ACTC_HUMAN 2019

Gene Name ACTC

Description Actin, alpha cardiac muscle 1

Length 377

9606

Sequence

>sp|P68032|ACTC_HUMAN Actin, alpha cardiac muscle 1
MCDDEETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

ACTA_HUMAN

Actin, aortic smooth muscle

0.251

ACTH_HUMAN

Actin, gamma-enteric smooth muscle

0.295

ACTS_HUMAN

Actin, alpha skeletal muscle

0.295

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

ACTA_HUMAN

Actin, aortic smooth muscle

0.234

ACTS_HUMAN

Actin, alpha skeletal muscle

0.238

ACTH_HUMAN

Actin, gamma-enteric smooth muscle

0.250

STXB3_HUMAN

Syntaxin-binding protein 3

0.308

VPP3_HUMAN

V-type proton ATPase 116 kDa subunit a isoform 3

0.319

VPP2_HUMAN

V-type proton ATPase 116 kDa subunit a isoform 2

0.325

TBB3_HUMAN

Tubulin beta-3 chain

0.330

VA0D2_HUMAN

V-type proton ATPase subunit d 2

0.336

TBB6_HUMAN

Tubulin beta-6 chain

0.338

HLTF_HUMAN

Helicase-like transcription factor

0.343

CSK22_HUMAN

Casein kinase II subunit alpha

0.345

AMPD1_HUMAN

AMP deaminase 1

0.347

CBWD5_HUMAN

COBW domain-containing protein 5

0.348

CBWD3_HUMAN

COBW domain-containing protein 3

0.348

CBWD2_HUMAN

COBW domain-containing protein 2

0.348

CBWD1_HUMAN

COBW domain-containing protein 1

0.348

TBA8_HUMAN

Tubulin alpha-8 chain

0.349

CBWD6_HUMAN

COBW domain-containing protein 6

0.351

SH3Y1_HUMAN

SH3 domain-containing YSC84-like protein 1

0.354

M3K3_HUMAN

Mitogen-activated protein kinase kinase kinase 3

0.354

THIK_HUMAN

3-ketoacyl-CoA thiolase, peroxisomal

0.355

H31_HUMAN

Histone H3.1

0.356

M3K2_HUMAN

Mitogen-activated protein kinase kinase kinase 2

0.358

GTR9_HUMAN

Solute carrier family 2, facilitated glucose transporter member 9

0.358

GTR5_HUMAN

Solute carrier family 2, facilitated glucose transporter member 5

0.358

DNPEP_HUMAN

Aspartyl aminopeptidase

0.360

FDFT_HUMAN

Squalene synthase

0.361

ERG7_HUMAN

Lanosterol synthase

0.361

TBA4A_HUMAN

Tubulin alpha-4A chain

0.363

FHIT_HUMAN

Bis(5-adenosyl)-triphosphatase

0.363

QCR1_HUMAN

Cytochrome b-c1 complex subunit 1, mitochondrial

0.363

CDK2_HUMAN

Cyclin-dependent kinase 2

0.364

MRS2_HUMAN

Magnesium transporter MRS2 homolog, mitochondrial

0.364

CP51A_HUMAN

Lanosterol 14-alpha demethylase

0.364

CLPB_HUMAN

Caseinolytic peptidase B protein homolog

0.367

OTC_HUMAN

Ornithine carbamoyltransferase, mitochondrial

0.371

AMPD3_HUMAN

AMP deaminase 3

0.371

S47A1_HUMAN

Multidrug and toxin extrusion protein 1

0.374

ERG1_HUMAN

Squalene monooxygenase

0.376

LETM2_HUMAN

LETM1 domain-containing protein LETM2, mitochondrial

0.376

DNJA2_HUMAN

DnaJ homolog subfamily A member 2

0.377

1433E_HUMAN

14-3-3 protein epsilon

0.377

MRP2_HUMAN

Canalicular multispecific organic anion transporter 1

0.378

GNAZ_HUMAN

Guanine nucleotide-binding protein G(z) subunit alpha

0.378

AK1A1_HUMAN

Aldo-keto reductase family 1 member A1

0.379

RANG_HUMAN

Ran-specific GTPase-activating protein

0.379

NSDHL_HUMAN

Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

0.380

IDHP_HUMAN

Isocitrate dehydrogenase [NADP], mitochondrial

0.382

TMCO4_HUMAN

Transmembrane and coiled-coil domain-containing protein 4

0.384

VP26A_HUMAN

Vacuolar protein sorting-associated protein 26A

0.384

MAOM_HUMAN

NAD-dependent malic enzyme, mitochondrial

0.385

MSMO1_HUMAN

Methylsterol monooxygenase 1

0.385

CATE_HUMAN

Cathepsin E

0.385

ERD23_HUMAN

ER lumen protein-retaining receptor 3

0.386

DECR2_HUMAN

Peroxisomal 2,4-dienoyl-CoA reductase

0.386

GSHR_HUMAN

Glutathione reductase, mitochondrial

0.387

GNAT1_HUMAN

Guanine nucleotide-binding protein G(t) subunit alpha-1

0.387

TBB5_HUMAN

Tubulin beta chain

0.388

IMA7_HUMAN

Importin subunit alpha-7

0.388

TBA1C_HUMAN

Tubulin alpha-1C chain

0.389

PP1B_HUMAN

Serine/threonine-protein phosphatase PP1-beta catalytic subunit

0.389

HS71L_HUMAN

Heat shock 70 kDa protein 1-like

0.389

AP1M2_HUMAN

AP-1 complex subunit mu-2

0.389

CDK3_HUMAN

Cyclin-dependent kinase 3

0.390

IMA5_HUMAN

Importin subunit alpha-5

0.390

PP1G_HUMAN

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

0.391

SERC5_HUMAN

Serine incorporator 5

0.394

TRUB1_HUMAN

Probable tRNA pseudouridine synthase 1

0.394

UNG_HUMAN

Uracil-DNA glycosylase

0.394

TBB2A_HUMAN

Tubulin beta-2A chain

0.395

CMBL_HUMAN

Carboxymethylenebutenolidase homolog

0.395

PPGB_HUMAN

Lysosomal protective protein

0.395

NARF_HUMAN

Nuclear prelamin A recognition factor

0.395

GTR11_HUMAN

Solute carrier family 2, facilitated glucose transporter member 11

0.396

ADCK2_HUMAN

Uncharacterized aarF domain-containing protein kinase 2

0.396

SC5D_HUMAN

Lathosterol oxidase

0.396

ABCG2_HUMAN

ATP-binding cassette sub-family G member 2

0.396

CD123_HUMAN

Cell division cycle protein 123 homolog

0.397

GNAT2_HUMAN

Guanine nucleotide-binding protein G(t) subunit alpha-2

0.397

XPOT_HUMAN

Exportin-T

0.397

RBBP7_HUMAN

Histone-binding protein RBBP7

0.397

IF2G_HUMAN

Eukaryotic translation initiation factor 2 subunit 3

0.398

GTR7_HUMAN

Solute carrier family 2, facilitated glucose transporter member 7

0.399

TBA1B_HUMAN

Tubulin alpha-1B chain

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 123 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy