TM35A_HUMAN 2019

Gene Name TM35A

Description Transmembrane protein 35A

Length 167

9606

Sequence

>sp|Q53FP2|TM35A_HUMAN Transmembrane protein 35A
MASPRTVTIVALSVALGLFFVFMGTIKLTPRLSKDAYSEMKRAYKSYVRALPLLKKMGINSILLRKSIGALEVACGIVMTLVPGRPKDVANFFLLLLVLAVLFFHQLVGDPLKRYAHALVFGILLTCRLLIARKPEDRSSEKKPLPGNAEEQPSLYEKAPQGKVKVS

Domains

Loading...

Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

TCF21_HUMAN

Transcription factor 21

0.354

SHCAF_HUMAN

SIN3-HDAC complex-associated factor

0.387

BOK_HUMAN

Bcl-2-related ovarian killer protein

0.392

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.392

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

CASZ1_HUMAN

Zinc finger protein castor homolog 1

0.302

TCF21_HUMAN

Transcription factor 21

0.302

BICL1_HUMAN

BICD family-like cargo adapter 1

0.316

GCM2_HUMAN

Chorion-specific transcription factor GCMb

0.319

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.323

DSCL1_HUMAN

Down syndrome cell adhesion molecule-like protein 1

0.327

ZMYM4_HUMAN

Zinc finger MYM-type protein 4

0.328

CRERF_HUMAN

CREB3 regulatory factor

0.335

A0A1C7CYV8_HUMAN

POU domain protein

0.336

NMBR_HUMAN

Neuromedin-B receptor

0.341

GABPA_HUMAN

GA-binding protein alpha chain

0.342

HMGX4_HUMAN

HMG domain-containing protein 4

0.344

SMO_HUMAN

Smoothened homolog

0.346

CTCF_HUMAN

Transcriptional repressor CTCF

0.354

ZMYM2_HUMAN

Zinc finger MYM-type protein 2

0.355

PHC2_HUMAN

Polyhomeotic-like protein 2

0.356

AXIN1_HUMAN

Axin-1

0.357

NRF1_HUMAN

Nuclear respiratory factor 1

0.358

AR6P1_HUMAN

ADP-ribosylation factor-like protein 6-interacting protein 1

0.359

SYTL4_HUMAN

Synaptotagmin-like protein 4

0.360

ZN704_HUMAN

Zinc finger protein 704

0.361

WHRN_HUMAN

Whirlin

0.363

USH1C_HUMAN

Harmonin

0.364

ID2_HUMAN

DNA-binding protein inhibitor ID-2

0.364

ETV6_HUMAN

Transcription factor ETV6

0.365

MBD5_HUMAN

Methyl-CpG-binding domain protein 5

0.365

ZN609_HUMAN

Zinc finger protein 609

0.366

NKRF_HUMAN

NF-kappa-B-repressing factor

0.367

SYTL5_HUMAN

Synaptotagmin-like protein 5

0.368

SYT14_HUMAN

Synaptotagmin-14

0.368

HOME1_HUMAN

Homer protein homolog 1

0.368

GP155_HUMAN

Integral membrane protein GPR155

0.369

MERL_HUMAN

Merlin

0.371

NINJ1_HUMAN

Ninjurin-1

0.372

CDR2_HUMAN

Cerebellar degeneration-related protein 2

0.372

LHPL2_HUMAN

LHFPL tetraspan subfamily member 2 protein

0.372

T179A_HUMAN

Transmembrane protein 179

0.372

TNNT3_HUMAN

Troponin T, fast skeletal muscle

0.373

G2E3_HUMAN

G2/M phase-specific E3 ubiquitin-protein ligase

0.374

ASXL2_HUMAN

Putative Polycomb group protein ASXL2

0.375

PHLB2_HUMAN

Pleckstrin homology-like domain family B member 2

0.375

DCA10_HUMAN

DDB1- and CUL4-associated factor 10

0.375

MED1_HUMAN

Mediator of RNA polymerase II transcription subunit 1

0.378

DSCAM_HUMAN

Down syndrome cell adhesion molecule

0.378

GOGA1_HUMAN

Golgin subfamily A member 1

0.378

AEBP2_HUMAN

Zinc finger protein AEBP2

0.379

PO6F2_HUMAN

POU domain, class 6, transcription factor 2

0.379

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.379

NFAT5_HUMAN

Nuclear factor of activated T-cells 5

0.380

CASP7_HUMAN

Caspase-7

0.381

ATP5J_HUMAN

ATP synthase-coupling factor 6, mitochondrial

0.381

SUFU_HUMAN

Suppressor of fused homolog

0.382

SHCAF_HUMAN

SIN3-HDAC complex-associated factor

0.383

VGLL2_HUMAN

Transcription cofactor vestigial-like protein 2

0.383

CNTN2_HUMAN

Contactin-2

0.383

CRBL2_HUMAN

cAMP-responsive element-binding protein-like 2

0.383

SOCS7_HUMAN

Suppressor of cytokine signaling 7

0.385

OAF_HUMAN

Out at first protein homolog

0.386

CNTN1_HUMAN

Contactin-1

0.387

REL_HUMAN

Proto-oncogene c-Rel

0.387

FA13B_HUMAN

Protein FAM13B

0.388

CASP3_HUMAN

Caspase-3

0.388

GPM6A_HUMAN

Neuronal membrane glycoprotein M6-a

0.389

CHSTB_HUMAN

Carbohydrate sulfotransferase 11

0.389

AXIN2_HUMAN

Axin-2

0.389

DFFB_HUMAN

DNA fragmentation factor subunit beta

0.389

RSLAB_HUMAN

Ras-like protein family member 10B

0.389

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.390

TMM11_HUMAN

Transmembrane protein 11, mitochondrial

0.391

OPN4_HUMAN

Melanopsin

0.392

OTOP1_HUMAN

Proton channel OTOP1

0.392

SPIR1_HUMAN

Protein spire homolog 1

0.392

PA2G3_HUMAN

Group 3 secretory phospholipase A2

0.393

RXFP1_HUMAN

Relaxin receptor 1

0.393

DIK2A_HUMAN

Divergent protein kinase domain 2A

0.393

CUED2_HUMAN

CUE domain-containing protein 2

0.393

CCD43_HUMAN

Coiled-coil domain-containing protein 43

0.393

FXL16_HUMAN

F-box/LRR-repeat protein 16

0.394

HOME2_HUMAN

Homer protein homolog 2

0.394

FRITZ_HUMAN

WD repeat-containing and planar cell polarity effector protein fritz homolog

0.395

LOXL2_HUMAN

Lysyl oxidase homolog 2

0.397

SYT11_HUMAN

Synaptotagmin-11

0.398

CRHBP_HUMAN

Corticotropin-releasing factor-binding protein

0.398

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.399

SNAI2_HUMAN

Zinc finger protein SNAI2

0.399

SPIR2_HUMAN

Protein spire homolog 2

0.400

TDRKH_HUMAN

Tudor and KH domain-containing protein

0.400

TNR6C_HUMAN

Trinucleotide repeat-containing gene 6C protein

0.400

PHC1_HUMAN

Polyhomeotic-like protein 1

0.400

TWSG1_HUMAN

Twisted gastrulation protein homolog 1

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 36 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy