LHPL2_HUMAN 2019

Gene Name LHPL2

Description LHFPL tetraspan subfamily member 2 protein

Length 228

9606

Sequence

>sp|Q6ZUX7|LHPL2_HUMAN LHFPL tetraspan subfamily member 2 protein
MCHVIVTCRSMLWTLLSIVVAFAELIAFMSADWLIGKARSRGGVEPAGPGGGSPEPYHPTLGIYARCIRNPGVQHFQRDTLCGPYAESFGEIASGFWQATAIFLAVGIFILCMVALVSVFTMCVQSIMKKSIFNVCGLLQGIAGLFLILGLILYPAGWGCQKAIDYCGHYASAYKPGDCSLGWAFYTAIGGTVLTFICAVFSAQAEIATSSDKVQEEIEEGKNLICLL

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

DIK2A_HUMAN

Divergent protein kinase domain 2A

0.312

AXIN1_HUMAN

Axin-1

0.341

BICL1_HUMAN

BICD family-like cargo adapter 1

0.345

SYTL5_HUMAN

Synaptotagmin-like protein 5

0.345

OTOP1_HUMAN

Proton channel OTOP1

0.378

SYTL4_HUMAN

Synaptotagmin-like protein 4

0.378

G2E3_HUMAN

G2/M phase-specific E3 ubiquitin-protein ligase

0.378

TNR6C_HUMAN

Trinucleotide repeat-containing gene 6C protein

0.387

ID2_HUMAN

DNA-binding protein inhibitor ID-2

0.387

CASP7_HUMAN

Caspase-7

0.394

SKI_HUMAN

Ski oncogene

0.394

41_HUMAN

Protein 4.1

0.399

PHC2_HUMAN

Polyhomeotic-like protein 2

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

BICL1_HUMAN

BICD family-like cargo adapter 1

0.343

SUFU_HUMAN

Suppressor of fused homolog

0.346

RECK_HUMAN

Reversion-inducing cysteine-rich protein with Kazal motifs

0.348

TNR6C_HUMAN

Trinucleotide repeat-containing gene 6C protein

0.349

AXIN1_HUMAN

Axin-1

0.350

GABPA_HUMAN

GA-binding protein alpha chain

0.351

DCA10_HUMAN

DDB1- and CUL4-associated factor 10

0.354

BCAP_HUMAN

Phosphoinositide 3-kinase adapter protein 1

0.354

AEBP2_HUMAN

Zinc finger protein AEBP2

0.359

ETV6_HUMAN

Transcription factor ETV6

0.359

VGLL2_HUMAN

Transcription cofactor vestigial-like protein 2

0.361

CASZ1_HUMAN

Zinc finger protein castor homolog 1

0.363

ZMYM2_HUMAN

Zinc finger MYM-type protein 2

0.364

ENOX1_HUMAN

Ecto-NOX disulfide-thiol exchanger 1

0.366

NRF1_HUMAN

Nuclear respiratory factor 1

0.367

MSL2_HUMAN

E3 ubiquitin-protein ligase MSL2

0.367

UBP1_HUMAN

Ubiquitin carboxyl-terminal hydrolase 1

0.367

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.369

HMGX4_HUMAN

HMG domain-containing protein 4

0.369

ASXL2_HUMAN

Putative Polycomb group protein ASXL2

0.369

SYTL4_HUMAN

Synaptotagmin-like protein 4

0.369

AXIN2_HUMAN

Axin-2

0.369

GPM6A_HUMAN

Neuronal membrane glycoprotein M6-a

0.369

DSCL1_HUMAN

Down syndrome cell adhesion molecule-like protein 1

0.369

ZMYM4_HUMAN

Zinc finger MYM-type protein 4

0.370

MYD88_HUMAN

Myeloid differentiation primary response protein MyD88

0.372

TM35A_HUMAN

Transmembrane protein 35A

0.372

CCD43_HUMAN

Coiled-coil domain-containing protein 43

0.373

ZN318_HUMAN

Zinc finger protein 318

0.373

CUED2_HUMAN

CUE domain-containing protein 2

0.373

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.374

FRITZ_HUMAN

WD repeat-containing and planar cell polarity effector protein fritz homolog

0.376

GCM2_HUMAN

Chorion-specific transcription factor GCMb

0.377

SYTL5_HUMAN

Synaptotagmin-like protein 5

0.377

HOME1_HUMAN

Homer protein homolog 1

0.377

CTCF_HUMAN

Transcriptional repressor CTCF

0.378

PHC2_HUMAN

Polyhomeotic-like protein 2

0.379

TCF21_HUMAN

Transcription factor 21

0.379

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.379

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.381

G2E3_HUMAN

G2/M phase-specific E3 ubiquitin-protein ligase

0.382

SPT2_HUMAN

Protein SPT2 homolog

0.383

CYTSA_HUMAN

Cytospin-A

0.383

CHSTB_HUMAN

Carbohydrate sulfotransferase 11

0.383

DFFB_HUMAN

DNA fragmentation factor subunit beta

0.384

AREL1_HUMAN

Apoptosis-resistant E3 ubiquitin protein ligase 1

0.385

TMM11_HUMAN

Transmembrane protein 11, mitochondrial

0.385

FBX28_HUMAN

F-box only protein 28

0.387

DIK2A_HUMAN

Divergent protein kinase domain 2A

0.388

CC191_HUMAN

Coiled-coil domain-containing protein 191

0.392

GP155_HUMAN

Integral membrane protein GPR155

0.392

GSAP_HUMAN

Gamma-secretase-activating protein

0.393

MERL_HUMAN

Merlin

0.394

CDR2_HUMAN

Cerebellar degeneration-related protein 2

0.396

T179A_HUMAN

Transmembrane protein 179

0.396

NINJ1_HUMAN

Ninjurin-1

0.396

ETV1_HUMAN

ETS translocation variant 1

0.396

MED28_HUMAN

Mediator of RNA polymerase II transcription subunit 28

0.397

GTSF1_HUMAN

Gametocyte-specific factor 1

0.397

RWDD4_HUMAN

RWD domain-containing protein 4

0.398

TSP4_HUMAN

Thrombospondin-4

0.399

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.399

MED1_HUMAN

Mediator of RNA polymerase II transcription subunit 1

0.399

DOK1_HUMAN

Docking protein 1

0.399

SMO_HUMAN

Smoothened homolog

0.400

TDRD9_HUMAN

ATP-dependent RNA helicase TDRD9

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 38 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy