TBB6_HUMAN 2019

Gene Name TBB6

Description Tubulin beta-6 chain

Length 446

9606

Sequence

>sp|Q9BUF5|TBB6_HUMAN Tubulin beta-6 chain
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNFIFGQTGAGNNWAKGHYTEGAELVDAVLDVVRKECEHCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDARNMMAACDPRHGRYLTVATVFRGPMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRGLKMASTFIGNSTAIQELFKRISEQFSAMFRRKAFLHWFTGEGMDEMEFTEAESNMNDLVSEYQQYQDATANDGEEAFEDEEEEIDG

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

TBB3_HUMAN

Tubulin beta-3 chain

0.319

STXB3_HUMAN

Syntaxin-binding protein 3

0.393

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

TBB3_HUMAN

Tubulin beta-3 chain

0.266

VPP3_HUMAN

V-type proton ATPase 116 kDa subunit a isoform 3

0.287

TBA8_HUMAN

Tubulin alpha-8 chain

0.306

STXB3_HUMAN

Syntaxin-binding protein 3

0.322

VPP2_HUMAN

V-type proton ATPase 116 kDa subunit a isoform 2

0.328

VA0D2_HUMAN

V-type proton ATPase subunit d 2

0.335

ACTC_HUMAN

Actin, alpha cardiac muscle 1

0.338

HLTF_HUMAN

Helicase-like transcription factor

0.343

TBA4A_HUMAN

Tubulin alpha-4A chain

0.344

ACTA_HUMAN

Actin, aortic smooth muscle

0.344

AMPD1_HUMAN

AMP deaminase 1

0.347

CSK22_HUMAN

Casein kinase II subunit alpha

0.348

H31_HUMAN

Histone H3.1

0.355

ACTS_HUMAN

Actin, alpha skeletal muscle

0.358

TBB8_HUMAN

Tubulin beta-8 chain

0.358

MRS2_HUMAN

Magnesium transporter MRS2 homolog, mitochondrial

0.361

THIK_HUMAN

3-ketoacyl-CoA thiolase, peroxisomal

0.361

TBB5_HUMAN

Tubulin beta chain

0.362

QCR1_HUMAN

Cytochrome b-c1 complex subunit 1, mitochondrial

0.363

LETM2_HUMAN

LETM1 domain-containing protein LETM2, mitochondrial

0.364

TBB4A_HUMAN

Tubulin beta-4A chain

0.366

GTR9_HUMAN

Solute carrier family 2, facilitated glucose transporter member 9

0.367

ACTH_HUMAN

Actin, gamma-enteric smooth muscle

0.368

TBB2A_HUMAN

Tubulin beta-2A chain

0.369

ERG7_HUMAN

Lanosterol synthase

0.370

CATE_HUMAN

Cathepsin E

0.370

CP51A_HUMAN

Lanosterol 14-alpha demethylase

0.370

AMPD3_HUMAN

AMP deaminase 3

0.371

CBWD3_HUMAN

COBW domain-containing protein 3

0.372

CBWD5_HUMAN

COBW domain-containing protein 5

0.372

CBWD1_HUMAN

COBW domain-containing protein 1

0.372

CBWD2_HUMAN

COBW domain-containing protein 2

0.372

FDFT_HUMAN

Squalene synthase

0.373

GTR5_HUMAN

Solute carrier family 2, facilitated glucose transporter member 5

0.373

SC11B_HUMAN

Putative signal peptidase complex catalytic subunit SEC11B

0.374

DNPEP_HUMAN

Aspartyl aminopeptidase

0.374

CBWD6_HUMAN

COBW domain-containing protein 6

0.375

ERG1_HUMAN

Squalene monooxygenase

0.379

TBA1C_HUMAN

Tubulin alpha-1C chain

0.380

TBB2B_HUMAN

Tubulin beta-2B chain

0.381

SH3Y1_HUMAN

SH3 domain-containing YSC84-like protein 1

0.381

CLPB_HUMAN

Caseinolytic peptidase B protein homolog

0.383

RBBP7_HUMAN

Histone-binding protein RBBP7

0.384

CDK3_HUMAN

Cyclin-dependent kinase 3

0.384

GNAZ_HUMAN

Guanine nucleotide-binding protein G(z) subunit alpha

0.384

AK1A1_HUMAN

Aldo-keto reductase family 1 member A1

0.384

DNJA2_HUMAN

DnaJ homolog subfamily A member 2

0.385

NSDHL_HUMAN

Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

0.386

GNAT1_HUMAN

Guanine nucleotide-binding protein G(t) subunit alpha-1

0.387

ADCK2_HUMAN

Uncharacterized aarF domain-containing protein kinase 2

0.388

TBA3E_HUMAN

Tubulin alpha-3E chain

0.389

HS71L_HUMAN

Heat shock 70 kDa protein 1-like

0.389

GSHR_HUMAN

Glutathione reductase, mitochondrial

0.390

MSMO1_HUMAN

Methylsterol monooxygenase 1

0.391

IMA6_HUMAN

Importin subunit alpha-6

0.391

S47A1_HUMAN

Multidrug and toxin extrusion protein 1

0.391

GNAT2_HUMAN

Guanine nucleotide-binding protein G(t) subunit alpha-2

0.391

PP1B_HUMAN

Serine/threonine-protein phosphatase PP1-beta catalytic subunit

0.391

CERS4_HUMAN

Ceramide synthase 4

0.392

ADT4_HUMAN

ADP/ATP translocase 4

0.392

CDK2_HUMAN

Cyclin-dependent kinase 2

0.392

TKTL1_HUMAN

Transketolase-like protein 1

0.393

1433E_HUMAN

14-3-3 protein epsilon

0.393

PP1G_HUMAN

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

0.394

ERD23_HUMAN

ER lumen protein-retaining receptor 3

0.394

UB2D1_HUMAN

Ubiquitin-conjugating enzyme E2 D1

0.394

MRP2_HUMAN

Canalicular multispecific organic anion transporter 1

0.395

VP26A_HUMAN

Vacuolar protein sorting-associated protein 26A

0.395

M3K2_HUMAN

Mitogen-activated protein kinase kinase kinase 2

0.395

IMA5_HUMAN

Importin subunit alpha-5

0.396

GTR11_HUMAN

Solute carrier family 2, facilitated glucose transporter member 11

0.396

MAOM_HUMAN

NAD-dependent malic enzyme, mitochondrial

0.396

IMA7_HUMAN

Importin subunit alpha-7

0.396

AP1M2_HUMAN

AP-1 complex subunit mu-2

0.397

M3K3_HUMAN

Mitogen-activated protein kinase kinase kinase 3

0.398

NARF_HUMAN

Nuclear prelamin A recognition factor

0.398

RANG_HUMAN

Ran-specific GTPase-activating protein

0.398

FHIT_HUMAN

Bis(5-adenosyl)-triphosphatase

0.399

AP1S3_HUMAN

AP-1 complex subunit sigma-3

0.399

HSP76_HUMAN

Heat shock 70 kDa protein 6

0.399

TMCO4_HUMAN

Transmembrane and coiled-coil domain-containing protein 4

0.400

OTC_HUMAN

Ornithine carbamoyltransferase, mitochondrial

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 119 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy