YAP1_HUMAN 2019

Gene Name YAP1

Description Transcriptional coactivator YAP1

Length 504

9606

Sequence

>sp|P46937|YAP1_HUMAN Transcriptional coactivator YAP1
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

WWTR1_HUMAN

WW domain-containing transcription regulator protein 1

0.305

DCA10_HUMAN

DDB1- and CUL4-associated factor 10

0.305

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.337

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.341

PHC2_HUMAN

Polyhomeotic-like protein 2

0.365

NRF1_HUMAN

Nuclear respiratory factor 1

0.369

PTN21_HUMAN

Tyrosine-protein phosphatase non-receptor type 21

0.374

CHRD_HUMAN

Chordin

0.378

RASF2_HUMAN

Ras association domain-containing protein 2

0.378

DAG1_HUMAN

Dystroglycan

0.390

TXD11_HUMAN

Thioredoxin domain-containing protein 11

0.394

TSHR_HUMAN

Thyrotropin receptor

0.394

MCF2L_HUMAN

Guanine nucleotide exchange factor DBS

0.394

CC85A_HUMAN

Coiled-coil domain-containing protein 85A

0.399

NF2L2_HUMAN

Nuclear factor erythroid 2-related factor 2

0.399

AREL1_HUMAN

Apoptosis-resistant E3 ubiquitin protein ligase 1

0.399

FRPD4_HUMAN

FERM and PDZ domain-containing protein 4

0.399

LMBL3_HUMAN

Lethal(3)malignant brain tumor-like protein 3

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.293

NRF1_HUMAN

Nuclear respiratory factor 1

0.302

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.304

PHC2_HUMAN

Polyhomeotic-like protein 2

0.318

DCA10_HUMAN

DDB1- and CUL4-associated factor 10

0.322

FRITZ_HUMAN

WD repeat-containing and planar cell polarity effector protein fritz homolog

0.330

USH1G_HUMAN

Usher syndrome type-1G protein

0.330

GPM6A_HUMAN

Neuronal membrane glycoprotein M6-a

0.338

TSP4_HUMAN

Thrombospondin-4

0.339

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.339

AREL1_HUMAN

Apoptosis-resistant E3 ubiquitin protein ligase 1

0.339

MYD88_HUMAN

Myeloid differentiation primary response protein MyD88

0.341

CHRD_HUMAN

Chordin

0.341

KANL2_HUMAN

KAT8 regulatory NSL complex subunit 2

0.342

WWTR1_HUMAN

WW domain-containing transcription regulator protein 1

0.342

CTCF_HUMAN

Transcriptional repressor CTCF

0.347

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.348

TNR6C_HUMAN

Trinucleotide repeat-containing gene 6C protein

0.349

AXIN1_HUMAN

Axin-1

0.351

TWSG1_HUMAN

Twisted gastrulation protein homolog 1

0.352

DSCL1_HUMAN

Down syndrome cell adhesion molecule-like protein 1

0.354

SMO_HUMAN

Smoothened homolog

0.356

INTU_HUMAN

Protein inturned

0.356

TDRD9_HUMAN

ATP-dependent RNA helicase TDRD9

0.357

MED1_HUMAN

Mediator of RNA polymerase II transcription subunit 1

0.358

AEBP2_HUMAN

Zinc finger protein AEBP2

0.358

RECK_HUMAN

Reversion-inducing cysteine-rich protein with Kazal motifs

0.364

TDRKH_HUMAN

Tudor and KH domain-containing protein

0.365

OAF_HUMAN

Out at first protein homolog

0.365

NINJ1_HUMAN

Ninjurin-1

0.366

GTSF1_HUMAN

Gametocyte-specific factor 1

0.368

CHSTB_HUMAN

Carbohydrate sulfotransferase 11

0.368

MED15_HUMAN

Mediator of RNA polymerase II transcription subunit 15

0.370

SPIR1_HUMAN

Protein spire homolog 1

0.371

NF2L2_HUMAN

Nuclear factor erythroid 2-related factor 2

0.372

ETV6_HUMAN

Transcription factor ETV6

0.374

SPSY_HUMAN

Spermine synthase

0.376

HOME1_HUMAN

Homer protein homolog 1

0.376

KIBRA_HUMAN

Protein KIBRA

0.377

NEUL2_HUMAN

Neuralized-like protein 2

0.377

CRBL2_HUMAN

cAMP-responsive element-binding protein-like 2

0.377

INT10_HUMAN

Integrator complex subunit 10

0.377

UBP31_HUMAN

Ubiquitin carboxyl-terminal hydrolase 31

0.379

ARG28_HUMAN

Rho guanine nucleotide exchange factor 28

0.379

LIPP_HUMAN

Pancreatic triacylglycerol lipase

0.379

SPIR2_HUMAN

Protein spire homolog 2

0.379

GABPA_HUMAN

GA-binding protein alpha chain

0.380

SAPC2_HUMAN

Suppressor APC domain-containing protein 2

0.380

ENOX1_HUMAN

Ecto-NOX disulfide-thiol exchanger 1

0.380

G2E3_HUMAN

G2/M phase-specific E3 ubiquitin-protein ligase

0.381

CG026_HUMAN

Uncharacterized protein C7orf26

0.381

MSL2_HUMAN

E3 ubiquitin-protein ligase MSL2

0.381

AIMP2_HUMAN

Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

0.381

MED28_HUMAN

Mediator of RNA polymerase II transcription subunit 28

0.382

MED16_HUMAN

Mediator of RNA polymerase II transcription subunit 16

0.382

DALD3_HUMAN

DALR anticodon-binding domain-containing protein 3

0.382

NCAM1_HUMAN

Neural cell adhesion molecule 1

0.382

RHBT2_HUMAN

Rho-related BTB domain-containing protein 2

0.383

TMM11_HUMAN

Transmembrane protein 11, mitochondrial

0.384

BAKOR_HUMAN

Beclin 1-associated autophagy-related key regulator

0.384

DSCAM_HUMAN

Down syndrome cell adhesion molecule

0.385

BICL1_HUMAN

BICD family-like cargo adapter 1

0.386

ZN318_HUMAN

Zinc finger protein 318

0.387

CUED2_HUMAN

CUE domain-containing protein 2

0.387

PA2G3_HUMAN

Group 3 secretory phospholipase A2

0.387

CCD43_HUMAN

Coiled-coil domain-containing protein 43

0.387

TET2_HUMAN

Methylcytosine dioxygenase TET2

0.387

BD1L1_HUMAN

Biorientation of chromosomes in cell division protein 1-like 1

0.387

USH1C_HUMAN

Harmonin

0.387

RHG19_HUMAN

Rho GTPase-activating protein 19

0.387

ZN609_HUMAN

Zinc finger protein 609

0.387

MBD5_HUMAN

Methyl-CpG-binding domain protein 5

0.388

GXLT1_HUMAN

Glucoside xylosyltransferase 1

0.388

GCM2_HUMAN

Chorion-specific transcription factor GCMb

0.389

FSCN1_HUMAN

Fascin

0.389

CUED1_HUMAN

CUE domain-containing protein 1

0.391

SAMTR_HUMAN

S-adenosylmethionine sensor upstream of mTORC1

0.391

PTN21_HUMAN

Tyrosine-protein phosphatase non-receptor type 21

0.392

MERL_HUMAN

Merlin

0.392

SNAI2_HUMAN

Zinc finger protein SNAI2

0.393

MED24_HUMAN

Mediator of RNA polymerase II transcription subunit 24

0.393

KAZRN_HUMAN

Kazrin

0.393

PHC1_HUMAN

Polyhomeotic-like protein 1

0.393

NF2L1_HUMAN

Endoplasmic reticulum membrane sensor NFE2L1

0.394

ERR3_HUMAN

Estrogen-related receptor gamma

0.394

T179A_HUMAN

Transmembrane protein 179

0.394

REL_HUMAN

Proto-oncogene c-Rel

0.394

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.394

TET3_HUMAN

Methylcytosine dioxygenase TET3

0.394

NCAM2_HUMAN

Neural cell adhesion molecule 2

0.394

ETS1_HUMAN

Protein C-ets-1

0.395

K0825_HUMAN

Uncharacterized protein KIAA0825

0.395

UBP1_HUMAN

Ubiquitin carboxyl-terminal hydrolase 1

0.395

RASF2_HUMAN

Ras association domain-containing protein 2

0.395

SPT2_HUMAN

Protein SPT2 homolog

0.395

HMGX4_HUMAN

HMG domain-containing protein 4

0.396

DFFB_HUMAN

DNA fragmentation factor subunit beta

0.396

ZN503_HUMAN

Zinc finger protein 503

0.396

TNR6A_HUMAN

Trinucleotide repeat-containing gene 6A protein

0.396

ZN704_HUMAN

Zinc finger protein 704

0.397

CLOCK_HUMAN

Circadian locomoter output cycles protein kaput

0.397

RM30_HUMAN

39S ribosomal protein L30, mitochondrial

0.397

ANS4B_HUMAN

Ankyrin repeat and SAM domain-containing protein 4B

0.398

WHRN_HUMAN

Whirlin

0.399

RHPN2_HUMAN

Rhophilin-2

0.399

RXFP1_HUMAN

Relaxin receptor 1

0.400

TM242_HUMAN

Transmembrane protein 242

0.400

ID2_HUMAN

DNA-binding protein inhibitor ID-2

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 41 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy