ZN503_HUMAN 2019

Gene Name ZN503

Description Zinc finger protein 503

Length 646

9606

Sequence

>sp|Q96F45|ZN503_HUMAN Zinc finger protein 503
MSTAPSLSALRSSKHSGGGGGGGGGGGADPAWTSALSGNSSGPGPGSSPAGSTKPFVHAVPPSDPLRQANRLPIKVLKMLTARTGHILHPEYLQPLPSTPVSPIELDAKKSPLALLAQTCSQIGKPDPSPSSKLSSVASNGGGAGGAGGGAAGDKDTKSGPLKLSDIGVEDKSSFKPYSKPGSDKKEPGGGGGGGGGGGGGGGGVSSEKSGFRVPSATCQPFTPRTGSPSSSASACSPGGMLSSAGGAPEGKDDKKDTDVGGGGKGTGGASAEGGPTGLAHGRISCGGGINVDVNQHPDGGPGGKALGSDCGGSSGSSSGSGPSAPTSSSVLGSGLVAPVSPYKPGQTVFPLPPAGMTYPGSLAGAYAGYPPQFLPHGVALDPTKPGSLVGAQLAAAAAGSLGCSKPAGSSPLAGASPPSVMTASLCRDPYCLSYHCASHLAGAAAASASCAHDPAAAAAALKSGYPLVYPTHPLHGVHSSLTAAAAAGATPPSLAGHPLYPYGFMLPNDPLPHICNWVSANGPCDKRFATSEELLSHLRTHTAFPGTDKLLSGYPSSSSLASAAAAAMACHMHIPTSGAPGSPGTLALRSPHHALGLSSRYHPYSKSPLPTPGAPVPVPAATGPYYSPYALYGQRLTTASALGYQ

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

NINJ1_HUMAN

Ninjurin-1

0.285

VGLL2_HUMAN

Transcription cofactor vestigial-like protein 2

0.285

SHRM2_HUMAN

Protein Shroom2

0.285

BCAP_HUMAN

Phosphoinositide 3-kinase adapter protein 1

0.289

SPRC_HUMAN

SPARC

0.320

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.320

CHRD_HUMAN

Chordin

0.324

PA2G3_HUMAN

Group 3 secretory phospholipase A2

0.324

ENOX1_HUMAN

Ecto-NOX disulfide-thiol exchanger 1

0.329

OAF_HUMAN

Out at first protein homolog

0.329

SMAD6_HUMAN

Mothers against decapentaplegic homolog 6

0.333

TAB3_HUMAN

TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

0.333

ZN703_HUMAN

Zinc finger protein 703

0.333

OTOP1_HUMAN

Proton channel OTOP1

0.354

DIK2A_HUMAN

Divergent protein kinase domain 2A

0.354

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.354

MOSMO_HUMAN

Modulator of smoothened protein

0.354

SKP2_HUMAN

S-phase kinase-associated protein 2

0.354

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.358

BTBDH_HUMAN

BTB/POZ domain-containing protein 17

0.358

OTOP2_HUMAN

Proton channel OTOP2

0.358

SPIR2_HUMAN

Protein spire homolog 2

0.358

NEUL2_HUMAN

Neuralized-like protein 2

0.358

MED29_HUMAN

Mediator of RNA polymerase II transcription subunit 29

0.363

USH1C_HUMAN

Harmonin

0.363

GSX1_HUMAN

GS homeobox 1

0.363

SPRE1_HUMAN

Sprouty-related, EVH1 domain-containing protein 1

0.363

ID2_HUMAN

DNA-binding protein inhibitor ID-2

0.363

AMNLS_HUMAN

Protein amnionless

0.363

TMED6_HUMAN

Transmembrane emp24 domain-containing protein 6

0.363

AGRA2_HUMAN

Adhesion G protein-coupled receptor A2

0.363

TNR6C_HUMAN

Trinucleotide repeat-containing gene 6C protein

0.363

NKRF_HUMAN

NF-kappa-B-repressing factor

0.363

T179A_HUMAN

Transmembrane protein 179

0.363

GPS2_HUMAN

G protein pathway suppressor 2

0.363

HXA2_HUMAN

Homeobox protein Hox-A2

0.363

TAB2_HUMAN

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

0.368

SPT2_HUMAN

Protein SPT2 homolog

0.368

VGLL4_HUMAN

Transcription cofactor vestigial-like protein 4

0.368

CTIF_HUMAN

CBP80/20-dependent translation initiation factor

0.368

F107B_HUMAN

Protein FAM107B

0.373

DFFB_HUMAN

DNA fragmentation factor subunit beta

0.373

JIP2_HUMAN

C-Jun-amino-terminal kinase-interacting protein 2

0.383

NRF1_HUMAN

Nuclear respiratory factor 1

0.383

DCA10_HUMAN

DDB1- and CUL4-associated factor 10

0.383

BICL1_HUMAN

BICD family-like cargo adapter 1

0.383

CG026_HUMAN

Uncharacterized protein C7orf26

0.387

SMO_HUMAN

Smoothened homolog

0.387

AMRP_HUMAN

Alpha-2-macroglobulin receptor-associated protein

0.387

HMGX4_HUMAN

HMG domain-containing protein 4

0.387

BEGIN_HUMAN

Brain-enriched guanylate kinase-associated protein

0.387

PTN21_HUMAN

Tyrosine-protein phosphatase non-receptor type 21

0.387

CTCF_HUMAN

Transcriptional repressor CTCF

0.387

FBXW5_HUMAN

F-box/WD repeat-containing protein 5

0.392

HXB2_HUMAN

Homeobox protein Hox-B2

0.392

RASF2_HUMAN

Ras association domain-containing protein 2

0.392

IKKA_HUMAN

Inhibitor of nuclear factor kappa-B kinase subunit alpha

0.392

SGCE_HUMAN

Epsilon-sarcoglycan

0.392

SOCS5_HUMAN

Suppressor of cytokine signaling 5

0.392

HOIL1_HUMAN

RanBP-type and C3HC4-type zinc finger-containing protein 1

0.392

CHST1_HUMAN

Carbohydrate sulfotransferase 1

0.392

SPRE2_HUMAN

Sprouty-related, EVH1 domain-containing protein 2

0.392

CHST3_HUMAN

Carbohydrate sulfotransferase 3

0.392

TWSG1_HUMAN

Twisted gastrulation protein homolog 1

0.392

RECK_HUMAN

Reversion-inducing cysteine-rich protein with Kazal motifs

0.392

SSR2_HUMAN

Somatostatin receptor type 2

0.392

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.397

GBX2_HUMAN

Homeobox protein GBX-2

0.397

UBL7_HUMAN

Ubiquitin-like protein 7

0.397

MSL2_HUMAN

E3 ubiquitin-protein ligase MSL2

0.397

SHRM3_HUMAN

Protein Shroom3

0.397

DRD5_HUMAN

D(1B) dopamine receptor

0.397

NOL11_HUMAN

Nucleolar protein 11

0.397

STAC3_HUMAN

SH3 and cysteine-rich domain-containing protein 3

0.397

MMS22_HUMAN

Protein MMS22-like

0.397

OSER1_HUMAN

Oxidative stress-responsive serine-rich protein 1

0.397

BOK_HUMAN

Bcl-2-related ovarian killer protein

0.397

BAG2_HUMAN

BAG family molecular chaperone regulator 2

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

NINJ1_HUMAN

Ninjurin-1

0.335

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.340

ZN703_HUMAN

Zinc finger protein 703

0.350

DSCL1_HUMAN

Down syndrome cell adhesion molecule-like protein 1

0.356

CHSTB_HUMAN

Carbohydrate sulfotransferase 11

0.356

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.361

ETV6_HUMAN

Transcription factor ETV6

0.361

CTCF_HUMAN

Transcriptional repressor CTCF

0.365

OAF_HUMAN

Out at first protein homolog

0.367

NRF1_HUMAN

Nuclear respiratory factor 1

0.369

GPM6A_HUMAN

Neuronal membrane glycoprotein M6-a

0.371

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.371

DCA10_HUMAN

DDB1- and CUL4-associated factor 10

0.371

TSP4_HUMAN

Thrombospondin-4

0.372

INTU_HUMAN

Protein inturned

0.373

SPIR1_HUMAN

Protein spire homolog 1

0.374

CHRD_HUMAN

Chordin

0.374

USH1C_HUMAN

Harmonin

0.376

PA2G3_HUMAN

Group 3 secretory phospholipase A2

0.376

CCD43_HUMAN

Coiled-coil domain-containing protein 43

0.376

USH1G_HUMAN

Usher syndrome type-1G protein

0.379

PHC2_HUMAN

Polyhomeotic-like protein 2

0.381

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.381

TNR6C_HUMAN

Trinucleotide repeat-containing gene 6C protein

0.383

TWSG1_HUMAN

Twisted gastrulation protein homolog 1

0.383

SAPC2_HUMAN

Suppressor APC domain-containing protein 2

0.384

T179A_HUMAN

Transmembrane protein 179

0.384

ENOX1_HUMAN

Ecto-NOX disulfide-thiol exchanger 1

0.384

SPT2_HUMAN

Protein SPT2 homolog

0.385

AREL1_HUMAN

Apoptosis-resistant E3 ubiquitin protein ligase 1

0.387

RHBT2_HUMAN

Rho-related BTB domain-containing protein 2

0.387

SMO_HUMAN

Smoothened homolog

0.388

TDRD9_HUMAN

ATP-dependent RNA helicase TDRD9

0.389

MYD88_HUMAN

Myeloid differentiation primary response protein MyD88

0.389

BICL1_HUMAN

BICD family-like cargo adapter 1

0.390

ZN318_HUMAN

Zinc finger protein 318

0.390

CUED2_HUMAN

CUE domain-containing protein 2

0.390

ID2_HUMAN

DNA-binding protein inhibitor ID-2

0.390

FRITZ_HUMAN

WD repeat-containing and planar cell polarity effector protein fritz homolog

0.392

HXA2_HUMAN

Homeobox protein Hox-A2

0.393

SYT14_HUMAN

Synaptotagmin-14

0.393

VGLL2_HUMAN

Transcription cofactor vestigial-like protein 2

0.394

KIBRA_HUMAN

Protein KIBRA

0.395

CASZ1_HUMAN

Zinc finger protein castor homolog 1

0.395

PTN21_HUMAN

Tyrosine-protein phosphatase non-receptor type 21

0.396

YAP1_HUMAN

Transcriptional coactivator YAP1

0.396

AXIN1_HUMAN

Axin-1

0.396

MED29_HUMAN

Mediator of RNA polymerase II transcription subunit 29

0.397

SPIR2_HUMAN

Protein spire homolog 2

0.397

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.398

REL_HUMAN

Proto-oncogene c-Rel

0.398

NMBR_HUMAN

Neuromedin-B receptor

0.399

MSL2_HUMAN

E3 ubiquitin-protein ligase MSL2

0.399

UBP1_HUMAN

Ubiquitin carboxyl-terminal hydrolase 1

0.399

HMGX4_HUMAN

HMG domain-containing protein 4

0.400

GTSF1_HUMAN

Gametocyte-specific factor 1

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 35 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy