MED29_HUMAN 2019

Gene Name MED29

Description Mediator of RNA polymerase II transcription subunit 29

Length 200

9606

Sequence

>sp|Q9NX70|MED29_HUMAN Mediator of RNA polymerase II transcription subunit 29
MAASQQQASAASSAAGVSGPSSAGGPGPQQQPQPPAQLVGPAQSGLLQQQQQDFDPVQRYKMLIPQLKESLQTLMKVAAQNLIQNTNIDNGQKSSDGPIQRFDKCLEEFYALCDQLELCLRLAHECLSQSCDSAKHSPTLVPTATKPDAVQPDSLPYPQYLAVIKAQISCAKDIHTALLDCANKVTGKTPAPPAGPGGTL

Domains

Loading...

Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.229

SMO_HUMAN

Smoothened homolog

0.277

CP110_HUMAN

Centriolar coiled-coil protein of 110 kDa

0.281

BOK_HUMAN

Bcl-2-related ovarian killer protein

0.285

GTSF1_HUMAN

Gametocyte-specific factor 1

0.316

SPIR2_HUMAN

Protein spire homolog 2

0.320

WHRN_HUMAN

Whirlin

0.320

NEUL2_HUMAN

Neuralized-like protein 2

0.320

USH1C_HUMAN

Harmonin

0.324

AMNLS_HUMAN

Protein amnionless

0.324

ZN318_HUMAN

Zinc finger protein 318

0.324

TMED6_HUMAN

Transmembrane emp24 domain-containing protein 6

0.324

NDUF4_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

0.324

GPS2_HUMAN

G protein pathway suppressor 2

0.324

NINJ1_HUMAN

Ninjurin-1

0.324

BRI3_HUMAN

Brain protein I3

0.324

STRAA_HUMAN

STE20-related kinase adapter protein alpha

0.349

NRF1_HUMAN

Nuclear respiratory factor 1

0.349

HMGX4_HUMAN

HMG domain-containing protein 4

0.354

NCAM2_HUMAN

Neural cell adhesion molecule 2

0.354

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.354

CTCF_HUMAN

Transcriptional repressor CTCF

0.354

PA2G3_HUMAN

Group 3 secretory phospholipase A2

0.358

CHRD_HUMAN

Chordin

0.358

TWSG1_HUMAN

Twisted gastrulation protein homolog 1

0.358

FER3L_HUMAN

Fer3-like protein

0.358

SSR2_HUMAN

Somatostatin receptor type 2

0.358

CHST3_HUMAN

Carbohydrate sulfotransferase 3

0.358

FA13B_HUMAN

Protein FAM13B

0.363

STRAB_HUMAN

STE20-related kinase adapter protein beta

0.363

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.363

OAF_HUMAN

Out at first protein homolog

0.363

GBX2_HUMAN

Homeobox protein GBX-2

0.363

MSL2_HUMAN

E3 ubiquitin-protein ligase MSL2

0.363

OSER1_HUMAN

Oxidative stress-responsive serine-rich protein 1

0.363

WFS1_HUMAN

Wolframin

0.363

ZN503_HUMAN

Zinc finger protein 503

0.363

UBL7_HUMAN

Ubiquitin-like protein 7

0.363

ST14_HUMAN

Suppressor of tumorigenicity 14 protein

0.368

UBAP2_HUMAN

Ubiquitin-associated protein 2

0.378

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.378

HAND2_HUMAN

Heart- and neural crest derivatives-expressed protein 2

0.378

ZN704_HUMAN

Zinc finger protein 704

0.378

PRD16_HUMAN

Histone-lysine N-methyltransferase PRDM16

0.383

GNRHR_HUMAN

Gonadotropin-releasing hormone receptor

0.383

UBP2L_HUMAN

Ubiquitin-associated protein 2-like

0.383

DIK2A_HUMAN

Divergent protein kinase domain 2A

0.383

BAG4_HUMAN

BAG family molecular chaperone regulator 4

0.383

GDF11_HUMAN

Growth/differentiation factor 11

0.383

CC85A_HUMAN

Coiled-coil domain-containing protein 85A

0.383

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.383

OTOP1_HUMAN

Proton channel OTOP1

0.383

NF2L2_HUMAN

Nuclear factor erythroid 2-related factor 2

0.383

MOSMO_HUMAN

Modulator of smoothened protein

0.383

SYT14_HUMAN

Synaptotagmin-14

0.383

AGRA3_HUMAN

Adhesion G protein-coupled receptor A3

0.387

MYD88_HUMAN

Myeloid differentiation primary response protein MyD88

0.387

TET3_HUMAN

Methylcytosine dioxygenase TET3

0.387

OPN4_HUMAN

Melanopsin

0.387

NCAM1_HUMAN

Neural cell adhesion molecule 1

0.387

T22D2_HUMAN

TSC22 domain family protein 2

0.387

ARG28_HUMAN

Rho guanine nucleotide exchange factor 28

0.387

TDRKH_HUMAN

Tudor and KH domain-containing protein

0.387

BICRL_HUMAN

BRD4-interacting chromatin-remodeling complex-associated protein-like

0.387

MTP_HUMAN

Microsomal triglyceride transfer protein large subunit

0.387

GCM2_HUMAN

Chorion-specific transcription factor GCMb

0.387

RXFP1_HUMAN

Relaxin receptor 1

0.387

MTMRA_HUMAN

Myotubularin-related protein 10

0.387

ELL2_HUMAN

RNA polymerase II elongation factor ELL2

0.387

SATB1_HUMAN

DNA-binding protein SATB1

0.387

VGLL2_HUMAN

Transcription cofactor vestigial-like protein 2

0.392

CDR2L_HUMAN

Cerebellar degeneration-related protein 2-like

0.392

SMIM8_HUMAN

Small integral membrane protein 8

0.392

AGRA2_HUMAN

Adhesion G protein-coupled receptor A2

0.392

REL_HUMAN

Proto-oncogene c-Rel

0.392

INHBA_HUMAN

Inhibin beta A chain

0.392

SHRM2_HUMAN

Protein Shroom2

0.392

SPIR1_HUMAN

Protein spire homolog 1

0.392

NKRF_HUMAN

NF-kappa-B-repressing factor

0.392

FRMD3_HUMAN

FERM domain-containing protein 3

0.392

T179A_HUMAN

Transmembrane protein 179

0.392

CHST6_HUMAN

Carbohydrate sulfotransferase 6

0.397

TAL1_HUMAN

T-cell acute lymphocytic leukemia protein 1

0.397

BCAP_HUMAN

Phosphoinositide 3-kinase adapter protein 1

0.397

PRDM8_HUMAN

PR domain zinc finger protein 8

0.397

VGLL4_HUMAN

Transcription cofactor vestigial-like protein 4

0.397

SPT2_HUMAN

Protein SPT2 homolog

0.397

RASD1_HUMAN

Dexamethasone-induced Ras-related protein 1

0.397

E41LA_HUMAN

Band 4.1-like protein 4A

0.397

NMBR_HUMAN

Neuromedin-B receptor

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

TF65_HUMAN

Transcription factor p65

0.332

NINJ1_HUMAN

Ninjurin-1

0.347

NDUBB_HUMAN

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

0.364

INTU_HUMAN

Protein inturned

0.369

ZN318_HUMAN

Zinc finger protein 318

0.371

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.371

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.377

DCA10_HUMAN

DDB1- and CUL4-associated factor 10

0.381

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.383

SMO_HUMAN

Smoothened homolog

0.384

WHRN_HUMAN

Whirlin

0.385

GPS2_HUMAN

G protein pathway suppressor 2

0.388

CTCF_HUMAN

Transcriptional repressor CTCF

0.390

NRF1_HUMAN

Nuclear respiratory factor 1

0.393

REL_HUMAN

Proto-oncogene c-Rel

0.394

HMGX4_HUMAN

HMG domain-containing protein 4

0.396

DSCL1_HUMAN

Down syndrome cell adhesion molecule-like protein 1

0.396

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.396

ZN503_HUMAN

Zinc finger protein 503

0.397

TSP4_HUMAN

Thrombospondin-4

0.397

MYD88_HUMAN

Myeloid differentiation primary response protein MyD88

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 36 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy