TBA8_HUMAN 2019

Gene Name TBA8

Description Tubulin alpha-8 chain

Length 449

9606

Sequence

>sp|Q9NY65|TBA8_HUMAN Tubulin alpha-8 chain
MRECISVHVGQAGVQIGNACWELFCLEHGIQADGTFDAQASKINDDDSFTTFFSETGNGKHVPRAVMIDLEPTVVDEVRAGTYRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLDRIRKLTDACSGLQGFLIFHSFGGGTGSGFTSLLMERLSLDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPIISAEKAYHEQLSVAEITSSCFEPNSQMVKCDPRHGKYMACCMLYRGDVVPKDVNVAIAAIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGTDSFEEENEGEEF

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

TBA4A_HUMAN

Tubulin alpha-4A chain

0.345

TBB3_HUMAN

Tubulin beta-3 chain

0.395

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

VPP3_HUMAN

V-type proton ATPase 116 kDa subunit a isoform 3

0.253

TBA4A_HUMAN

Tubulin alpha-4A chain

0.287

VA0D2_HUMAN

V-type proton ATPase subunit d 2

0.304

TBB3_HUMAN

Tubulin beta-3 chain

0.305

TBB6_HUMAN

Tubulin beta-6 chain

0.306

H31_HUMAN

Histone H3.1

0.308

VPP2_HUMAN

V-type proton ATPase 116 kDa subunit a isoform 2

0.326

STXB3_HUMAN

Syntaxin-binding protein 3

0.327

AMPD1_HUMAN

AMP deaminase 1

0.327

CSK22_HUMAN

Casein kinase II subunit alpha

0.332

ACTH_HUMAN

Actin, gamma-enteric smooth muscle

0.336

HLTF_HUMAN

Helicase-like transcription factor

0.344

MRS2_HUMAN

Magnesium transporter MRS2 homolog, mitochondrial

0.345

ACTA_HUMAN

Actin, aortic smooth muscle

0.349

ACTC_HUMAN

Actin, alpha cardiac muscle 1

0.349

ACTS_HUMAN

Actin, alpha skeletal muscle

0.349

THIK_HUMAN

3-ketoacyl-CoA thiolase, peroxisomal

0.349

RBBP7_HUMAN

Histone-binding protein RBBP7

0.352

ADT4_HUMAN

ADP/ATP translocase 4

0.354

QCR1_HUMAN

Cytochrome b-c1 complex subunit 1, mitochondrial

0.355

TBA1C_HUMAN

Tubulin alpha-1C chain

0.357

CERS4_HUMAN

Ceramide synthase 4

0.358

CERS3_HUMAN

Ceramide synthase 3

0.358

TKTL1_HUMAN

Transketolase-like protein 1

0.361

GTR5_HUMAN

Solute carrier family 2, facilitated glucose transporter member 5

0.362

AMPD3_HUMAN

AMP deaminase 3

0.363

TBB2A_HUMAN

Tubulin beta-2A chain

0.364

LETM2_HUMAN

LETM1 domain-containing protein LETM2, mitochondrial

0.365

CATE_HUMAN

Cathepsin E

0.365

DNPEP_HUMAN

Aspartyl aminopeptidase

0.367

GTR7_HUMAN

Solute carrier family 2, facilitated glucose transporter member 7

0.367

CBWD1_HUMAN

COBW domain-containing protein 1

0.367

CBWD3_HUMAN

COBW domain-containing protein 3

0.367

CBWD2_HUMAN

COBW domain-containing protein 2

0.367

CBWD5_HUMAN

COBW domain-containing protein 5

0.367

AP1S3_HUMAN

AP-1 complex subunit sigma-3

0.367

GSHR_HUMAN

Glutathione reductase, mitochondrial

0.367

AL1A3_HUMAN

Aldehyde dehydrogenase family 1 member A3

0.369

CDK3_HUMAN

Cyclin-dependent kinase 3

0.370

MRP2_HUMAN

Canalicular multispecific organic anion transporter 1

0.370

ERG7_HUMAN

Lanosterol synthase

0.371

CP51A_HUMAN

Lanosterol 14-alpha demethylase

0.371

TBA3E_HUMAN

Tubulin alpha-3E chain

0.371

UB2D1_HUMAN

Ubiquitin-conjugating enzyme E2 D1

0.372

CBWD6_HUMAN

COBW domain-containing protein 6

0.373

EPAB2_HUMAN

Embryonic polyadenylate-binding protein 2

0.375

FDFT_HUMAN

Squalene synthase

0.377

AK1A1_HUMAN

Aldo-keto reductase family 1 member A1

0.377

VATC2_HUMAN

V-type proton ATPase subunit C 2

0.377

SC11B_HUMAN

Putative signal peptidase complex catalytic subunit SEC11B

0.377

AL1A1_HUMAN

Retinal dehydrogenase 1

0.378

ERD23_HUMAN

ER lumen protein-retaining receptor 3

0.378

TBB4A_HUMAN

Tubulin beta-4A chain

0.379

RL3L_HUMAN

60S ribosomal protein L3-like

0.379

GTR9_HUMAN

Solute carrier family 2, facilitated glucose transporter member 9

0.380

DNJA2_HUMAN

DnaJ homolog subfamily A member 2

0.380

MAOM_HUMAN

NAD-dependent malic enzyme, mitochondrial

0.380

TRUB1_HUMAN

Probable tRNA pseudouridine synthase 1

0.380

NSDHL_HUMAN

Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

0.380

CLPB_HUMAN

Caseinolytic peptidase B protein homolog

0.381

HS71L_HUMAN

Heat shock 70 kDa protein 1-like

0.381

NARF_HUMAN

Nuclear prelamin A recognition factor

0.382

FHIT_HUMAN

Bis(5-adenosyl)-triphosphatase

0.382

ERG1_HUMAN

Squalene monooxygenase

0.383

GNAT2_HUMAN

Guanine nucleotide-binding protein G(t) subunit alpha-2

0.383

PP1G_HUMAN

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

0.384

PP1B_HUMAN

Serine/threonine-protein phosphatase PP1-beta catalytic subunit

0.384

VPP4_HUMAN

V-type proton ATPase 116 kDa subunit a isoform 4

0.384

VP26A_HUMAN

Vacuolar protein sorting-associated protein 26A

0.385

SH3Y1_HUMAN

SH3 domain-containing YSC84-like protein 1

0.385

MSMO1_HUMAN

Methylsterol monooxygenase 1

0.386

NB5R2_HUMAN

NADH-cytochrome b5 reductase 2

0.386

S47A1_HUMAN

Multidrug and toxin extrusion protein 1

0.386

TMCO4_HUMAN

Transmembrane and coiled-coil domain-containing protein 4

0.387

TBA1B_HUMAN

Tubulin alpha-1B chain

0.387

AP1M2_HUMAN

AP-1 complex subunit mu-2

0.387

TBA3C_HUMAN

Tubulin alpha-3C chain

0.387

CDK2_HUMAN

Cyclin-dependent kinase 2

0.387

TBA3D_HUMAN

Tubulin alpha-3D chain

0.388

ADCK2_HUMAN

Uncharacterized aarF domain-containing protein kinase 2

0.388

GRPE2_HUMAN

GrpE protein homolog 2, mitochondrial

0.388

HSP76_HUMAN

Heat shock 70 kDa protein 6

0.388

S47A2_HUMAN

Multidrug and toxin extrusion protein 2

0.388

IMA5_HUMAN

Importin subunit alpha-5

0.391

TBB8_HUMAN

Tubulin beta-8 chain

0.391

IMA6_HUMAN

Importin subunit alpha-6

0.391

GNAZ_HUMAN

Guanine nucleotide-binding protein G(z) subunit alpha

0.393

GNAT3_HUMAN

Guanine nucleotide-binding protein G(t) subunit alpha-3

0.394

TBB5_HUMAN

Tubulin beta chain

0.394

TBB2B_HUMAN

Tubulin beta-2B chain

0.395

M3K3_HUMAN

Mitogen-activated protein kinase kinase kinase 3

0.396

PP1A_HUMAN

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

0.396

M3K2_HUMAN

Mitogen-activated protein kinase kinase kinase 2

0.396

1433E_HUMAN

14-3-3 protein epsilon

0.396

HSP72_HUMAN

Heat shock-related 70 kDa protein 2

0.397

THTR_HUMAN

Thiosulfate sulfurtransferase

0.397

TPC3L_HUMAN

Trafficking protein particle complex subunit 3-like protein

0.397

PSB10_HUMAN

Proteasome subunit beta type-10

0.397

RIR2B_HUMAN

Ribonucleoside-diphosphate reductase subunit M2 B

0.399

IDHP_HUMAN

Isocitrate dehydrogenase [NADP], mitochondrial

0.399

GTR11_HUMAN

Solute carrier family 2, facilitated glucose transporter member 11

0.399

IMA7_HUMAN

Importin subunit alpha-7

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 112 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy