CRHBP_HUMAN 2019

Gene Name CRHBP

Description Corticotropin-releasing factor-binding protein

Length 322

9606

Sequence

>sp|P24387|CRHBP_HUMAN Corticotropin-releasing factor-binding protein
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

ETV6_HUMAN

Transcription factor ETV6

0.319

NINJ1_HUMAN

Ninjurin-1

0.328

CTCF_HUMAN

Transcriptional repressor CTCF

0.342

CIDEC_HUMAN

Cell death activator CIDE-3

0.349

DSCL1_HUMAN

Down syndrome cell adhesion molecule-like protein 1

0.349

F107B_HUMAN

Protein FAM107B

0.351

CCD43_HUMAN

Coiled-coil domain-containing protein 43

0.354

RHG19_HUMAN

Rho GTPase-activating protein 19

0.354

VGLL2_HUMAN

Transcription cofactor vestigial-like protein 2

0.357

TCF21_HUMAN

Transcription factor 21

0.360

ENOX1_HUMAN

Ecto-NOX disulfide-thiol exchanger 1

0.362

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.362

NRF1_HUMAN

Nuclear respiratory factor 1

0.363

NMBR_HUMAN

Neuromedin-B receptor

0.363

CHSTB_HUMAN

Carbohydrate sulfotransferase 11

0.365

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.365

GPM6A_HUMAN

Neuronal membrane glycoprotein M6-a

0.365

CHRD_HUMAN

Chordin

0.369

USH1C_HUMAN

Harmonin

0.370

FST_HUMAN

Follistatin

0.371

ZCH18_HUMAN

Zinc finger CCCH domain-containing protein 18

0.374

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.376

LYSC_HUMAN

Lysozyme C

0.377

TDRKH_HUMAN

Tudor and KH domain-containing protein

0.377

SPIR2_HUMAN

Protein spire homolog 2

0.377

OAF_HUMAN

Out at first protein homolog

0.377

T179A_HUMAN

Transmembrane protein 179

0.378

CDR2_HUMAN

Cerebellar degeneration-related protein 2

0.378

UBP1_HUMAN

Ubiquitin carboxyl-terminal hydrolase 1

0.379

DDIT4_HUMAN

DNA damage-inducible transcript 4 protein

0.379

DCA10_HUMAN

DDB1- and CUL4-associated factor 10

0.380

DFFB_HUMAN

DNA fragmentation factor subunit beta

0.380

TSP4_HUMAN

Thrombospondin-4

0.381

CLOCK_HUMAN

Circadian locomoter output cycles protein kaput

0.381

BCAP_HUMAN

Phosphoinositide 3-kinase adapter protein 1

0.382

SMO_HUMAN

Smoothened homolog

0.383

INTU_HUMAN

Protein inturned

0.383

OPN4_HUMAN

Melanopsin

0.383

SPIR1_HUMAN

Protein spire homolog 1

0.384

MYD88_HUMAN

Myeloid differentiation primary response protein MyD88

0.384

DSCAM_HUMAN

Down syndrome cell adhesion molecule

0.384

BICL1_HUMAN

BICD family-like cargo adapter 1

0.385

ID2_HUMAN

DNA-binding protein inhibitor ID-2

0.385

PA2G3_HUMAN

Group 3 secretory phospholipase A2

0.385

BD1L1_HUMAN

Biorientation of chromosomes in cell division protein 1-like 1

0.385

CUED2_HUMAN

CUE domain-containing protein 2

0.385

PQLC3_HUMAN

PQ-loop repeat-containing protein 3

0.386

FRITZ_HUMAN

WD repeat-containing and planar cell polarity effector protein fritz homolog

0.387

GCM2_HUMAN

Chorion-specific transcription factor GCMb

0.388

USH1G_HUMAN

Usher syndrome type-1G protein

0.388

CRBL2_HUMAN

cAMP-responsive element-binding protein-like 2

0.389

CASZ1_HUMAN

Zinc finger protein castor homolog 1

0.389

SSR2_HUMAN

Somatostatin receptor type 2

0.390

PO2F1_HUMAN

POU domain, class 2, transcription factor 1

0.390

TDRD7_HUMAN

Tudor domain-containing protein 7

0.391

TWSG1_HUMAN

Twisted gastrulation protein homolog 1

0.392

REL_HUMAN

Proto-oncogene c-Rel

0.393

SPT2_HUMAN

Protein SPT2 homolog

0.394

MSL2_HUMAN

E3 ubiquitin-protein ligase MSL2

0.394

GTSF1_HUMAN

Gametocyte-specific factor 1

0.395

HMGX4_HUMAN

HMG domain-containing protein 4

0.395

RSLAB_HUMAN

Ras-like protein family member 10B

0.395

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.396

TDRD9_HUMAN

ATP-dependent RNA helicase TDRD9

0.397

TM35A_HUMAN

Transmembrane protein 35A

0.398

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.399

POPD1_HUMAN

Blood vessel epicardial substance

0.399

ZN318_HUMAN

Zinc finger protein 318

0.399

CA043_HUMAN

Uncharacterized protein C1orf43

0.400

SPRE2_HUMAN

Sprouty-related, EVH1 domain-containing protein 2

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 30 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy