GPS2_HUMAN 2019

Gene Name GPS2

Description G protein pathway suppressor 2

Length 327

9606

Sequence

>sp|Q13227|GPS2_HUMAN G protein pathway suppressor 2
MPALLERPKLSNAMARALHRHIMMERERKRQEEEEVDKMMEQKMKEEQERRKKKEMEERMSLEETKEQILKLEEKLLALQEEKHQLFLQLKKVLHEEEKRRRKEQSDLTTLTSAAYQQSLTVHTGTHLLSMQGSPGGHNRPGTLMAADRAKQMFGPQVLTTRHYVGSAAAFAGTPEHGQFQGSPGGAYGTAQPPPHYGPTQPAYSPSQQLRAPSAFPAVQYLSQPQPQPYAVHGHFQPTQTGFLQPGGALSLQKQMEHANQQTGFSDSSSLRPMHPQALHPAPGLLASPQLPVQMQPAGKSGFAATSQPGPRLPFIQHSQNPRFYHK

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

SYT14_HUMAN

Synaptotagmin-14

0.316

SPIR2_HUMAN

Protein spire homolog 2

0.320

TET3_HUMAN

Methylcytosine dioxygenase TET3

0.320

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.320

TMED6_HUMAN

Transmembrane emp24 domain-containing protein 6

0.324

MED29_HUMAN

Mediator of RNA polymerase II transcription subunit 29

0.324

NINJ1_HUMAN

Ninjurin-1

0.324

USH1C_HUMAN

Harmonin

0.324

TRIB2_HUMAN

Tribbles homolog 2

0.349

NRF1_HUMAN

Nuclear respiratory factor 1

0.349

IGLO5_HUMAN

IgLON family member 5

0.354

SMO_HUMAN

Smoothened homolog

0.354

SYT16_HUMAN

Synaptotagmin-16

0.354

HMGX4_HUMAN

HMG domain-containing protein 4

0.354

CTCF_HUMAN

Transcriptional repressor CTCF

0.354

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.354

PA2G3_HUMAN

Group 3 secretory phospholipase A2

0.358

RHBT2_HUMAN

Rho-related BTB domain-containing protein 2

0.358

SSR2_HUMAN

Somatostatin receptor type 2

0.358

CHRD_HUMAN

Chordin

0.358

CHST3_HUMAN

Carbohydrate sulfotransferase 3

0.358

IKKA_HUMAN

Inhibitor of nuclear factor kappa-B kinase subunit alpha

0.358

CHST1_HUMAN

Carbohydrate sulfotransferase 1

0.358

HOIL1_HUMAN

RanBP-type and C3HC4-type zinc finger-containing protein 1

0.358

SPRE2_HUMAN

Sprouty-related, EVH1 domain-containing protein 2

0.358

FA13B_HUMAN

Protein FAM13B

0.363

OTP_HUMAN

Homeobox protein orthopedia

0.363

ZN503_HUMAN

Zinc finger protein 503

0.363

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.363

OAF_HUMAN

Out at first protein homolog

0.363

GBX2_HUMAN

Homeobox protein GBX-2

0.363

BOK_HUMAN

Bcl-2-related ovarian killer protein

0.363

FJX1_HUMAN

Four-jointed box protein 1

0.368

LIX1L_HUMAN

LIX1-like protein

0.373

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.378

HAND2_HUMAN

Heart- and neural crest derivatives-expressed protein 2

0.378

ZN704_HUMAN

Zinc finger protein 704

0.378

LIN37_HUMAN

Protein lin-37 homolog

0.383

GNRHR_HUMAN

Gonadotropin-releasing hormone receptor

0.383

PRD13_HUMAN

PR domain zinc finger protein 13

0.383

NF2L2_HUMAN

Nuclear factor erythroid 2-related factor 2

0.383

MOSMO_HUMAN

Modulator of smoothened protein

0.383

GTSF1_HUMAN

Gametocyte-specific factor 1

0.383

DIK2A_HUMAN

Divergent protein kinase domain 2A

0.383

OTOP1_HUMAN

Proton channel OTOP1

0.383

RNF31_HUMAN

E3 ubiquitin-protein ligase RNF31

0.383

CC85A_HUMAN

Coiled-coil domain-containing protein 85A

0.383

PRD16_HUMAN

Histone-lysine N-methyltransferase PRDM16

0.383

GDF11_HUMAN

Growth/differentiation factor 11

0.383

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.383

SPSY_HUMAN

Spermine synthase

0.383

OPN4_HUMAN

Melanopsin

0.387

TCAIM_HUMAN

T-cell activation inhibitor, mitochondrial

0.387

GOGA1_HUMAN

Golgin subfamily A member 1

0.387

NEUL2_HUMAN

Neuralized-like protein 2

0.387

MTP_HUMAN

Microsomal triglyceride transfer protein large subunit

0.387

TDRKH_HUMAN

Tudor and KH domain-containing protein

0.387

GCM2_HUMAN

Chorion-specific transcription factor GCMb

0.387

NFAT5_HUMAN

Nuclear factor of activated T-cells 5

0.387

NKAI1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

0.387

MYD88_HUMAN

Myeloid differentiation primary response protein MyD88

0.387

RXFP1_HUMAN

Relaxin receptor 1

0.387

T179A_HUMAN

Transmembrane protein 179

0.392

ZN318_HUMAN

Zinc finger protein 318

0.392

ERR3_HUMAN

Estrogen-related receptor gamma

0.392

SHRM2_HUMAN

Protein Shroom2

0.392

NDUF4_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

0.392

AMNLS_HUMAN

Protein amnionless

0.392

NKRF_HUMAN

NF-kappa-B-repressing factor

0.392

STK40_HUMAN

Serine/threonine-protein kinase 40

0.392

VGLL2_HUMAN

Transcription cofactor vestigial-like protein 2

0.392

RPC7L_HUMAN

DNA-directed RNA polymerase III subunit RPC7-like

0.392

SPRE1_HUMAN

Sprouty-related, EVH1 domain-containing protein 1

0.392

BOD1_HUMAN

Biorientation of chromosomes in cell division protein 1

0.392

REL_HUMAN

Proto-oncogene c-Rel

0.392

IKKB_HUMAN

Inhibitor of nuclear factor kappa-B kinase subunit beta

0.392

SPIR1_HUMAN

Protein spire homolog 1

0.392

BRI3_HUMAN

Brain protein I3

0.392

CKLF4_HUMAN

CKLF-like MARVEL transmembrane domain-containing protein 4

0.392

FRMD3_HUMAN

FERM domain-containing protein 3

0.392

TAL1_HUMAN

T-cell acute lymphocytic leukemia protein 1

0.397

SPT2_HUMAN

Protein SPT2 homolog

0.397

NMBR_HUMAN

Neuromedin-B receptor

0.397

VGLL4_HUMAN

Transcription cofactor vestigial-like protein 4

0.397

TF65_HUMAN

Transcription factor p65

0.397

ZN367_HUMAN

Zinc finger protein 367

0.397

CHST6_HUMAN

Carbohydrate sulfotransferase 6

0.397

BCAP_HUMAN

Phosphoinositide 3-kinase adapter protein 1

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

LIN37_HUMAN

Protein lin-37 homolog

0.360

TF65_HUMAN

Transcription factor p65

0.378

CYHR1_HUMAN

Cysteine and histidine-rich protein 1

0.387

MED29_HUMAN

Mediator of RNA polymerase II transcription subunit 29

0.388

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 35 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy