ERR3_HUMAN 2019

Gene Name ERR3

Description Estrogen-related receptor gamma

Length 458

9606

Sequence

>sp|P62508|ERR3_HUMAN Estrogen-related receptor gamma
MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

ERR2_HUMAN

Steroid hormone receptor ERR2

0.289

SPSY_HUMAN

Spermine synthase

0.316

SPIR2_HUMAN

Protein spire homolog 2

0.320

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.354

CTCF_HUMAN

Transcriptional repressor CTCF

0.354

PAIP1_HUMAN

Polyadenylate-binding protein-interacting protein 1

0.354

IKKA_HUMAN

Inhibitor of nuclear factor kappa-B kinase subunit alpha

0.358

CHST1_HUMAN

Carbohydrate sulfotransferase 1

0.358

SSR2_HUMAN

Somatostatin receptor type 2

0.358

RREB1_HUMAN

Ras-responsive element-binding protein 1

0.368

ZN704_HUMAN

Zinc finger protein 704

0.378

MED16_HUMAN

Mediator of RNA polymerase II transcription subunit 16

0.383

SYT14_HUMAN

Synaptotagmin-14

0.383

GOGA1_HUMAN

Golgin subfamily A member 1

0.387

GPS2_HUMAN

G protein pathway suppressor 2

0.392

IKKB_HUMAN

Inhibitor of nuclear factor kappa-B kinase subunit beta

0.392

TMED6_HUMAN

Transmembrane emp24 domain-containing protein 6

0.392

SPIR1_HUMAN

Protein spire homolog 1

0.392

MIDN_HUMAN

Midnolin

0.392

CHST6_HUMAN

Carbohydrate sulfotransferase 6

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

ERR2_HUMAN

Steroid hormone receptor ERR2

0.309

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.320

SPSY_HUMAN

Spermine synthase

0.329

TDRKH_HUMAN

Tudor and KH domain-containing protein

0.332

NRF1_HUMAN

Nuclear respiratory factor 1

0.335

TSP4_HUMAN

Thrombospondin-4

0.338

FRITZ_HUMAN

WD repeat-containing and planar cell polarity effector protein fritz homolog

0.345

USH1G_HUMAN

Usher syndrome type-1G protein

0.346

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.355

RHBT2_HUMAN

Rho-related BTB domain-containing protein 2

0.355

INTU_HUMAN

Protein inturned

0.356

SPIR1_HUMAN

Protein spire homolog 1

0.357

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.359

SYT14_HUMAN

Synaptotagmin-14

0.362

CTCF_HUMAN

Transcriptional repressor CTCF

0.363

TCF21_HUMAN

Transcription factor 21

0.364

SPIR2_HUMAN

Protein spire homolog 2

0.365

OAF_HUMAN

Out at first protein homolog

0.365

GABPA_HUMAN

GA-binding protein alpha chain

0.367

SPT2_HUMAN

Protein SPT2 homolog

0.367

GTSF1_HUMAN

Gametocyte-specific factor 1

0.369

AREL1_HUMAN

Apoptosis-resistant E3 ubiquitin protein ligase 1

0.370

SMO_HUMAN

Smoothened homolog

0.371

MYD88_HUMAN

Myeloid differentiation primary response protein MyD88

0.372

ETV6_HUMAN

Transcription factor ETV6

0.374

PHC2_HUMAN

Polyhomeotic-like protein 2

0.379

RECK_HUMAN

Reversion-inducing cysteine-rich protein with Kazal motifs

0.379

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.379

CHST3_HUMAN

Carbohydrate sulfotransferase 3

0.379

UBP31_HUMAN

Ubiquitin carboxyl-terminal hydrolase 31

0.380

TNR6C_HUMAN

Trinucleotide repeat-containing gene 6C protein

0.380

REL_HUMAN

Proto-oncogene c-Rel

0.381

TET3_HUMAN

Methylcytosine dioxygenase TET3

0.381

MSL1_HUMAN

Male-specific lethal 1 homolog

0.383

MED16_HUMAN

Mediator of RNA polymerase II transcription subunit 16

0.383

DCA10_HUMAN

DDB1- and CUL4-associated factor 10

0.383

DSCL1_HUMAN

Down syndrome cell adhesion molecule-like protein 1

0.383

ASXL2_HUMAN

Putative Polycomb group protein ASXL2

0.383

ZN704_HUMAN

Zinc finger protein 704

0.385

MED15_HUMAN

Mediator of RNA polymerase II transcription subunit 15

0.386

TDRD9_HUMAN

ATP-dependent RNA helicase TDRD9

0.387

DSCAM_HUMAN

Down syndrome cell adhesion molecule

0.387

CHRD_HUMAN

Chordin

0.387

BICL1_HUMAN

BICD family-like cargo adapter 1

0.388

AEBP2_HUMAN

Zinc finger protein AEBP2

0.388

CUED2_HUMAN

CUE domain-containing protein 2

0.388

RHG19_HUMAN

Rho GTPase-activating protein 19

0.388

ZN318_HUMAN

Zinc finger protein 318

0.388

TET2_HUMAN

Methylcytosine dioxygenase TET2

0.388

DTBP1_HUMAN

Dysbindin

0.389

MBD5_HUMAN

Methyl-CpG-binding domain protein 5

0.389

GXLT1_HUMAN

Glucoside xylosyltransferase 1

0.390

MIDN_HUMAN

Midnolin

0.392

INT10_HUMAN

Integrator complex subunit 10

0.392

CRBL2_HUMAN

cAMP-responsive element-binding protein-like 2

0.392

SYT16_HUMAN

Synaptotagmin-16

0.393

MGST1_HUMAN

Microsomal glutathione S-transferase 1

0.393

SSR2_HUMAN

Somatostatin receptor type 2

0.393

KS6C1_HUMAN

Ribosomal protein S6 kinase delta-1

0.393

AXIN1_HUMAN

Axin-1

0.394

YAP1_HUMAN

Transcriptional coactivator YAP1

0.394

KAZRN_HUMAN

Kazrin

0.395

TSP3_HUMAN

Thrombospondin-3

0.396

NINJ1_HUMAN

Ninjurin-1

0.396

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.396

ENOX1_HUMAN

Ecto-NOX disulfide-thiol exchanger 1

0.396

IKKA_HUMAN

Inhibitor of nuclear factor kappa-B kinase subunit alpha

0.396

SMIM8_HUMAN

Small integral membrane protein 8

0.397

CP110_HUMAN

Centriolar coiled-coil protein of 110 kDa

0.397

MSL2_HUMAN

E3 ubiquitin-protein ligase MSL2

0.397

NMBR_HUMAN

Neuromedin-B receptor

0.397

VKGC_HUMAN

Vitamin K-dependent gamma-carboxylase

0.397

CHSTB_HUMAN

Carbohydrate sulfotransferase 11

0.397

GPM6A_HUMAN

Neuronal membrane glycoprotein M6-a

0.397

MED28_HUMAN

Mediator of RNA polymerase II transcription subunit 28

0.397

HMGX4_HUMAN

HMG domain-containing protein 4

0.397

ZMYM4_HUMAN

Zinc finger MYM-type protein 4

0.399

TMM11_HUMAN

Transmembrane protein 11, mitochondrial

0.399

APLF_HUMAN

Aprataxin and PNK-like factor

0.400

ANS4B_HUMAN

Ankyrin repeat and SAM domain-containing protein 4B

0.400

NF2L2_HUMAN

Nuclear factor erythroid 2-related factor 2

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 36 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy