MED28_HUMAN 2019

Gene Name MED28

Description Mediator of RNA polymerase II transcription subunit 28

Length 178

9606

Sequence

>sp|Q9H204|MED28_HUMAN Mediator of RNA polymerase II transcription subunit 28
MAAPLGGMFSGQPPGPPQAPPGLPGQASLLQAAPGAPRPSSSTLVDELESSFEACFASLVSQDYVNGTDQEEIRTGVDQCIQKFLDIARQTECFFLQKRLQLSVQKPEQVIKEDVSELRNELQRKDALVQKHLTKLRHWQQVLEDINVQHKKPADIPQGSLAYLEQASANIPAPLKPT

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

ZN704_HUMAN

Zinc finger protein 704

0.361

CDK6_HUMAN

Cyclin-dependent kinase 6

0.369

CASP7_HUMAN

Caspase-7

0.382

GABPA_HUMAN

GA-binding protein alpha chain

0.386

CNTN2_HUMAN

Contactin-2

0.390

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.394

MED19_HUMAN

Mediator of RNA polymerase II transcription subunit 19

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

NRF1_HUMAN

Nuclear respiratory factor 1

0.323

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.330

FRITZ_HUMAN

WD repeat-containing and planar cell polarity effector protein fritz homolog

0.332

SPIR2_HUMAN

Protein spire homolog 2

0.336

PHC2_HUMAN

Polyhomeotic-like protein 2

0.337

GABPA_HUMAN

GA-binding protein alpha chain

0.339

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.342

SPSY_HUMAN

Spermine synthase

0.349

USH1G_HUMAN

Usher syndrome type-1G protein

0.349

CTCF_HUMAN

Transcriptional repressor CTCF

0.350

AXIN1_HUMAN

Axin-1

0.354

DSCL1_HUMAN

Down syndrome cell adhesion molecule-like protein 1

0.357

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.357

TSP4_HUMAN

Thrombospondin-4

0.358

GCM2_HUMAN

Chorion-specific transcription factor GCMb

0.365

HOME1_HUMAN

Homer protein homolog 1

0.365

CRBL2_HUMAN

cAMP-responsive element-binding protein-like 2

0.366

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.367

TDRKH_HUMAN

Tudor and KH domain-containing protein

0.368

GPM6A_HUMAN

Neuronal membrane glycoprotein M6-a

0.371

HMGX4_HUMAN

HMG domain-containing protein 4

0.371

RHBT2_HUMAN

Rho-related BTB domain-containing protein 2

0.372

RWDD4_HUMAN

RWD domain-containing protein 4

0.373

MED15_HUMAN

Mediator of RNA polymerase II transcription subunit 15

0.374

CHRD_HUMAN

Chordin

0.375

SPIR1_HUMAN

Protein spire homolog 1

0.375

DSCAM_HUMAN

Down syndrome cell adhesion molecule

0.375

MYD88_HUMAN

Myeloid differentiation primary response protein MyD88

0.375

MED1_HUMAN

Mediator of RNA polymerase II transcription subunit 1

0.375

BD1L1_HUMAN

Biorientation of chromosomes in cell division protein 1-like 1

0.376

BOD1_HUMAN

Biorientation of chromosomes in cell division protein 1

0.376

RXFP1_HUMAN

Relaxin receptor 1

0.376

AEBP2_HUMAN

Zinc finger protein AEBP2

0.376

ETV6_HUMAN

Transcription factor ETV6

0.377

CRERF_HUMAN

CREB3 regulatory factor

0.378

CASP7_HUMAN

Caspase-7

0.378

SUFU_HUMAN

Suppressor of fused homolog

0.379

SYT14_HUMAN

Synaptotagmin-14

0.379

CNTN2_HUMAN

Contactin-2

0.380

TCF21_HUMAN

Transcription factor 21

0.381

RECK_HUMAN

Reversion-inducing cysteine-rich protein with Kazal motifs

0.381

YAP1_HUMAN

Transcriptional coactivator YAP1

0.382

OAF_HUMAN

Out at first protein homolog

0.382

PHC1_HUMAN

Polyhomeotic-like protein 1

0.383

ETV1_HUMAN

ETS translocation variant 1

0.383

G2E3_HUMAN

G2/M phase-specific E3 ubiquitin-protein ligase

0.384

SPT2_HUMAN

Protein SPT2 homolog

0.385

UBP1_HUMAN

Ubiquitin carboxyl-terminal hydrolase 1

0.385

AIMP2_HUMAN

Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

0.385

ASXL2_HUMAN

Putative Polycomb group protein ASXL2

0.385

CHSTB_HUMAN

Carbohydrate sulfotransferase 11

0.385

DCA10_HUMAN

DDB1- and CUL4-associated factor 10

0.385

MTP_HUMAN

Microsomal triglyceride transfer protein large subunit

0.385

CYTSA_HUMAN

Cytospin-A

0.385

AXIN2_HUMAN

Axin-2

0.385

SYTL4_HUMAN

Synaptotagmin-like protein 4

0.385

ZN704_HUMAN

Zinc finger protein 704

0.387

ZMYM4_HUMAN

Zinc finger MYM-type protein 4

0.387

TMM11_HUMAN

Transmembrane protein 11, mitochondrial

0.387

INTU_HUMAN

Protein inturned

0.388

SMO_HUMAN

Smoothened homolog

0.388

TDRD9_HUMAN

ATP-dependent RNA helicase TDRD9

0.388

BICL1_HUMAN

BICD family-like cargo adapter 1

0.389

RHG19_HUMAN

Rho GTPase-activating protein 19

0.390

ZN318_HUMAN

Zinc finger protein 318

0.390

NDUF4_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

0.391

HOME2_HUMAN

Homer protein homolog 2

0.391

ATP5J_HUMAN

ATP synthase-coupling factor 6, mitochondrial

0.392

GXLT1_HUMAN

Glucoside xylosyltransferase 1

0.392

HXA2_HUMAN

Homeobox protein Hox-A2

0.392

SYTL5_HUMAN

Synaptotagmin-like protein 5

0.393

SHRM2_HUMAN

Protein Shroom2

0.393

KIBRA_HUMAN

Protein KIBRA

0.394

MGST1_HUMAN

Microsomal glutathione S-transferase 1

0.395

ZMYM2_HUMAN

Zinc finger MYM-type protein 2

0.395

ARG28_HUMAN

Rho guanine nucleotide exchange factor 28

0.396

UBP31_HUMAN

Ubiquitin carboxyl-terminal hydrolase 31

0.396

MERL_HUMAN

Merlin

0.396

SNAI2_HUMAN

Zinc finger protein SNAI2

0.396

TNR6C_HUMAN

Trinucleotide repeat-containing gene 6C protein

0.396

ERR3_HUMAN

Estrogen-related receptor gamma

0.397

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.397

CDR2_HUMAN

Cerebellar degeneration-related protein 2

0.397

ZCHC2_HUMAN

Zinc finger CCHC domain-containing protein 2

0.397

LHPL2_HUMAN

LHFPL tetraspan subfamily member 2 protein

0.397

NINJ1_HUMAN

Ninjurin-1

0.397

IKKA_HUMAN

Inhibitor of nuclear factor kappa-B kinase subunit alpha

0.397

NCAM2_HUMAN

Neural cell adhesion molecule 2

0.398

CASP3_HUMAN

Caspase-3

0.398

NMBR_HUMAN

Neuromedin-B receptor

0.399

DALD3_HUMAN

DALR anticodon-binding domain-containing protein 3

0.399

MED16_HUMAN

Mediator of RNA polymerase II transcription subunit 16

0.399

NCAM1_HUMAN

Neural cell adhesion molecule 1

0.399

GTSF1_HUMAN

Gametocyte-specific factor 1

0.399

HEY1_HUMAN

Hairy/enhancer-of-split related with YRPW motif protein 1

0.399

RSLAB_HUMAN

Ras-like protein family member 10B

0.400

AREL1_HUMAN

Apoptosis-resistant E3 ubiquitin protein ligase 1

0.400

CNTN3_HUMAN

Contactin-3

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 42 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy