KANL2_HUMAN 2019

Gene Name KANL2

Description KAT8 regulatory NSL complex subunit 2

Length 492

9606

Sequence

>sp|Q9H9L4|KANL2_HUMAN KAT8 regulatory NSL complex subunit 2
MNRIRIHVLPTNRGRITPVPRSQEPLSCAFTHRPCSHPRLEGQEFCIKHILEDKNAPFKQCSYISTKNGKRCPNAAPKPEKKDGVSFCAEHVRRNALALHAQMKKTNPGPVGETLLCQLSSYAKTELGSQTPESSRSEASRILDEDSWSDGEQEPITVDQTWRGDPDSEADSIDSDQEDPLKHAGVYTAEEVALIMREKLIRLQSLYIDQFKRLQHLLKEKKRRYLHNRKVEHEALGSSLLTGPEGLLAKERENLKRLKCLRRYRQRYGVEALLHRQLKERRMLATDGAAQQAHTTRSSQRCLAFVDDVRCSNQSLPMTRHCLTHICQDTNQVLFKCCQGSEEVPCNKPVPVSLSEDPCCPLHFQLPPQMYKPEQVLSVPDDLEAGPMDLYLSAAELQPTESLPLEFSDDLDVVGDGMQCPPSPLLFDPSLTLEDHLVKEIAEDPVDILGQMQMAGDGCRSQGSRNSEKASAPLSQSGLATANGKPEPTSIS

Domains

Loading...

Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

TSHR_HUMAN

Thyrotropin receptor

0.394

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.394

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

NRF1_HUMAN

Nuclear respiratory factor 1

0.310

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.318

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.329

DCA10_HUMAN

DDB1- and CUL4-associated factor 10

0.329

USH1G_HUMAN

Usher syndrome type-1G protein

0.337

PHC2_HUMAN

Polyhomeotic-like protein 2

0.341

YAP1_HUMAN

Transcriptional coactivator YAP1

0.342

GPM6A_HUMAN

Neuronal membrane glycoprotein M6-a

0.344

AEBP2_HUMAN

Zinc finger protein AEBP2

0.350

FRITZ_HUMAN

WD repeat-containing and planar cell polarity effector protein fritz homolog

0.352

TNR6C_HUMAN

Trinucleotide repeat-containing gene 6C protein

0.356

DSCL1_HUMAN

Down syndrome cell adhesion molecule-like protein 1

0.359

TSP4_HUMAN

Thrombospondin-4

0.360

TDRD9_HUMAN

ATP-dependent RNA helicase TDRD9

0.363

USH1C_HUMAN

Harmonin

0.364

RHG19_HUMAN

Rho GTPase-activating protein 19

0.364

HOME1_HUMAN

Homer protein homolog 1

0.368

RECK_HUMAN

Reversion-inducing cysteine-rich protein with Kazal motifs

0.369

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.369

ARG28_HUMAN

Rho guanine nucleotide exchange factor 28

0.371

AXIN1_HUMAN

Axin-1

0.371

NINJ1_HUMAN

Ninjurin-1

0.371

TWSG1_HUMAN

Twisted gastrulation protein homolog 1

0.372

HMGX4_HUMAN

HMG domain-containing protein 4

0.374

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.375

AREL1_HUMAN

Apoptosis-resistant E3 ubiquitin protein ligase 1

0.375

MED15_HUMAN

Mediator of RNA polymerase II transcription subunit 15

0.376

INTU_HUMAN

Protein inturned

0.376

MYD88_HUMAN

Myeloid differentiation primary response protein MyD88

0.377

CHRD_HUMAN

Chordin

0.377

NF2L2_HUMAN

Nuclear factor erythroid 2-related factor 2

0.377

MED1_HUMAN

Mediator of RNA polymerase II transcription subunit 1

0.377

ETV6_HUMAN

Transcription factor ETV6

0.379

SPSY_HUMAN

Spermine synthase

0.381

SUFU_HUMAN

Suppressor of fused homolog

0.381

CUED1_HUMAN

CUE domain-containing protein 1

0.382

CTCF_HUMAN

Transcriptional repressor CTCF

0.382

UBP31_HUMAN

Ubiquitin carboxyl-terminal hydrolase 31

0.384

OAF_HUMAN

Out at first protein homolog

0.384

TDRKH_HUMAN

Tudor and KH domain-containing protein

0.384

SPIR2_HUMAN

Protein spire homolog 2

0.384

GABPA_HUMAN

GA-binding protein alpha chain

0.385

SAPC2_HUMAN

Suppressor APC domain-containing protein 2

0.385

ENOX1_HUMAN

Ecto-NOX disulfide-thiol exchanger 1

0.385

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.385

RASF2_HUMAN

Ras association domain-containing protein 2

0.387

UBP1_HUMAN

Ubiquitin carboxyl-terminal hydrolase 1

0.387

MSL2_HUMAN

E3 ubiquitin-protein ligase MSL2

0.387

DALD3_HUMAN

DALR anticodon-binding domain-containing protein 3

0.387

MED16_HUMAN

Mediator of RNA polymerase II transcription subunit 16

0.387

GTSF1_HUMAN

Gametocyte-specific factor 1

0.387

CHSTB_HUMAN

Carbohydrate sulfotransferase 11

0.387

DFFB_HUMAN

DNA fragmentation factor subunit beta

0.388

RHBT2_HUMAN

Rho-related BTB domain-containing protein 2

0.388

RM30_HUMAN

39S ribosomal protein L30, mitochondrial

0.389

SMO_HUMAN

Smoothened homolog

0.389

WHRN_HUMAN

Whirlin

0.391

SPIR1_HUMAN

Protein spire homolog 1

0.391

BICL1_HUMAN

BICD family-like cargo adapter 1

0.391

CCD43_HUMAN

Coiled-coil domain-containing protein 43

0.392

ZN318_HUMAN

Zinc finger protein 318

0.392

TET2_HUMAN

Methylcytosine dioxygenase TET2

0.392

BD1L1_HUMAN

Biorientation of chromosomes in cell division protein 1-like 1

0.392

CUED2_HUMAN

CUE domain-containing protein 2

0.392

HOME2_HUMAN

Homer protein homolog 2

0.393

GXLT1_HUMAN

Glucoside xylosyltransferase 1

0.393

RASF6_HUMAN

Ras association domain-containing protein 6

0.394

FGOP2_HUMAN

FGFR1 oncogene partner 2

0.394

GCM2_HUMAN

Chorion-specific transcription factor GCMb

0.394

INT10_HUMAN

Integrator complex subunit 10

0.395

CRBL2_HUMAN

cAMP-responsive element-binding protein-like 2

0.396

NEUL2_HUMAN

Neuralized-like protein 2

0.396

PTN21_HUMAN

Tyrosine-protein phosphatase non-receptor type 21

0.397

MED24_HUMAN

Mediator of RNA polymerase II transcription subunit 24

0.397

LIPP_HUMAN

Pancreatic triacylglycerol lipase

0.398

HPS1_HUMAN

Hermansky-Pudlak syndrome 1 protein

0.398

PHC1_HUMAN

Polyhomeotic-like protein 1

0.398

NF2L1_HUMAN

Endoplasmic reticulum membrane sensor NFE2L1

0.398

TET3_HUMAN

Methylcytosine dioxygenase TET3

0.399

ELL2_HUMAN

RNA polymerase II elongation factor ELL2

0.399

T179A_HUMAN

Transmembrane protein 179

0.399

NCAM2_HUMAN

Neural cell adhesion molecule 2

0.399

CG026_HUMAN

Uncharacterized protein C7orf26

0.399

G2E3_HUMAN

G2/M phase-specific E3 ubiquitin-protein ligase

0.399

TBC30_HUMAN

TBC1 domain family member 30

0.399

ETS1_HUMAN

Protein C-ets-1

0.399

K0825_HUMAN

Uncharacterized protein KIAA0825

0.400

NMBR_HUMAN

Neuromedin-B receptor

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 39 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy