T183A_HUMAN 2019

Gene Name T183A

Description Transmembrane protein 183A

Length 376

9606

Sequence

>sp|Q8IXX5|T183A_HUMAN Transmembrane protein 183A
MARGPGPLGRPRPDTVAMPKRGKRLKFRAHDACSGRVTVADYANSDPAVVRSGRVKKAVANAVQQEVKSLCGLEASQVPAEEALSGAGEPCDIIDSSDEMDAQEESIHERTVSRKKKSKRHKEELDGAGGEEYPMDIWLLLASYIRPEDIVNFSLICKNAWTVTCTAAFWTRLYRRHYTLDASLPLRLRPESMEKLRCLRACVIRSLYHMYEPFAARISKNPAIPESTPSTLKNSKCLLFWCRKIVGNRQEPMWEFNFKFKKQSPRLKSKCTGGLQPPVQYEDVHTNPDQDCCLLQVTTLNFIFIPIVMGMIFTLFTINVSTDMRHHRVRLVFQDSPVHGGRKLRSEQGVQVILDPVHSVRLFDWWHPQYPFSLRA

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

T183B_HUMAN

Transmembrane protein 183B

0.174

CHRD_HUMAN

Chordin

0.329

NR2E1_HUMAN

Nuclear receptor subfamily 2 group E member 1

0.329

UBP1_HUMAN

Ubiquitin carboxyl-terminal hydrolase 1

0.338

SHRM2_HUMAN

Protein Shroom2

0.368

VGLL2_HUMAN

Transcription cofactor vestigial-like protein 2

0.368

BCAP_HUMAN

Phosphoinositide 3-kinase adapter protein 1

0.373

RASD1_HUMAN

Dexamethasone-induced Ras-related protein 1

0.373

NKD1_HUMAN

Protein naked cuticle homolog 1

0.383

NRBF2_HUMAN

Nuclear receptor-binding factor 2

0.383

PRGC1_HUMAN

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

0.383

SPRC_HUMAN

SPARC

0.392

PA2G3_HUMAN

Group 3 secretory phospholipase A2

0.397

SOCS5_HUMAN

Suppressor of cytokine signaling 5

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

UBP1_HUMAN

Ubiquitin carboxyl-terminal hydrolase 1

0.309

CHRD_HUMAN

Chordin

0.316

ETV6_HUMAN

Transcription factor ETV6

0.318

BCAP_HUMAN

Phosphoinositide 3-kinase adapter protein 1

0.330

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.332

CUED2_HUMAN

CUE domain-containing protein 2

0.335

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.342

NKD1_HUMAN

Protein naked cuticle homolog 1

0.343

RSLAB_HUMAN

Ras-like protein family member 10B

0.347

DFFB_HUMAN

DNA fragmentation factor subunit beta

0.347

GTSF1_HUMAN

Gametocyte-specific factor 1

0.348

CCD43_HUMAN

Coiled-coil domain-containing protein 43

0.352

JARD2_HUMAN

Protein Jumonji

0.357

KAZRN_HUMAN

Kazrin

0.360

TNR6C_HUMAN

Trinucleotide repeat-containing gene 6C protein

0.360

ENOX1_HUMAN

Ecto-NOX disulfide-thiol exchanger 1

0.361

F234B_HUMAN

Protein FAM234B

0.362

NRF1_HUMAN

Nuclear respiratory factor 1

0.362

SPT2_HUMAN

Protein SPT2 homolog

0.362

GPM6A_HUMAN

Neuronal membrane glycoprotein M6-a

0.364

CHSTB_HUMAN

Carbohydrate sulfotransferase 11

0.364

PRGC1_HUMAN

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

0.367

ZN318_HUMAN

Zinc finger protein 318

0.369

ID2_HUMAN

DNA-binding protein inhibitor ID-2

0.369

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.369

VGLL2_HUMAN

Transcription cofactor vestigial-like protein 2

0.372

NKRF_HUMAN

NF-kappa-B-repressing factor

0.372

KIBRA_HUMAN

Protein KIBRA

0.373

CTCF_HUMAN

Transcriptional repressor CTCF

0.373

TCF21_HUMAN

Transcription factor 21

0.374

RECK_HUMAN

Reversion-inducing cysteine-rich protein with Kazal motifs

0.374

T183B_HUMAN

Transmembrane protein 183B

0.375

OAF_HUMAN

Out at first protein homolog

0.376

TDRKH_HUMAN

Tudor and KH domain-containing protein

0.376

IKKA_HUMAN

Inhibitor of nuclear factor kappa-B kinase subunit alpha

0.377

MSL2_HUMAN

E3 ubiquitin-protein ligase MSL2

0.378

K0825_HUMAN

Uncharacterized protein KIAA0825

0.378

DSCL1_HUMAN

Down syndrome cell adhesion molecule-like protein 1

0.379

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.379

AREL1_HUMAN

Apoptosis-resistant E3 ubiquitin protein ligase 1

0.380

NOL11_HUMAN

Nucleolar protein 11

0.380

INTU_HUMAN

Protein inturned

0.381

SMO_HUMAN

Smoothened homolog

0.381

HLX_HUMAN

H2.0-like homeobox protein

0.382

TDRD9_HUMAN

ATP-dependent RNA helicase TDRD9

0.382

MYD88_HUMAN

Myeloid differentiation primary response protein MyD88

0.383

USH1C_HUMAN

Harmonin

0.384

PA2G3_HUMAN

Group 3 secretory phospholipase A2

0.384

RHG19_HUMAN

Rho GTPase-activating protein 19

0.384

IKKB_HUMAN

Inhibitor of nuclear factor kappa-B kinase subunit beta

0.384

SIX4_HUMAN

Homeobox protein SIX4

0.385

PQLC3_HUMAN

PQ-loop repeat-containing protein 3

0.385

SPSY_HUMAN

Spermine synthase

0.387

USH1G_HUMAN

Usher syndrome type-1G protein

0.387

CRBL2_HUMAN

cAMP-responsive element-binding protein-like 2

0.388

ZCH18_HUMAN

Zinc finger CCCH domain-containing protein 18

0.388

GSAP_HUMAN

Gamma-secretase-activating protein

0.389

XYLK_HUMAN

Glycosaminoglycan xylosylkinase

0.389

GNMT_HUMAN

Glycine N-methyltransferase

0.390

LYSC_HUMAN

Lysozyme C

0.391

TWSG1_HUMAN

Twisted gastrulation protein homolog 1

0.391

NINJ1_HUMAN

Ninjurin-1

0.392

SAPC2_HUMAN

Suppressor APC domain-containing protein 2

0.392

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.392

CP110_HUMAN

Centriolar coiled-coil protein of 110 kDa

0.393

DCA10_HUMAN

DDB1- and CUL4-associated factor 10

0.393

SPY4_HUMAN

Protein sprouty homolog 4

0.394

ZN704_HUMAN

Zinc finger protein 704

0.395

TSP4_HUMAN

Thrombospondin-4

0.395

CIDEC_HUMAN

Cell death activator CIDE-3

0.395

SOBP_HUMAN

Sine oculis-binding protein homolog

0.396

SPIR1_HUMAN

Protein spire homolog 1

0.397

HPS4_HUMAN

Hermansky-Pudlak syndrome 4 protein

0.398

MBD5_HUMAN

Methyl-CpG-binding domain protein 5

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 33 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy