ZPBP2_HUMAN 2019

Gene Name ZPBP2

Description Zona pellucida-binding protein 2

Length 338

9606

Sequence

>sp|Q6X784|ZPBP2_HUMAN Zona pellucida-binding protein 2
MMRTCVLLSAVLWCLTGVQCPRFTLFNKKGFIYGKTGQPDKIYVELHQNSPVLICMDFKLSKKEIVDPTYLWIGPNEKTLTGNNRINITETGQLMVKDFLEPLSGLYTCTLSYKTVKAETQEEKTVKKRYDFMVFAYREPDYSYQMAVRFTTRSCIGRYNDVFFRVLKKILDSLISDLSCHVIEPSYKCHSVEIPEHGLIHELFIAFQVNPFAPGWKGACNGSVDCEDTTNHNILQARDRIEDFFRSQAYIFYHNFNKTLPAMHFVDHSLQVVRLDSCRPGFGKNERLHSNCASCCVVCSPATFSPDVNVTCQTCVSVLTYGAKSCPQTSNKNQQYED

Domains

Loading...

Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

SHSA5_HUMAN

Protein shisa-5

0.000

EGLN_HUMAN

Endoglin

0.289

L37A1_HUMAN

Leucine-rich repeat-containing protein 37A

0.289

L37A3_HUMAN

Leucine-rich repeat-containing protein 37A3

0.289

MB214_HUMAN

Protein mab-21-like 4

0.289

L37A2_HUMAN

Leucine-rich repeat-containing protein 37A2

0.289

SACA1_HUMAN

Sperm acrosome membrane-associated protein 1

0.289

SIAL_HUMAN

Bone sialoprotein 2

0.289

A0A0G2JMZ2_HUMAN

Uncharacterized protein

0.289

IQCJ_HUMAN

IQ domain-containing protein J

0.289

VSIG4_HUMAN

V-set and immunoglobulin domain-containing protein 4

0.289

CD019_HUMAN

Uncharacterized protein C4orf19

0.302

IGSF1_HUMAN

Immunoglobulin superfamily member 1

0.392

ZN654_HUMAN

Zinc finger protein 654

0.392

IRAK2_HUMAN

Interleukin-1 receptor-associated kinase-like 2

0.392

IL22_HUMAN

Interleukin-22

0.392

AKND1_HUMAN

Protein AKNAD1

0.392

AKAP8_HUMAN

A-kinase anchor protein 8

0.392

GIMD1_HUMAN

GTPase IMAP family member GIMD1

0.392

INGR1_HUMAN

Interferon gamma receptor 1

0.392

ICOSL_HUMAN

ICOS ligand

0.392

LPAR5_HUMAN

Lysophosphatidic acid receptor 5

0.392

TAF1D_HUMAN

TATA box-binding protein-associated factor RNA polymerase I subunit D

0.392

MFAP5_HUMAN

Microfibrillar-associated protein 5

0.392

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

CD34_HUMAN

Hematopoietic progenitor cell antigen CD34

0.283

INGR1_HUMAN

Interferon gamma receptor 1

0.283

CF132_HUMAN

Uncharacterized protein C6orf132

0.285

THY1_HUMAN

Thy-1 membrane glycoprotein

0.306

ACRBP_HUMAN

Acrosin-binding protein

0.308

ICOS_HUMAN

Inducible T-cell costimulator

0.310

INAR1_HUMAN

Interferon alpha/beta receptor 1

0.322

SUGP2_HUMAN

SURP and G-patch domain-containing protein 2

0.322

MFAP3_HUMAN

Microfibril-associated glycoprotein 3

0.322

CLD16_HUMAN

Claudin-16

0.324

ZN654_HUMAN

Zinc finger protein 654

0.324

BPIB4_HUMAN

BPI fold-containing family B member 4

0.327

PIANP_HUMAN

PILR alpha-associated neural protein

0.327

CD47_HUMAN

Leukocyte surface antigen CD47

0.327

SNTAN_HUMAN

Sentan

0.329

ODFP1_HUMAN

Outer dense fiber protein 1

0.329

EGLN_HUMAN

Endoglin

0.329

TNFL8_HUMAN

Tumor necrosis factor ligand superfamily member 8

0.329

SHSA5_HUMAN

Protein shisa-5

0.331

UTS2_HUMAN

Urotensin-2

0.338

VTDB_HUMAN

Vitamin D-binding protein

0.340

GSG1_HUMAN

Germ cell-specific gene 1 protein

0.344

CDHR3_HUMAN

Cadherin-related family member 3

0.344

S10AB_HUMAN

Protein S100-A11

0.346

RESF1_HUMAN

Retroelement silencing factor 1

0.346

TAF1D_HUMAN

TATA box-binding protein-associated factor RNA polymerase I subunit D

0.346

IL22_HUMAN

Interleukin-22

0.346

LIF_HUMAN

Leukemia inhibitory factor

0.346

TREM2_HUMAN

Triggering receptor expressed on myeloid cells 2

0.346

SIAL_HUMAN

Bone sialoprotein 2

0.349

VEXIN_HUMAN

Vexin

0.349

SPERT_HUMAN

Spermatid-associated protein

0.349

CA094_HUMAN

Uncharacterized protein C1orf94

0.349

ZN777_HUMAN

Zinc finger protein 777

0.349

GKN2_HUMAN

Gastrokine-2

0.351

VSIG4_HUMAN

V-set and immunoglobulin domain-containing protein 4

0.354

TNF15_HUMAN

Tumor necrosis factor ligand superfamily member 15

0.356

CE57L_HUMAN

Centrosomal protein CEP57L1

0.356

CD40L_HUMAN

CD40 ligand

0.358

HXD13_HUMAN

Homeobox protein Hox-D13

0.360

I13R1_HUMAN

Interleukin-13 receptor subunit alpha-1

0.363

TM215_HUMAN

Transmembrane protein 215

0.363

BCAS1_HUMAN

Breast carcinoma-amplified sequence 1

0.363

LAPM5_HUMAN

Lysosomal-associated transmembrane protein 5

0.363

IL23R_HUMAN

Interleukin-23 receptor

0.365

MYOZ3_HUMAN

Myozenin-3

0.365

LNP1_HUMAN

Leukemia NUP98 fusion partner 1

0.365

CAMP_HUMAN

Cathelicidin antimicrobial peptide

0.365

TM52B_HUMAN

Transmembrane protein 52B

0.365

CD72_HUMAN

B-cell differentiation antigen CD72

0.365

TM171_HUMAN

Transmembrane protein 171

0.365

I10R1_HUMAN

Interleukin-10 receptor subunit alpha

0.365

INAR2_HUMAN

Interferon alpha/beta receptor 2

0.365

TSN32_HUMAN

Tetraspanin-32

0.368

OPT_HUMAN

Opticin

0.368

EPCR_HUMAN

Endothelial protein C receptor

0.368

IL15_HUMAN

Interleukin-15

0.368

FYB2_HUMAN

FYN-binding protein 2

0.368

TM139_HUMAN

Transmembrane protein 139

0.368

PDCD1_HUMAN

Programmed cell death protein 1

0.368

CD019_HUMAN

Uncharacterized protein C4orf19

0.370

IL5RA_HUMAN

Interleukin-5 receptor subunit alpha

0.373

SPT16_HUMAN

Spermatogenesis-associated protein 16

0.376

RAMP2_HUMAN

Receptor activity-modifying protein 2

0.376

SHPS1_HUMAN

Tyrosine-protein phosphatase non-receptor type substrate 1

0.378

TRI14_HUMAN

Tripartite motif-containing protein 14

0.380

CD8B2_HUMAN

Putative T-cell surface glycoprotein CD8 beta-2 chain

0.380

MFAP5_HUMAN

Microfibrillar-associated protein 5

0.380

MMRN1_HUMAN

Multimerin-1

0.380

RAI3_HUMAN

Retinoic acid-induced protein 3

0.380

I22R1_HUMAN

Interleukin-22 receptor subunit alpha-1

0.380

AKND1_HUMAN

Protein AKNAD1

0.380

INGR2_HUMAN

Interferon gamma receptor 2

0.380

ZN639_HUMAN

Zinc finger protein 639

0.383

PML_HUMAN

Protein PML

0.383

TB182_HUMAN

182 kDa tankyrase-1-binding protein

0.383

INLR1_HUMAN

Interferon lambda receptor 1

0.383

TOX2_HUMAN

TOX high mobility group box family member 2

0.385

ZN326_HUMAN

DBIRD complex subunit ZNF326

0.385

CD28_HUMAN

T-cell-specific surface glycoprotein CD28

0.385

IL9R_HUMAN

Interleukin-9 receptor

0.386

LSME1_HUMAN

Leucine-rich single-pass membrane protein 1

0.386

CL050_HUMAN

Uncharacterized protein C12orf50

0.386

MB214_HUMAN

Protein mab-21-like 4

0.386

MAS_HUMAN

Proto-oncogene Mas

0.386

CNTF_HUMAN

Ciliary neurotrophic factor

0.386

CX3C1_HUMAN

CX3C chemokine receptor 1

0.386

UPK1B_HUMAN

Uroplakin-1b

0.387

AREG_HUMAN

Amphiregulin

0.387

CCGL_HUMAN

Voltage-dependent calcium channel gamma-like subunit

0.387

TRI29_HUMAN

Tripartite motif-containing protein 29

0.387

C1S_HUMAN

Complement C1s subcomponent

0.387

SCG1_HUMAN

Secretogranin-1

0.387

MUCEN_HUMAN

Endomucin

0.388

IGJ_HUMAN

Immunoglobulin J chain

0.388

SUSD4_HUMAN

Sushi domain-containing protein 4

0.390

IL18_HUMAN

Interleukin-18

0.390

IL4RA_HUMAN

Interleukin-4 receptor subunit alpha

0.390

TACT_HUMAN

T-cell surface protein tactile

0.391

FA83A_HUMAN

Protein FAM83A

0.392

IKZF3_HUMAN

Zinc finger protein Aiolos

0.392

LY86_HUMAN

Lymphocyte antigen 86

0.392

PPR17_HUMAN

Protein phosphatase 1 regulatory subunit 17

0.395

EMP1_HUMAN

Epithelial membrane protein 1

0.395

CD8B_HUMAN

T-cell surface glycoprotein CD8 beta chain

0.395

CCD27_HUMAN

Coiled-coil domain-containing protein 27

0.395

KCD19_HUMAN

BTB/POZ domain-containing protein KCTD19

0.395

AMGO2_HUMAN

Amphoterin-induced protein 2

0.395

TIG1_HUMAN

Retinoic acid receptor responder protein 1

0.397

ICOSL_HUMAN

ICOS ligand

0.397

CKLF6_HUMAN

CKLF-like MARVEL transmembrane domain-containing protein 6

0.397

LRC55_HUMAN

Leucine-rich repeat-containing protein 55

0.397

GKN1_HUMAN

Gastrokine-1

0.397

A1AG1_HUMAN

Alpha-1-acid glycoprotein 1

0.397

ECSCR_HUMAN

Endothelial cell-specific chemotaxis regulator

0.397

MALL_HUMAN

MAL-like protein

0.397

TNF11_HUMAN

Tumor necrosis factor ligand superfamily member 11

0.398

KCD18_HUMAN

BTB/POZ domain-containing protein KCTD18

0.400

PDZD9_HUMAN

PDZ domain-containing protein 9

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 11 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy