CATE_HUMAN 2019

Gene Name CATE

Description Cathepsin E

Length 396

9606

Sequence

>sp|P14091|CATE_HUMAN Cathepsin E
MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGAAPVDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDIHPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAPAVP

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

PEPA5_HUMAN

Pepsin A-5

0.361

PEPA4_HUMAN

Pepsin A-4

0.373

PEPA3_HUMAN

Pepsin A-3

0.383

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

PEPA5_HUMAN

Pepsin A-5

0.309

PEPA3_HUMAN

Pepsin A-3

0.336

PEPA4_HUMAN

Pepsin A-4

0.336

VPP3_HUMAN

V-type proton ATPase 116 kDa subunit a isoform 3

0.340

GTR5_HUMAN

Solute carrier family 2, facilitated glucose transporter member 5

0.349

THIK_HUMAN

3-ketoacyl-CoA thiolase, peroxisomal

0.349

VPP2_HUMAN

V-type proton ATPase 116 kDa subunit a isoform 2

0.351

STXB3_HUMAN

Syntaxin-binding protein 3

0.353

QCR1_HUMAN

Cytochrome b-c1 complex subunit 1, mitochondrial

0.354

MRS2_HUMAN

Magnesium transporter MRS2 homolog, mitochondrial

0.355

LETM2_HUMAN

LETM1 domain-containing protein LETM2, mitochondrial

0.355

VP26A_HUMAN

Vacuolar protein sorting-associated protein 26A

0.359

HLTF_HUMAN

Helicase-like transcription factor

0.359

TBB3_HUMAN

Tubulin beta-3 chain

0.360

CBWD5_HUMAN

COBW domain-containing protein 5

0.360

CBWD1_HUMAN

COBW domain-containing protein 1

0.360

CBWD2_HUMAN

COBW domain-containing protein 2

0.360

CBWD3_HUMAN

COBW domain-containing protein 3

0.360

SH3Y1_HUMAN

SH3 domain-containing YSC84-like protein 1

0.363

TBA8_HUMAN

Tubulin alpha-8 chain

0.365

AMPD1_HUMAN

AMP deaminase 1

0.366

CBWD6_HUMAN

COBW domain-containing protein 6

0.367

GRPE2_HUMAN

GrpE protein homolog 2, mitochondrial

0.368

VA0D2_HUMAN

V-type proton ATPase subunit d 2

0.368

TBB6_HUMAN

Tubulin beta-6 chain

0.370

NAPSA_HUMAN

Napsin-A

0.370

AMPD3_HUMAN

AMP deaminase 3

0.371

CSK22_HUMAN

Casein kinase II subunit alpha

0.372

GNAZ_HUMAN

Guanine nucleotide-binding protein G(z) subunit alpha

0.372

ERG7_HUMAN

Lanosterol synthase

0.373

CP51A_HUMAN

Lanosterol 14-alpha demethylase

0.374

NB5R2_HUMAN

NADH-cytochrome b5 reductase 2

0.374

DNPEP_HUMAN

Aspartyl aminopeptidase

0.375

TMCO4_HUMAN

Transmembrane and coiled-coil domain-containing protein 4

0.375

MRP2_HUMAN

Canalicular multispecific organic anion transporter 1

0.376

NARF_HUMAN

Nuclear prelamin A recognition factor

0.376

FDFT_HUMAN

Squalene synthase

0.376

GTR9_HUMAN

Solute carrier family 2, facilitated glucose transporter member 9

0.376

MSMO1_HUMAN

Methylsterol monooxygenase 1

0.379

IDHP_HUMAN

Isocitrate dehydrogenase [NADP], mitochondrial

0.379

S47A1_HUMAN

Multidrug and toxin extrusion protein 1

0.380

ADT4_HUMAN

ADP/ATP translocase 4

0.381

AL1A3_HUMAN

Aldehyde dehydrogenase family 1 member A3

0.381

M3K3_HUMAN

Mitogen-activated protein kinase kinase kinase 3

0.381

ERG1_HUMAN

Squalene monooxygenase

0.382

NSDHL_HUMAN

Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

0.383

CATD_HUMAN

Cathepsin D

0.385

ACTC_HUMAN

Actin, alpha cardiac muscle 1

0.385

GNAT2_HUMAN

Guanine nucleotide-binding protein G(t) subunit alpha-2

0.385

HEM3_HUMAN

Porphobilinogen deaminase

0.386

TBA4A_HUMAN

Tubulin alpha-4A chain

0.386

M3K2_HUMAN

Mitogen-activated protein kinase kinase kinase 2

0.387

AK1A1_HUMAN

Aldo-keto reductase family 1 member A1

0.387

DNJA2_HUMAN

DnaJ homolog subfamily A member 2

0.388

MAOM_HUMAN

NAD-dependent malic enzyme, mitochondrial

0.388

SERC5_HUMAN

Serine incorporator 5

0.388

H2B1C_HUMAN

Histone H2B type 1-C/E/F/G/I

0.388

KDM5B_HUMAN

Lysine-specific demethylase 5B

0.388

H31_HUMAN

Histone H3.1

0.389

PP1B_HUMAN

Serine/threonine-protein phosphatase PP1-beta catalytic subunit

0.389

EPAB2_HUMAN

Embryonic polyadenylate-binding protein 2

0.389

NADK_HUMAN

NAD kinase

0.390

IMA5_HUMAN

Importin subunit alpha-5

0.390

1433E_HUMAN

14-3-3 protein epsilon

0.390

VATC2_HUMAN

V-type proton ATPase subunit C 2

0.391

UCHL1_HUMAN

Ubiquitin carboxyl-terminal hydrolase isozyme L1

0.391

PP1G_HUMAN

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

0.391

TRUB1_HUMAN

Probable tRNA pseudouridine synthase 1

0.391

OTC_HUMAN

Ornithine carbamoyltransferase, mitochondrial

0.392

DECR2_HUMAN

Peroxisomal 2,4-dienoyl-CoA reductase

0.392

ACTH_HUMAN

Actin, gamma-enteric smooth muscle

0.392

GSHR_HUMAN

Glutathione reductase, mitochondrial

0.392

GNAT1_HUMAN

Guanine nucleotide-binding protein G(t) subunit alpha-1

0.393

GTR11_HUMAN

Solute carrier family 2, facilitated glucose transporter member 11

0.393

GNAT3_HUMAN

Guanine nucleotide-binding protein G(t) subunit alpha-3

0.393

IMA7_HUMAN

Importin subunit alpha-7

0.394

TPC3L_HUMAN

Trafficking protein particle complex subunit 3-like protein

0.394

XPR1_HUMAN

Xenotropic and polytropic retrovirus receptor 1

0.394

GANC_HUMAN

Neutral alpha-glucosidase C

0.394

NB5R3_HUMAN

NADH-cytochrome b5 reductase 3

0.394

ASNS_HUMAN

Asparagine synthetase [glutamine-hydrolyzing]

0.394

DCR1A_HUMAN

DNA cross-link repair 1A protein

0.394

MPI_HUMAN

Mannose-6-phosphate isomerase

0.395

AP1M2_HUMAN

AP-1 complex subunit mu-2

0.395

HEM6_HUMAN

Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

0.395

HEM2_HUMAN

Delta-aminolevulinic acid dehydratase

0.395

TOP1_HUMAN

DNA topoisomerase 1

0.395

TAD2A_HUMAN

Transcriptional adapter 2-alpha

0.396

KIN17_HUMAN

DNA/RNA-binding protein KIN17

0.396

MON1B_HUMAN

Vacuolar fusion protein MON1 homolog B

0.396

GTR7_HUMAN

Solute carrier family 2, facilitated glucose transporter member 7

0.396

COQ4_HUMAN

Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial

0.396

NAA15_HUMAN

N-alpha-acetyltransferase 15, NatA auxiliary subunit

0.396

H2B2F_HUMAN

Histone H2B type 2-F

0.396

MPCP_HUMAN

Phosphate carrier protein, mitochondrial

0.396

FANCM_HUMAN

Fanconi anemia group M protein

0.396

VPP4_HUMAN

V-type proton ATPase 116 kDa subunit a isoform 4

0.397

PIR_HUMAN

Pirin

0.397

AL1A1_HUMAN

Retinal dehydrogenase 1

0.397

AP1G2_HUMAN

AP-1 complex subunit gamma-like 2

0.397

RL3L_HUMAN

60S ribosomal protein L3-like

0.398

DCUP_HUMAN

Uroporphyrinogen decarboxylase

0.398

MPPB_HUMAN

Mitochondrial-processing peptidase subunit beta

0.398

ADCK1_HUMAN

Uncharacterized aarF domain-containing protein kinase 1

0.398

EIF3B_HUMAN

Eukaryotic translation initiation factor 3 subunit B

0.399

RM03_HUMAN

39S ribosomal protein L3, mitochondrial

0.399

GLYC_HUMAN

Serine hydroxymethyltransferase, cytosolic

0.399

AFG1L_HUMAN

AFG1-like ATPase

0.399

TBB2B_HUMAN

Tubulin beta-2B chain

0.400

SF3B3_HUMAN

Splicing factor 3B subunit 3

0.400

OAT_HUMAN

Ornithine aminotransferase, mitochondrial

0.400

H2B2E_HUMAN

Histone H2B type 2-E

0.400

VPS35_HUMAN

Vacuolar protein sorting-associated protein 35

0.400

CISY_HUMAN

Citrate synthase, mitochondrial

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 110 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy