TM242_HUMAN 2019

Gene Name TM242

Description Transmembrane protein 242

Length 141

9606

Sequence

>sp|Q9NWH2|TM242_HUMAN Transmembrane protein 242
METAGAATGQPASGLEAPGSTNDRLFLVKGGIFLGTVAAAGMLAGFITTLSLAKKKSPEWFNKGSMATAALPESGSSLALRALGWGSLYAWCGVGVISFAVWKALGVHSMNDFRSKMQSIFPTIPKNSESAVEWEETLKSK

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

MMS22_HUMAN

Protein MMS22-like

0.281

F1142_HUMAN

Protein FAM114A2

0.345

CC28B_HUMAN

Coiled-coil domain-containing protein 28B

0.349

RASF2_HUMAN

Ras association domain-containing protein 2

0.354

DRD5_HUMAN

D(1B) dopamine receptor

0.358

ENOX1_HUMAN

Ecto-NOX disulfide-thiol exchanger 1

0.358

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.374

TXD11_HUMAN

Thioredoxin domain-containing protein 11

0.374

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.378

LMBL3_HUMAN

Lethal(3)malignant brain tumor-like protein 3

0.378

NXP20_HUMAN

Protein NOXP20

0.378

ELL2_HUMAN

RNA polymerase II elongation factor ELL2

0.383

WNT1_HUMAN

Proto-oncogene Wnt-1

0.383

NEUL2_HUMAN

Neuralized-like protein 2

0.383

TNR6C_HUMAN

Trinucleotide repeat-containing gene 6C protein

0.387

NKRF_HUMAN

NF-kappa-B-repressing factor

0.387

RASF6_HUMAN

Ras association domain-containing protein 6

0.387

ID2_HUMAN

DNA-binding protein inhibitor ID-2

0.387

MBD5_HUMAN

Methyl-CpG-binding domain protein 5

0.387

SHRM2_HUMAN

Protein Shroom2

0.387

TM192_HUMAN

Transmembrane protein 192

0.392

K0825_HUMAN

Uncharacterized protein KIAA0825

0.392

DFFB_HUMAN

DNA fragmentation factor subunit beta

0.397

PHC2_HUMAN

Polyhomeotic-like protein 2

0.399

AXIN1_HUMAN

Axin-1

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.322

NRF1_HUMAN

Nuclear respiratory factor 1

0.326

DSCL1_HUMAN

Down syndrome cell adhesion molecule-like protein 1

0.328

FRITZ_HUMAN

WD repeat-containing and planar cell polarity effector protein fritz homolog

0.336

K0825_HUMAN

Uncharacterized protein KIAA0825

0.342

CUED2_HUMAN

CUE domain-containing protein 2

0.349

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.350

USH1G_HUMAN

Usher syndrome type-1G protein

0.354

NEUL2_HUMAN

Neuralized-like protein 2

0.355

PHC2_HUMAN

Polyhomeotic-like protein 2

0.357

AXIN1_HUMAN

Axin-1

0.358

RASF2_HUMAN

Ras association domain-containing protein 2

0.359

DFFB_HUMAN

DNA fragmentation factor subunit beta

0.360

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.361

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.362

MYD88_HUMAN

Myeloid differentiation primary response protein MyD88

0.364

RASF6_HUMAN

Ras association domain-containing protein 6

0.367

CRBL2_HUMAN

cAMP-responsive element-binding protein-like 2

0.370

OAF_HUMAN

Out at first protein homolog

0.372

TDRKH_HUMAN

Tudor and KH domain-containing protein

0.372

TNR6C_HUMAN

Trinucleotide repeat-containing gene 6C protein

0.372

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.373

ENOX1_HUMAN

Ecto-NOX disulfide-thiol exchanger 1

0.373

GABPA_HUMAN

GA-binding protein alpha chain

0.374

NMBR_HUMAN

Neuromedin-B receptor

0.374

DCA10_HUMAN

DDB1- and CUL4-associated factor 10

0.376

SYTL4_HUMAN

Synaptotagmin-like protein 4

0.376

CHSTB_HUMAN

Carbohydrate sulfotransferase 11

0.376

AREL1_HUMAN

Apoptosis-resistant E3 ubiquitin protein ligase 1

0.377

RHBT2_HUMAN

Rho-related BTB domain-containing protein 2

0.377

TSP4_HUMAN

Thrombospondin-4

0.377

ZN704_HUMAN

Zinc finger protein 704

0.377

INTU_HUMAN

Protein inturned

0.378

TDRD9_HUMAN

ATP-dependent RNA helicase TDRD9

0.379

DSCAM_HUMAN

Down syndrome cell adhesion molecule

0.379

RHG19_HUMAN

Rho GTPase-activating protein 19

0.380

RXFP1_HUMAN

Relaxin receptor 1

0.380

MBD5_HUMAN

Methyl-CpG-binding domain protein 5

0.381

ETV6_HUMAN

Transcription factor ETV6

0.381

HOME1_HUMAN

Homer protein homolog 1

0.383

SPSY_HUMAN

Spermine synthase

0.383

NKRF_HUMAN

NF-kappa-B-repressing factor

0.384

MGST1_HUMAN

Microsomal glutathione S-transferase 1

0.386

RECK_HUMAN

Reversion-inducing cysteine-rich protein with Kazal motifs

0.386

TET3_HUMAN

Methylcytosine dioxygenase TET3

0.388

CDR2_HUMAN

Cerebellar degeneration-related protein 2

0.388

UBP1_HUMAN

Ubiquitin carboxyl-terminal hydrolase 1

0.389

GPM6A_HUMAN

Neuronal membrane glycoprotein M6-a

0.390

DALD3_HUMAN

DALR anticodon-binding domain-containing protein 3

0.390

INPP_HUMAN

Inositol polyphosphate 1-phosphatase

0.393

CHRD_HUMAN

Chordin

0.393

BD1L1_HUMAN

Biorientation of chromosomes in cell division protein 1-like 1

0.395

TET2_HUMAN

Methylcytosine dioxygenase TET2

0.395

BOD1_HUMAN

Biorientation of chromosomes in cell division protein 1

0.395

ID2_HUMAN

DNA-binding protein inhibitor ID-2

0.395

CC28A_HUMAN

Coiled-coil domain-containing protein 28A

0.396

CRERF_HUMAN

CREB3 regulatory factor

0.396

SYTL5_HUMAN

Synaptotagmin-like protein 5

0.397

GCM2_HUMAN

Chorion-specific transcription factor GCMb

0.397

SUFU_HUMAN

Suppressor of fused homolog

0.397

CTCF_HUMAN

Transcriptional repressor CTCF

0.399

YAP1_HUMAN

Transcriptional coactivator YAP1

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 38 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy