LIN37_HUMAN 2019

Gene Name LIN37

Description Protein lin-37 homolog

Length 246

9606

Sequence

>sp|Q96GY3|LIN37_HUMAN Protein lin-37 homolog
MFPVKVKVEKSELEMAKARNQLDAVLQCLLEKSHMDRERLDEEAGKTPSDTHNKDCSIAATGKRPSARFPHQRRKKRREMDDGLAEGGPQRSNTYVIKLFDRSVDLAQFSENTPLYPICRAWMRNSPSVRERECSPSSPLPPLPEDEEGSEVTNSKSRDVYKLPPPTPPGPPGDACRSRIPSPLQPEMQGTPDDEPSEPEPSPSTLIYRNMQRWKRIRQRWKEASHRNQLRYSESMKILREMYERQ

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

DIK2A_HUMAN

Divergent protein kinase domain 2A

0.309

SKI_HUMAN

Ski oncogene

0.333

CASP7_HUMAN

Caspase-7

0.333

RIMS1_HUMAN

Regulating synaptic membrane exocytosis protein 1

0.333

SKIL_HUMAN

Ski-like protein

0.337

PHC2_HUMAN

Polyhomeotic-like protein 2

0.337

GABPA_HUMAN

GA-binding protein alpha chain

0.337

AXIN1_HUMAN

Axin-1

0.337

41_HUMAN

Protein 4.1

0.337

SNAI2_HUMAN

Zinc finger protein SNAI2

0.337

SYTL5_HUMAN

Synaptotagmin-like protein 5

0.341

CRERF_HUMAN

CREB3 regulatory factor

0.341

BICL1_HUMAN

BICD family-like cargo adapter 1

0.341

MEN1_HUMAN

Menin

0.345

HMGX4_HUMAN

HMG domain-containing protein 4

0.345

MED1_HUMAN

Mediator of RNA polymerase II transcription subunit 1

0.361

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.361

STON1_HUMAN

Stonin-1

0.361

HINFP_HUMAN

Histone H4 transcription factor

0.361

ELF2_HUMAN

ETS-related transcription factor Elf-2

0.365

AT1B2_HUMAN

Sodium/potassium-transporting ATPase subunit beta-2

0.365

AHR_HUMAN

Aryl hydrocarbon receptor

0.365

E41L2_HUMAN

Band 4.1-like protein 2

0.369

AXIN2_HUMAN

Axin-2

0.369

ZN704_HUMAN

Zinc finger protein 704

0.369

SCMH1_HUMAN

Polycomb protein SCMH1

0.369

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.369

OPCM_HUMAN

Opioid-binding protein/cell adhesion molecule

0.369

SYTL4_HUMAN

Synaptotagmin-like protein 4

0.374

CRBL2_HUMAN

cAMP-responsive element-binding protein-like 2

0.374

SYT14_HUMAN

Synaptotagmin-14

0.374

OTOP1_HUMAN

Proton channel OTOP1

0.374

BAG4_HUMAN

BAG family molecular chaperone regulator 4

0.374

NEUL2_HUMAN

Neuralized-like protein 2

0.378

TCF21_HUMAN

Transcription factor 21

0.378

GCM2_HUMAN

Chorion-specific transcription factor GCMb

0.378

TET3_HUMAN

Methylcytosine dioxygenase TET3

0.378

GPS2_HUMAN

G protein pathway suppressor 2

0.383

BOD1_HUMAN

Biorientation of chromosomes in cell division protein 1

0.383

HEY1_HUMAN

Hairy/enhancer-of-split related with YRPW motif protein 1

0.386

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.386

RUND1_HUMAN

RUN domain-containing protein 1

0.386

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.386

MACOI_HUMAN

Macoilin

0.386

AT1B4_HUMAN

Protein ATP1B4

0.386

HOME1_HUMAN

Homer protein homolog 1

0.386

NUMB_HUMAN

Protein numb homolog

0.386

SMAD4_HUMAN

Mothers against decapentaplegic homolog 4

0.386

ACK1_HUMAN

Activated CDC42 kinase 1

0.390

NPC2_HUMAN

NPC intracellular cholesterol transporter 2

0.390

VAS1_HUMAN

V-type proton ATPase subunit S1

0.390

CSTN1_HUMAN

Calsyntenin-1

0.390

STON2_HUMAN

Stonin-2

0.390

TBC30_HUMAN

TBC1 domain family member 30

0.390

TRIO_HUMAN

Triple functional domain protein

0.390

SLIT1_HUMAN

Slit homolog 1 protein

0.394

CSTN3_HUMAN

Calsyntenin-3

0.394

SCML2_HUMAN

Sex comb on midleg-like protein 2

0.394

RIMS3_HUMAN

Regulating synaptic membrane exocytosis protein 3

0.394

CSTN2_HUMAN

Calsyntenin-2

0.394

A0A1B0GVI7_HUMAN

Uncharacterized protein (Fragment)

0.394

GATD1_HUMAN

GATA zinc finger domain-containing protein 1

0.394

SYDE2_HUMAN

Rho GTPase-activating protein SYDE2

0.394

NF2L1_HUMAN

Endoplasmic reticulum membrane sensor NFE2L1

0.399

CNTN4_HUMAN

Contactin-4

0.399

E41L3_HUMAN

Band 4.1-like protein 3

0.399

CNTN2_HUMAN

Contactin-2

0.399

MIC19_HUMAN

MICOS complex subunit MIC19

0.399

F1142_HUMAN

Protein FAM114A2

0.399

NK3R_HUMAN

Neuromedin-K receptor

0.399

NRF1_HUMAN

Nuclear respiratory factor 1

0.399

KI26B_HUMAN

Kinesin-like protein KIF26B

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

DAXX_HUMAN

Death domain-associated protein 6

0.321

HMGX4_HUMAN

HMG domain-containing protein 4

0.356

GPS2_HUMAN

G protein pathway suppressor 2

0.360

GABPA_HUMAN

GA-binding protein alpha chain

0.369

HOME1_HUMAN

Homer protein homolog 1

0.379

CYHR1_HUMAN

Cysteine and histidine-rich protein 1

0.381

AXIN1_HUMAN

Axin-1

0.382

ZN704_HUMAN

Zinc finger protein 704

0.387

TF65_HUMAN

Transcription factor p65

0.387

BICL1_HUMAN

BICD family-like cargo adapter 1

0.390

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.390

SUFU_HUMAN

Suppressor of fused homolog

0.393

SYTL5_HUMAN

Synaptotagmin-like protein 5

0.393

PHC2_HUMAN

Polyhomeotic-like protein 2

0.395

MEN1_HUMAN

Menin

0.396

CNTN1_HUMAN

Contactin-1

0.398

ASXL2_HUMAN

Putative Polycomb group protein ASXL2

0.400

SYTL4_HUMAN

Synaptotagmin-like protein 4

0.400

AXIN2_HUMAN

Axin-2

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 40 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy