CA043_HUMAN 2019

Gene Name CA043

Description Uncharacterized protein C1orf43

Length 253

9606

Sequence

>sp|Q9BWL3|CA043_HUMAN Uncharacterized protein C1orf43
MASGSNWLSGVNVVLVMAYGSLVFVLLFIFVKRQIMRFAMKSRRGPHVPVGHNAPKDLKEEIDIRLSRVQDIKYEPQLLADDDARLLQLETQGNQSCYNYLYRMKALDAIRTSEIPFHSEGRHPRSLMGKNFRSYLLDLRNTSTPFKGVRKALIDTLLDGYETARYGTGVFGQNEYLRYQEALSELATAVKARIGSSQRHHQSAAKDLTQSPEVSPTTIQVTYLPSSQKSKRAKHFLELKSFKDNYNTLESTL

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

HMGX4_HUMAN

HMG domain-containing protein 4

0.316

NINJ1_HUMAN

Ninjurin-1

0.358

SKIL_HUMAN

Ski-like protein

0.374

SYTL5_HUMAN

Synaptotagmin-like protein 5

0.378

HXA1_HUMAN

Homeobox protein Hox-A1

0.378

SCHI1_HUMAN

Schwannomin-interacting protein 1

0.383

SSR2_HUMAN

Somatostatin receptor type 2

0.387

GPM6B_HUMAN

Neuronal membrane glycoprotein M6-b

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

MED1_HUMAN

Mediator of RNA polymerase II transcription subunit 1

0.338

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.353

AEBP2_HUMAN

Zinc finger protein AEBP2

0.353

FGOP2_HUMAN

FGFR1 oncogene partner 2

0.358

NRF1_HUMAN

Nuclear respiratory factor 1

0.360

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.363

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.364

MYD88_HUMAN

Myeloid differentiation primary response protein MyD88

0.366

ZN318_HUMAN

Zinc finger protein 318

0.367

RHG19_HUMAN

Rho GTPase-activating protein 19

0.367

FRITZ_HUMAN

WD repeat-containing and planar cell polarity effector protein fritz homolog

0.369

MIB1_HUMAN

E3 ubiquitin-protein ligase MIB1

0.371

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.372

RECK_HUMAN

Reversion-inducing cysteine-rich protein with Kazal motifs

0.372

TBK1_HUMAN

Serine/threonine-protein kinase TBK1

0.373

PHC2_HUMAN

Polyhomeotic-like protein 2

0.373

GABPA_HUMAN

GA-binding protein alpha chain

0.375

TWSG1_HUMAN

Twisted gastrulation protein homolog 1

0.375

MED24_HUMAN

Mediator of RNA polymerase II transcription subunit 24

0.375

UBP1_HUMAN

Ubiquitin carboxyl-terminal hydrolase 1

0.376

SPT2_HUMAN

Protein SPT2 homolog

0.376

APBP2_HUMAN

Amyloid protein-binding protein 2

0.376

GPM6A_HUMAN

Neuronal membrane glycoprotein M6-a

0.377

SYTL4_HUMAN

Synaptotagmin-like protein 4

0.377

DCA10_HUMAN

DDB1- and CUL4-associated factor 10

0.377

HMGX4_HUMAN

HMG domain-containing protein 4

0.377

CLOCK_HUMAN

Circadian locomoter output cycles protein kaput

0.378

BAKOR_HUMAN

Beclin 1-associated autophagy-related key regulator

0.379

FBX28_HUMAN

F-box only protein 28

0.380

CHRD_HUMAN

Chordin

0.380

BICL1_HUMAN

BICD family-like cargo adapter 1

0.381

CCD43_HUMAN

Coiled-coil domain-containing protein 43

0.381

SPRE2_HUMAN

Sprouty-related, EVH1 domain-containing protein 2

0.382

TRIB2_HUMAN

Tribbles homolog 2

0.383

41_HUMAN

Protein 4.1

0.383

SYTL5_HUMAN

Synaptotagmin-like protein 5

0.384

SPSY_HUMAN

Spermine synthase

0.384

SYT14_HUMAN

Synaptotagmin-14

0.384

SUFU_HUMAN

Suppressor of fused homolog

0.384

ZCH18_HUMAN

Zinc finger CCCH domain-containing protein 18

0.385

CTCF_HUMAN

Transcriptional repressor CTCF

0.385

TCF21_HUMAN

Transcription factor 21

0.387

AXIN1_HUMAN

Axin-1

0.387

TDRKH_HUMAN

Tudor and KH domain-containing protein

0.388

TNR6C_HUMAN

Trinucleotide repeat-containing gene 6C protein

0.388

OAF_HUMAN

Out at first protein homolog

0.388

NINJ1_HUMAN

Ninjurin-1

0.389

ENOX1_HUMAN

Ecto-NOX disulfide-thiol exchanger 1

0.389

G2E3_HUMAN

G2/M phase-specific E3 ubiquitin-protein ligase

0.389

MSL2_HUMAN

E3 ubiquitin-protein ligase MSL2

0.390

ETS1_HUMAN

Protein C-ets-1

0.390

DSCL1_HUMAN

Down syndrome cell adhesion molecule-like protein 1

0.391

GTSF1_HUMAN

Gametocyte-specific factor 1

0.391

ASXL2_HUMAN

Putative Polycomb group protein ASXL2

0.391

TSP4_HUMAN

Thrombospondin-4

0.392

TMM11_HUMAN

Transmembrane protein 11, mitochondrial

0.392

BCAP_HUMAN

Phosphoinositide 3-kinase adapter protein 1

0.392

SMO_HUMAN

Smoothened homolog

0.393

MED15_HUMAN

Mediator of RNA polymerase II transcription subunit 15

0.393

INTU_HUMAN

Protein inturned

0.393

UBAP2_HUMAN

Ubiquitin-associated protein 2

0.393

SPIR1_HUMAN

Protein spire homolog 1

0.394

PAIRB_HUMAN

Plasminogen activator inhibitor 1 RNA-binding protein

0.394

TET2_HUMAN

Methylcytosine dioxygenase TET2

0.395

SPRE1_HUMAN

Sprouty-related, EVH1 domain-containing protein 1

0.396

SCMH1_HUMAN

Polycomb protein SCMH1

0.396

NDUF4_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

0.396

CC28A_HUMAN

Coiled-coil domain-containing protein 28A

0.396

ETV6_HUMAN

Transcription factor ETV6

0.396

CRERF_HUMAN

CREB3 regulatory factor

0.397

HOME1_HUMAN

Homer protein homolog 1

0.397

GCM2_HUMAN

Chorion-specific transcription factor GCMb

0.398

USH1G_HUMAN

Usher syndrome type-1G protein

0.398

CRBL2_HUMAN

cAMP-responsive element-binding protein-like 2

0.399

F13A_HUMAN

Coagulation factor XIII A chain

0.399

CRHBP_HUMAN

Corticotropin-releasing factor-binding protein

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 37 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy