RASF6_HUMAN 2019

Gene Name RASF6

Description Ras association domain-containing protein 6

Length 369

9606

Sequence

>sp|Q6ZTQ3|RASF6_HUMAN Ras association domain-containing protein 6
MLWEETGAAPAPARASDLPYRISSDHLKKEEKMTMMAHQYPSWIFINEKTFITREQLNSLLKTYNIFYENQKNLHILYGETEDGKLIVEGMLDIFWGVKRPIQLKIQDEKPFSSFTSMKSSDVFSSKGMTRWGEFDDLYRISELDRTQIPMSEKRNSQEDYLSYHSNTLKPHAKDEPDSPVLYRTMSEAALVRKRMKPLMMDRKERQKNRASINGHFYNHETSIFIPAFESETKVRVNSNMRTEEVIKQLLQKFKIENSPQDFALHIIFATGEQRRLKKTDIPLLQRLLQGPSEKNARIFLMDKDAEEISSDVAQYINFHFSLLESILQRLNEEEKREIQRIVTKFNKEKAIILKCLQNKLVIKTETTV

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

RASF2_HUMAN

Ras association domain-containing protein 2

0.164

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.316

MBD5_HUMAN

Methyl-CpG-binding domain protein 5

0.324

TMED6_HUMAN

Transmembrane emp24 domain-containing protein 6

0.324

DCA10_HUMAN

DDB1- and CUL4-associated factor 10

0.349

NRF1_HUMAN

Nuclear respiratory factor 1

0.349

CC28B_HUMAN

Coiled-coil domain-containing protein 28B

0.354

MMS22_HUMAN

Protein MMS22-like

0.363

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.363

MSL2_HUMAN

E3 ubiquitin-protein ligase MSL2

0.363

DRD5_HUMAN

D(1B) dopamine receptor

0.363

TXD11_HUMAN

Thioredoxin domain-containing protein 11

0.378

LTOR1_HUMAN

Ragulator complex protein LAMTOR1

0.378

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.378

PKHA7_HUMAN

Pleckstrin homology domain-containing family A member 7

0.383

FRITZ_HUMAN

WD repeat-containing and planar cell polarity effector protein fritz homolog

0.383

CC85A_HUMAN

Coiled-coil domain-containing protein 85A

0.383

NF2L2_HUMAN

Nuclear factor erythroid 2-related factor 2

0.383

LMBL3_HUMAN

Lethal(3)malignant brain tumor-like protein 3

0.383

TM242_HUMAN

Transmembrane protein 242

0.387

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.387

ELL2_HUMAN

RNA polymerase II elongation factor ELL2

0.387

MTF1_HUMAN

Metal regulatory transcription factor 1

0.387

BICRL_HUMAN

BRD4-interacting chromatin-remodeling complex-associated protein-like

0.387

SPIR2_HUMAN

Protein spire homolog 2

0.387

RXFP1_HUMAN

Relaxin receptor 1

0.387

USH1G_HUMAN

Usher syndrome type-1G protein

0.387

SEM6D_HUMAN

Semaphorin-6D

0.387

TET3_HUMAN

Methylcytosine dioxygenase TET3

0.387

TNR6C_HUMAN

Trinucleotide repeat-containing gene 6C protein

0.392

SHRM2_HUMAN

Protein Shroom2

0.392

AMNLS_HUMAN

Protein amnionless

0.392

T179A_HUMAN

Transmembrane protein 179

0.392

SPIR1_HUMAN

Protein spire homolog 1

0.392

NINJ1_HUMAN

Ninjurin-1

0.392

MIDN_HUMAN

Midnolin

0.392

VGLL2_HUMAN

Transcription cofactor vestigial-like protein 2

0.392

BCAP_HUMAN

Phosphoinositide 3-kinase adapter protein 1

0.397

CUED2_HUMAN

CUE domain-containing protein 2

0.397

NMBR_HUMAN

Neuromedin-B receptor

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

RASF2_HUMAN

Ras association domain-containing protein 2

0.181

MYD88_HUMAN

Myeloid differentiation primary response protein MyD88

0.333

RXFP1_HUMAN

Relaxin receptor 1

0.334

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.341

NRF1_HUMAN

Nuclear respiratory factor 1

0.345

DCA10_HUMAN

DDB1- and CUL4-associated factor 10

0.347

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.347

CUED2_HUMAN

CUE domain-containing protein 2

0.351

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.353

FRITZ_HUMAN

WD repeat-containing and planar cell polarity effector protein fritz homolog

0.355

MGST1_HUMAN

Microsomal glutathione S-transferase 1

0.358

TNR6C_HUMAN

Trinucleotide repeat-containing gene 6C protein

0.359

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.360

GABPA_HUMAN

GA-binding protein alpha chain

0.361

AIMP2_HUMAN

Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

0.361

HELZ_HUMAN

Probable helicase with zinc finger domain

0.361

MTP_HUMAN

Microsomal triglyceride transfer protein large subunit

0.363

MMS22_HUMAN

Protein MMS22-like

0.366

ZDH23_HUMAN

Palmitoyltransferase ZDHHC23

0.367

TM242_HUMAN

Transmembrane protein 242

0.367

RHG19_HUMAN

Rho GTPase-activating protein 19

0.367

CC28A_HUMAN

Coiled-coil domain-containing protein 28A

0.369

RNF37_HUMAN

RING finger protein 37

0.369

SHRM2_HUMAN

Protein Shroom2

0.371

SPSY_HUMAN

Spermine synthase

0.371

USH1G_HUMAN

Usher syndrome type-1G protein

0.371

XYLK_HUMAN

Glycosaminoglycan xylosylkinase

0.373

PHC2_HUMAN

Polyhomeotic-like protein 2

0.374

MSL2_HUMAN

E3 ubiquitin-protein ligase MSL2

0.377

UBP1_HUMAN

Ubiquitin carboxyl-terminal hydrolase 1

0.377

GTSF1_HUMAN

Gametocyte-specific factor 1

0.378

AREL1_HUMAN

Apoptosis-resistant E3 ubiquitin protein ligase 1

0.379

INTU_HUMAN

Protein inturned

0.380

TDRD9_HUMAN

ATP-dependent RNA helicase TDRD9

0.381

SPIR1_HUMAN

Protein spire homolog 1

0.381

TMED6_HUMAN

Transmembrane emp24 domain-containing protein 6

0.382

XXLT1_HUMAN

Xyloside xylosyltransferase 1

0.383

IKKB_HUMAN

Inhibitor of nuclear factor kappa-B kinase subunit beta

0.383

MBD5_HUMAN

Methyl-CpG-binding domain protein 5

0.384

ETV6_HUMAN

Transcription factor ETV6

0.384

BOK_HUMAN

Bcl-2-related ovarian killer protein

0.384

CB042_HUMAN

Uncharacterized protein C2orf42

0.384

SUFU_HUMAN

Suppressor of fused homolog

0.386

RXFP2_HUMAN

Relaxin receptor 2

0.387

RECK_HUMAN

Reversion-inducing cysteine-rich protein with Kazal motifs

0.388

PKHM2_HUMAN

Pleckstrin homology domain-containing family M member 2

0.389

CRCM_HUMAN

Colorectal mutant cancer protein

0.390

IKKA_HUMAN

Inhibitor of nuclear factor kappa-B kinase subunit alpha

0.390

T179A_HUMAN

Transmembrane protein 179

0.390

K0825_HUMAN

Uncharacterized protein KIAA0825

0.392

NMBR_HUMAN

Neuromedin-B receptor

0.392

MED16_HUMAN

Mediator of RNA polymerase II transcription subunit 16

0.392

CHSTB_HUMAN

Carbohydrate sulfotransferase 11

0.392

DSCL1_HUMAN

Down syndrome cell adhesion molecule-like protein 1

0.392

ASXL2_HUMAN

Putative Polycomb group protein ASXL2

0.392

SYTL4_HUMAN

Synaptotagmin-like protein 4

0.392

DFFB_HUMAN

DNA fragmentation factor subunit beta

0.393

RHBT2_HUMAN

Rho-related BTB domain-containing protein 2

0.393

TSP4_HUMAN

Thrombospondin-4

0.393

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.393

KANL2_HUMAN

KAT8 regulatory NSL complex subunit 2

0.394

RAB34_HUMAN

Ras-related protein Rab-34

0.394

BCAP_HUMAN

Phosphoinositide 3-kinase adapter protein 1

0.394

MED15_HUMAN

Mediator of RNA polymerase II transcription subunit 15

0.395

NF2L2_HUMAN

Nuclear factor erythroid 2-related factor 2

0.395

CHRD_HUMAN

Chordin

0.396

AEBP2_HUMAN

Zinc finger protein AEBP2

0.396

TET2_HUMAN

Methylcytosine dioxygenase TET2

0.397

CCD43_HUMAN

Coiled-coil domain-containing protein 43

0.397

ZN318_HUMAN

Zinc finger protein 318

0.397

NDUF4_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

0.398

HOME1_HUMAN

Homer protein homolog 1

0.399

INT10_HUMAN

Integrator complex subunit 10

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 36 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy