SUFU_HUMAN 2019

Gene Name SUFU

Description Suppressor of fused homolog

Length 484

9606

Sequence

>sp|Q9UMX1|SUFU_HUMAN Suppressor of fused homolog
MAELRPSGAPGPTAPPAPGPTAPPAFASLFPPGLHAIYGECRRLYPDQPNPLQVTAIVKYWLGGPDPLDYVSMYRNVGSPSANIPEHWHYISFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSENTFCSGDHVSWHSPLDNSESRIQHMLLTEDPQMQPVQTPFGVVTFLQIVGVCTEELHSAQQWNGQGILELLRTVPIAGGPWLITDMRRGETIFEIDPHLQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDDEDSRSICIGTQPRRLSGKDTEQIRETLRRGLEINSKPVLPPINPQRQNGLAHDRAPSRKDSLESDSSTAIIPHELIRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYKSITGDMAITFVSTGVEGAFATEEHPYAAHGPWLQILLTEEFVEKMLEDLEDLTSPEEFKLPKEYSWPEKKLKVSILPDVVFDSPLH

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

G2E3_HUMAN

G2/M phase-specific E3 ubiquitin-protein ligase

0.333

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

GABPA_HUMAN

GA-binding protein alpha chain

0.277

G2E3_HUMAN

G2/M phase-specific E3 ubiquitin-protein ligase

0.277

HOME1_HUMAN

Homer protein homolog 1

0.293

AEBP2_HUMAN

Zinc finger protein AEBP2

0.305

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.305

HMGX4_HUMAN

HMG domain-containing protein 4

0.316

BICL1_HUMAN

BICD family-like cargo adapter 1

0.323

CASP7_HUMAN

Caspase-7

0.327

ZMYM2_HUMAN

Zinc finger MYM-type protein 2

0.327

PHC2_HUMAN

Polyhomeotic-like protein 2

0.330

AXIN1_HUMAN

Axin-1

0.330

DSCL1_HUMAN

Down syndrome cell adhesion molecule-like protein 1

0.333

SYTL4_HUMAN

Synaptotagmin-like protein 4

0.333

ASXL2_HUMAN

Putative Polycomb group protein ASXL2

0.333

ZMYM4_HUMAN

Zinc finger MYM-type protein 4

0.334

TDRD9_HUMAN

ATP-dependent RNA helicase TDRD9

0.338

ZN609_HUMAN

Zinc finger protein 609

0.340

SYT14_HUMAN

Synaptotagmin-14

0.342

SYTL5_HUMAN

Synaptotagmin-like protein 5

0.342

CASZ1_HUMAN

Zinc finger protein castor homolog 1

0.343

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.344

ENOX1_HUMAN

Ecto-NOX disulfide-thiol exchanger 1

0.346

LHPL2_HUMAN

LHFPL tetraspan subfamily member 2 protein

0.346

NRF1_HUMAN

Nuclear respiratory factor 1

0.347

DCA10_HUMAN

DDB1- and CUL4-associated factor 10

0.349

ZN704_HUMAN

Zinc finger protein 704

0.350

MYD88_HUMAN

Myeloid differentiation primary response protein MyD88

0.353

TMM11_HUMAN

Transmembrane protein 11, mitochondrial

0.353

CUED2_HUMAN

CUE domain-containing protein 2

0.354

RHG19_HUMAN

Rho GTPase-activating protein 19

0.354

MED1_HUMAN

Mediator of RNA polymerase II transcription subunit 1

0.355

ASXL1_HUMAN

Putative Polycomb group protein ASXL1

0.355

FRITZ_HUMAN

WD repeat-containing and planar cell polarity effector protein fritz homolog

0.357

CRERF_HUMAN

CREB3 regulatory factor

0.357

CC28B_HUMAN

Coiled-coil domain-containing protein 28B

0.357

HOME2_HUMAN

Homer protein homolog 2

0.357

GCM2_HUMAN

Chorion-specific transcription factor GCMb

0.358

USH1G_HUMAN

Usher syndrome type-1G protein

0.358

GP155_HUMAN

Integral membrane protein GPR155

0.359

TNR6C_HUMAN

Trinucleotide repeat-containing gene 6C protein

0.361

FSCN2_HUMAN

Fascin-2

0.365

GPM6A_HUMAN

Neuronal membrane glycoprotein M6-a

0.365

CHSTB_HUMAN

Carbohydrate sulfotransferase 11

0.365

GTSF1_HUMAN

Gametocyte-specific factor 1

0.365

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.365

CYTSA_HUMAN

Cytospin-A

0.365

ZN318_HUMAN

Zinc finger protein 318

0.369

ATP5J_HUMAN

ATP synthase-coupling factor 6, mitochondrial

0.371

SPSY_HUMAN

Spermine synthase

0.372

CTCF_HUMAN

Transcriptional repressor CTCF

0.374

LOXL2_HUMAN

Lysyl oxidase homolog 2

0.374

TCF21_HUMAN

Transcription factor 21

0.375

CYHR1_HUMAN

Cysteine and histidine-rich protein 1

0.375

SPIR2_HUMAN

Protein spire homolog 2

0.376

MERL_HUMAN

Merlin

0.376

ARG28_HUMAN

Rho guanine nucleotide exchange factor 28

0.376

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.377

SAPC2_HUMAN

Suppressor APC domain-containing protein 2

0.377

NINJ1_HUMAN

Ninjurin-1

0.377

PHC1_HUMAN

Polyhomeotic-like protein 1

0.377

MSL2_HUMAN

E3 ubiquitin-protein ligase MSL2

0.378

NF2L1_HUMAN

Endoplasmic reticulum membrane sensor NFE2L1

0.378

RASF2_HUMAN

Ras association domain-containing protein 2

0.378

UBP1_HUMAN

Ubiquitin carboxyl-terminal hydrolase 1

0.378

CASP3_HUMAN

Caspase-3

0.379

VIR_HUMAN

Protein virilizer homolog

0.379

AXIN2_HUMAN

Axin-2

0.379

MED28_HUMAN

Mediator of RNA polymerase II transcription subunit 28

0.379

DFFB_HUMAN

DNA fragmentation factor subunit beta

0.379

RWDD4_HUMAN

RWD domain-containing protein 4

0.380

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.380

TSP4_HUMAN

Thrombospondin-4

0.380

PRKRA_HUMAN

Interferon-inducible double-stranded RNA-dependent protein kinase activator A

0.380

CLOCK_HUMAN

Circadian locomoter output cycles protein kaput

0.380

KANL2_HUMAN

KAT8 regulatory NSL complex subunit 2

0.381

INTU_HUMAN

Protein inturned

0.381

TRBP2_HUMAN

RISC-loading complex subunit TARBP2

0.382

TM35A_HUMAN

Transmembrane protein 35A

0.382

DSCAM_HUMAN

Down syndrome cell adhesion molecule

0.382

SPIR1_HUMAN

Protein spire homolog 1

0.382

RHPN2_HUMAN

Rhophilin-2

0.383

USH1C_HUMAN

Harmonin

0.383

DIK2A_HUMAN

Divergent protein kinase domain 2A

0.383

CCD43_HUMAN

Coiled-coil domain-containing protein 43

0.383

CA043_HUMAN

Uncharacterized protein C1orf43

0.384

CC28A_HUMAN

Coiled-coil domain-containing protein 28A

0.385

41_HUMAN

Protein 4.1

0.385

RASF6_HUMAN

Ras association domain-containing protein 6

0.386

CRBL2_HUMAN

cAMP-responsive element-binding protein-like 2

0.388

CNTN2_HUMAN

Contactin-2

0.388

TBK1_HUMAN

Serine/threonine-protein kinase TBK1

0.388

SYT16_HUMAN

Synaptotagmin-16

0.389

MGST1_HUMAN

Microsomal glutathione S-transferase 1

0.389

MEN1_HUMAN

Menin

0.389

SNAI2_HUMAN

Zinc finger protein SNAI2

0.390

CNTN1_HUMAN

Contactin-1

0.391

T179A_HUMAN

Transmembrane protein 179

0.391

REL_HUMAN

Proto-oncogene c-Rel

0.391

ELL2_HUMAN

RNA polymerase II elongation factor ELL2

0.391

CDR2_HUMAN

Cerebellar degeneration-related protein 2

0.391

RFX7_HUMAN

DNA-binding protein RFX7

0.392

LOXL3_HUMAN

Lysyl oxidase homolog 3

0.392

MSL1_HUMAN

Male-specific lethal 1 homolog

0.392

FA13B_HUMAN

Protein FAM13B

0.392

VKGC_HUMAN

Vitamin K-dependent gamma-carboxylase

0.392

TBC30_HUMAN

TBC1 domain family member 30

0.392

TNNT3_HUMAN

Troponin T, fast skeletal muscle

0.392

NMBR_HUMAN

Neuromedin-B receptor

0.392

LIN37_HUMAN

Protein lin-37 homolog

0.393

AREL1_HUMAN

Apoptosis-resistant E3 ubiquitin protein ligase 1

0.394

LIX1L_HUMAN

LIX1-like protein

0.395

SMO_HUMAN

Smoothened homolog

0.395

ANRA2_HUMAN

Ankyrin repeat family A protein 2

0.395

MED15_HUMAN

Mediator of RNA polymerase II transcription subunit 15

0.395

APLF_HUMAN

Aprataxin and PNK-like factor

0.395

CNTN5_HUMAN

Contactin-5

0.395

FBX28_HUMAN

F-box only protein 28

0.396

UBAP2_HUMAN

Ubiquitin-associated protein 2

0.396

PP1RA_HUMAN

Serine/threonine-protein phosphatase 1 regulatory subunit 10

0.396

PRD13_HUMAN

PR domain zinc finger protein 13

0.396

WHRN_HUMAN

Whirlin

0.396

CHRD_HUMAN

Chordin

0.396

TM242_HUMAN

Transmembrane protein 242

0.397

ID2_HUMAN

DNA-binding protein inhibitor ID-2

0.397

BOD1_HUMAN

Biorientation of chromosomes in cell division protein 1

0.397

NFAT5_HUMAN

Nuclear factor of activated T-cells 5

0.398

ETV6_HUMAN

Transcription factor ETV6

0.399

HOME3_HUMAN

Homer protein homolog 3

0.399

FGOP2_HUMAN

FGFR1 oncogene partner 2

0.399

HXA2_HUMAN

Homeobox protein Hox-A2

0.400

A0A1C7CYV8_HUMAN

POU domain protein

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 41 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy