MGST1_HUMAN 2019

Gene Name MGST1

Description Microsomal glutathione S-transferase 1

Length 155

9606

Sequence

>sp|P10620|MGST1_HUMAN Microsomal glutathione S-transferase 1
MVDLTQVMDDEVFMAFASYATIILSKMMLMSTATAFYRLTRKVFANPEDCVAFGKGENAKKYLRTDDRVERVRRAHLNDLENIIPFLGIGLLYSLSGPDPSTAILHFRLFVGARIYHTIAYLTPLPQPNRALSFFVGYGVTLSMAYRLLKSKLYL

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

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What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

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What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.336

UBP1_HUMAN

Ubiquitin carboxyl-terminal hydrolase 1

0.349

NRF1_HUMAN

Nuclear respiratory factor 1

0.349

GABPA_HUMAN

GA-binding protein alpha chain

0.349

GPM6A_HUMAN

Neuronal membrane glycoprotein M6-a

0.351

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.351

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.357

ETV6_HUMAN

Transcription factor ETV6

0.357

RASF6_HUMAN

Ras association domain-containing protein 6

0.358

USH1G_HUMAN

Usher syndrome type-1G protein

0.360

RASF2_HUMAN

Ras association domain-containing protein 2

0.365

DCA10_HUMAN

DDB1- and CUL4-associated factor 10

0.367

RHBT2_HUMAN

Rho-related BTB domain-containing protein 2

0.368

CUED2_HUMAN

CUE domain-containing protein 2

0.371

RHG19_HUMAN

Rho GTPase-activating protein 19

0.371

FRITZ_HUMAN

WD repeat-containing and planar cell polarity effector protein fritz homolog

0.374

SPSY_HUMAN

Spermine synthase

0.375

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.377

AXIN1_HUMAN

Axin-1

0.378

ENOX1_HUMAN

Ecto-NOX disulfide-thiol exchanger 1

0.379

K0825_HUMAN

Uncharacterized protein KIAA0825

0.380

AXIN2_HUMAN

Axin-2

0.381

DSCL1_HUMAN

Down syndrome cell adhesion molecule-like protein 1

0.381

AREL1_HUMAN

Apoptosis-resistant E3 ubiquitin protein ligase 1

0.382

TSP4_HUMAN

Thrombospondin-4

0.382

BCAP_HUMAN

Phosphoinositide 3-kinase adapter protein 1

0.383

TDRD9_HUMAN

ATP-dependent RNA helicase TDRD9

0.384

MYD88_HUMAN

Myeloid differentiation primary response protein MyD88

0.385

SPIR1_HUMAN

Protein spire homolog 1

0.385

AEBP2_HUMAN

Zinc finger protein AEBP2

0.385

TM242_HUMAN

Transmembrane protein 242

0.386

ZN318_HUMAN

Zinc finger protein 318

0.386

CCD43_HUMAN

Coiled-coil domain-containing protein 43

0.386

BAIP2_HUMAN

Brain-specific angiogenesis inhibitor 1-associated protein 2

0.386

SUFU_HUMAN

Suppressor of fused homolog

0.389

VGLL2_HUMAN

Transcription cofactor vestigial-like protein 2

0.389

MIDN_HUMAN

Midnolin

0.389

NEUL2_HUMAN

Neuralized-like protein 2

0.390

CTCF_HUMAN

Transcriptional repressor CTCF

0.390

PHC2_HUMAN

Polyhomeotic-like protein 2

0.391

SAMTR_HUMAN

S-adenosylmethionine sensor upstream of mTORC1

0.391

RECK_HUMAN

Reversion-inducing cysteine-rich protein with Kazal motifs

0.391

TNR6C_HUMAN

Trinucleotide repeat-containing gene 6C protein

0.392

TDRKH_HUMAN

Tudor and KH domain-containing protein

0.392

REL_HUMAN

Proto-oncogene c-Rel

0.393

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.393

CDR2_HUMAN

Cerebellar degeneration-related protein 2

0.393

NINJ1_HUMAN

Ninjurin-1

0.393

ERR3_HUMAN

Estrogen-related receptor gamma

0.393

AIMP2_HUMAN

Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

0.395

MED28_HUMAN

Mediator of RNA polymerase II transcription subunit 28

0.395

CHSTB_HUMAN

Carbohydrate sulfotransferase 11

0.395

LIX1L_HUMAN

LIX1-like protein

0.397

NOL11_HUMAN

Nucleolar protein 11

0.397

APLF_HUMAN

Aprataxin and PNK-like factor

0.397

INTU_HUMAN

Protein inturned

0.397

ASXL1_HUMAN

Putative Polycomb group protein ASXL1

0.399

BICL1_HUMAN

BICD family-like cargo adapter 1

0.399

TET2_HUMAN

Methylcytosine dioxygenase TET2

0.400

IKKB_HUMAN

Inhibitor of nuclear factor kappa-B kinase subunit beta

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 37 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy