PTCA_HUMAN 2019

Gene Name PTCA

Description Protein tyrosine phosphatase receptor type C-associated protein

Length 206

9606

Sequence

>sp|Q14761|PTCA_HUMAN Protein tyrosine phosphatase receptor type C-associated protein
MALPCTLGLGMLLALPGALGSGGSAEDSVGSSSVTVVLLLLLLLLLATGLALAWRRLSRDSGGYYHPARLGAALWGRTRRLLWASPPGRWLQARAELGSTDNDLERQEDEQDTDYDHVADGGLQADPGEGEQQCGEASSPEQVPVRAEEARDSDTEGDLVLGSPGPASAGGSAEALLSDLHAFAGSAAWDDSARAAGGQGLHVTAL

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

SPAT9_HUMAN

Spermatogenesis-associated protein 9

0.333

OR6Y1_HUMAN

Olfactory receptor 6Y1

0.333

O13A1_HUMAN

Olfactory receptor 13A1

0.333

M4A8_HUMAN

Membrane-spanning 4-domains subfamily A member 8

0.333

O2AP1_HUMAN

Olfactory receptor 2AP1

0.333

OR6F1_HUMAN

Olfactory receptor 6F1

0.333

VSIG8_HUMAN

V-set and immunoglobulin domain-containing protein 8

0.333

OR1N2_HUMAN

Olfactory receptor 1N2

0.354

C2D4D_HUMAN

C2 calcium-dependent domain-containing protein 4D

0.354

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

ZNF18_HUMAN

Zinc finger protein 18

0.291

SPAT9_HUMAN

Spermatogenesis-associated protein 9

0.291

JSPR1_HUMAN

Junctional sarcoplasmic reticulum protein 1

0.302

TBC21_HUMAN

TBC1 domain family member 21

0.314

F186B_HUMAN

Protein FAM186B

0.319

IL1A_HUMAN

Interleukin-1 alpha

0.319

ZKSC5_HUMAN

Zinc finger protein with KRAB and SCAN domains 5

0.319

G6B_HUMAN

Megakaryocyte and platelet inhibitory receptor G6b

0.322

FNDC8_HUMAN

Fibronectin type III domain-containing protein 8

0.339

AKAP4_HUMAN

A-kinase anchor protein 4

0.339

TRML1_HUMAN

Trem-like transcript 1 protein

0.342

LAX1_HUMAN

Lymphocyte transmembrane adapter 1

0.342

IL24_HUMAN

Interleukin-24

0.342

ZN202_HUMAN

Zinc finger protein 202

0.342

O13C7_HUMAN

Olfactory receptor 13C7

0.344

IL2_HUMAN

Interleukin-2

0.344

CSF2_HUMAN

Granulocyte-macrophage colony-stimulating factor

0.344

K2C7_HUMAN

Keratin, type II cytoskeletal 7

0.344

ZN496_HUMAN

Zinc finger protein 496

0.344

TMCO2_HUMAN

Transmembrane and coiled-coil domain-containing protein 2

0.344

LAT_HUMAN

Linker for activation of T-cells family member 1

0.344

IL5_HUMAN

Interleukin-5

0.344

PRS37_HUMAN

Probable inactive serine protease 37

0.344

DKKL1_HUMAN

Dickkopf-like protein 1

0.344

ETV2_HUMAN

ETS translocation variant 2

0.347

MEPE_HUMAN

Matrix extracellular phosphoglycoprotein

0.347

PRR19_HUMAN

Proline-rich protein 19

0.347

CLD9_HUMAN

Claudin-9

0.347

LMTD2_HUMAN

Lamin tail domain-containing protein 2

0.347

OCEL1_HUMAN

Occludin/ELL domain-containing protein 1

0.350

ARM12_HUMAN

Armadillo repeat-containing protein 12

0.356

F187B_HUMAN

Protein FAM187B

0.356

AKAP3_HUMAN

A-kinase anchor protein 3

0.362

GL6D1_HUMAN

Putative glycosyltransferase 6 domain-containing protein 1

0.362

S10A5_HUMAN

Protein S100-A5

0.362

CD20_HUMAN

B-lymphocyte antigen CD20

0.362

SPNDC_HUMAN

Spindlin interactor and repressor of chromatin-binding protein

0.362

GPC5D_HUMAN

G-protein coupled receptor family C group 5 member D

0.362

DMKN_HUMAN

Dermokine

0.365

CD14_HUMAN

Monocyte differentiation antigen CD14

0.365

ZKSC2_HUMAN

Zinc finger protein with KRAB and SCAN domains 2

0.365

IPIL1_HUMAN

Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1

0.365

RAGE_HUMAN

Advanced glycosylation end product-specific receptor

0.365

S10A8_HUMAN

Protein S100-A8

0.365

ZSC29_HUMAN

Zinc finger and SCAN domain-containing protein 29

0.365

CC196_HUMAN

Putative coiled-coil domain-containing protein 196

0.365

RTBDN_HUMAN

Retbindin

0.365

ZKSC1_HUMAN

Zinc finger protein with KRAB and SCAN domains 1

0.365

TM219_HUMAN

Insulin-like growth factor-binding protein 3 receptor

0.365

CQ080_HUMAN

Uncharacterized protein C17orf80

0.365

F229B_HUMAN

Protein FAM229B

0.368

NGAL_HUMAN

Neutrophil gelatinase-associated lipocalin

0.368

CC116_HUMAN

Coiled-coil domain-containing protein 116

0.368

KRBA1_HUMAN

Protein KRBA1

0.368

DBND2_HUMAN

Dysbindin domain-containing protein 2

0.368

OPALI_HUMAN

Opalin

0.368

F205A_HUMAN

Protein FAM205A

0.368

ZN189_HUMAN

Zinc finger protein 189

0.368

CJ120_HUMAN

Uncharacterized protein C10orf120

0.368

ZN449_HUMAN

Zinc finger protein 449

0.368

F170A_HUMAN

Protein FAM170A

0.368

REL2_HUMAN

Prorelaxin H2

0.368

TREM1_HUMAN

Triggering receptor expressed on myeloid cells 1

0.368

ZFP1_HUMAN

Zinc finger protein 1 homolog

0.368

ZN200_HUMAN

Zinc finger protein 200

0.368

ZN263_HUMAN

Zinc finger protein 263

0.368

TMC5A_HUMAN

Transmembrane and coiled-coil domain-containing protein 5A

0.368

CD70_HUMAN

CD70 antigen

0.368

ZN446_HUMAN

Zinc finger protein 446

0.371

ZCCHL_HUMAN

Zinc finger CCCH-type antiviral protein 1-like

0.371

LY6H_HUMAN

Lymphocyte antigen 6H

0.371

TSP50_HUMAN

Probable threonine protease PRSS50

0.375

NUTM1_HUMAN

NUT family member 1

0.378

DMP1_HUMAN

Dentin matrix acidic phosphoprotein 1

0.381

PRIC4_HUMAN

Prickle-like protein 4

0.381

T53G5_HUMAN

TP53-target gene 5 protein

0.381

I27RA_HUMAN

Interleukin-27 receptor subunit alpha

0.381

T4S19_HUMAN

Transmembrane 4 L6 family member 19

0.381

PA2GF_HUMAN

Group IIF secretory phospholipase A2

0.384

NAR3_HUMAN

Ecto-ADP-ribosyltransferase 3

0.384

NKG7_HUMAN

Protein NKG7

0.384

ZSC20_HUMAN

Zinc finger and SCAN domain-containing protein 20

0.384

CD19_HUMAN

B-lymphocyte antigen CD19

0.387

TMG2_HUMAN

Transmembrane gamma-carboxyglutamic acid protein 2

0.387

MEFV_HUMAN

Pyrin

0.387

ZSC10_HUMAN

Zinc finger and SCAN domain-containing protein 10

0.387

ZN691_HUMAN

Zinc finger protein 691

0.387

CCL22_HUMAN

C-C motif chemokine 22

0.387

BPIA1_HUMAN

BPI fold-containing family A member 1

0.387

ACTT3_HUMAN

Actin-related protein T3

0.387

ZN184_HUMAN

Zinc finger protein 184

0.387

BPIB1_HUMAN

BPI fold-containing family B member 1

0.387

TNF18_HUMAN

Tumor necrosis factor ligand superfamily member 18

0.387

SPT25_HUMAN

Spermatogenesis-associated protein 25

0.387

ZNF48_HUMAN

Zinc finger protein 48

0.391

CKLF5_HUMAN

CKLF-like MARVEL transmembrane domain-containing protein 5

0.391

ZSC25_HUMAN

Zinc finger and SCAN domain-containing protein 25

0.391

CB074_HUMAN

Uncharacterized protein C2orf74

0.391

ODAM_HUMAN

Odontogenic ameloblast-associated protein

0.391

TEX35_HUMAN

Testis-expressed protein 35

0.391

MASTR_HUMAN

MEF2-activating motif and SAP domain-containing transcriptional regulator

0.391

ZN445_HUMAN

Zinc finger protein 445

0.391

SYNE4_HUMAN

Nesprin-4

0.391

BEX3_HUMAN

Protein BEX3

0.391

ZN174_HUMAN

Zinc finger protein 174

0.391

CDSN_HUMAN

Corneodesmosin

0.391

IL33_HUMAN

Interleukin-33

0.391

IRGQ_HUMAN

Immunity-related GTPase family Q protein

0.391

TRIMM_HUMAN

Probable E3 ubiquitin-protein ligase TRIML2

0.391

IL13_HUMAN

Interleukin-13

0.391

BPIA3_HUMAN

BPI fold-containing family A member 3

0.391

CAVN3_HUMAN

Caveolae-associated protein 3

0.391

MROH7_HUMAN

Maestro heat-like repeat-containing protein family member 7

0.392

BEX2_HUMAN

Protein BEX2

0.394

ZN697_HUMAN

Zinc finger protein 697

0.394

FSCN3_HUMAN

Fascin-3

0.395

GFRA3_HUMAN

GDNF family receptor alpha-3

0.398

TROAP_HUMAN

Tastin

0.398

S10A9_HUMAN

Protein S100-A9

0.398

ZN436_HUMAN

Zinc finger protein 436

0.398

TFF3_HUMAN

Trefoil factor 3

0.398

DMRTD_HUMAN

Doublesex- and mab-3-related transcription factor C2

0.398

PRS54_HUMAN

Inactive serine protease 54

0.398

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 55 organisms (of 929)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy