMAN

Transmembrane protein 139

0.368

SHLD1_HUMAN

Shieldin complex subunit 1

0.373

NXPH3_HUMAN

Neurexophilin-3

0.373

IL5RA_HUMAN

Interleukin-5 receptor subunit alpha

0.373

VTDB_HUMAN

Vitamin D-binding protein

0.373

BPIB2_HUMAN

BPI fold-containing family B member 2

0.375

SH22A_HUMAN

SH2 domain-containing protein 2A

0.376

CK074_HUMAN

Protein C11orf74

0.376

FSHB_HUMAN

Follitropin subunit beta

0.378

SHPS1_HUMAN

Tyrosine-protein phosphatase non-receptor type substrate 1

0.378

GSG1_HUMAN

Germ cell-specific gene 1 protein

0.378

MFAP5_HUMAN

Microfibrillar-associated protein 5

0.380

S10AB_HUMAN

Protein S100-A11

0.380

CD8B2_HUMAN

Putative T-cell surface glycoprotein CD8 beta-2 chain

0.380

MMRN1_HUMAN

Multimerin-1

0.380

ACRBP_HUMAN

Acrosin-binding protein

0.380

RESF1_HUMAN

Retroelement silencing factor 1

0.380

SPERT_HUMAN

Spermatid-associated protein

0.383

IFNG_HUMAN

Interferon gamma

0.383

ZN639_HUMAN

Zinc finger protein 639

0.383

ZN777_HUMAN

Zinc finger protein 777

0.383

PML_HUMAN

Protein PML

0.383

RARR2_HUMAN

Retinoic acid receptor responder protein 2

0.386

GKN2_HUMAN

Gastrokine-2

0.386

MB214_HUMAN

Protein mab-21-like 4

0.386

IL9R_HUMAN

Interleukin-9 receptor

0.386

CCGL_HUMAN

Voltage-dependent calcium channel gamma-like subunit

0.387

UPK1B_HUMAN

Uroplakin-1b

0.387

CE57L_HUMAN

Centrosomal protein CEP57L1

0.387

TNF15_HUMAN

Tumor necrosis factor ligand superfamily member 15

0.387

IGSF1_HUMAN

Immunoglobulin superfamily member 1

0.388

DMB_HUMAN

HLA class II histocompatibility antigen, DM beta chain

0.388

IGJ_HUMAN

Immunoglobulin J chain

0.388

IL18_HUMAN

Interleukin-18

0.390

F166A_HUMAN

Protein FAM166A

0.390

CD40L_HUMAN

CD40 ligand

0.390

SUSD4_HUMAN

Sushi domain-containing protein 4

0.390

COL_HUMAN

Colipase

0.392

HXD13_HUMAN

Homeobox protein Hox-D13

0.392

ZN654_HUMAN

Zinc finger protein 654

0.392

CD8B_HUMAN

T-cell surface glycoprotein CD8 beta chain

0.395

CD47_HUMAN

Leukocyte surface antigen CD47

0.395

PPR17_HUMAN

Protein phosphatase 1 regulatory subunit 17

0.395

TM171_HUMAN

Transmembrane protein 171

0.397

SNTAN_HUMAN

Sentan

0.397

TNFL8_HUMAN

Tumor necrosis factor ligand superfamily member 8

0.397

LRAD1_HUMAN

Low-density lipoprotein receptor class A domain-containing protein 1

0.397

INAR2_HUMAN

Interferon alpha/beta receptor 2

0.397

IL23R_HUMAN

Interleukin-23 receptor

0.397

FYB2_HUMAN

FYN-binding protein 2

0.400

GP162_HUMAN

Probable G-protein coupled receptor 162

0.400

EPCR_HUMAN

Endothelial protein C receptor

0.400

IL15_HUMAN

Interleukin-15

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 13 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy